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Angiogenesis

Angiogenesis

Angiogenesis inhibitors are compounds that interfere with the formation of new blood vessels, a process critical in cancer growth and metastasis. By inhibiting angiogenesis, these compounds can restrict the blood supply to tumors, slowing or halting their growth. Angiogenesis inhibitors are essential in cancer research and therapeutic development, providing insights into the mechanisms of tumor progression and offering potential treatments for cancer and other angiogenesis-related diseases. At CymitQuimica, we offer a wide range of high-quality angiogenesis inhibitors to support your research in oncology and vascular biology.

Subcategories of "Angiogenesis"

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Found 1424 products of "Angiogenesis"

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  • EGFR-IN-139
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    EGFR-IN-139

    CAS:
    <p>EGFR-IN-139 (compound PD 18) is an EGFR inhibitor with IC50 values of 12.88 nM (wild type), 10.84 nM (L858R/T790M), and 42.68 nM (L858R/T790M/C797S). It demonstrates significant anticancer activity against the A549 and H1975 cancer cell lines, which express high levels of EGFR. EGFR-IN-139 exhibits strong selectivity for cancer cells and can be utilized in research on non-small cell lung cancer (NSCLC).</p>
    Formula:C27H25ClN2O4
    Color and Shape:Solid
    Molecular weight:476.951

    Ref: TM-T204772

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    ALK-IN-23

    <p>ALK-IN-23 inhibits ALK (IC50: 1.6-0.71 nM), hinders cancer cell spread, forms colonies in vitro, and reduces tumors in mice with low toxicity.</p>
    Formula:C26H29ClN8O3S
    Color and Shape:Solid
    Molecular weight:569.08

    Ref: TM-T64027

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    EGFR-IN-47

    <p>EGFR-IN-47: strong oral EGFRL858R/T790M/C797S blocker, induces cell death; promising for NSCLC research. IC50: 0.01 μM.</p>
    Formula:C29H35N7
    Color and Shape:Solid
    Molecular weight:481.64

    Ref: TM-T63185

  • Protein kinase inhibitor 11
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    Protein kinase inhibitor 11

    CAS:
    <p>Protein kinase inhibitor 11 (Compound I-96) is an agent that inhibits the activity of PIM-1, CDK-2, GSK-3, and SRC. It shows potential for research in cancer, autoimmune diseases, and neurodegenerative disorders.</p>
    Formula:C21H18FN5O2S
    Color and Shape:Solid
    Molecular weight:423.463

    Ref: TM-T205016

  • BTK-IN-10
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    BTK-IN-10

    CAS:
    <p>BTK-IN-10 is a potent inhibitor of BTK, acting on wild-type BTK (IC50&lt;5 nM) or mutant BTK (C481S) (IC50&lt;5 nM).</p>
    Formula:C25H24F2N4O2
    Color and Shape:Solid
    Molecular weight:450.48

    Ref: TM-T62716

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    Ki11502

    CAS:
    <p>Ki11502 is a multi-target receptor tyrosine kinase (RTK) inhibitor that selectively inhibits the activity of PDGFβ/α receptors (with an IC50 of less than 10 nM). It specifically suppresses PDGFβ receptor phosphorylation, proliferation, and proteoglycan synthesis in human vascular smooth muscle cells. Additionally, Ki11502 induces apoptosis and exhibits significant antiproliferative effects against specific leukemia subgroups, including those with Imatinib-resistant mutations. It is particularly suitable for studying the role of PDGF in vascular diseases and the involvement of proteoglycans in atherosclerosis.</p>
    Formula:C26H23N3O4S
    Molecular weight:473.54

    Ref: TM-T208725

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    VEGFR-2-IN-14

    <p>VEGFR-2-IN-14 (Compound 5) is a potent inhibitor of VEGFR-2, which inhibits the growth of HepG2 cells in the Pre-G1 phase and induces apoptosis.</p>
    Formula:C24H23N3O3S
    Color and Shape:Solid
    Molecular weight:433.52

    Ref: TM-T62439

  • DHFR-IN-4
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    DHFR-IN-4

    CAS:
    <p>DHFR-IN-4 is a potent dihydrofolate reductase (DHFR) inhibitor with anti-tumour activity, inhibits EGFR and HER2 and can be used to study pancreatic cancer.</p>
    Formula:C18H21N5O2S
    Purity:99.41%
    Color and Shape:Solid
    Molecular weight:371.46

    Ref: TM-T61486

  • NSC381467
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    NSC381467

    CAS:
    <p>NSC381467: Potent, oral EGFR-TK inhibitor with strong antiproliferative effects, promising for cancer research.</p>
    Formula:C20H16O7
    Color and Shape:Solid
    Molecular weight:368.34

    Ref: TM-T61441

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    EGFR/HER2/DHFR-IN-1

    <p>Potent EGFR/HER2/DHFR inhibitor for MCF-7 breast cancer; IC50: 0.153/0.108/0.291 μM; arrests G1/S phase, triggers apoptosis.</p>
    Formula:C14H11BrN4O2S
    Color and Shape:Solid
    Molecular weight:379.23

    Ref: TM-T61596

  • AZD0424
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    AZD0424

    CAS:
    <p>AZD0424: oral Src/Abl kinase inhibitor; potential anticancer; induces apoptosis, cell cycle arrest in lymphoma.</p>
    Formula:C25H29ClN6O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:528.99

    Ref: TM-T14370

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    Ten01

    <p>Ten01 exhibits a 5.0 nM inhibition of JAK1 kinase.</p>
    Formula:C18H20F6N4O
    Color and Shape:Solid
    Molecular weight:422.37

    Ref: TM-T62257

  • VVD-118313
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    VVD-118313

    CAS:
    <p>VVD-118313 (5a) is a potent JAK1 inhibitor targeting allosteric cysteine, blocking cytokine signaling for cancer research.</p>
    Formula:C19H22Cl2N2O3S
    Color and Shape:Solid
    Molecular weight:429.36

    Ref: TM-T62361

  • FGFR3-IN-4
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    FGFR3-IN-4

    CAS:
    <p>FGFR3-IN-4 is a selective inhibitor targeting FGFR3, demonstrating an IC50 value of under 50 nM.</p>
    Formula:C26H24ClN7O
    Color and Shape:Solid
    Molecular weight:485.97

    Ref: TM-T73145

  • W23-1006
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    W23-1006

    CAS:
    <p>W23-1006 is a selective covalent ALKBH5 inhibitor. It binds to the ALKBH5 C200 residue with an IC50 value of 3.848 μM. The inhibitory activity of W23-1006 is approximately 30 times stronger than that of FTO and 8 times greater than that of ALKBH3. W23-1006 is applicable for research in triple-negative breast cancer (TNBC).</p>
    Formula:C17H12BrN3O5
    Color and Shape:Solid
    Molecular weight:418.198

    Ref: TM-T205034

  • Tofacitinib Prodrug-1
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    Tofacitinib Prodrug-1

    <p>Tofacitinib Prodrug-1: an oral prodrug reducing Tofacitinib's side effects, treats ulcerative colitis in mice effectively with low toxicity.</p>
    Formula:C36H39ClN10O7
    Color and Shape:Solid
    Molecular weight:759.21

    Ref: TM-T72406

  • FGFR1 inhibitor-15
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    FGFR1 inhibitor-15

    CAS:
    <p>FGFR1inhibitor-15 (Compound 23) is an FGFR1 inhibitor with an IC50 value of 27 μM, useful for tumor research.</p>
    Formula:C17H13FN4O
    Color and Shape:Solid
    Molecular weight:308.31

    Ref: TM-T205729

  • Clifutinib
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    Clifutinib

    CAS:
    <p>Clifutinib (Compound 9e) is an orally active, selective inhibitor of FMS-like tyrosine kinase 3 (FLT3-ITD) with an IC50 of 15.1 nM. It inhibits FLT3-ITD kinase activity and blocks downstream signaling pathways, including RAS/MAPK, PI3K/AKT, and JAK/STAT5. Clifutinib induces apoptosis in FLT3-ITD mutated acute myeloid leukemia (AML) cells and is a potential candidate for research in relapsed/refractory FLT3-ITD positive AML.</p>
    Formula:C29H34N4O4
    Color and Shape:Solid
    Molecular weight:502.605

    Ref: TM-T206767

  • EGFR-IN-149
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    EGFR-IN-149

    CAS:
    <p>EGFR-IN-149 (Compound 3-OH) is an EGFR inhibitor with an IC50 value of 0.42 nM.</p>
    Formula:C16H15N3OS
    Color and Shape:Solid
    Molecular weight:297.375

    Ref: TM-T205658

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    VEGFR-2-IN-10

    <p>VEGFR-2-IN-10 has enhanced antiangiogenic potency against VEGFR2 phosphorylation induced by VEGF with an IC50 value of 0.7 μM and no cytotoxic effects.</p>
    Formula:C20H21N3O2
    Color and Shape:Solid
    Molecular weight:335.4

    Ref: TM-T61038