Angiogenesis
Angiogenesis inhibitors are compounds that interfere with the formation of new blood vessels, a process critical in cancer growth and metastasis. By inhibiting angiogenesis, these compounds can restrict the blood supply to tumors, slowing or halting their growth. Angiogenesis inhibitors are essential in cancer research and therapeutic development, providing insights into the mechanisms of tumor progression and offering potential treatments for cancer and other angiogenesis-related diseases. At CymitQuimica, we offer a wide range of high-quality angiogenesis inhibitors to support your research in oncology and vascular biology.
Subcategories of "Angiogenesis"
- BTK(166 products)
- Bcr-Abl(117 products)
- EGFR(580 products)
- FAK(72 products)
- FLT(86 products)
- Fibroblast Growth Factor Receptor (FGFR)(180 products)
- JAK(244 products)
- PDGFR(129 products)
- RAAS(89 products)
- Src(82 products)
- Syk(37 products)
- Thrombin(56 products)
- VDA(2 products)
- VEGFR(242 products)
Show 6 more subcategories
Found 2372 products of "Angiogenesis"
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Cediranib
CAS:Cediranib (AZD2171) is a potent KDR tyrosine kinase inhibitor (IC50 < 1nM), also targets Flt1/4, PDGFRβ, c-Kit, and more selective for VEGFR.Formula:C25H27FN4O3Purity:97.21% - 99.94%Color and Shape:SolidMolecular weight:450.51Ref: TM-T2500
2mg39.00€5mg59.00€10mg87.00€25mg129.00€50mg168.00€100mg240.00€200mg439.00€500mg703.00€1mL*10mM (DMSO)65.00€Oclacitinib
CAS:Oclacitinib (PF-03394197)(PF03394197) is a potent and selective JAKs inhibitor with IC50 of 10-99 nM; not inhibit a panel of 38 non-JAK kinases (IC50 's > 1000Formula:C15H23N5O2SPurity:98% - 98.45%Color and Shape:White To Off-White SolidMolecular weight:337.44AZ-5104
CAS:AZ5104 is a potent EGFR inhibitor.Formula:C27H31N7O2Purity:98.40% - 99.59%Color and Shape:Solid PowderMolecular weight:485.58PF-04929113 Mesylate
CAS:PF-04929113 Mesylate (SNX-5422 Mesylate), a prodrug of SNX-2112, is an orally available Hsp90 inhibitor (Kd: 41 nM) and also induces Her-2 degradation (IC50: 37Formula:C26H34F3N5O7SPurity:99% - 99.46%Color and Shape:SolidMolecular weight:617.63Ref: TM-T4342
1mg73.00€2mg95.00€5mg150.00€10mg273.00€25mg396.00€50mg583.00€100mg832.00€500mg1,684.00€1mL*10mM (DMSO)220.00€PP 3
CAS:PP 3 is a Negative control for the Src kinase inhibitor PP 2Formula:C11H9N5Purity:98.61%Color and Shape:Whit To Off-White SolidMolecular weight:211.22Peficitinib
CAS:Peficitinib (ASP015K) (ASP015K, JNJ-54781532) is an orally bioavailable JAK inhibitor. Phase 3.Formula:C18H22N4O2Purity:98.67% - 99.4%Color and Shape:SolidMolecular weight:326.39Ref: TM-T6933
2mg38.00€5mg63.00€10mg99.00€25mg172.00€50mg268.00€100mg416.00€200mg610.00€1mL*10mM (DMSO)70.00€Branebrutinib
CAS:Branebrutinib (BMS986195) is a potent, covalent inhibitor of Bruton's tyrosine kinase (BTK), >5,000-fold selective over all kinases outside of the Tec family.Formula:C20H23FN4O2Purity:95.86% - 99.31%Color and Shape:SolidMolecular weight:370.42Pamufetinib mesylate
CAS:Pamufetinib mesylate (TAS-115 mesylate) is a VEGFR antagonist and c-Met inhibitor used in the study of cancer and respiratory diseases.Formula:C28H27FN4O7S2Purity:98.91%Color and Shape:SolidMolecular weight:614.67PT-2385
CAS:PT-2385 is a selective HIF-2α inhibitor (Kd<50 nM).Formula:C17H12F3NO4SPurity:98.91% - 99.55%Color and Shape:SolidMolecular weight:383.34Ref: TM-T7848
1mg63.00€2mg93.00€5mg144.00€10mg222.00€25mg379.00€50mg532.00€100mg740.00€200mg982.00€1mL*10mM (DMSO)119.00€Spebrutinib
CAS:Spebrutinib (LMK-435) is an orally bioavailable, selective inhibitor of Bruton's agammaglobulinemia tyrosine kinase (BTK), with potential antineoplasticFormula:C22H22FN5O3Purity:97.02% - >99.99%Color and Shape:SolidMolecular weight:423.44squarunkinA
CAS:squarunkinA is a novel modulator of the UNC119-Cargo Interaction, potently and selectively inhibiting the binding of a myristoylated peptide representing the N-Formula:C25H32F3N5O4Purity:99.29%Color and Shape:SolidMolecular weight:523.55SYR127063
CAS:SYR127063 (BDBM-92454) (BDBM92454) is a potent and selective HER2 inhibitor, binds to HER2 in a reactive conformation.Formula:C23H20ClF3N4O3Purity:98.57%Color and Shape:SolidMolecular weight:492.88N-Acryloyl Osimertinib (>85%)
CAS:Applications N-Acryloyl Osimertinib is used in the preparation of pyrimidinyl indole derivative as EGFR inhibitor for targeted therapy of cancer
References Rao, Y., et al.: Faming Zhuanli Shenqing (2016), CN 105777716 A 20160720Formula:C31H35N7O3Purity:>85%Color and Shape:Off White SolidMolecular weight:553.65Cavutilide
CAS:Cavutilide has antiarrhythmic activity, inhibits hERG K(+) channels, and can be used to study heart failure and persistent atrial fibrillation.Formula:C22H26FN3O3Purity:99.82% - 99.85%Color and Shape:SolidMolecular weight:399.458Donafenib
CAS:Donafenib(Bay 43-9006 (D3)) is a deuterium-labeled Sorafenib which is a multikinase inhibitor(IC50s: 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3,Formula:C21H13ClD3F3N4O3Purity:99.88%Color and Shape:SolidMolecular weight:467.84Ref: TM-T16909
1mg87.00€5mg178.00€10mg321.00€25mg532.00€50mg770.00€100mg1,035.00€1mL*10mM (DMSO)192.00€Pulsatilla Saponin D (90%)
CAS:Controlled ProductApplications Pulsatilla Saponin D shows antiangiogenic and antitumor activity.
References Sang-Won, H. et al.: Carcinogen., 34, 2156 (2013);Formula:C47H76O17Purity:90%Color and Shape:NeatMolecular weight:913.1AZ 12799734
CAS:AZ 12799734 is an orally active, selective and potent dual inhibitor of TGFBR1 and ALK5 with inhibitory effects on BMP and TGFβ for the study of tumours.Formula:C18H18N4O3SPurity:98.23%Color and Shape:SolidMolecular weight:370.43Dapolsertib
CAS:Dapolsertib (SEL24-B489) is an orally active and efficient PIM and FLT3-ITD inhibitor, reducing PIM-specific substrate phosphorylation.Formula:C15H18Br2N4O2Purity:99.61%Color and Shape:SolidMolecular weight:446.14Toceranib
CAS:Toceranib phosphate, orally active, inhibits RTK, PDGFR, VEGFR, Kit; Kis 5 nM PDGFRβ, 6 nM KDR; has antitumor effects.Formula:C22H25FN4O2Purity:97.62%Color and Shape:SolidMolecular weight:396.46Itacnosertib
CAS:Itacnosertib (TP-0184) is an orally available ACRV1 (ALK-2), FLT3 and JAK2 inhibitor that inhibits the growth of tumor cells,antitumor and antileukemic.Formula:C26H28N8OPurity:99.38%Color and Shape:SolidMolecular weight:468.55Ref: TM-T39104
1mg92.00€5mg192.00€10mg313.00€25mg595.00€50mg888.00€100mg1,234.00€200mg1,665.00€1mL*10mM (DMSO)212.00€Cpd27
CAS:Cpd27 (TIE-2/VEGFR-2 kinase-IN-2) is a TIE-2 and VEGFR-2 inhibitor that inhibits RIPK1 and can be used to study glaucoma.Formula:C20H13F4N5O2Purity:98.89%Color and Shape:SolidMolecular weight:431.34Bosutinib hydrate
CAS:Bosutinib hydrate (SKI-606 hydrate) is a kinase inhibitor of BCR-ABL and Src tyrosine kinases for the study of leukemia.Formula:C26H31Cl2N5O4Purity:99.87%Color and Shape:SolidMolecular weight:548.46SB 203580 hydrochloride
CAS:SB 203580 hydrochloride (Adezmapimod hydrochloride) is a p38 MAPK inhibitor that induces mitochondrial autophagy and cytosolic autophagy.Formula:C21H17ClFN3OSPurity:97.79%Color and Shape:SolidMolecular weight:413.9GS-829845
CAS:GS-829845 is a JAK1 inhibitor, the main component of the active metabolite of Filgotinib, which is approximately 10-fold less potent and has a longer half-lifeFormula:C17H19N5O2SPurity:99.93%Color and Shape:SolidMolecular weight:357.43PDGFR Tyrosine Kinase Inhibitor III
CAS:PDGFR Tyrosine Kinase Inhibitor III (PDGF Receptor Tyrosine Kinase Inhibitor III) (PDGF Receptor Tyrosine Kinase Inhibitor III) is a multikinase inhibitor thatFormula:C27H27N5O4Purity:99.50%Color and Shape:SoildMolecular weight:485.53Ref: TM-T60108
5mg52.00€10mg78.00€25mg160.00€50mg225.00€100mg325.00€200mg445.00€1mL*10mM (DMSO)50.00€SB-505124 hydrochloride
CAS:SB-505124 hydrochloride (SB505124 hydrochloride) is a TGF-β type I receptor (ALK4, ALK5, ALK7) inhibitor for the study of colorectal cancer.Formula:C20H22ClN3O2Purity:98.71%Color and Shape:SolidMolecular weight:371.86Seribantumab
CAS:Seribantumab (MM 121) is a humanized monoclonal antibody targeting HER3, inhibiting cancer cell proliferation.Purity:>95%Color and Shape:LiquidMolecular weight:143.14 kDaOsunprotafib
CAS:Osunprotafib (ABBV-CLS-484) is a potent, orally bioavailable PTP1B/PTPN2 inhibitor in clinical trials for solid tumors.Cost-effective and quality-assured.Formula:C17H24FN3O4SPurity:97.11% - 99.91%Color and Shape:SolidMolecular weight:385.45Gefitinib hydrochloride
CAS:Obtustatin triacetate is an integrin derived from the venom of Vipera lebetina obtusa and is an α1β1 integrin and in vivo angiogenesis inhibitor.Formula:C22H25Cl2FN4O3Purity:99.8%Color and Shape:SolidMolecular weight:483.36Cerdulatinib hydrochloride
CAS:Cerdulatinib hydrochloride is an oral tyrosine kinase inhibitor targeting JAK1/2/3, TYK2, Syk, and 19 others with IC50 < 200 nM.Formula:C20H28ClN7O3SPurity:99.85%Color and Shape:SolidMolecular weight:482Alpha-Eudesmol
CAS:Applications α-Eudesmol is an isomer of β-Eudesmol (E938600), a sesquiterpenoid known to induce neurite outgrowth. β-Eudesmol exhibits antiangiogenic activity.
References Obara, Y. et al.: J. Pharmacol. Exp . Ther., 30, 803 (2011); Tsuneki, H. et al.: Eur. J. Pharmacol., 512, 105 (2005);Formula:C15H26OColor and Shape:White To Off-WhiteMolecular weight:222.37Glycerol 1-Monobutyrate (Technical Grade)
CAS:Applications Glycerol 1-Monobutyrate functions as a key regulatory molecule in angiogenic process.
References Dobson, D. E., et al.: Cell (Cambridge, MA, U. S.), 61, 223 (1990)Formula:C7H14O4Color and Shape:NeatMolecular weight:162.18CCT241161
CAS:CCT241161: oral pan-RAF inhibitor; IC50s: LCK (3 nM), CRAF (6), SRC (10), V600E-BRAF (15), BRAF (30); fights BRAF/NRAS melanomas, anti-proliferative.Formula:C28H27N7O3SPurity:99.76% - 99.77%Color and Shape:SolidMolecular weight:541.62FAK activator 1
CAS:ZINC40099027 is a FAK activator that induces gastric mucosal repair in persistent aspirin-associated gastric injury.Formula:C23H26F3N3O3Purity:99.19%Color and Shape:SoildMolecular weight:449.47Ref: TM-T77665
1mg94.00€5mg217.00€10mg362.00€25mg594.00€50mg952.00€100mg1,506.00€200mg1,969.00€1mL*10mM (DMSO)281.00€GSK1904529A
CAS:GSK1904529A (GSK 4529) is a specific inhibitor of IGF-1R (IC50=27 nM) and IR(IC50=25 nM) .Formula:C44H47F2N9O5SPurity:98.2% - 99.76%Color and Shape:SolidMolecular weight:851.96Tivozanib hydrochloride hydrate
CAS:Tivozanib hydrochloride hydrate (AV-951 hydrochloride hydrate) is a VEGFR tyrosine kinase inhibitor that inhibits VEGFR-1, VEGFR-2, VEGFR-3 .Formula:C22H22Cl2N4O6Purity:98.66% - 99.99%Color and Shape:SolidMolecular weight:509.34TG 100801
CAS:TG 100801 is a dual inhibitor of VEGFr2 and Src family kinases and is a candidate compound for the treatment of age-related macular degeneration (AMD).Formula:C33H30ClN5O3Purity:99.28% - 99.61%Color and Shape:SolidMolecular weight:580.08Anumigilimab
CAS:Anumigilimab (CSL-324) is a fully human therapeutic anti-G-CSFR antibody with potential anti-tumor activity for the study of inflammation.Purity:95.75% (SEC-HPLC) - 98.43% (SEC-HPLC)Color and Shape:LiquidMolecular weight:143.86 kDaClopidogrel Related Compound B
CAS:Impurity Clopidogrel Impurity B; Clopidogrel USP B; Clopidogrel USP Related Compound B
Applications Clopidogrel Related Compound B (Clopidogrel Impurity B; Clopidogrel USP B; Clopidogrel USP Related Compound B) is a tetrahydrothienopyridine as inhibitor of angiogenesis.
References Maffrand, J. P., et al.: Eur. J. Med. Chem., 9, 483 (1974), Thebault, J.J., et al.: Clin. Pharmacol. Ther., 18, 485 (1975),Formula:C16H16ClNO2S·ClHColor and Shape:NeatMolecular weight:358.28Tirabrutinib
CAS:Tirabrutinib, an oral Btk inhibitor (IC50=6.8 nM), crosses the BBB and halts B cell signaling for autoimmune and hematologic studies.
Formula:C25H22N6O3Purity:99.64%Color and Shape:SolidMolecular weight:454.48Syk Inhibitor II
CAS:Syk inhibitor II, a cell-permeable, ATP-competitive, pyrimidine-carboxamide compound, selectively and reversibly inhibits Syk (IC50 = 41 nM).Formula:C14H15F3N6OPurity:97.63%Color and Shape:SolidMolecular weight:340.3Gefitinib-d6
CAS:Gefitinib-d6 is a deuterated compound of Gefitinib. Gefitinib has a CAS number of 184475-35-2. Gefitinib is an EGFR tyrosine kinase inhibitor and can inhibit Tyr1173, Tyr992, Tyr1173 and Tyr992 (IC50s: 37/37/26/57 nM).Formula:C22H18D6ClFN4O3Color and Shape:SolidMolecular weight:452.94NVP-BSK805
CAS:NVP-BSK805 (BSK 805) is an ATP-competitive JAK2 inhibitor.Formula:C27H28F2N6OPurity:98%Color and Shape:SolidMolecular weight:490.55(Rac)-SAR131675
CAS:(Rac)-SAR131675 is an effective and specific VEGFR-3 inhibitor, which inhibited VEGFR-3 tyrosine kinase activity and VEGFR-3 autophosphorylation in HEK cells.Formula:C18H22N4O4Purity:98.73% - 99.1%Color and Shape:SolidMolecular weight:358.39BIBF 1202
CAS:BIBF 1202 is a VEGFR2 kinase inhibitor (IC50 = 62 nM).Formula:C30H31N5O4Purity:98.04%Color and Shape:SolidMolecular weight:525.6BMS-690514
CAS:BMS-690514 is a potent and orally active inhibitor of EGFR and VEGFR. It has IC50s of 5, 20 and 60 nM for EGFR, HER 2 and HER 4, respectively.Formula:C19H24N6O2Purity:99.08%Color and Shape:SolidMolecular weight:368.43Naquotinib mesylate
CAS:Naquotinib mesylate (ASP8273 (mesylate)) is an orally available, mutant-selective and irreversible inhibitor of EGFR(iC50s of 8-33 nM and 230 nM for toward EGFRFormula:C31H46N8O6SPurity:98%Color and Shape:SolidMolecular weight:658.81PF-03814735
CAS:PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1. Phase 1.Formula:C23H25F3N6O2Purity:98%Color and Shape:SolidMolecular weight:474.48Canertinib dihydrochloride
CAS:Canertinib dihydrochloride (PD-183805 dihydrochloride) is the hydrochloride salt of an orally bio-available quinazoline with potential antineoplastic andFormula:C24H27Cl3FN5O3Purity:99.13% - >99.99%Color and Shape:SolidMolecular weight:558.86Almonertinib hydrochloride
CAS:Almonertinib hydrochloride (HS-10296 hydrochloride) is a small molecule inhibitor of EGFR-activating mutations and T790M-resistant mutation.Formula:C30H36ClN7O2Purity:98.01% - 98.12%Color and Shape:SolidMolecular weight:562.1Brivanib (alaninate)
CAS:Brivanib Alaninate (BMS-582664) is an alaninate salt of a vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with potential antineoplastic effect.Formula:C22H24FN5O4Purity:99.46% - 99.66%Color and Shape:SolidMolecular weight:441.46(5E)-5-(4-Hydroxybenzylidene)-1,3-thiazolidine-2,4-dione
CAS:Controlled ProductApplications 5-[(4-Hydroxyphenyl)methylene]-2,4-thiazolidinedione is a 5-Benzylidene-2,4-thiazolidenedione derivative designed as inhibitors of angiogenesis targeting VEGFR-2. Also, it is an intermediate used in the synthesis of MSDC 0602 (M755420), which is an analogue of thiazolidinediones, exhibits low affinity for binding and activation of peroxisome proliferator-activated receptor γ (PPARγ). Thiazolidinediones are effective insulin-sensitizing drugs for treating various metabolic and inflammatory diseases.
References Bhanushali, U., et al.: Bioorg. Chem., 67, 139-147 (2016); Chen, Z., et al.: J. Biol. Chem. 287, 23537 (2012); Fukunaga, T., et al.: J. Bone Miner. Res., 30, 508 (2015)Formula:C10H7NO3SColor and Shape:NeatMolecular weight:221.23Behenamide
CAS:Controlled ProductApplications Behenamide is a fatty acid amide as an angiogenic. The mechanism of angiogenic activity is unknown and this lipid does not promote proliferation of endothelial cells or induce inflammatory effects.
References Wakamatsu, K., et al.: Biochem. Biophysical Res. Comm., 168, 423 (1990),Formula:C22H45NOColor and Shape:White To Off-WhiteMolecular weight:339.6Methyl 6-[[[(2-Chloroethyl)amino]carbonyl]amino]-6-deoxy-Alpha-D-glucopyranoside
CAS:Controlled ProductFormula:C10H19ClN2O6Color and Shape:NeatMolecular weight:298.72Tarcocimab
CAS:Tarcocimab (OG1953) is a humanized IgG1 monoclonal antibody targeting VEGFA, researched for RVO and wet AMD.Color and Shape:LiquidZalutumumab
CAS:Zalutumumab is a high-affinity fully human monoclonal antibody ,the extracellular domain of the EGFR squamous cell carcinoma of the head and neck (SCCHN).Purity:95%Color and Shape:LiquidMolecular weight:146.63 kDaAnti-Mouse VEGFR-2 Antibody (DC101)
Anti-Mouse VEGFR-2 Antibody (DC101) is a rat-derived monoclonal antibody against mouse VEGFR2/KDR/Flk-1, serving as a mouse analogue of ramucirumab.Purity:99%Color and Shape:LiquidMolecular weight:150 kDaIzalontamab
CAS:Izalontamab (SI-B001) is a bispecific EGFR/HER3 monoclonal antibody that binds to both EGFR×EGFR homodimers and EGFR×HER3 heterodimers.Purity:95%+ - 95.3% (SDS-PAGE); 99.2% (SEC-HPLC)Color and Shape:LiquidMolecular weight:197.21 kDaFutuximab
CAS:Futuximab is a chimeric monoclonal antibody targeting EGFR, commonly used in combination with zatuximab to form Sym004.Purity:95% - 97.5% (SDS-PAGE); 96.3% (SEC-HPLC)Color and Shape:LiquidMolecular weight:146.28 kDaPonezumab
CAS:Ponezumab (PF-04360365), a humanized IgG2 antibody, lowers Aβ in the CNS & boosts mice memory. Used in Alzheimer's research.Color and Shape:LiquidFaricimab
CAS:Faricimab,Bispecific antibody targeting Ang-2/VEGF-A. Prevents retinal I/R injury. Improves vision in w-AMD, DME, RVO.Purity:>95% (SDS-PAGE); >95% (SEC-HPLC) - >95% (SDS-PAGE); >95% (SEC-HPLC)Color and Shape:LiquidMolecular weight:146 kDaTovetumab
CAS:Tovetumab (MEDI-575) is an anti-PDGFRα mAb inhibiting its signaling, in trials for glioblastoma and NSCLC.Purity:95%Color and Shape:LiquidMolecular weight:144.78 kDaSolrikitug
CAS:Solrikitug,Anti-CRLF2 humanized IgG1κ monoclonal antibody.Purity:95%Color and Shape:LiquidMolecular weight:~150 kDaImgatuzumab
CAS:Imgatuzumab (RG 7160) is a humanized anti-EGFR monoclonal antibody and immunomodulator for cancer research.
Color and Shape:LiquidMolecular weight:145.0 (kDa)Ivonescimab
CAS:Ivonescimab (AK112) is a PD-1/VEGF bispecific antibody with cancer immunotherapy and anti-angiogenic effects, NSCLC).Purity:95% - >95.0% (SDS-PAGE); 98.99% (SEC-HPLC)Color and Shape:LiquidMolecular weight:201.12 kDaElgemtumab
CAS:Elgemtumab (LJM716) is a fully humanised monoclonal antibody targeting HER3/ERBB3, acting as an antagonist to block HER3/Akt phosphorylation antitumour.Purity:95%Color and Shape:LiquidMolecular weight:144.15 kDaVanucizumab
CAS:Vanucizumab is a bispecific humanised monoclonal antibody that simultaneously inhibits the receptor interactions of VEGF-A and Angiopoietin-2 (Ang-2)Purity:95%Color and Shape:LiquidMolecular weight:146.89 kDaFidasimtamab
CAS:Fidasimtamab, a recombinant human IgG1 bispecific antibody, targets both HER2 and PD-1, bridging T cells and tumor cells to modulate immune responses.Purity:95% - 98.0% (SDS-PAGE); 98.3% (SEC-HPLC)Color and Shape:LiquidMolecular weight:144.72 kDaBecotatug
CAS:Becotatug (JMT101) is a humanised monoclonal antibody targeting EGFR, antitumour when combined with Osimertinib for treating EGFR-mutated advanced NSCLC.Purity:95% - 99.1% (SDS-PAGE); 98.1% (SEC-HPLC)Color and Shape:LiquidMolecular weight:145.52 kDaEGFR T790M/L858R-IN-8
CAS:EGFRT790M/L858R-IN-8 (compound 9) is a potent inhibitor of EGFR, specifically targeting the EGFRT790M/L858R mutations with an IC50 of 56.8 μM. This compound does not show significant antiproliferative effects on cancer cell lines A549, A431, and NHI-H1975.Formula:C16H11BrN2O3Color and Shape:SolidMolecular weight:359.17Dilpacimab
CAS:Dilpacimab (ABT165) is a dual-variable antibody that targets DLL4 and VEGF pathways, showing potential in cancer research by blocking angiogenesis and Notch.Purity:95% - 97.7% (SDS-PAGE); 95.6% (SEC-HPLC)Color and Shape:LiquidAnbenitamab
CAS:Anbenitamab (KN-026) is a bispecific HER2 antibody for metastatic breast cancer research, blocking HER2 pathways and mediating ADCC.Color and Shape:LiquidBafisontamab
CAS:Bafisontamab (EMB-01) is a bispecific antibody that targets EGFR and cMET, displaying antitumor activity [1].Color and Shape:LiquidApatinib-d8
CAS:Apatinib-d8 is a deuterated compound of Apatinib. Apatinib has a CAS number of 811803-05-1. Apatinib is an orally bioavailable and specific VEGFR2 inhibitor (IC50: 1 nM). In addition, this agent mildly inhibits c-Kit and c-SRC tyrosine kinases.Formula:C24H15D8N5OColor and Shape:SolidMolecular weight:405.52Dasatinib-d8
CAS:Dasatinib D8 is deuterium-labeled dasatinib. Dasatinib is a dual Bcr-Abl and Src family tyrosine kinase inhibitor.Formula:C22H26ClN7O2SPurity:98%Color and Shape:SolidMolecular weight:496.06Ibrutinib-d5
CAS:Ibrutinib D5 is a deuterium-labeled Ibrutinib. Ibrutinib is an irreversible Btk inhibitor.Formula:C25H24N6O2Purity:98%Color and Shape:SolidMolecular weight:445.53Erlotinib mesylate
CAS:Erlotinib: reversible inhibitor binding to ATP site of epidermal growth factor receptor.Formula:C23H27N3O7SPurity:98%Color and Shape:SolidMolecular weight:489.54GZD856 formic
CAS:GZD856 formic inhibits PDGFRα/β (IC50: 68.6, 136.6 nM) & Bcr-Abl (IC50: 19.9, 15.4 nM), with antitumor properties.Formula:C30H29F3N6O3Color and Shape:SolidMolecular weight:578.58ZM39923
CAS:ZM39923 is a JAK3 inhibitor (pIC50: 7.1). ZM39923 also effectively inhibits tissue transglutaminase (IC50: 10 nM).Formula:C23H25NOPurity:98%Color and Shape:SolidMolecular weight:331.45EGFR-IN-117
CAS:EGFR-IN-117 (Compound 8h) exhibits inhibitory activity against EGFR mutations, specifically targeting the tumor environment and inducing apoptosis in cancer cells. This compound effectively inhibits the proliferation of H1975, PC-9, and mutant EGFR cells including BaF3-EGFRL858R/T790M/C797S and BaF3–C797S/Del19/T790M, with IC50 values of 13 nM, 19 nM, 1.2 nM, and 1.3 nM respectively. Additionally, EGFR-IN-117 demonstrates anti-tumor activity in mouse models.Formula:C25H30BrN7O2SColor and Shape:SolidMolecular weight:572.52IGF-1R modulator 1
CAS:IGF-1Rmodulator 1 (Example 5) is an IGF-1R modulator featuring an EC50 of 0.29 μM (FGFR1), 0.25 μM (IGF1R), 0.34 μM (TrkA), and 0.39 μM (TrkB). This compound is useful in research on diseases characterized by impaired signaling of neurotrophic and/or other trophic factors, such as Alzheimer's disease.Formula:C22H17N3O4Color and Shape:SolidMolecular weight:387.39EGFR-IN-109
CAS:EGFR-IN-109 (compound 4), an EGFR inhibitor, displays IC 50 values of 25.8 nM for EGFR WT and 182.3 nM for EGFR T790M. This compound halts the growth of cancer cells at the G2/M phase and triggers both early and late apoptosis. It is applicable in cancer research [1].Formula:C12H16N4OSColor and Shape:SolidMolecular weight:264.35HVH-2930
CAS:HVH-2930 is an inhibitor of Heat Shock Protein 90 (HSP90). It suppresses the cell viability of BT474 (Trastuzumab sensitive) and JIMT-1 (Trastuzumab resistant) by downregulating HSP90 client proteins such as HER2, p-HER2, AKT, p-AKT, cyclin D1, and survivin, with IC50 values of 6.86 μM and 4.42 μM, respectively. Additionally, HVH-2930 demonstrates antitumor efficacy in a mouse model and exhibits favorable pharmacokinetic properties in vivo.Formula:C29H36N4O3Color and Shape:SolidMolecular weight:488.62AD1058
CAS:AD1058 is a selective ATR inhibitor that crosses the blood-brain barrier with in vivo anticancer activity, used in the study of brain and CNS metastasis.Formula:C19H20N6O3SPurity:98.24%Color and Shape:SolidMolecular weight:412.47Ref: TM-T200105
1mg73.00€5mg160.00€10mg250.00€25mg537.00€50mg827.00€100mg1,108.00€200mg1,485.00€1mL*10mM (DMSO)170.00€ALK5-IN-79
CAS:ALK5-IN-79 (compound 57), an ALK inhibitor, exhibits anticancer activity by inhibiting the TGF-β1/SMAD signaling pathway. It effectively reduces the production of extracellular matrix (ECM) and collagen deposition. Moreover, ALK5-IN-79 demonstrates satisfactory pharmacokinetic (PK) properties and favorable in vivo tolerance.Formula:C23H27N7OColor and Shape:SolidMolecular weight:417.51ALKBH5-IN-3
CAS:ALKBH5-IN-3 (Compound 20m) is a selective ALKBH5 inhibitor (IC50=21 nM), effectively stabilizes ALKBH5 in HepG2 cells and elevates m6A levels in intact cells.Formula:C11H7F3N2O3Purity:98.32%Color and Shape:SolidMolecular weight:272.18ZM323881 hydrochloride
CAS:ZM323881 hydrochloride (ZM 323881 HCl) is a potent and selective VEGFR2 inhibitor.Formula:C22H19ClFN3O2Purity:99.43%Color and Shape:SolidMolecular weight:411.86Ref: TM-T1991
1mg34.00€5mg66.00€10mg96.00€25mg225.00€50mg369.00€100mg550.00€200mg780.00€1mL*10mM (DMSO)69.00€Icotinib
CAS:Icotinib (Conmana) is an orally available quinazoline-based inhibitor of epidermal growth factor receptor (EGFR), with potential antineoplastic activity.Formula:C22H21N3O4Purity:99.76% - 99.94%Color and Shape:SolidMolecular weight:391.42Dovitinib Dilactic Acid
CAS:Dovitinib dilactic acid: multitarget RTK inhibitor for FLT3/c-Kit (IC50=1-2 nM), FGFR1/3, VEGFR1-4 (IC50=8-13 nM), less effective on InsR, EGFR. Phase 4.Formula:C21H21FN6O·2C3H6O3Purity:98%Color and Shape:SolidMolecular weight:572.59MAPK-IN-2
MAPK-IN-2 (compound 3h) is an efficacious MAPK inhibitor with antineoplastic properties that significantly hinders proliferation across various cancer cellFormula:C20H11Cl2N3OPurity:98%Color and Shape:SolidMolecular weight:380.23(3S,4S)-Tofacitinib
CAS:(3S,4S)-Tofacitinib, a less active enantiomer of tofacitinib, is a Janus kinases inhibitor.Formula:C16H20N6OPurity:98%Color and Shape:SolidMolecular weight:312.37Des-(4-(dimethylamino)-2-butenoyl)-Neratinib
CAS:Controlled ProductApplications 6-Amino-4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxyquinoline-3-carbonitrile, is used in the synthetic preparation of aminopropanamides which is used in irreversible inhibition of epidermal growth factor receptor (EGFR) for potential use in cancer therapy.
References Carmi, C., et al.: J. Med. Chem., 55, 2251 (2012)Formula:C24H20ClN5O2Color and Shape:NeatMolecular weight:445.9Tyrphostin AG 1478
CAS:Controlled ProductApplications Tyrphostin AG 1478 is a potent and selective inhibitor of EGFR.
Formula:C16H14ClN3O2Color and Shape:NeatMolecular weight:315.75N-(4-Fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)-2-pyrimidinamine
CAS:Controlled ProductFormula:C20H16FN5O3Color and Shape:Light Yellow To YellowMolecular weight:393.37N4-(2,3-Dimethyl-2H-indazol-6-yl)-N4-methyl-2,4-pyrimidinediamine
CAS:Controlled ProductApplications N4-(2,3-Dimethyl-2H-indazol-6-yl)-N4-methyl-2,4-pyrimidinediamine is a degredation product of Pazopanib (P210925), an oral angiogenesis inhibitor targeting VEGFR and PDGFR.
References Olaussen, K., et al.: Oncogen., 28, 4249 (2009), Sleijfer, S., et al.: J. Clin. Oncol., 27, 3126 (2009), Chan, A., et al.: Drugs, 69, 167 (2009), Patel, P. et al.: J. Mass. Spec., 50, 918 (2015);Formula:C14H16N6Color and Shape:NeatMolecular weight:268.324-Fmoc-3(R)-morpholinecarboxylic Acid
CAS:Controlled ProductApplications 4-Fmoc-3(R)-morpholinecarboxylic Acid is used to prepare 125I-labeled morpholine-containing RGD ligand of αvβ3 integrin as angiogenesis imaging probe.
References Bianchini, F., et al.: J. Med. Chem., 55, 5024 (2012)Formula:C20H19NO5Color and Shape:NeatMolecular weight:353.372,3-Naphthalic Anhydride
CAS:Controlled ProductStability Moisture Sensitive
Applications 2,3-Naphthalic anhydride is used as a reagent to synthesize analogues of Thalidomide (T338850), an inhibitor of tumour necrosis factor that was once abandoned because it caused birth defects, but is currently used as an inhibitor of angiogenesis in patients with multiple myeloma.
References D’Amato, R., et al.: Proc. Nat. Acad. Sci., 91, 4082 (1994); Ehrenpreis, E., et al.: Gastroenterology, 117, 1271 (1999); Parma, T., et al.: Nat. Med., 5, 582 (1999); Singhal, S., et al.: New Engl. J. Med., 341, 1565 (1999)Formula:C12H6O3Color and Shape:NeatMolecular weight:198.17rac trans-3-Hydroxy Apatinib Dihydrochloride
CAS:Controlled ProductStability Hygroscopic
Applications Dihydrochloride salt of trans-3-Hydroxy Apatinib, a metabolite of the antiangiogenic agent and selective VEGFR2 inhibitor Apatinib (A726150).
References Ding, J, et al.: J. Chrom B Anal. Technol. Biomed. Life Sci., 895, 108 (2012);Formula:C24H25Cl2N5O2Color and Shape:NeatMolecular weight:486.39AZ 5104
CAS:Controlled ProductApplications AZ 5104 is a derivative of AZD 9291 (A808075) is a selective EGFR inhibitor (epidermal growth factor receptor), used in the treatments of nonsmall-cell lung cancer (NSCLC).
References Finlay, M.R.V., et al.: J. Med. Chem., 57, 8249 (2014);Formula:C27H31N7O2Color and Shape:Off-WhiteMolecular weight:485.58
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