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Angiogenesis

Angiogenesis

Angiogenesis inhibitors are compounds that interfere with the formation of new blood vessels, a process critical in cancer growth and metastasis. By inhibiting angiogenesis, these compounds can restrict the blood supply to tumors, slowing or halting their growth. Angiogenesis inhibitors are essential in cancer research and therapeutic development, providing insights into the mechanisms of tumor progression and offering potential treatments for cancer and other angiogenesis-related diseases. At CymitQuimica, we offer a wide range of high-quality angiogenesis inhibitors to support your research in oncology and vascular biology.

Subcategories of "Angiogenesis"

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Found 1424 products of "Angiogenesis"

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  • Gamendazole
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    Gamendazole

    CAS:
    <p>Gamendazole is a novel drug candidate for male contraception. It has been shown to reduce fertility in male rats without affecting testosterone levels.</p>
    Formula:C18H11Cl2F3N2O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:415.19

    Ref: TM-T24084

  • EGFR-IN-159
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    EGFR-IN-159

    CAS:
    <p>EGFR-IN-159 (compound 12) is a dihydropyrimidine and a potent EGFR inhibitor with an IC50 of 29.00 nM. It exhibits dose-dependent inhibition of EGFR and HER2. The compound shows cytotoxicity against MCF-7 breast cancer cells and Vero cells with IC50 values of 16.07 μg/mL and 35.98 μg/mL, respectively. EGFR-IN-159 does not cross the blood-brain barrier (BBB) and demonstrates significant anticancer activity.</p>
    Formula:C21H23N3O5
    Color and Shape:Solid
    Molecular weight:397.424

    Ref: TM-T206989

  • EGFR-IN-23
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    EGFR-IN-23

    CAS:
    <p>EGFR-IN-23, identified as compound 8 in WO2021244502A1, is a potent EGFR tyrosine kinase inhibitor (TKI) demonstrating an inhibitory concentration (IC50) of 8.</p>
    Formula:C36H44BrN10O3P
    Color and Shape:Solid
    Molecular weight:775.68

    Ref: TM-T73104

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    JAK-2/3-IN-3

    <p>JAK-2-/3-IN-3 (ST4j) is a potent JAK2/3 inhibitor for leukemia research, with IC50s: JAK2, 13 nM; JAK3, 14.86 nM; induces apoptosis.</p>
    Formula:C13H10Cl2N4O2
    Color and Shape:Solid
    Molecular weight:325.15

    Ref: TM-T60895

  • FGFR2/3-IN-2
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    FGFR2/3-IN-2

    CAS:
    <p>FGFR2/3-IN-2 (compound 10) is an orally active inhibitor targeting FGFR2 and FGFR3. It exhibits IC50 values of 3.7 nM for FGFR2 and 31.2 nM for FGFR3, with a pre-incubation time of 1 hour. FGFR2/3-IN-2 demonstrates selectivity over FGFR1/4 and other kinases, and does not cause diarrhea or increased serum phosphate in vivo. In the SNU-16 gastric cancer model, FGFR2/3-IN-2 can induce tumor stasis or regression.</p>
    Formula:C29H23FN6O3
    Color and Shape:Solid
    Molecular weight:522.53

    Ref: TM-T205706

  • MM-589
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    MM-589

    CAS:
    <p>MM-589 is a potent WD repeat domain 5 (WDR5) inhibitor and mixed lineage leukemia (MLL) protein-protein interaction.</p>
    Formula:C28H44N8O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:572.70

    Ref: TM-T12091

  • HER2-IN-8
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    HER2-IN-8

    CAS:
    <p>HER2-IN-8 is an inhibitor of HER-2 that can be used in the study of cancer and inflammation-related diseases.</p>
    Formula:C26H25F2N9O3
    Color and Shape:Solid
    Molecular weight:549.53

    Ref: TM-T63881

  • Lomonitinib
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    Lomonitinib

    CAS:
    <p>Lomonitinib is a potent and selective pan-FLT3/IRAK4 inhibitor with antitumor properties. It shows promise for research in myeloid leukemia.</p>
    Formula:C27H24N4O2
    Color and Shape:Solid
    Molecular weight:436.505

    Ref: TM-T205470

  • CGP062464
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    CGP062464

    CAS:
    <p>CGP062464 is an inhibitor of the tyrosine kinase c-Src, with an IC50 of less than 50 nM. It is utilized in research related to osteoporosis and tumor-induced hypercalcemia.</p>
    Formula:C18H14N4
    Color and Shape:Solid
    Molecular weight:286.331

    Ref: TM-T205732

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    HER2-IN-12

    <p>HER2-IN-12 is an HER2 inhibitor with an IC50 value of 121 nM and can be used to study cancers such as breast cancer.</p>
    Formula:C17H18BrN5O2S
    Color and Shape:Solid
    Molecular weight:436.33

    Ref: TM-T62487

  • VEGFR-IN-3
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    VEGFR-IN-3

    CAS:
    <p>VEGFR-IN-3 inhibits cancer cell growth (OVCAR-4, MDA-MB-468) with IC50s: 0.29, 0.35μM. Used in cancer research.</p>
    Formula:C27H28N2O6
    Color and Shape:Solid
    Molecular weight:476.52

    Ref: TM-T63112

  • EGFR-IN-146
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    EGFR-IN-146

    CAS:
    <p>EGFR-IN-146 is an EGFR inhibitor that suppresses the EGFR signaling pathway and improves insulin sensitivity by activating the AMPK pathway. It effectively reduces blood glucose levels and body weight, showing great potential in the study of diabetes and obesity.</p>
    Formula:C20H16N4
    Color and Shape:Solid
    Molecular weight:312.368

    Ref: TM-T206146

  • Protein kinase inhibitor 13
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    Protein kinase inhibitor 13

    CAS:
    <p>Protein kinase inhibitor 13 (Compound I-90) functions as a kinase inhibitor, specifically targeting kinases such as PIM-1, CDK-2, GSK-3, and SRC.</p>
    Formula:C19H20FN5OS
    Color and Shape:Solid
    Molecular weight:385.458

    Ref: TM-T205679

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    JAK2/FLT3-IN-1 TFA

    <p>JAK2/FLT3-IN-1 (TFA), an oral JAK2/FLT3 inhibitor, shows anticancer properties; IC50: JAK2 (0.7 nM), FLT3 (4 nM), JAK1 (26 nM), JAK3 (39 nM).</p>
    Formula:C27H35F4N7O3
    Color and Shape:Solid
    Molecular weight:581.61

    Ref: TM-T64104

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    BTK-IN-6

    <p>BTK-IN-6, a potent BTK inhibitor, may treat immune, cardiac, cancer, viral, inflammatory, metabolic, and neurological disorders.</p>
    Formula:C23H22FN5O3
    Color and Shape:Solid
    Molecular weight:435.45

    Ref: TM-T62472

  • Paeoniflorin-6′-O-benzene sulfonate
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    Paeoniflorin-6′-O-benzene sulfonate

    CAS:
    <p>Paeoniflorin-6′-O-benzene sulfonate (CP-25) acts as an inhibitor of G protein-coupled receptor kinase 2 (GRK2), preventing its translocation to the cell membrane and inhibiting the JAK1/STAT3 signaling pathway. It suppresses HaCaT cell proliferation induced by IL-17A/CXCL2. In mouse models, CP-25 reduces the levels of inflammatory cytokines and chemokines such as IL-17A, IL-17F, IFN-γ, TNF-α, IL-22, IL-23, CXCL2, CXCL3, and CXCL9, thereby alleviating psoriasis induced by Imiquimod.</p>
    Formula:C29H32O13S
    Color and Shape:Solid
    Molecular weight:620.622

    Ref: TM-T206189

  • Brefeldin A 4-O-nicotinate
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    Brefeldin A 4-O-nicotinate

    CAS:
    <p>Brefeldin A 4-O-nicotinate (CHNQD-01228) is a dual inhibitor of Arf1 and BMX proteins with an IC50 value of 0.22 μM for T24 cell proliferation. It also suppresses T24 cell migration and colony formation in a dose-dependent manner, induces G1 phase arrest, and triggers apoptosis. By targeting BMX proteins, it inhibits the AKT/p-AKT and STAT3/p-STAT3 signaling pathways, while also inhibiting Arf1 proteins to eliminate bladder cancer stem cells and activate antitumor immunity, thus exhibiting anticancer activity. Brefeldin A 4-O-nicotinate is applicable in research related to bladder cancer.</p>
    Formula:C22H27NO5
    Color and Shape:Solid
    Molecular weight:385.453

    Ref: TM-T206652

  • Multi-kinase-IN-1
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    Multi-kinase-IN-1

    CAS:
    <p>Multi-kinase-IN-1, a powerful kinase inhibitor, exhibits antitumor properties by inducing cell apoptosis.</p>
    Formula:C35H36F2N6O6S
    Color and Shape:Solid
    Molecular weight:706.76

    Ref: TM-T72604

  • E6201
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    E6201

    CAS:
    <p>E6201, a dual kinase inhibitor, blocks MEK1/FLT3 and has anti-tumor/psoriasis effects with low IC50s: ERK2 (5.2 nM), JNK (91 nM), p38 MAPK (19 nM).</p>
    Formula:C21H27NO6
    Color and Shape:Solid
    Molecular weight:389.44

    Ref: TM-T61755

  • JAK3/BTK-IN-7
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    JAK3/BTK-IN-7

    CAS:
    <p>JAK3/BTK-IN-7 (XL-12), characterized as a JAK3/BTK inhibitor, exhibits IC 50 values of 2 nM and 14 nM for JAK3 and BTK respectively. This compound demonstrates anti-inflammatory properties and is applicable in research related to rheumatoid arthritis [1].</p>
    Formula:C29H30N8O4
    Color and Shape:Solid
    Molecular weight:554.6

    Ref: TM-T86758