CAS 405169-16-6

Dovitinib

Description:

Dovitinib, with the CAS number 405169-16-6, is a small molecule tyrosine kinase inhibitor primarily developed for the treatment of various cancers, including renal cell carcinoma and breast cancer. It functions by inhibiting multiple receptor tyrosine kinases, which are involved in tumor growth and angiogenesis. Dovitinib exhibits a unique mechanism of action by targeting pathways that are crucial for cancer cell proliferation and survival. The compound is characterized by its ability to interfere with signaling pathways associated with vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF), thereby disrupting the tumor microenvironment. Dovitinib is typically administered orally and has undergone various clinical trials to assess its efficacy and safety profile. Its chemical structure includes a pyrimidine core, which is common among many kinase inhibitors, contributing to its biological activity. As with many targeted therapies, the effectiveness of Dovitinib can vary based on the specific genetic and molecular characteristics of the tumors being treated.

Formula: C₂₁H₂₁FN₆O

InChI: InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29)

InChI key: InChIKey=PIQCTGMSNWUMAF-UHFFFAOYSA-N

SMILES: NC1=C(C(=O)NC=2C1=C(F)C=CC2)C=3NC=4C(N3)=CC=C(C4)N5CCN(C)CC5

Synonyms:

• 2(1H)-Quinolinone, 4-amino-5-fluoro-3-[5-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-
• 2(1H)-Quinolinone, 4-amino-5-fluoro-3-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-
• 4-Amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one
• 4-Amino-5-fluoro-3-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-2(1H)-quinolinone
• Gfki 258
• Tk-258
• Tki 258
• Dovitinib

2(1H)-Quinolinone,4-amino-5-fluoro-3-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-

CAS: 405169-16-6

Formula: C₂₁H₂₁FN₆O

Purity: 99%

Color and Shape: Solid

Molecular weight: 392.4294

Ref: IN-DA0076Y3

Dovitinib

CAS: 405169-16-6

Formula: C₂₁H₂₁FN₆O

Molecular weight: 392.43

Ref: 7W-GP8558

Dovitinib-d8

CAS: 405169-16-6

Formula: C₂₁H₁₃D₈FN₆O

Color and Shape: Yellow Solid

Molecular weight: 400.49

Ref: 4Z-D-121002

Dovitinib

CAS: 405169-16-6

Dovitinib

Purity: ≥98%

Molecular weight: 392.43g/mol

Ref: 54-BUP15395

Dovitinib

CAS: 405169-16-6

Formula: C₂₁H₂₁FN₆O

Molecular weight: 392.44

Ref: 4Z-D-121001

Dovitinib

CAS: 405169-16-6

Dovitinib is an orally active, multi-targeted tyrosine kinase (RTK) inhibitor with anti-tumor effects.Cost-effective and quality-assured.

Formula: C₂₁H₂₁FN₆O

Purity: 99.35% - 99.92%

Color and Shape: Solid

Molecular weight: 392.43

Ref: TM-T6289

Dovitinib base

CAS: 405169-16-6

Receptor tyrosine kinase inhibitor; anti-angiogenesis; anti-oncogenesis

Formula: C₂₁H₂₁FN₆O

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 392.43 g/mol

Ref: 3D-FD22602