CAS 168079-32-1: Lixivaptan

Description: Lixivaptan is a selective vasopressin V2 receptor antagonist, primarily used in the treatment of conditions associated with excessive vasopressin, such as hyponatremia and certain forms of heart failure. It functions by inhibiting the action of vasopressin on the kidneys, leading to increased water excretion without significant electrolyte loss. This mechanism helps to correct fluid imbalances in patients. Lixivaptan is characterized by its chemical structure, which includes a specific arrangement of atoms that contributes to its pharmacological activity. It is typically administered orally and has a favorable pharmacokinetic profile, allowing for once-daily dosing. The substance is also noted for its relatively low potential for drug interactions, making it a suitable option for patients on multiple medications. As with any medication, potential side effects may include dehydration, hypotension, and electrolyte imbalances, necessitating careful monitoring during treatment. Overall, lixivaptan represents a targeted approach to managing disorders related to vasopressin dysregulation.

Formula: C₂₇H₂₁ClFN₃O₂

InChI: InChI=1S/C27H21ClFN3O2/c1-17-8-9-19(29)13-23(17)26(33)30-20-10-11-22(24(28)14-20)27(34)32-16-21-6-4-12-31(21)15-18-5-2-3-7-25(18)32/h2-14H,15-16H2,1H3,(H,30,33)

InChI key: InChIKey=PPHTXRNHTVLQED-UHFFFAOYSA-N

SMILES: O=C(NC1=CC=C(C(Cl)=C1)C(=O)N2C=3C=CC=CC3CN4C=CC=C4C2)C5=CC(F)=CC=C5C

Synonyms:

• Benzamide, N-[3-chloro-4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-ylcarbonyl)phenyl]-5-fluoro-2-methyl-
• N-[3-Chloro-4-(10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-10-ylcarbonyl)phenyl]-5-fluoro-2-methylbenzamide
• N-[3-chloro-4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-ylcarbonyl)phenyl]-5-fluoro-2-methylbenzamide
• Vpa-985
• Way-Vpa-985
• Lixivaptan

Benzamide, N-[3-chloro-4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-ylcarbonyl)phenyl]-5-fluoro-2-methyl-

CAS: 168079-32-1

• Formula: C₂₇H₂₁ClFN₃O₂
• Purity: 99%
• Color and Shape: Solid
• Molecular weight: 473.9259

N-(3-Chloro-4-(10,11-Dihydro-5H-Benzo[e]Pyrrolo[1,2-a][1,4]Diazepine-10-Carbonyl)Phenyl)-5-Fluoro-2-Methylbenzamide

CAS: 168079-32-1

• Purity: 95%
• Molecular weight: 473.93g/mol

LIXIVAPTAN

CAS: 168079-32-1

• Purity: 99%
• Molecular weight: 473.93g/mol

LIXIVAPTAN

CAS: 168079-32-1

Lixivaptan (VPA-985) is an orally active and selective vasopressin receptor V2 antagonist(Ki = 2.3 nM)

• Formula: C₂₇H₂₁ClFN₃O₂
• Purity: 98.36%
• Color and Shape: Solid
• Molecular weight: 473.93

Lixivaptan

CAS: 168079-32-1

Applications Drug used in the treatment and prevention of cardiovascular diseases. References Lo, R., et …

• Formula: C₂₇H₂₁ClFN₃O₂
• Color and Shape: Neat
• Molecular weight: 473.93

Lixivaptan

CAS: 168079-32-1

Selective vasopressin receptor V2 agonist

• Formula: C₂₇H₂₁ClFN₃O₂
• Purity: Min. 95%
• Color and Shape: Yellow Powder
• Molecular weight: 473.93 g/mol