CAS 53-60-1

Promazine hydrochloride

Description:

Promazine hydrochloride is an antipsychotic medication belonging to the phenothiazine class, primarily used to manage psychotic disorders and severe anxiety. It exhibits sedative and antiemetic properties, making it effective in treating agitation and nausea. The compound has a molecular formula that reflects its complex structure, which includes a tricyclic ring system characteristic of phenothiazines. Promazine hydrochloride acts primarily as a dopamine antagonist, blocking dopamine receptors in the brain, which helps alleviate symptoms of psychosis. It is typically administered orally or via intramuscular injection, with its pharmacokinetics influenced by factors such as metabolism and individual patient characteristics. The substance is known for its side effects, which may include sedation, dry mouth, and extrapyramidal symptoms, necessitating careful monitoring during treatment. Additionally, it is important to consider contraindications and potential drug interactions when prescribing this medication. Overall, promazine hydrochloride plays a significant role in psychiatric care, contributing to the management of various mental health conditions.

Formula: C₁₇H₂₀N₂S·ClH

InChI: InChI=1S/C17H20N2S.ClH/c1-18(2)12-7-13-19-14-8-3-5-10-16(14)20-17-11-6-4-9-15(17)19;/h3-6,8-11H,7,12-13H2,1-2H3;1H

InChI key: InChIKey=JIVSXRLRGOICGA-UHFFFAOYSA-N

SMILES: C(CCN(C)C)N1C=2C(SC=3C1=CC=CC3)=CC=CC2.Cl

Synonyms:

• 10-(γ-Dimethylamino-n-propyl)phenothiazine hydrochloride
• 10H-Phenothiazine-10-propanamine, N,N-dimethyl-, hydrochloride (1:1)
• 10H-Phenothiazine-10-propanamine, N,N-dimethyl-, monohydrochloride
• Esparinal
• Liranol
• N,N-dimethyl-3-(10H-phenothiazin-10-yl)propan-1-amine hydrochloride (1:1)
• Phenothiazine, 10-[3-(dimethylamino)propyl]-, monohydrochloride
• Prolactyl
• Promazine HCl
• Promazine monohydrochloride
• Promwill
• Propazin
• Propazin (pharmaceutical)
• Propazine
• Prozine
• Sparine
• Talofen

Promazine Hydrochloride

CAS: 53-60-1

Color and Shape: Neat

Ref: 61-FOR0290.00

Promazine Hydrochloride 1.0 mg/ml in Methanol (as free base)

CAS: 53-60-1

Color and Shape: Single Solution

Ref: 61-AMP0290.00-01

PROMAZINE HYDROCHLORIDE CRS

CAS: 53-60-1

PROMAZINE HYDROCHLORIDE CRS

Formula: C₁₇H₂₁ClN₂S

Color and Shape: Powder

Molecular weight: 320.88

Ref: 41-P3390000

Promazine Hydrochloride

CAS: 53-60-1

Antidepressants, tranquilizers and other pschotherapeutic agents

Formula: C₁₇H₂₀N₂S·HCl

Color and Shape: White Yellow Powder

Molecular weight: 284.13472

Ref: 45-1569000

Promazine hydrochloride

CAS: 53-60-1

Promazine hydrochloride, a phenothiazine less potent than chlorpromazine, treats disturbed behavior and nausea.

Formula: C₁₇H₂₁ClN₂S

Purity: 99.90%

Color and Shape: Solid

Molecular weight: 320.88

Ref: TM-T0766

Promazine hydrochloride

CAS: 53-60-1

Formula: C₁₇H₂₁ClN₂S

Purity: 98%

Color and Shape: Solid

Molecular weight: 320.8800

Ref: IN-DA01A4WH

Promazine HCl (Chlorpromazine EP Impurity C HCl)

CAS: 53-60-1

Formula: C₁₇H₂₀N₂S·HCl

Color and Shape: White To Off-White Solid

Molecular weight: 284.42 36.46

Ref: 4Z-P-117001

Promazine hydrochloride

CAS: 53-60-1

Formula: C₁₇H₂₀N₂S·HCl

Molecular weight: 320.88

Ref: 7W-GP2638

Promazine hydrochloride

CAS: 53-60-1

Promazine hydrochloride

Purity: ≥98%

Molecular weight: 320.88g/mol

Ref: 54-BUP18247

Promazine Hydrochloride

CAS: 53-60-1

Color and Shape: Neat

Ref: 86-MM0290.00

Promazine hydrochloride

CAS: 53-60-1

Formula: C₁₇H₂₀N₂S·ClH

Color and Shape: Neat

Molecular weight: 320.88

Ref: 04-C16345700

Promazine Hydrochloride

Controlled Product

CAS: 53-60-1

Impurity Chlorpromazine EP Impurity C
Applications Antipsychotic. Tranquilizer.
References Banci, L., et al.: Biochemistry, 38, 3205 (1999), Lawal, O., et al.: Food Chemi., 87, 205 (2004), Shleev, S., et al.: Bioorg. Chem., 35, 35 (2007),

Formula: C₁₇H₂₀N₂S·ClH

Color and Shape: Neat

Molecular weight: 320.88

Ref: TR-P756300

Chlorpromazine EP impurity C

CAS: 53-60-1

Formula: C₁₇H₂₀N₂SHCl

Molecular weight: 284.42 : 36.46

Ref: ST-EA-CP-C19003

Promazine hydrochloride

Controlled Product

CAS: 53-60-1

Promazine hydrochloride is an amphiphilic phenothiazine drug that blocks postsynaptic dopaminergic receptors (D1, D2 and D4) in the mesolimbic and medullary chemoreceptor trigger zone (antipsychotic effects, decreasing stimulation of the vomiting centre). Promazine is an antagonist at serotonin 5HT receptors, exhibits anticholinergic activity by blocking alpha-1 adrenergic receptors and blocks histamine H1 and muscarinic receptors. Promazine is used for adults in the treatment of psychomotor agitation, to prevent and treat nausea and vomiting, to treat allergy symptoms. Promazine hydrochloride is also used in veterinary medicine especially in horses as a pre-anaesthetic agent. Promazine is showed to be among drugs that can be used as starting points for designing SARS-CoV proteinase inhibitors.

Formula: C₁₇H₂₀N₂S•HCl

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 320.88 g/mol

Ref: 3D-FP27180