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Trifluoroacetic acid

CAS 76-05-1: Trifluoroacetic acid

Description:Trifluoroacetic acid (TFA) is a colorless, pungent liquid with the chemical formula C2HF3O2. It is a strong organic acid, characterized by the presence of three fluorine atoms attached to the carbon backbone, which significantly enhances its acidity compared to acetic acid. TFA is highly soluble in water and many organic solvents, making it a versatile reagent in various chemical reactions. Its strong acidity is utilized in organic synthesis, particularly in the preparation of trifluoroacetyl derivatives and as a catalyst in certain reactions. TFA is also known for its ability to stabilize carbanions and is commonly used in peptide synthesis and protein chemistry. However, it is important to handle TFA with care, as it is corrosive and can cause severe burns upon contact with skin. Additionally, TFA is considered environmentally persistent, and its use is regulated in some regions due to potential ecological impacts. Overall, trifluoroacetic acid is a valuable compound in both industrial and laboratory settings, owing to its unique chemical properties.

Formula:C2HF3O2

InChI:InChI=1S/C2HF3O2/c3-2(4,5)1(6)7/h(H,6,7)

InChI key:InChIKey=DTQVDTLACAAQTR-UHFFFAOYSA-N

SMILES:O=C(O)C(F)(F)F

  • Synonyms:
  • 2,2,2-Trifluoroacetic acid
  • Acetic acid, 2,2,2-trifluoro-
  • Acetic acid, trifluoro-
  • Aceticacid, trifluoro-
  • Acide trifluoroacetique
  • Acido Trifluoroacetico
  • Chlorinated Paraffin-52
  • Kyselina trifluoroctova
  • Kyselinatrifluoroctova
  • Nsc 77366
  • See more synonyms
  • Perfluoroacetic acid
  • Perfluoroaceticacid
  • TFA
  • Trifluoracetic acid
  • Trifluoraceticacid
  • Trifluoressigsaeure
  • Trifluoressigsaure
  • Trifluoressigs~ure
  • Trifluoro-Aceticacid
  • Trifluoroacetetic Acid
  • Trifluoroaceticacidmincolorlessliq
  • Trifluoroethanoic acid
  • Trifluoroethanoicacid
  • Trifluoroacetic acid
  • Aceticacid, 2,2,2-trifluoro-
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BrandProduct dataPurityPrice rangeEstimated delivery
TCI logo
Trifluoroacetic Acid (ca. 0.5mol/L in Water) [Ion-Pair Reagent for LC-MS]
REF: 3B-A5711
CAS: 76-05-1
- - -31.00 €Wed 25 Jun 25
TCI logo
Trifluoroacetic Acid [Sequenation Reagent]
REF: 3B-Q0053
CAS: 76-05-1
>99.0%(T)69.00 €Wed 25 Jun 25
TCI logo
Trifluoroacetic Acid
REF: 3B-T0431
CAS: 76-05-1
>99.0%(T)27.00 €~116.00 €Wed 25 Jun 25
Alfa Aesar By Thermo Fisher Scientific logo
Trifluoroacetic acid, 99%
REF: 02-A12198
CAS: 76-05-1
99%To inquireMon 23 Jun 25
Alfa Aesar By Thermo Fisher Scientific logo
Trifluoroacetic acid, biochemical grade, 99.5+%
REF: 02-A14365
CAS: 76-05-1
99.5+%To inquireMon 23 Jun 25
Alfa Aesar By Thermo Fisher Scientific logo
Trifluoroacetic acid, 99%
REF: 02-L06374
CAS: 76-05-1
99%36.00 €~260.00 €Mon 23 Jun 25
Alfa Aesar By Thermo Fisher Scientific logo
Trifluoroacetic acid, HPLC Grade, 99.5+%
REF: 02-044630
CAS: 76-05-1
99.5+%To inquireMon 23 Jun 25
Alfa Aesar By Thermo Fisher Scientific logo
Trifluoroacetic acid, 99.5+%
REF: 02-031771
CAS: 76-05-1
99.5+%To inquireMon 23 Jun 25
Strem logo
Trifluoroacetic acid, 99%
REF: 08-09-7160
CAS: 76-05-1
99%71.00 €~266.00 €Wed 25 Jun 25
Apollo Scientific logo
Trifluoroacetic acid
REF: 54-PC7160
CAS: 76-05-1
99.5%40.00 €~170.00 €Mon 30 Jun 25
Glentham logo
Trifluoroacetic acid
REF: 7W-GK6959
CAS: 76-05-1
(Titration) ≥ 99.0%148.00 €~243.00 €Mon 30 Jun 25
Apollo Scientific logo
Trifluoroacetic acid
REF: 54-PC7161A
CAS: 76-05-1
biochemical grade 99.9%102.00 €~188.00 €Mon 30 Jun 25
Apollo Scientific logo
Trifluoroacetic acid
REF: 54-PC7161
CAS: 76-05-1
biochemical grade 99.9%46.00 €~332.00 €Mon 30 Jun 25
Doctor Ehrenstorfer logo
Trifluoroacetic acid 50 µg/mL in Methanol:Water
REF: 04-A17844400MW-50
CAS: 76-05-1
- - -To inquireWed 02 Jul 25
Doctor Ehrenstorfer logo
Trifluoroacetic acid
REF: 04-C17844400
CAS: 76-05-1
- - -To inquireWed 02 Jul 25
Doctor Ehrenstorfer logo
Ultrashort-chain-PFAS (C1-C4) Mixture 50 µg/mL in Methanol:Water
REF: 04-A30000064MW
CAS:
- - -To inquireWed 02 Jul 25
Apollo Scientific logo
Peptide trifluoroacetic acid
REF: 54-PC8841
CAS: 76-05-1
- - -52.00 €~549.00 €Tue 08 Jul 25
Glentham logo
Trifluoroacetic acid, Ultrapure for synthesis
REF: 7W-GK2000
CAS: 76-05-1
≥ 99.80%53.00 €~321.00 €Tue 08 Jul 25
Apollo Scientific logo
Trifluoroacetic acid
REF: 54-PC7160A
CAS: 76-05-1
99.5%69.00 €~115.00 €Tue 08 Jul 25
TLC logo
Trifluoroacetic Acid
REF: 4Z-A-138096
CAS: 76-05-1
- - -To inquireTue 08 Jul 25
discount label

Ref: 3B-A5711

10ml31.00 €
Estimated delivery in United States, on Wednesday 25 Jun 2025
discount label

Ref: 3B-Q0053

25ml69.00 €
Estimated delivery in United States, on Wednesday 25 Jun 2025
discount label

Trifluoroacetic acid, 99%

CAS:76-05-1

Ref: 02-A12198

100g57.00 €
500g155.00 €
2500gTo inquire
Estimated delivery in United States, on Monday 23 Jun 2025
discount label

Trifluoroacetic acid, biochemical grade, 99.5+%

CAS:76-05-1

Ref: 02-A14365

1kgTo inquire
50g55.00 €
250g152.00 €
Estimated delivery in United States, on Monday 23 Jun 2025
discount label

Trifluoroacetic acid, 99%

CAS:76-05-1

Ref: 02-L06374

25ml36.00 €
100ml75.00 €
500ml260.00 €
Estimated delivery in United States, on Monday 23 Jun 2025
discount label

Trifluoroacetic acid, HPLC Grade, 99.5+%

CAS:76-05-1

Ref: 02-044630

500mlTo inquire
4x500ml1,206.00 €
Estimated delivery in United States, on Monday 23 Jun 2025
discount label

Trifluoroacetic acid, 99.5+%

CAS:76-05-1

Ref: 02-031771

100g84.00 €
500g253.00 €
2500gTo inquire
Estimated delivery in United States, on Monday 23 Jun 2025
discount label

Trifluoroacetic acid, 99%

CAS:76-05-1

Ref: 08-09-7160

100g71.00 €
500g266.00 €
Estimated delivery in United States, on Wednesday 25 Jun 2025
discount label

Trifluoroacetic acid

CAS:76-05-1

Ref: 54-PC7160

1kg89.00 €
250g40.00 €
2.5kg170.00 €
Estimated delivery in United States, on Monday 30 Jun 2025
discount label

Trifluoroacetic acid

CAS:76-05-1

Ref: 7W-GK6959

1l243.00 €
500ml148.00 €
Estimated delivery in United States, on Monday 30 Jun 2025
discount label

Trifluoroacetic acid

CAS:76-05-1

Ref: 54-PC7161A

1l188.00 €
500ml102.00 €
Estimated delivery in United States, on Monday 30 Jun 2025
discount label

Trifluoroacetic acid

CAS:76-05-1

Ref: 54-PC7161

1kg97.00 €
5kg332.00 €
250g46.00 €
Estimated delivery in United States, on Monday 30 Jun 2025
discount label

Trifluoroacetic acid 50 µg/mL in Methanol:Water

CAS:76-05-1

Ref: 04-A17844400MW-50

1mlTo inquire
Estimated delivery in United States, on Wednesday 2 Jul 2025
discount label

Trifluoroacetic acid

Controlled Product
CAS:76-05-1

Ref: 04-C17844400

1mlTo inquire
Estimated delivery in United States, on Wednesday 2 Jul 2025
discount label

Ref: 04-A30000064MW

1mlTo inquire
Estimated delivery in United States, on Wednesday 2 Jul 2025
discount label

Peptide trifluoroacetic acid

CAS:76-05-1

Ref: 54-PC8841

1kg549.00 €
Estimated delivery in United States, on Tuesday 8 Jul 2025
discount label

Trifluoroacetic acid, Ultrapure for synthesis

CAS:76-05-1

Ref: 7W-GK2000

1l321.00 €
100ml53.00 €
Estimated delivery in United States, on Tuesday 8 Jul 2025
discount label

Trifluoroacetic acid

CAS:76-05-1

Ref: 54-PC7160A

1l115.00 €
500ml69.00 €
Estimated delivery in United States, on Tuesday 8 Jul 2025
discount label

Ref: 4Z-A-138096

5mgTo inquire
10mgTo inquire
25mgTo inquire
50mgTo inquire
100mgTo inquire
Estimated delivery in United States, on Tuesday 8 Jul 2025
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