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Angiogenesis

Angiogenesis

Angiogenesis inhibitors are compounds that interfere with the formation of new blood vessels, a process critical in cancer growth and metastasis. By inhibiting angiogenesis, these compounds can restrict the blood supply to tumors, slowing or halting their growth. Angiogenesis inhibitors are essential in cancer research and therapeutic development, providing insights into the mechanisms of tumor progression and offering potential treatments for cancer and other angiogenesis-related diseases. At CymitQuimica, we offer a wide range of high-quality angiogenesis inhibitors to support your research in oncology and vascular biology.

Subcategories of "Angiogenesis"

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Found 2092 products of "Angiogenesis"

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  • FGFR-IN-5
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    FGFR-IN-5

    CAS:
    FGFR-IN-5 is a potent inhibitor of FGFR. FGFR-IN-5 has potential for research in cancer diseases.
    Formula:C25H22N6O3
    Color and Shape:Solid
    Molecular weight:454.48

    Ref: TM-T62794

  • MTX-216
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    MTX-216

    CAS:
    MTX-216 is an ATP-competitive inhibitor targeting both PI3K and EGFR. It simultaneously inhibits Ki-67 and ribosomal S6 phosphorylation, inducing apoptosis in NF1LOF cells. Additionally, MTX-216 suppresses SYK kinase activity with an IC50 of 281 nM. This compound is applicable for melanoma research.
    Formula:C22H14Cl2FN5O2S
    Color and Shape:Solid
    Molecular weight:502.348

    Ref: TM-T206251

  • Oxamic acid
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    Oxamic acid

    CAS:
    Oxamic acid is an LDHA inhibitor, antitumor, induces apoptosis, downregulates EGFR expression, and inhibits cancer stem cell properties and EMT.
    Formula:C2H3NO3
    Color and Shape:Solid
    Molecular weight:89.05

    Ref: TM-T201584

  • EGFR-IN-35
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    EGFR-IN-35

    CAS:
    EGFR-IN-35, an acrylamide-based EGFR inhibitor, shows promise for EGFR mutation-related cancers like NSCLC.
    Formula:C25H24ClN7O2
    Color and Shape:Solid
    Molecular weight:489.96

    Ref: TM-T63282

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    VEGFR-2-IN-12

    VEGFR-2-IN-12 (compound 6g), a 2-oxoquinoxalinyl-1,2,4-triazole, is a potent inhibitor of VEGFR-2 (IC50: 0.037 μM). VEGFR-2-IN-12 has anti-tumour effects.
    Formula:C22H24N6O3S
    Color and Shape:Solid
    Molecular weight:452.53

    Ref: TM-T62763

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    EGFR-IN-45

    EGFR-IN-45: Strong EGFR/CDK2 inhibitor (IC50s: 0.4 & 1.6 μM), halts cancer cell cycle pre-G1, prompts apoptosis, also targets Topo I/II.
    Formula:C28H23N7O
    Color and Shape:Solid
    Molecular weight:473.53

    Ref: TM-T63070

  • BPI-15086
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    BPI-15086

    CAS:
    BPI-15086 is an orally active, effective, irreversible inhibitor selective for mutations, targeting both EGFR and the T790M resistance mutation tyrosine kinase. It can be utilized in the study of non-small cell lung cancer.
    Formula:C29H33ClN8O4
    Color and Shape:Solid
    Molecular weight:593.08

    Ref: TM-T200004

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    FLT3/TrKA-IN-1

    FLT3/TrKA-IN-1: Potent dual kinase inhibitor for FLT3 & TrKA, promising for AML research.
    Formula:C28H30N4O2
    Color and Shape:Solid
    Molecular weight:454.56

    Ref: TM-T62801

  • Cernuumolide J
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    Cernuumolide J

    CAS:
    Cernuumolide J (TMJ-105) functions as a JAK2/STAT3 inhibitor and exhibits potent activity against HEL leukemia cells by inhibiting their growth in both time-dependent and concentration-dependent manners, with an IC 50 value of 1.79 μM. This compound effectively induces G2/M phase arrest and apoptosis by downregulating the phosphorylation of JAK2, STAT3, and Erk, while simultaneously upregulating the phosphorylation of JNK and p38 MAPK. Cernuumolide J holds potential for research applications in anti-cancer therapy.
    Formula:C24H34O8
    Color and Shape:Solid
    Molecular weight:450.52

    Ref: TM-T200239

  • DDO-02267
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    DDO-02267

    CAS:
    <p>DDO-02267 is a selective lysine-targeted covalent inhibitor of ALKBH5, with an IC50 value of 0.49 μM. It increases levels of N6-methyladenosine (m6A) and targets the ALKBH5-AXL signaling axis. DDO-02267 serves as a probe for studying the biological function of mRNA demethylases.</p>
    Formula:C18H12N2O7S
    Color and Shape:Solid
    Molecular weight:400.362

    Ref: TM-T204967

  • NSC381467
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    NSC381467

    CAS:
    NSC381467: Potent, oral EGFR-TK inhibitor with strong antiproliferative effects, promising for cancer research.
    Formula:C20H16O7
    Color and Shape:Solid
    Molecular weight:368.34

    Ref: TM-T61441

  • iBFAR2
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    iBFAR2

    CAS:
    <p>iBFAR2, an inhibitor of BFAR, restores the CD8+ tumor-resident memory T cell subset against solid tumors. It promotes the binding of JAK2-STAT1 and enhances the phosphorylation of STAT1.</p>
    Formula:C19H15F3N2O2
    Color and Shape:Solid
    Molecular weight:360.33

    Ref: TM-T204531

  • VEGFR-2-IN-25
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    VEGFR-2-IN-25

    CAS:
    VEGFR-2-IN-25 (compound 5d) is a potent inhibitor of VEGFR-2 (IC50: 12.1 nM).
    Formula:C24H22N6O2
    Color and Shape:Solid
    Molecular weight:426.47

    Ref: TM-T62314

  • VEGFR-2-IN-26
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    VEGFR-2-IN-26

    CAS:
    VEGFR-2-IN-26 inhibits VEGFR-2 (IC50: 15.5 nM), combating various cancers' cell growth.
    Formula:C24H19F3N6O2
    Color and Shape:Solid
    Molecular weight:480.44

    Ref: TM-T63168

  • EGFR-IN-146
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    EGFR-IN-146

    CAS:
    EGFR-IN-146 is an EGFR inhibitor that suppresses the EGFR signaling pathway and improves insulin sensitivity by activating the AMPK pathway. It effectively reduces blood glucose levels and body weight, showing great potential in the study of diabetes and obesity.
    Formula:C20H16N4
    Color and Shape:Solid
    Molecular weight:312.368

    Ref: TM-T206146

  • Tyk2-IN-10
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    Tyk2-IN-10

    CAS:
    Tyk2-IN-10 acts as an inhibitor of the Tyrosine Kinase 2 (Tyk2)-mediated signaling pathway, which plays a role in inflammation regulation.
    Formula:C25H27N5O3
    Color and Shape:Solid
    Molecular weight:445.51

    Ref: TM-T89889

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    FAK-IN-6

    FAK-IN-6: Potent FAK inhibitor (IC50=1.415 nM), anti-cancer, for pancreatic studies.
    Formula:C25H31ClN5O6PS
    Color and Shape:Solid
    Molecular weight:596.04

    Ref: TM-T64207

  • VEGFR-2-IN-52
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    VEGFR-2-IN-52

    CAS:
    VEGFR-2-IN-52 (compound 14d) serves as a powerful inhibitor of VEGFR-2, exhibiting an IC 50 of 191.1 nM. It effectively reduces the protein expression levels of p-VEGFR-2, MMP9, p-ERK1/2, and p-MEK1. In addition, VEGFR-2-IN-52 demonstrates cytotoxic properties by inducing apoptosis and arresting the cell cycle at the G0/G1 phase, and it enhances the levels of ROS.
    Formula:C20H25ClN4O2S
    Color and Shape:Solid
    Molecular weight:420.96

    Ref: TM-T89976

  • Lomonitinib
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    Lomonitinib

    CAS:
    <p>Lomonitinib is a potent and selective pan-FLT3/IRAK4 inhibitor with antitumor properties. It shows promise for research in myeloid leukemia.</p>
    Formula:C27H24N4O2
    Color and Shape:Solid
    Molecular weight:436.505

    Ref: TM-T205470

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    LT-850-166

    LT-850-166 is a potent inhibitor of FLT3 and has shown efficacy in overcoming a wide range of FLT3 mutations.
    Formula:C30H29Cl2N7O
    Color and Shape:Solid
    Molecular weight:574.5

    Ref: TM-T64062