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CAS 66-81-9

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(-)-Cycloheximide

Description:
(-)-Cycloheximide is a naturally occurring compound that serves as an important inhibitor of protein synthesis in eukaryotic cells. It is derived from the bacterium Streptomyces griseus and is primarily used in research to study gene expression and protein function. The substance is characterized by its ability to inhibit the elongation phase of translation by interfering with the ribosomal machinery, specifically targeting the 60S ribosomal subunit. This inhibition leads to a decrease in the synthesis of proteins, making it a valuable tool in molecular biology and biochemistry. (-)-Cycloheximide is typically a white to off-white crystalline powder, and it is soluble in organic solvents such as ethanol and dimethyl sulfoxide (DMSO), but has limited solubility in water. Due to its potent biological activity, it is important to handle (-)-Cycloheximide with care, as it can be toxic to cells and may pose health risks if not managed properly in laboratory settings.
Formula:C15H23NO4
InChI:InChI=1/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1
InChI key:InChIKey=YPHMISFOHDHNIV-FSZOTQKASA-N
SMILES:[C@H](CC1CC(=O)NC(=O)C1)(O)[C@]2(C(=O)[C@@H](C)C[C@H](C)C2)[H]
Synonyms:
  • 2,6-Piperidinedione
  • 2,6-Piperidinedione, 4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]-
  • 2,6-Piperidinedione, 4-[2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]-, [1S-[1α(S*),3α,5β]]-
  • 3-(2-(3,5-Dimethyl-2-Oxocyclohexyl)-2-Hydroxyethyl)Glutarimide
  • 3-[2-(3,5-Dimethyl-2-oxo-1-cyclohexyl)-2-hydroxyethyl]glutarimide
  • 4-(2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)
  • 4-[(2R)-2-[(1S,3S,5S)-3,5-Dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]-2,6-piperidinedione
  • 4-[2-(3,5-Dimethyl-2-Oxocyclohexyl)-2-Hydroxyethyl]Piperidine-2,6-Dione
  • 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione
  • Acti-Aid
  • See more synonyms
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