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CAS 56-75-7

:

(-)-Chloramphenicol

Description:
(-)-Chloramphenicol, with the CAS number 56-75-7, is a broad-spectrum antibiotic originally derived from the bacterium Streptomyces venezuelae. It is characterized by its ability to inhibit bacterial protein synthesis by binding to the 50S subunit of the bacterial ribosome, effectively blocking peptide bond formation. This compound is a white to off-white crystalline powder that is soluble in water and alcohol but has limited solubility in organic solvents. Its molecular formula is C11H12Cl2N2O5, and it has a molecular weight of approximately 323.13 g/mol. (-)-Chloramphenicol exhibits antibacterial activity against a wide range of Gram-positive and Gram-negative bacteria, making it useful in treating various infections. However, its use is limited due to potential side effects, including aplastic anemia and gray baby syndrome in newborns. As a result, it is often reserved for serious infections where other antibiotics are ineffective. Proper handling and dosage are crucial to minimize adverse effects and ensure therapeutic efficacy.
Formula:C11H12Cl2N2O5
InChI:InChI=1/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9?/m1/s1
InChI key:InChIKey=WIIZWVCIJKGZOK-RKDXNWHRSA-N
SMILES:[C@@H]([C@H](NC(C(Cl)Cl)=O)CO)(O)C1=CC=C(N(=O)=O)C=C1
Synonyms:
  • 2,2-Dichloro-N-(2-Hydroxy-1-(Hydroxymethyl)-2-(4-Nitrophenyl)Ethyl)-Acetamid
  • 2,2-Dichloro-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide
  • 2,2-Dichloro-N-[2-Hydroxy-1-(Hydroxymethyl)-2-(4-Nitrophenyl)Ethyl]Acetamide
  • 2,2-dichloro-N-[(1R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide
  • 2,2-dichloro-N-[(1R,2S)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide
  • 2,2-dichloro-N-[(1S,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide
  • Ak-Chlor
  • Alficetyn
  • Amphenicol
  • Amphicol
  • See more synonyms
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