CAS 154361-50-9

Capecitabine

Description:

Capecitabine is an oral chemotherapeutic agent primarily used in the treatment of various cancers, including colorectal and breast cancer. It is a prodrug, meaning it is metabolized in the body to its active form, 5-fluorouracil (5-FU), which interferes with DNA synthesis and inhibits tumor growth. Capecitabine is characterized by its ability to selectively target cancer cells, which enhances its efficacy while minimizing damage to normal tissues. The compound is typically administered in a tablet form and is known for its favorable pharmacokinetic profile, allowing for convenient dosing schedules. Its mechanism of action involves the inhibition of thymidylate synthase, an enzyme critical for DNA replication. Capecitabine is generally well-tolerated, but it can cause side effects such as gastrointestinal disturbances, hand-foot syndrome, and myelosuppression. The drug's effectiveness can be influenced by genetic factors, particularly variations in enzymes involved in its metabolism, making pharmacogenomic testing relevant in some cases. Overall, capecitabine represents a significant advancement in targeted cancer therapy.

Formula: C₁₅H₂₂FN₃O₆

InChI: InChI=1S/C15H22FN3O6/c1-3-4-5-6-24-15(23)18-12-9(16)7-19(14(22)17-12)13-11(21)10(20)8(2)25-13/h7-8,10-11,13,20-21H,3-6H2,1-2H3,(H,17,18,22,23)/t8-,10-,11-,13-/m1/s1

InChI key: InChIKey=GAGWJHPBXLXJQN-UORFTKCHSA-N

SMILES: O[C@H]1[C@@H](O[C@H](C)[C@H]1O)N2C(=O)N=C(NC(OCCCCC)=O)C(F)=C2

Synonyms:

• 1-(5-deoxypentofuranosyl)-5-fluoro-4-{[(pentyloxy)carbonyl]amino}pyrimidin-2(1H)-one
• 5-Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine
• 5′-Deoxy-5-fluoro-N⁴-(pentyloxycarbonyl)cytidine
• Capacetrine
• Capecitabine Accord
• Capecitabine Medac
• Capecitabine SUN
• Capecitabine Teva
• Capecitibine
• Capecytabine
• Capiibine
• Captabin
• Carbamic acid, [1-(5-deoxy-β-<span class="text-smallcaps">D</span>-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl]-, pentyl ester
• Cytidine, 5′-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]-
• Ecansya
• N4-[(pentyloxy)carbonyl]-5'-deoxy-5-fluorocytidine
• N⁴-Pentyloxycarbonyl-5′-deoxy-5-fluorocytidine
• Pentyl [1-(3,4-dihydroxy-5-methyl-oxolan-2-yl)-5-fluoro-2-oxo-pyrimidin-4-yl]aminoformate
• R-340
• Ro 09-1978/000
• Ro-09-1978
• Xeloda
• Xeltabin
• Carbamic acid, [1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl]-, pentyl ester

Capecitabine

CAS: 154361-50-9

Formula: C₁₅H₂₂FN₃O₆

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 359.35

Ref: 3B-C2878

CAPECITABINE CRS

CAS: 154361-50-9

CAPECITABINE CRS

Formula: C₁₅H₂₂FN₃O₆

Color and Shape: White. Whitish. Powder.

Molecular weight: 359.3501

Ref: 41-Y0001642

Capecitabine

CAS: 154361-50-9

Capecitabine

Formula: C₁₅H₂₂FN₃O₆

Purity: 99.9%

Color and Shape: White

Molecular weight: 359.14926

Ref: 47-1229

Capecitabine

CAS: 154361-50-9

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₁₅H₂₂FN₃O₆

Color and Shape: White Off-White Powder

Molecular weight: 359.14926

Ref: 45-1090706

5'-Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine

CAS: 154361-50-9

Formula: C₁₅H₂₂FN₃O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 359.3501

Ref: IN-DA00389L

Capecitabine

CAS: 154361-50-9

Capecitabine is a prodrug in the antimetabolite class, transformed into cytotoxic 5-FU by tumor cells, inhibiting DNA and RNA synthesis.

Formula: C₁₅H₂₂FN₃O₆

Purity: 99.81% - >99.99%

Color and Shape: Less Solid Colourless Solid

Molecular weight: 359.35

Ref: TM-T1408

Capecitabine, EP grade

CAS: 154361-50-9

Formula: C₁₅H₂₂FN₃O₆

Purity: 98.0 - 102.0 % (anhydrous substance)

Color and Shape: White or almost white powder

Molecular weight: 359.35

Ref: 7W-GP3241

Capecitabine

CAS: 154361-50-9

Capecitabine

Purity: 98%

Molecular weight: 359.35g/mol

Ref: 54-PC109245

Capecitabine

CAS: 154361-50-9

Formula: C₁₅H₂₂FN₃O₆

Purity: 98.0 - 102.0 % (dried basis)

Color and Shape: White to off-white powder

Molecular weight: 359.35

Ref: 7W-GP6220

Capecitabine

CAS: 154361-50-9

Formula: C₁₅H₂₂FN₃O₆

Color and Shape: White To Off-White Solid

Molecular weight: 359.35

Ref: 4Z-C-352

Capecitabine

CAS: 154361-50-9

Capecitabine

Purity: ≥98%

Molecular weight: 359.35g/mol

Ref: 54-BUP18473

Capecitabine

Controlled Product

CAS: 154361-50-9

Applications Capecitabine is an antineoplastic agent. Capecitabine is a prodrug of Doxifluridine (D556750).
References Muss, H., et al.: New Eng. J. Med., 360, 2055 (2009), Takahashi, S., et al.: Drug Metab. Disposition, 37, 956 (2009), Saltz, L., et al.: J. Clin. Oncol., 27, 653 (2009), Sanderson, H., et al.: Toxicol. Lett., 187, 84 (2009),

Formula: C₁₅H₂₂FN₃O₆

Color and Shape: Neat

Molecular weight: 359.35

Ref: TR-C175650

Capecitabine

CAS: 154361-50-9

Pro-drug of 5-FU; anti-cancer agent

Formula: C₁₅H₂₂FN₃O₆

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 359.35 g/mol

Ref: 3D-ND09160

Capecitabine - Bio-X ™

CAS: 154361-50-9

Capecitabine is a chemotherapeutic agent that is used in the treatment of various cancers such as gastrointestinal, breast and pancreatic. This drug is a nucleotide metabolic inhibitor and inhibits DNA synthesis and slows the growth of tumor tissue. It is a prodrug of Fluorouracil.

Formula: C₁₅H₂₂FN₃O₆

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 359.35 g/mol

Ref: 3D-BC164277

Capecitibine

CAS: 154361-50-9

Formula: C₁₅H₂₂FN₃O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 359.354

Ref: 10-F048966

Capecitabine

Controlled Product

CAS: 154361-50-9

Formula: C₁₅H₂₂FN₃O₆

Color and Shape: Neat

Molecular weight: 359.35

Ref: 86-MM0992.00