CAS 64924-67-0

Halofuginone hydrobromide

Description:

Halofuginone hydrobromide is a synthetic compound primarily recognized for its use in veterinary medicine, particularly as an anti-coccidial agent. It is derived from the natural alkaloid fuginone, which is obtained from the plant species *Fusarium* and exhibits a range of biological activities. The hydrobromide salt form enhances its solubility and stability, making it suitable for pharmaceutical applications. Halofuginone hydrobromide is characterized by its ability to inhibit collagen synthesis, which has implications in various therapeutic areas, including fibrosis and inflammation. The compound typically appears as a crystalline solid and is soluble in water and organic solvents. Its mechanism of action involves the modulation of signaling pathways related to cell proliferation and differentiation. Safety and efficacy profiles are critical for its use, and it is subject to regulatory scrutiny in veterinary and potentially human applications. As with any chemical substance, proper handling and adherence to safety guidelines are essential to mitigate any risks associated with its use.

Formula: C₁₆H₁₇BrClN₃O₃·BrH

InChI: InChI=1/C16H17BrClN3O3.BrH/c17-11-6-13-10(5-12(11)18)16(24)21(8-20-13)7-9(22)4-14-15(23)2-1-3-19-14;/h5-6,8,14-15,19,23H,1-4,7H2;1H/t14-,15+;/s2

InChI key: InChIKey=SJUWEPZBTXEUMU-AJYMSAGVNA-N

SMILES: O=C1C=2C(N=CN1CC(C[C@H]3[C@H](O)CCCN3)=O)=CC(Br)=C(Cl)C2.Br

Synonyms:

• 4(3H)-Quinazolinone, 7-bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-, monohydrobromide, trans-
• 4(3H)-Quinazolinone, 7-bromo-6-chloro-3-[3-[(2R,3S)-3-hydroxy-2-piperidinyl]-2-oxopropyl]-, hydrobromide (1:1), rel-
• 4(3H)-Quinazolinone, 7-bromo-6-chloro-3-[3-[(2R,3S)-3-hydroxy-2-piperidinyl]-2-oxopropyl]-, monohydrobromide, rel-
• 7-Bromo-6-chloro-3-[3-[(2S,3R)-3-hydroxypiperidin-2-yl]-2-oxopropyl]quinazolin-4-one hydrobromide
• 7-bromo-6-chloro-3-{3-[(2S,3R)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one hydrobromide
• Ru 19110
• Stenorol

Halofuginone HBr

CAS: 64924-67-0

Formula: C₁₆H₁₇BrClN₃O₃·HBr

Color and Shape: White To Off-White Solid

Molecular weight: 414.69 80.91

Ref: 4Z-H-035001

Halofuginone Hydrobromide

CAS: 64924-67-0

Halofuginone Hydrobromide

Purity: 98%

Molecular weight: 495.59g/mol

Ref: 54-OR1030466

Halofuginone hydrobromide

CAS: 64924-67-0

Halofuginone hydrobromide

Purity: ≥95%

Molecular weight: 495.59g/mol

Ref: 54-BUP06985

Halofuginone hydrobromide

CAS: 64924-67-0

Formula: C₁₆H₁₇BrClN₃O₃·HBr

Purity: ≥ 95.0%

Color and Shape: White to light-yellow powder

Molecular weight: 495.59

Ref: 7W-GK8532

Halofuginone hydrobromide

CAS: 64924-67-0

Formula: C₁₆H₁₈Br₂ClN₃O₃

Purity: 95%~99%

Molecular weight: 495.596

Ref: BP-BP4353

Halofuginone hydrobromide

Controlled Product

CAS: 64924-67-0

Formula: C₁₆H₁₇BrClN₃O₃·BrH

Color and Shape: Neat

Molecular weight: 495.59

Ref: 04-C14059280

Halofuginone Hydrobromide

Controlled Product

CAS: 64924-67-0

Applications Halogenated derivative of Febrifugine. Used as an antiprotozoal (coccidiostat).
References McIntosh, L., et al.: Biochem. Cell Biol., 73, 181 (1995), Leshem, Y., et al.: Exp. Cell Res., 274, 288 (2002),

Formula: C₁₆H₁₇BrClN₃O₃·BrH

Color and Shape: Neat

Molecular weight: 495.59

Ref: TR-H102490

Halofuginone hydrobromide

CAS: 64924-67-0

Halogenated derivative of febrifugine; coccidiostat

Formula: C₁₆H₁₈Br₂ClN₃O₃

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 495.59 g/mol

Ref: 3D-FH23731

Halofuginone Hydrobromide

CAS: 64924-67-0

Formula: C₁₆H₁₇BrClN₃O₃HBr

Molecular weight: 414.69 : 80.91

Ref: ST-EA-CP-H22002

Halofuginone hydrobromide

CAS: 64924-67-0

Halofuginone specifically inhibits collagen type I and MMP-2 gene expression, which may result in the suppression of angiogenesis and tumor cell growth.

Formula: C₁₆H₁₇BrClN₃O₃·HBr

Purity: 97.01% - 99.73%

Color and Shape: Solid

Molecular weight: 495.59

Ref: TM-T3524