CAS 738-70-5: Trimethoprim

Description: Trimethoprim is an antibiotic primarily used to treat bacterial infections, particularly urinary tract infections. It functions as a dihydrofolate reductase inhibitor, disrupting the bacterial synthesis of folate, which is essential for DNA and RNA production. The chemical formula of trimethoprim is C14H18N4O3, and it has a molecular weight of approximately 290.33 g/mol. This compound is typically a white to off-white crystalline powder that is soluble in water and methanol but has limited solubility in organic solvents like chloroform. Trimethoprim exhibits a moderate to high bioavailability when administered orally and is often combined with sulfamethoxazole to enhance its antibacterial efficacy, as seen in the co-trimoxazole formulation. Its pharmacokinetics include rapid absorption and distribution, with a half-life that allows for once or twice daily dosing. Trimethoprim is generally well-tolerated, though it can cause side effects such as gastrointestinal disturbances and, in rare cases, hematological reactions.

Formula: C₁₄H₁₈N₄O₃

InChI: InChI=1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)

InChI key: InChIKey=IEDVJHCEMCRBQM-UHFFFAOYSA-N

SMILES: N=1C=C(C(=NC1N)N)CC2=CC(OC)=C(OC)C(OC)=C2

Synonyms:

• 2,4-Diamino-5-(3',4',5'-trimethoxybenzyl)pyrimidine
• 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine
• 2,4-Pyrimidinediamine, 5-[(3,4,5-trimethoxyphenyl)methyl]-
• 5-((3,4,5-Trimethoxyphenyl)Methyl)-2,4-Pyrimidinediamine
• 5-(3,4,5-Trimethoxybenzyl)Pyrimidine-2,4-Diyldiamine
• Antibiotic synergist
• Bw 56-72
• Infectotrimet
• Instalac
• Monotrim
• Nih 204
• Nsc 106568
• Proloprim
• Pyrimidine, 2,4-diamino-5-(3,4,5-trimethoxybenzyl)-
• Syraprim
• Tiempe
• Trimanyl
• Trimethioprim
• Trimethoprim Crystalline
• Trimethoprim(TMP)
• Trimethoprime
• Trimetoprim
• Trimetoprima
• Trimogal
• Trimopan
• Trimpex
• Triprim
• Uretrim
• Wellcoprim

Trimethoprim

CAS: 738-70-5

• Formula: C₁₄H₁₈N₄O₃
• Purity: >98.0%(T)(HPLC)
• Color and Shape: White to Almost white powder to crystal
• Molecular weight: 290.32

Trimethoprim, 50 mg/ml in DMSO, sterile-filtered

CAS: 738-70-5

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. …

• Formula: C₁₄H₁₈N₄O₃
• Color and Shape: Clear colorless to yellow, Liquid
• Molecular weight: 290.32

Trimethoprim RS

CAS: 738-70-5

Trimethoprim CRS

CAS: 738-70-5

• Formula: C₁₄H₁₈N₄O₃
• Color and Shape: White. Light Yellow. Powder.
• Molecular weight: 290.3177

Trimethoprim

CAS: 738-70-5

• Formula: C₁₄H₁₈N₄O₃
• Purity: 99.8%
• Color and Shape: Off White Solid
• Molecular weight: 290.13789

Trimethoprim

CAS: 738-70-5

Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure

• Formula: C₁₄H₁₈N₄O₃
• Color and Shape: White Yellow Cream Powder
• Molecular weight: 290.13789

2,4-Diamino-5-(3,4,5-Trimethoxybenzyl)Pyrimidine

CAS: 738-70-5

• Formula: C₁₄H₁₈N₄O₃
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 290.3177

Trimethoprim

CAS: 738-70-5

Trimethoprim (NSC-106568) inhibits dihydrofolate reductase, CYP2C8, and OCT2 - an antibacterial agent.

• Formula: C₁₄H₁₈N₄O₃
• Purity: 99.80% - 99.81%
• Color and Shape: White To Yellowish Powder
• Molecular weight: 290.32

Trimethoprim

CAS: 738-70-5

• Formula: C₁₄H₁₈N₄O₃
• Purity: 99.8%
• Color and Shape: White Powder
• Molecular weight: 290.32g/mol

Trimethoprim

CAS: 738-70-5

• Formula: C₁₄H₁₈N₄O₃
• Color and Shape: White To Off-White Solid
• Molecular weight: 290.32

Trimethoprim

CAS: 738-70-5

• Purity: ≥98%
• Molecular weight: 290.32g/mol

Trimethoprim

CAS: 738-70-5

• Formula: C₁₄H₁₈N₄O₃
• Purity: (Titration) 99.0 - 101.0 % (dried basis)
• Color and Shape: White to pale yellow powder
• Molecular weight: 290.32

Trimethoprim, USP grade

CAS: 738-70-5

• Formula: C₁₄H₁₈N₄O₃
• Purity: ≤ 0.1%
• Color and Shape: White to light yellow powder
• Molecular weight: 290.32

Ministry of Agriculture Veterinary Drug Mixture 348 10 µg/mL in Acetonitrile:Water

CAS: 102-65-8 112398-08-0 115550-35-1 122-11-2 1220-83-3 127-69-5 127-71-9 127-79-7 144-80-9 144-83-2 23282-55-5 2447-57-6 2462-17-1 526-08-9 57-67-0 59-40-5 63-74-1 68-35-9 70458-92-3 723-46-6 738-70-582419-36-1 91296-86-5 93106-60-6 98079-51-7

• Color and Shape: Mixture

Sulfonamides Mixture for GB/T 21316-2007 100 µg/mL in Acetonitrile

CAS: 122-11-2 122-16-7 1220-83-3 127-69-5 127-71-9 127-79-7 144-80-9 144-82-1 144-83-2 2447-57-6 515-64-0 526-08-9 57-67-0 57-68-1 59-40-5 651-06-9 68-35-9 72-14-0 723-46-6 729-99-7 738-70-580-32-0 80-35-3

• Color and Shape: Mixture

Pharmaceuticals Mixture 326 200 µg/mL in Methanol

CAS: 103-90-2 114-07-8 298-46-4 56296-78-7 58-08-2 723-46-6 738-70-593107-08-5

• Color and Shape: Mixture

Trimethoprim 100 µg/mL in Acetonitrile

CAS: 738-70-5

• Formula: C₁₄H₁₈N₄O₃
• Color and Shape: Single Solution
• Molecular weight: 290.32

Trimethoprim

CAS: 738-70-5

• Formula: C₁₄H₁₈N₄O₃
• Color and Shape: Neat
• Molecular weight: 290.32

Trimethoprim

CAS: 738-70-5

• Formula: C₁₄H₁₈N₄O₃
• Color and Shape: Neat
• Molecular weight: 290.32

Trimethoprim, 98%

CAS: 738-70-5

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. …

• Formula: C₁₄H₁₈N₄O₃
• Purity: 98%
• Color and Shape: Powder, White to off-white
• Molecular weight: 290.32