Angiogenesis
Angiogenesis inhibitors are compounds that interfere with the formation of new blood vessels, a process critical in cancer growth and metastasis. By inhibiting angiogenesis, these compounds can restrict the blood supply to tumors, slowing or halting their growth. Angiogenesis inhibitors are essential in cancer research and therapeutic development, providing insights into the mechanisms of tumor progression and offering potential treatments for cancer and other angiogenesis-related diseases. At CymitQuimica, we offer a wide range of high-quality angiogenesis inhibitors to support your research in oncology and vascular biology.
Subcategories of "Angiogenesis"
- BTK(145 products)
- Bcr-Abl(102 products)
- EGFR(572 products)
- FAK(72 products)
- FLT(92 products)
- Fibroblast Growth Factor Receptor (FGFR)(170 products)
- JAK(245 products)
- PDGFR(126 products)
- RAAS(86 products)
- Src(78 products)
- Syk(38 products)
- Thrombin(47 products)
- VDA(2 products)
- VEGFR(268 products)
Show 6 more subcategories
Found 1414 products of "Angiogenesis"
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AG 1406
CAS:<p>AG 1406 is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2.</p>Formula:C16H18N2OPurity:98.12%Color and Shape:SolidMolecular weight:254.33Bafetinib
CAS:<p>Bafetinib (INNO-406): Dual Bcr-Abl/Lyn inhibitor; IC50: 5.8/19 nM; ineffective against T315I mutant, less on c-Kit/PDGFR.</p>Formula:C30H31F3N8OPurity:94.16% - 99.68%Color and Shape:SolidMolecular weight:576.62PRT062607 hydrochloride
CAS:<p>PRT062607 hydrochloride (P505-15 Hydrochloride) is a selective inhibitor of Syk. PRT062607 displays at least 80-fold selectivity for Syk over other kinases.</p>Formula:C19H23N9O·HClPurity:97.7% - 99.81%Color and Shape:SolidMolecular weight:429.91Tropisetron
CAS:<p>Tropisetron (ICS 205-930) is an α7-nicotinic receptor agonist and 5-HT3 receptor antagonist with Kis of 6.9 nM and 5.3 nM, respectively.</p>Formula:C17H20N2O2Purity:99.68%Color and Shape:White SolidMolecular weight:284.35EHop-016
CAS:<p>EHop-016 is a specific Rac GTPase inhibitor with IC50 of 1.1 μM for Rac1 in MDA-MB-231 and MDA-MB-435 cells, equally effective inhibition for Rac3.</p>Formula:C25H30N6OPurity:98.99% - >99.99%Color and Shape:SolidMolecular weight:430.55Filgotinib maleate
CAS:<p>Filgotinib maleate, a selective oral JAK1 inhibitor, treats RA and Crohn's. IC50s: JAK1-10nM, JAK2-28nM, JAK3-810nM, TYK2-116nM.</p>Formula:C25H27N5O7SColor and Shape:SolidMolecular weight:541.58BMS 599626 2HCl
CAS:<p>BMS 599626 2HCl (873837-23-1(HCl)) (AC480 dihydrochloride) is a selective inhibitor of HER1 and HER2 (IC50s: 20 nM and 30 nM), ~8-fold less potent to HER4, >100</p>Formula:C27H29FN8O3Cl2Purity:99.94%Color and Shape:SoildMolecular weight:603.48Regorafenib
CAS:<p>Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orally</p>Formula:C21H15ClF4N4O3Purity:98% - 99.95%Color and Shape:SolidMolecular weight:482.82KRCA-0008
CAS:<p>KRCA-0008 is an effective and specific ALK/Ack1 inhibitor (IC50: 12/4 nM); displays drug-like properties without hERG liability.</p>Formula:C30H37ClN8O4Purity:96.19%Color and Shape:SolidMolecular weight:609.12N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-bromoaniline
CAS:<p>Compound 12d is a potent ALK5 inhibitor with an IC50 of 7nM.</p>Formula:C22H18BrN7Purity:99.935%Color and Shape:SolidMolecular weight:460.33NRC-2694 hydrochloride
CAS:<p>NRC-2694 hydrochloride is an epidermal growth factor receptor (EGFR) antagonist potentially for the treatment of solid tumors.</p>Formula:C24H27ClN4O3Color and Shape:SolidMolecular weight:454.95Epitinib
CAS:<p>Epitinib is an orally active, selective, blood-brain barrier crossing epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI).</p>Formula:C24H26N6O2Color and Shape:SolidMolecular weight:430.5(E/Z)-Zotiraciclib citrate
<p>(E/Z)-Zotiraciclib ((E/Z)-TG02) citrate is a potent inhibitor of CDK2, JAK2 and FLT3 and can be used in cancer research.</p>Formula:C29H32N4O8Color and Shape:SolidMolecular weight:564.59PKI-166 hydrochloride
CAS:<p>EGFR-kinase inhibitor, IC50 0.7 nM, >3000x selective, cuts metastasis and angiogenesis in mice, antihypertensive, oral use.</p>Formula:C20H19ClN4OColor and Shape:SolidMolecular weight:366.85Treprostinil Sodium
CAS:<p>Treprostinil Sodium (UT-15) is a potent DP1, IP and EP2 agonist (EC50: 0.6/1.9/6.2 nM).</p>Formula:C23H33NaO5Purity:99.67% - >99.99%Color and Shape:SolidMolecular weight:412.5Ritlecitinib tosylate
CAS:<p>Ritlecitinib (PF-06651600) is a potent, selective JAK3 inhibitor with proven in vivo efficacy, low clearance, and has undergone clinical trials.</p>Formula:C22H27N5O4SColor and Shape:SolidMolecular weight:457.549ALK kinase inhibitor-1
CAS:<p>SAR348830 is an ALK inhibitor, targeting anaplastic lymphoma kinase.</p>Formula:C28H32FN5O3SPurity:99.84%Color and Shape:SolidMolecular weight:537.65Afatinib Dimaleate
CAS:<p>Afatinib Dimaleate (BIBW 2992MA2) is an orally bioavailable anilino-quinazoline derivative and inhibitor of the EGFR family, with antineoplastic activity.</p>Formula:C32H33ClFN5O11Purity:98.11% - 99.87%Color and Shape:SolidMolecular weight:718.08Atopaxar hydrochloride
CAS:<p>Atopaxar hydrochloride is used in the Treatment of Cardiovascular Disorders.</p>Formula:C29H39ClFN3O5Color and Shape:SolidMolecular weight:564.1Vandetanib trifluoroacetate
CAS:<p>Vandetanib trifluoroacetate: oral VEGFR2/KDR inhibitor, IC50=40nM, also blocks VEGFR3/FLT4 (110nM) and EGFR/HER1 (500nM).</p>Formula:C24H25BrF4N4O4Color and Shape:SolidMolecular weight:589.386Cevidoplenib dimesylate hydrochloride
CAS:<p>Cevidoplenib dimesylate hydrochloride is a spleen tyrosine kinase (Syk) inhibitor showing potential immunomodulating and anti-inflammatory properties.</p>Formula:C90H132Cl5N27O12Purity:97.52%Color and Shape:SolidMolecular weight:1957.9Dapagliflozin
CAS:<p>Dapagliflozin (BMS-512148) is a selective sodium-glucose co-transporter subtype 2 (SGLT2) inhibitor with antihyperglycemic activity.</p>Formula:C21H25ClO6Purity:99.5% - 99.93%Color and Shape:SolidMolecular weight:408.87MGCD-265 analog
CAS:<p>Glesatinib, an oral tyrosine kinase inhibitor, targets c-Met and VEGFR2 with IC50s of 29 nM and 10 nM, may treat cancer.</p>Formula:C26H20FN5O2S2Purity:98.06% - 98.68%Color and Shape:SolidMolecular weight:517.6Cabozantinib hydrochloride
CAS:<p>Cabozantinib hydrochloride (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt4 (IC50s: 0.035, 1.3, 4.6, 7 and 6</p>Formula:C28H25ClFN3O5Purity:99.97%Color and Shape:SolidMolecular weight:537.96Derazantinib dihydrochloride
CAS:<p>Derazantinib, a multi-kinase inhibitor targeting FGFR, benefits FGFR2-positive iCCA; its dihydrochloride form is a salt variant.</p>Formula:C29H31Cl2FN4OColor and Shape:SolidMolecular weight:541.49Tandutinib hydrochloride
CAS:<p>Tandutinib hydrochloride: FLT3 inhibitor (IC50 0.22 μM), targets c-Kit, PDGFR, treats AML, crosses blood-brain barrier.</p>Formula:C31H43ClN6O4Color and Shape:SolidMolecular weight:599.16(S)-Sunvozertinib
CAS:<p>(S)-Sunvozertinib (DZD9008) is a rationally designed selective, irreversible EGFR/HER2 inhibitor.</p>Formula:C29H35ClFN7O3Purity:99.64%Color and Shape:SolidMolecular weight:584.08ZM323881
CAS:<p>ZM323881 is a potent and selective inhibitor of VEGFR2 with an IC 50 of less than 2 nM.</p>Formula:C22H18FN3O2Color and Shape:SolidMolecular weight:375.4Saracatinib difumarate
CAS:<p>Saracatinib difumarate is an orally available dual-specific inhibitor of Src and Abl with anti-invasive and anti-tumor activities.</p>Formula:C35H40ClN5O13Color and Shape:SolidMolecular weight:774.18TG 100801
CAS:<p>TG 100801 is a dual inhibitor of VEGFr2 and Src family kinases and is a candidate compound for the treatment of age-related macular degeneration (AMD).</p>Formula:C33H30ClN5O3Purity:99.28% - 99.61%Color and Shape:SolidMolecular weight:580.08AZ 5104
CAS:Controlled Product<p>Applications AZ 5104 is a derivative of AZD 9291 (A808075) is a selective EGFR inhibitor (epidermal growth factor receptor), used in the treatments of nonsmall-cell lung cancer (NSCLC).<br>References Finlay, M.R.V., et al.: J. Med. Chem., 57, 8249 (2014);<br></p>Formula:C27H31N7O2Color and Shape:Off-WhiteMolecular weight:485.58N-Acryloyl Osimertinib (>85%)
CAS:<p>Applications N-Acryloyl Osimertinib is used in the preparation of pyrimidinyl indole derivative as EGFR inhibitor for targeted therapy of cancer<br>References Rao, Y., et al.: Faming Zhuanli Shenqing (2016), CN 105777716 A 20160720<br></p>Formula:C31H35N7O3Purity:>85%Color and Shape:Off White SolidMolecular weight:553.65SB 203580 hydrochloride
CAS:<p>SB 203580 hydrochloride (Adezmapimod hydrochloride) is a p38 MAPK inhibitor that induces mitochondrial autophagy and cytosolic autophagy.</p>Formula:C21H17ClFN3OSPurity:97.79%Color and Shape:SolidMolecular weight:413.9CCT241161
CAS:<p>CCT241161: oral pan-RAF inhibitor; IC50s: LCK (3 nM), CRAF (6), SRC (10), V600E-BRAF (15), BRAF (30); fights BRAF/NRAS melanomas, anti-proliferative.</p>Formula:C28H27N7O3SPurity:99.76% - 99.77%Color and Shape:SolidMolecular weight:541.62rac-Clopidogrel Hydrochloride
CAS:<p>Impurity Clopidogrel Impurity B; Clopidogrel USP B; Clopidogrel USP Related Compound B<br>Applications Clopidogrel Related Compound B (Clopidogrel Impurity B; Clopidogrel USP B; Clopidogrel USP Related Compound B) is a tetrahydrothienopyridine as inhibitor of angiogenesis.<br>References Maffrand, J. P., et al.: Eur. J. Med. Chem., 9, 483 (1974), Thebault, J.J., et al.: Clin. Pharmacol. Ther., 18, 485 (1975),<br></p>Formula:C16H16ClNO2S·ClHColor and Shape:NeatMolecular weight:358.28rac trans-3-Hydroxy Apatinib Dihydrochloride
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Dihydrochloride salt of trans-3-Hydroxy Apatinib, a metabolite of the antiangiogenic agent and selective VEGFR2 inhibitor Apatinib (A726150).<br>References Ding, J, et al.: J. Chrom B Anal. Technol. Biomed. Life Sci., 895, 108 (2012);<br></p>Formula:C24H25Cl2N5O2Color and Shape:NeatMolecular weight:486.39Glycerol 1-Monobutyrate (Technical Grade)
CAS:<p>Applications Glycerol 1-Monobutyrate functions as a key regulatory molecule in angiogenic process.<br>References Dobson, D. E., et al.: Cell (Cambridge, MA, U. S.), 61, 223 (1990)<br></p>Formula:C7H14O4Color and Shape:NeatMolecular weight:162.18Dapolsertib
CAS:<p>Dapolsertib (SEL24-B489) is an orally active and efficient PIM and FLT3-ITD inhibitor, reducing PIM-specific substrate phosphorylation.</p>Formula:C15H18Br2N4O2Purity:99.61%Color and Shape:SolidMolecular weight:446.14Itacnosertib
CAS:<p>Itacnosertib (TP-0184) is an orally available ACRV1 (ALK-2), FLT3 and JAK2 inhibitor that inhibits the growth of tumor cells,antitumor and antileukemic.</p>Formula:C26H28N8OPurity:99.38%Color and Shape:SolidMolecular weight:468.55Seribantumab
CAS:<p>Seribantumab (MM 121) is a humanized monoclonal antibody targeting HER3, inhibiting cancer cell proliferation.</p>Purity:>95%Color and Shape:LiquidMolecular weight:143.2 (kDa)Amivantamab
CAS:<p>Amivantamab (JNJ-61186372) is an antibody that recognizes EGFR and MET and has anticancer and antitumor activities.</p>Purity:97.24% (SEC-HPLC) - 99.74%Color and Shape:LiquidMolecular weight:145.88 kDaTirabrutinib
CAS:<p>Tirabrutinib, an oral Btk inhibitor (IC50=6.8 nM), crosses the BBB and halts B cell signaling for autoimmune and hematologic studies.</p>Formula:C25H22N6O3Purity:99.64%Color and Shape:SolidMolecular weight:454.48α-Eudesmol
CAS:<p>Applications α-Eudesmol is an isomer of β-Eudesmol (E938600), a sesquiterpenoid known to induce neurite outgrowth. β-Eudesmol exhibits antiangiogenic activity.<br>References Obara, Y. et al.: J. Pharmacol. Exp . Ther., 30, 803 (2011); Tsuneki, H. et al.: Eur. J. Pharmacol., 512, 105 (2005);<br></p>Formula:C15H26OColor and Shape:White To Off-WhiteMolecular weight:222.37Cpd27
CAS:<p>Cpd27 (TIE-2/VEGFR-2 kinase-IN-2) is a TIE-2 and VEGFR-2 inhibitor that inhibits RIPK1 and can be used to study glaucoma.</p>Formula:C20H13F4N5O2Purity:98.89%Color and Shape:SolidMolecular weight:431.34SB-505124 hydrochloride
CAS:<p>SB-505124 hydrochloride (SB505124 hydrochloride) is a TGF-β type I receptor (ALK4, ALK5, ALK7) inhibitor for the study of colorectal cancer.</p>Formula:C20H22ClN3O2Purity:98.71%Color and Shape:SolidMolecular weight:371.86Cavutilide
CAS:<p>Cavutilide has antiarrhythmic activity, inhibits hERG K(+) channels, and can be used to study heart failure and persistent atrial fibrillation.</p>Formula:C22H26FN3O3Purity:99.82% - 99.85%Color and Shape:SolidMolecular weight:399.458Donafenib
CAS:<p>Donafenib(Bay 43-9006 (D3)) is a deuterium-labeled Sorafenib which is a multikinase inhibitor(IC50s: 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3,</p>Formula:C21H13ClD3F3N4O3Purity:99.88%Color and Shape:SolidMolecular weight:467.84AZ 12799734
CAS:<p>AZ 12799734 is an orally active, selective and potent dual inhibitor of TGFBR1 and ALK5 with inhibitory effects on BMP and TGFβ for the study of tumours.</p>Formula:C18H18N4O3SPurity:98.23%Color and Shape:SolidMolecular weight:370.43Behenamide
CAS:Controlled Product<p>Applications Behenamide is a fatty acid amide as an angiogenic. The mechanism of angiogenic activity is unknown and this lipid does not promote proliferation of endothelial cells or induce inflammatory effects.<br>References Wakamatsu, K., et al.: Biochem. Biophysical Res. Comm., 168, 423 (1990),<br></p>Formula:C22H45NOColor and Shape:White To Off-WhiteMolecular weight:339.6
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