CAS 27848-84-6: Nicergoline

Description: Nicergoline is a synthetic compound classified as an ergoline derivative, primarily used for its neuroprotective and cognitive-enhancing properties. It is known for its ability to improve cerebral blood flow and enhance oxygen utilization in the brain, making it beneficial in treating cognitive disorders associated with aging and vascular issues. Nicergoline exhibits a complex structure, featuring a bicyclic ring system characteristic of ergolines, and it is typically administered in the form of its mesylate salt. The substance is soluble in water and exhibits moderate lipophilicity, allowing it to cross the blood-brain barrier effectively. Its pharmacological effects are attributed to its action as an alpha-adrenergic antagonist and a serotonin receptor modulator, which contribute to its vasodilatory effects. Nicergoline is generally well-tolerated, with a side effect profile that may include dizziness, gastrointestinal disturbances, and headache. Due to its cognitive-enhancing properties, it has been explored in various clinical settings, particularly in the management of dementia and other cognitive impairments.

Formula: C₂₄H₂₆BrN₃O₃

InChI: InChI=1S/C24H26BrN3O3/c1-27-13-17-8-21-24(30-3,19-5-4-6-20(27)22(17)19)9-15(12-28(21)2)14-31-23(29)16-7-18(25)11-26-10-16/h4-7,10-11,13,15,21H,8-9,12,14H2,1-3H3/t15-,21-,24+/m1/s1

InChI key: InChIKey=YSEXMKHXIOCEJA-FVFQAYNVSA-N

SMILES: O=C(OCC1CN(C)C2CC3=CN(C4=CC=CC(=C43)C2(OC)C1)C)C=5C=NC=C(Br)C5

Synonyms:

• (+)-10-Methoxy-1,6-dimethylergoline-8-beta-methanol 5-bromonicotinate
• (10-Methoxy-1,6-Dimethylergolin-8-Yl)Methyl 5-Bromopyridine-3-Carboxylate
• (8β)-10-Methoxy-1,6-dimethylergoline-8-methanol-5-bromo-3-pyridinecarboxylate ester
• 1,6-Dimethyl-8β-(5-bromonicotinoyloxymethyl)-10α-methoxyergoline
• 1-Methyl-lumilysergol 8-(5-bromonicotinate) 10-methyl ether
• 10-Methoxy-1,6-dimethyl-ergolin-8-beta-methanol-(5-bromnicotinat)
• 10-Methoxy-1,6-dimethyl-ergolin-8-beta-methanol-(5-bromnicotinat) [German]
• 10-Methoxy-1,6-dimethylergoline-8-methanol 5-bromo-3-pyrindinecarboxylate (ester)
• 10-Methoxy-1,6-dimethylergoline-8beta-methanol 5-bromonicotinate
• 10-Methoxy-1,6-dimethylergoline-8beta-methanol 5-bromonicotinate (ester)
• 8-beta-((5-Bromonicotinoyloxy)methyl)-1,6-dimethyl-10-alpha-methoxyergoline
• Brn 4828393
• Cergodum
• Circo-Maren
• Dilasenil
• Duracebrol
• Ergobel
• Ergoline-8-beta-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester)
• Ergoline-8-beta-methanol, 10-methoxy-1,6-dimethyl-, 5-bromonicotinate (ester)
• Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, (8beta)-, 5-bromo-3-pyridinecarboxylate (ester)
• Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester), (8beta)-
• Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester), (8β)-
• Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 8-(5-bromo-3-pyridinecarboxylate), (8β)-
• Ergoline-8beta-methanol, 10-methoxy-1,6-dimethyl-, 5-bromonicotinate (ester) (8CI)
• Ergoline-8β-methanol, 10-methoxy-1,6-dimethyl-, 5-bromonicotinate (ester)
• Ergotop
• Fi 6714
• Indolo[4,3-fg]quinoline, ergoline-8-methanol deriv.
• MNE
• Memoq
• Nicergolent
• Nicergolin
• Nicergolin [German]
• Nicergolina
• Nicergolina [DCIT]
• Nicergoline [USAN:INN:BAN:JAN]
• Nicergolinum
• Nicergolinum [INN-Latin]
• Nicotergoline
• Nicotinic acid, 5-bromo-, (10-methoxy-1,6-dimethylergolin-8β-yl)methyl ester
• Nimergoline
• Nimergoline base
• Nsc 150531
• Rp 19651
• Sermion
• Ta 079
• Unii-Jcv8365Fwn
• Vasospan
• [(8Beta)-10-Methoxy-1,6-Dimethylergolin-6-Ium-8-Yl]Methyl 5-Bromopyridine-3-Carboxylate
• [(8Beta)-10-Methoxy-1,6-Dimethylergolin-8-Yl]Methyl 5-Bromopyridine-3-Carboxylate

Nicergoline

CAS: 27848-84-6

Nicergoline is an ergot derivative and vasodilator which increases blood flow in the brain. Nicergoline …

• Formula: C₂₄H₂₇BrN₃O₃
• Color and Shape: White to yellow, Powder or granular powder
• Molecular weight: 485.40

Nicergoline CRS

CAS: 27848-84-6

• Formula: C₂₄H₂₆BrN₃O₃
• Color and Shape: Powder
• Molecular weight: 484.3855

Nicergoline for system suitability CRS

CAS: 27848-84-6

• Formula: C₂₄H₂₆BrN₃O₃
• Color and Shape: Powder
• Molecular weight: 484.3855

Nicergoline for peak identification CRS

CAS: 27848-84-6

• Formula: C₂₄H₂₆BrN₃O₃
• Color and Shape: Powder
• Molecular weight: 484.3855

Nicergoline

CAS: 27848-84-6

Nicergoline (Nicergolinum) is an ergot derivative used to treat senile dementia and other disorders with …

• Formula: C₂₄H₂₆BrN₃O₃
• Purity: 100% - 99.53%
• Color and Shape: Solid
• Molecular weight: 484.39

Nicergoline

CAS: 27848-84-6

• Purity: 99%
• Molecular weight: 484.39g/mol

Nicergoline

CAS: 27848-84-6

• Molecular weight: 484.39g/mol

Nicergoline-13C-d3

CAS: 27848-84-6

• Formula: C₂₃₁₃CH₂₃D₃BrN₃O₃
• Color and Shape: White To Off-White Solid
• Molecular weight: 488.40

Nicergoline

CAS: 27848-84-6

• Formula: C₂₄H₂₆BrN₃O₃
• Color and Shape: White To Off-White Solid
• Molecular weight: 484.39

Nicergoline

CAS: 27848-84-6

• Formula: C₂₄H₂₆BrN₃O₃
• Purity: 98.5 - 102.0 % (anhydrous basis)
• Color and Shape: White to off-white or light-yellow powder
• Molecular weight: 484.39

Nicergoline

CAS: 27848-84-6

• Formula: C₂₄H₂₆BrN₃O₃
• Purity: >98.0%(T)(HPLC)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 484.39

Nicergoline

CAS: 27848-84-6

• Formula: C₂₄H₂₆BrN₃O₃
• Color and Shape: Neat
• Molecular weight: 484.39

Nicergoline-N1-13C-d3

CAS: 27848-84-6

• Formula: C₂₃₁₃CH₂₃D₃BrN₃O₃
• Molecular weight: 488.40

Nicergoline-d3

CAS: 27848-84-6

Applications Nicergoline-d3 is the labeled analogue of Nicergoline(N394550), a drug used for age-dependent cognitive impairment …

• Formula: C₂₄D₃H₂₃BrN₃O₃
• Color and Shape: Neat
• Molecular weight: 487.404

Nicergoline

CAS: 27848-84-6

Applications Nicergoline is a drug used for age-dependent cognitive impairment such as Alzheimers disease and …

• Formula: C₂₄H₂₆BrN₃O₃
• Color and Shape: White To Off-White
• Molecular weight: 484.39

Nicergoline - Bio-X ™

CAS: 27848-84-6

Nicergoline is an ergot derivative drug that is used for the treatment of any symptoms …

• Formula: C₂₄H₂₆BrN₃O₃
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 484.39 g/mol

Nicergoline

CAS: 27848-84-6

α1-adrenoceptor antagonist; inhibitor of platelet aggregation; antioxidant

• Formula: C₂₄H₂₆BrN₃O₃
• Purity: Min. 95%
• Color and Shape: White Powder
• Molecular weight: 484.4 g/mol

Nicergoline N-Dimer

CAS: 27848-84-6

• Formula: C₄₇H₄₈Br₂N₆O₆
• Color and Shape: Neat
• Molecular weight: 952.73