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Angiogenesis

Angiogenesis

Angiogenesis inhibitors are compounds that interfere with the formation of new blood vessels, a process critical in cancer growth and metastasis. By inhibiting angiogenesis, these compounds can restrict the blood supply to tumors, slowing or halting their growth. Angiogenesis inhibitors are essential in cancer research and therapeutic development, providing insights into the mechanisms of tumor progression and offering potential treatments for cancer and other angiogenesis-related diseases. At CymitQuimica, we offer a wide range of high-quality angiogenesis inhibitors to support your research in oncology and vascular biology.

Subcategories of "Angiogenesis"

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Found 1522 products of "Angiogenesis"

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  • MM-589 TFA
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    MM-589 TFA

    CAS:
    <p>MM-589 TFA is a potent WD repeat domain 5 (WDR5)inhibitor and mixed lineage leukemia (MLL) protein-protein interaction.</p>
    Formula:C30H45F3N8O7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:686.72

    Ref: TM-T12091L

  • RGB-286638
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    RGB-286638

    CAS:
    <p>RGB-286638 inhibits multiple CDKs and GSK-3β, TAK1, Jak2, MEK1 with IC50s as low as 1-54 nM.</p>
    Formula:C29H37Cl2N7O4
    Color and Shape:Solid
    Molecular weight:618.55

    Ref: TM-T73196

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    EGFR-IN-17

    <p>EGFR-IN-17: potent, selective EGFR inhibitor, IC50 of 0.2 nM, overcomes C797S drug resistance.</p>
    Formula:C27H31ClN7O3P
    Color and Shape:Solid
    Molecular weight:568.01

    Ref: TM-T64020

  • E7090 succinate
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    E7090 succinate

    CAS:
    <p>E7090 succinate inhibits FGFR1, FGFR2, and FGFR3 with IC50: 0.71, 0.50, 1.2 nM; less so FGFR4 at 120 nM.</p>
    Formula:C76H92N10O24
    Color and Shape:Solid
    Molecular weight:1529.60

    Ref: TM-T72749

  • ALK-IN-31
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    ALK-IN-31

    CAS:
    <p>ALK-IN-31 (Compound Ld-10) is an orally active ALK inhibitor with an IC50 of 1135 nM. It demonstrates excellent antiproliferative activity against lung cancer cells H2228, with an IC50 value of 1.35 μM. ALK-IN-31 induces apoptosis and arrests cell proliferation at the G0/G1 phase by affecting mitochondrial function. It exhibits antitumor effects by downregulating the expression of p-AKT and p-mTOR in the PI3K-AKT-mTOR signaling pathway downstream of ALK. This compound is applicable for research into non-small cell lung cancer (NSCLC).</p>
    Formula:C30H33N5O2S
    Color and Shape:Solid
    Molecular weight:527.68

    Ref: TM-T207183

  • CLM3
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    CLM3

    CAS:
    <p>CLM3, a pyrazolopyrimidine derivative, functions as a multitargeted tyrosine kinase inhibitor. It exhibits antiproliferative and proapoptotic activities on endothelial and cancer cells, activities that are synergistically enhanced by SN38. The primary mechanism of action for CLM3 involves the inhibition of phosphorylation in tyrosine kinases such as VEGFR-2, EGFR, and RET, along with their associated signaling pathways.</p>
    Formula:C21H21N5
    Color and Shape:Solid
    Molecular weight:343.43

    Ref: TM-T200080

  • SYHA1815
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    SYHA1815

    CAS:
    SYHA1815, an orally active RET inhibitor (IC50=0.9 nmol/L), demonstrates antitumor activity. It exhibits greater selectivity for RET over KDR (IC50=15.9 nmol/L). SYHA1815 operates by downregulating c-Myc, arresting the G1 cell cycle, and inhibiting RET-driven cell proliferation.
    Formula:C27H26ClF4N5O
    Color and Shape:Solid
    Molecular weight:547.98

    Ref: TM-T200124

  • Protein Kinase Inhibitor 12
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    Protein Kinase Inhibitor 12

    CAS:
    <p>Protein Kinase Inhibitor 12 (compound 1-91) is protein kinase inhibitor,PIM-1, CDK-2, GSK-3, and SRC mammalian protein kinases.</p>
    Formula:C14H14N4OS
    Purity:98.06%
    Color and Shape:Solid
    Molecular weight:286.35

    Ref: TM-T204404

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    Anticancer agent 69

    <p>Anticancer agent 69 targets PC3 cells (IC50=26 nM), raises ROS, lowers EGFR, and induces apoptosis.</p>
    Formula:C19H26N8S
    Color and Shape:Solid
    Molecular weight:398.53

    Ref: TM-T61902

  • Multi-kinase inhibitor 3
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    Multi-kinase inhibitor 3

    CAS:
    <p>Multi-kinase inhibitor 3 (compound 12) is an orally active and effective multikinase (multikinase) inhibitor, demonstrating potent IC50 values against FLT1/VEGFR1, KDR/VEGFR2, FLT4/VEGFR3, FLT3, PDGFRα, and PDGFRβ, at 1.59, 1.23, 1.19, 0.59, 0.22, and 1.15 nM respectively. This compound exhibits anti-proliferative and anticancer activities.</p>
    Formula:C26H26N6O2
    Color and Shape:Solid
    Molecular weight:454.52

    Ref: TM-T200518

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    Antiallergic agent-1

    <p>Antiallergic agent-1, an Src family kinase inhibitor, is a new and valuable lead compound with potential as an anti-allergic agent.</p>
    Formula:C27H19F6N5O
    Color and Shape:Solid
    Molecular weight:543.46

    Ref: TM-T63825

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    EGFR-IN-58

    <p>EGFR-IN-58 is a potent, selective, ATP-competitive inhibitor of EGFR. EGFR-IN-58 exhibits significant cytotoxicity against melanoma, colon and blood cancers.</p>
    Formula:C31H30FN7O
    Color and Shape:Solid
    Molecular weight:535.61

    Ref: TM-T63774

  • SILA-123
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    SILA-123

    CAS:
    <p>SILA-123, an inhibitor of FLT3 (FLT3-WT: IC50=2.1 nM; FLT3-ITD: IC50=1.0 nM), induces cell apoptosis by hindering the cell cycle progression at the G0/G1 phase through the suppression of FLT3 phosphorylation and its downstream signaling pathways. This compound is utilized in the study of acute myeloid leukemia.</p>
    Formula:C24H25N5O2
    Color and Shape:Solid
    Molecular weight:415.49

    Ref: TM-T200498

  • RET-IN-14
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    RET-IN-14

    CAS:
    <p>RET-IN-14 inhibits RET (IC50: &lt;0.51-9.3 nM) &amp; BTK (C481S) (IC50: 9.2-15 nM), promising for tumor research.</p>
    Formula:C24H23FN8O4
    Color and Shape:Solid
    Molecular weight:506.49

    Ref: TM-T63468

  • I194496
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    I194496

    CAS:
    <p>I194496 is an effective inhibitor of cystathionine γ-lyase (CSE) with an IC50 value of 0.79 mM. It inhibits the growth of human TNBC cells by dual targeting the PI3K/Akt and Ras/Raf/ERK pathways. Additionally, I194496 suppresses the metastasis of human TNBC cells by downregulating the Anxa2/STAT3 and VEGF/FAK/Paxillin signaling pathways.</p>
    Formula:C28H23F2N5O5S
    Color and Shape:Solid
    Molecular weight:579.58

    Ref: TM-T201096

  • JAK3/BTK-IN-4
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    JAK3/BTK-IN-4

    CAS:
    <p>JAK3/BTK-IN-4, a dual inhibitor for JAK3/BTK, shows synergy in autoimmune disease treatment. (Patent WO2021147953A1, compound 003)</p>
    Formula:C21H25ClN8O
    Color and Shape:Solid
    Molecular weight:440.93

    Ref: TM-T62553

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    FAK-IN-6

    <p>FAK-IN-6: Potent FAK inhibitor (IC50=1.415 nM), anti-cancer, for pancreatic studies.</p>
    Formula:C25H31ClN5O6PS
    Color and Shape:Solid
    Molecular weight:596.04

    Ref: TM-T64207

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    VEGFR-2/DHFR-IN-1

    <p>Compound 8b inhibits VEGFR-2/DHFR, combats various bacteria, and fights cancer cells.</p>
    Formula:C20H18ClNO4
    Color and Shape:Solid
    Molecular weight:371.81

    Ref: TM-T61489

  • YSY01A
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    YSY01A

    CAS:
    <p>YSY01A is a proteasome inhibitor that suppresses cancer cell survival by inducing apoptosis (Apoptosis). It demonstrates IC50 values against various cell lines such as HEK293T, A549, MCF-7, MGC-803, and PC-3M with values of 51.01, 9.21, 5.21, 8.9, and 35.4 nM respectively. Additionally, YSY01A serves as a degrader of gp130 and JAK2, eliminating constitutive STAT3 signaling in human A549 lung cancer cells by downregulating gp130 and JAK2. YSY01A holds potential for research in cancer therapeutics.</p>
    Formula:C29H38BN5O5
    Color and Shape:Solid
    Molecular weight:547.45

    Ref: TM-T200778

  • EGFR-IN-125
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    EGFR-IN-125

    CAS:
    <p>EGFR-IN-125 (example 37) is a potent EGFR inhibitor with IC50 values of &lt;0.3 nM for EGFR(d746-750/T790M/C797S), 0.52 nM for EGFR(L858R/T790M/C797S), 0.5 nM for EGFR(d746-750/C797S), 0.69 nM for EGFR(L858R/C797S), and 0.92 nM for EGFR (wild type).</p>
    Formula:C30H26N8O
    Color and Shape:Solid
    Molecular weight:514.58

    Ref: TM-T204450