CAS 405169-16-6: Dovitinib

Description: Dovitinib, with the CAS number 405169-16-6, is a small molecule tyrosine kinase inhibitor primarily developed for the treatment of various cancers, including renal cell carcinoma and breast cancer. It functions by inhibiting multiple receptor tyrosine kinases, which are involved in tumor growth and angiogenesis. Dovitinib exhibits a unique mechanism of action by targeting pathways that are crucial for cancer cell proliferation and survival. The compound is characterized by its ability to interfere with signaling pathways associated with vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF), thereby disrupting the tumor microenvironment. Dovitinib is typically administered orally and has undergone various clinical trials to assess its efficacy and safety profile. Its chemical structure includes a pyrimidine core, which is common among many kinase inhibitors, contributing to its biological activity. As with many targeted therapies, the effectiveness of Dovitinib can vary based on the specific genetic and molecular characteristics of the tumors being treated.

Formula: C₂₁H₂₁FN₆O

InChI: InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29)

InChI key: InChIKey=PIQCTGMSNWUMAF-UHFFFAOYSA-N

SMILES: O=C1NC=2C=CC=C(F)C2C(N)=C1C3=NC4=CC=C(C=C4N3)N5CCN(C)CC5

Synonyms:

• 2(1H)-Quinolinone, 4-amino-5-fluoro-3-[5-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-
• 2(1H)-Quinolinone, 4-amino-5-fluoro-3-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-
• 4-Amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one
• 4-Amino-5-fluoro-3-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-2(1H)-quinolinone
• Gfki 258
• Tk-258
• Tki 258
• Dovitinib

2(1H)-Quinolinone,4-amino-5-fluoro-3-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-

CAS: 405169-16-6

• Formula: C₂₁H₂₁FN₆O
• Purity: 99%
• Color and Shape: Solid
• Molecular weight: 392.42944319999987

Dovitinib

CAS: 405169-16-6

• Formula: C₂₁H₂₁FN₆O
• Molecular weight: 392.43

Dovitinib-d8

CAS: 405169-16-6

• Formula: C₂₁H₁₃D₈FN₆O
• Color and Shape: Yellow Solid
• Molecular weight: 400.49

Dovitinib

CAS: 405169-16-6

• Purity: 99.78%
• Molecular weight: 392.43g/mol

Dovitinib

CAS: 405169-16-6

• Formula: C₂₁H₂₁FN₆O
• Molecular weight: 392.44

Dovitinib

CAS: 405169-16-6

Dovitinib is an orally active, multi-targeted tyrosine kinase (RTK) inhibitor with anti-tumor effects.Cost-effective and quality-assured.

• Formula: C₂₁H₂₁FN₆O
• Purity: 99.66% - 99.78%
• Color and Shape: Solid
• Molecular weight: 392.43

Dovitinib base

CAS: 405169-16-6

Receptor tyrosine kinase inhibitor; anti-angiogenesis; anti-oncogenesis

• Formula: C₂₁H₂₁FN₆O
• Purity: Min. 98 Area-%
• Color and Shape: Powder
• Molecular weight: 392.43 g/mol