CAS 27848-84-6
:Nicergoline
Description:
Nicergoline is a synthetic compound classified as an ergoline derivative, primarily used for its neuroprotective and cognitive-enhancing properties. It is known for its ability to improve cerebral blood flow and enhance oxygen utilization in the brain, making it beneficial in treating cognitive disorders associated with aging and vascular issues. Nicergoline exhibits a complex structure, featuring a bicyclic ring system characteristic of ergolines, and it is typically administered in the form of its mesylate salt. The substance is soluble in water and exhibits moderate lipophilicity, allowing it to cross the blood-brain barrier effectively. Its pharmacological effects are attributed to its action as an alpha-adrenergic antagonist and a serotonin receptor modulator, which contribute to its vasodilatory effects. Nicergoline is generally well-tolerated, with a side effect profile that may include dizziness, gastrointestinal disturbances, and headache. Due to its cognitive-enhancing properties, it has been explored in various clinical settings, particularly in the management of dementia and other cognitive impairments.
Formula:C24H26BrN3O3
InChI:InChI=1S/C24H26BrN3O3/c1-27-13-17-8-21-24(30-3,19-5-4-6-20(27)22(17)19)9-15(12-28(21)2)14-31-23(29)16-7-18(25)11-26-10-16/h4-7,10-11,13,15,21H,8-9,12,14H2,1-3H3/t15-,21-,24+/m1/s1
InChI key:InChIKey=YSEXMKHXIOCEJA-FVFQAYNVSA-N
SMILES:O(C)[C@@]12C=3C=4C(C[C@]1(N(C)C[C@H](COC(=O)C=5C=C(Br)C=NC5)C2)[H])=CN(C)C4C=CC3
Synonyms:- (+)-10-Methoxy-1,6-dimethylergoline-8-beta-methanol 5-bromonicotinate
- (10-Methoxy-1,6-Dimethylergolin-8-Yl)Methyl 5-Bromopyridine-3-Carboxylate
- (8β)-10-Methoxy-1,6-dimethylergoline-8-methanol-5-bromo-3-pyridinecarboxylate ester
- 1,6-Dimethyl-8β-(5-bromonicotinoyloxymethyl)-10α-methoxyergoline
- 1-Methyl-lumilysergol 8-(5-bromonicotinate) 10-methyl ether
- 10-Methoxy-1,6-dimethyl-ergolin-8-beta-methanol-(5-bromnicotinat)
- 10-Methoxy-1,6-dimethyl-ergolin-8-beta-methanol-(5-bromnicotinat) [German]
- 10-Methoxy-1,6-dimethylergoline-8-methanol 5-bromo-3-pyrindinecarboxylate (ester)
- 10-Methoxy-1,6-dimethylergoline-8beta-methanol 5-bromonicotinate
- 10-Methoxy-1,6-dimethylergoline-8beta-methanol 5-bromonicotinate (ester)
- 8-beta-((5-Bromonicotinoyloxy)methyl)-1,6-dimethyl-10-alpha-methoxyergoline
- Brn 4828393
- Cergodum
- Circo-Maren
- Dilasenil
- Duracebrol
- Ergobel
- Ergoline-8-beta-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester)
- Ergoline-8-beta-methanol, 10-methoxy-1,6-dimethyl-, 5-bromonicotinate (ester)
- Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, (8beta)-, 5-bromo-3-pyridinecarboxylate (ester)
- Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester), (8beta)-
- Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester), (8β)-
- Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 8-(5-bromo-3-pyridinecarboxylate), (8β)-
- Ergoline-8beta-methanol, 10-methoxy-1,6-dimethyl-, 5-bromonicotinate (ester) (8CI)
- Ergoline-8β-methanol, 10-methoxy-1,6-dimethyl-, 5-bromonicotinate (ester)
- Ergotop
- Fi 6714
- Indolo[4,3-fg]quinoline, ergoline-8-methanol deriv.
- MNE
- Memoq
- Nicergolent
- Nicergolin
- Nicergolin [German]
- Nicergolina
- Nicergolina [DCIT]
- Nicergoline [USAN:INN:BAN:JAN]
- Nicergolinum
- Nicergolinum [INN-Latin]
- Nicotergoline
- Nicotinic acid, 5-bromo-, (10-methoxy-1,6-dimethylergolin-8β-yl)methyl ester
- Nimergoline
- Nimergoline base
- Nsc 150531
- Rp 19651
- Sermion
- Ta 079
- Unii-Jcv8365Fwn
- Vasospan
- [(8Beta)-10-Methoxy-1,6-Dimethylergolin-6-Ium-8-Yl]Methyl 5-Bromopyridine-3-Carboxylate
- See more synonyms
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Found 20 products.
Nicergoline
CAS:Formula:C24H26BrN3O3Purity:>98.0%(T)(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:484.39Nicergoline
CAS:Nicergoline is an ergot derivative and vasodilator which increases blood flow in the brain. Nicergoline inhibits the vasoconstrictor effect of catecholamines by inhibiting the postsynaptic 1-adrenoceptors on vascular smooth muscle. This Thermo Scientific Chemicals brand product was originally part
Formula:C24H27BrN3O3Color and Shape:White to yellow, Powder or granular powderMolecular weight:485.40NICERGOLINE CRS
CAS:NICERGOLINE CRSFormula:C24H26BrN3O3Color and Shape:PowderMolecular weight:484.3855NICERGOLINE FOR SYSTEM SUITABILITY CRS
CAS:NICERGOLINE FOR SYSTEM SUITABILITY CRSFormula:C24H26BrN3O3Color and Shape:PowderMolecular weight:484.3855NICERGOLINE FOR PEAK IDENTIFICATION CRS
CAS:NICERGOLINE FOR PEAK IDENTIFICATION CRSFormula:C24H26BrN3O3Color and Shape:PowderMolecular weight:484.3855Nicergoline
CAS:Nicergoline (Nicergolinum) is an ergot derivative used to treat senile dementia and other disorders with vascular origins.Formula:C24H26BrN3O3Purity:98% - 99.80%Color and Shape:SolidMolecular weight:484.39Nicergoline-13C-d3
CAS:Formula:C2313CH23D3BrN3O3Color and Shape:White To Off-White SolidMolecular weight:488.40Nicergoline
CAS:Formula:C24H26BrN3O3Purity:98.5 - 102.0 % (anhydrous basis)Color and Shape:White to off-white or light-yellow powderMolecular weight:484.39Nicergoline-d3
CAS:Controlled ProductApplications Nicergoline-d3 is the labeled analogue of Nicergoline(N394550), a drug used for age-dependent cognitive impairment such as Alzheimers disease and other types of dementia.
References Caraci, F., et. al.: Brain Res., 1047, 30 (2005); Mizuno, T., et. al.: Brain Res., 1066, 78 (2005)Formula:C24D3H23BrN3O3Color and Shape:NeatMolecular weight:487.404Nicergoline
CAS:Controlled ProductApplications Nicergoline is a drug used for age-dependent cognitive impairment such as Alzheimers disease and other types of dementia. Nicergoline has shown to protect cultured neurons against β-amyloid toxicity. Nicergoline protects against neuronal cell death induced by activated microglia and astrocytes through the inhibition of inflammatory mediators and the upregulation of neurotrophic factors by glial cells. Nicergoline is a drug used for age-dependent cognitive impairment and it protects cultured neurons against β-amyloid toxicity.
References Caraci, F., et. al.: Brain Res., 1047, 30 (2005); Mizuno, T., et. al.: Brain Res., 1066, 78 (2005)Formula:C24H26BrN3O3Color and Shape:White To Off-WhiteMolecular weight:484.39Nicergoline - Bio-X ™
CAS:Nicergoline is an ergot derivative drug that is used for the treatment of any symptoms associated with cerebrovascular abnormalities. This drug works by inhibiting alpha-1 adrenoreceptors on vascular smooth muscles which results in peripheral vasodilation. Furthermore, this drug has been suggested to ameliorate cognitive deficits.Formula:C24H26BrN3O3Purity:Min. 95%Color and Shape:PowderMolecular weight:484.39 g/molNicergoline
CAS:α1-adrenoceptor antagonist; inhibitor of platelet aggregation; antioxidant
Formula:C24H26BrN3O3Purity:Min. 95%Color and Shape:White PowderMolecular weight:484.4 g/molNicergoline N-Dimer
CAS:Controlled ProductFormula:C47H48Br2N6O6Color and Shape:NeatMolecular weight:952.73
