TGF-beta/Smad
TGF-beta/Smad inhibitors are compounds that interfere with the TGF-beta (Transforming Growth Factor-beta) signaling pathway, which is mediated by Smad proteins. This pathway is involved in the regulation of cell growth, differentiation, apoptosis, and stem cell function. Dysregulation of TGF-beta/Smad signaling is associated with cancer, fibrosis, and other diseases. Inhibitors of this pathway are important tools for studying these conditions and developing potential therapies. At CymitQuimica, we provide TGF-beta/Smad inhibitors to support your research in cell signaling, oncology, and tissue repair.
Found 83 products for "TGF-beta/Smad".
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Garetosmab
CAS:Garetosmab (REGN 2477), a human IgG4 monoclonal antibody, inhibits activin A for potential cancer treatment and FOP study.Purity:95% - >95% (SDS-PAGE); 99.25% (SEC-HPLC)Color and Shape:Transparent LiquidMolecular weight:145.52 kDa (Predicted)Isoviolanthin
CAS:Isoviolanthin, a flavonoid from Dendrobium Officinale, inhibits migration of TGF-β1-treated HCC cells, non-toxic to normal cells, potential HCC therapy.Formula:C27H30O14Purity:99.25% - 99.66%Color and Shape:SolidMolecular weight:578.5187Hydrochlorothiazide
CAS:Hydrochlorothiazide (HCTZ) 是一种口服有效的噻嗪类的利尿药，可抑制转化 TGF-β/Smad 信号通路。它通过打开钙激活钾 (KCA) 通道发挥直接的血管松弛作用。它改善心脏功能，减少纤维化并具有降压作用。Formula:C7H8ClN3O4S2Purity:99.43% - 99.50%Color and Shape:White SolidMolecular weight:297.739Oxymatrine
CAS:Oxymatrine (Oxysophoridine) is an alkaloid isolated from Sophora flavescens, used as the antibiotic.Formula:C15H24N2O2Purity:98.72% - 99.72%Color and Shape:White SolidMolecular weight:264.36SLLK
CAS:SLLK is a control peptide for LSKL.Formula:C21H41N5O6Purity:98%Color and Shape:SolidMolecular weight:459.58ALK5-IN-83
ALK5-IN-83 (compound 13b) is an ALK5 inhibitor with an IC50 of 0.13 μM. It suppresses TGF-β1-induced Smad2 phosphorylation and cell motility in A549 cells.Formula:C20H23N7O2SColor and Shape:SolidMolecular weight:425.51LSKL TFA
CAS:LSKL TFA (H-Leu-Ser-Lys-Leu-NH2 TFA) is a TGF-尾1 antagonist that inhibits TSP-1 binding to LAP and reduces renal interstitial fibrosis and liver fibrosis.Formula:C23H43F3N6O7Purity:99.33%Color and Shape:SolidMolecular weight:572.6187Sotatercept
CAS:Sotatercept (ACE-011) is an ActRIIA-Fc fusion protein and an inhibitor of activin signaling.Purity:96.2% (SDS-PAGE); 98.8% (SEC-HPLC) - 97% (SDS-PAGE); 97.8% (SEC-HPLC)Color and Shape:Transparent LiquidMolecular weight:38.94 kDa (Predicted)P17 Peptide
CAS:P17 Peptide, a human TGF-β1 inhibitory peptide, effectively blocks the activity of woodchuck TGF-β1.Formula:C95H139N27O21Color and Shape:SolidMolecular weight:1995.29Tubastatin
CAS:Tubastatin inhibits TGF-β1-induced S6K phosphorylation, HIF-1α expression and VEG F expression.Formula:C21H22N2O2Purity:98.43%Color and Shape:SolidMolecular weight:334.4116Linavonkibart
CAS:Linavonkibart (SRK181) is a humanized antibody targeting TGFβ1 that blocks the release of TGF-β1 protein by specifically binding latent TGF-β1.Purity:97.4% (SDS-PAGE); 99.4% (SEC-HPLC) - 97.4% (SDS-PAGE); 99.4% (SEC-HPLC)Color and Shape:LiquidMolecular weight:144.68 kDa (Predicted)Domagrozumab
CAS:Domagrozumab (PF-06252616) is a humanized monoclonal antibody targeting myostatin, used in studies of muscle wasting diseases.Purity:95.83% (SEC-HPLC) - >95.0% (SDS-PAGE); 98% (SEC-HPLC)Color and Shape:LiquidMolecular weight:143.96 kDa (Predicted)Depiperazine-DM3189
CAS:Depiperazine-DM3189 inhibits the phosphorylation of SMAD 1/5/8 induced by bone morphogenetic protein 4 and can be used in biochemical experiments .Formula:C21H14N4Purity:99.69%Molecular weight:322.36Myostatin inhibitory peptide 2 TFA
Myostatin Inhibitory Peptide 2 (compd 2) TFA is a potent inhibitor of muscle growth suppressant with a dissociation constant (Kd) of 35.9 nM. It is utilized in the study of muscle atrophy diseases.Color and Shape:Odour SolidFresolimumab
CAS:Fresolimumab (GC1008) is a human monoclonal antibody targeting active TGFβ1, TGFβ2, TGFβ3, studied for cancer and focal segmental glomerulosclerosis.Purity:> 95% - > 95%Color and Shape:Transparent LiquidMolecular weight:144.4 kDa (Predicted)TGF-β1/Smad3-IN-1
CAS:TGF-β1/Smad3-IN-1 is an orally administrable dual inhibitor of TGF-β1/Smad3 with anti-fibrotic activity, idiopathic pulmonary fibrosis (IPF).Formula:C30H34N4O6SPurity:99.83%Molecular weight:578.68Elritercept
CAS:Elritercept (KER-050) is a recombinant fusion protein composed of a modified extracellular domain of the activin receptor type IIA fused to human IgG1 Fc. It functions by inhibiting activin A and other specific ligands of the TGF-β superfamily.Landogrozumab
CAS:Landogrozumab (LY2495655) is a humanized anti-GDF-8 monoclonal antibody that improves muscle size and may be used to study cancer and neurological disorders.Purity:99% (SDS-PAGE); 97.5% (SEC-HPLC) - 99% (SDS-PAGE); 97.5% (SEC-HPLC)Color and Shape:Transparent LiquidMolecular weight:142.86 kDa (Predicted)Luspatercept
CAS:Luspatercept (ACE-536), a recombinant modified ActRIIB fusion protein, selectively binds to transforming growth factor β superfamily ligands, thereby enhancing erythrocyte production and advancing the maturation of erythroid precursors. Moreover, by binding with GDF11, it inhibits Smad2/3 signaling. This compound is instrumental in anemia research [1].Color and Shape:LiquidDisitertide acetate
Disitertide acetate: a TGF-β1 and PI3K blocker, promotes apoptosis; inhibits receptor interaction.Formula:C70H113N17O24S2Purity:95.77%Color and Shape:White SolidMolecular weight:1640.88
