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Angiogenesis

Angiogenesis

Angiogenesis inhibitors are compounds that interfere with the formation of new blood vessels, a process critical in cancer growth and metastasis. By inhibiting angiogenesis, these compounds can restrict the blood supply to tumors, slowing or halting their growth. Angiogenesis inhibitors are essential in cancer research and therapeutic development, providing insights into the mechanisms of tumor progression and offering potential treatments for cancer and other angiogenesis-related diseases. At CymitQuimica, we offer a wide range of high-quality angiogenesis inhibitors to support your research in oncology and vascular biology.

Subcategories of "Angiogenesis"

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Found 1424 products of "Angiogenesis"

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  • MTX-216
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    MTX-216

    CAS:
    <p>MTX-216 is an ATP-competitive inhibitor targeting both PI3K and EGFR. It simultaneously inhibits Ki-67 and ribosomal S6 phosphorylation, inducing apoptosis in NF1LOF cells. Additionally, MTX-216 suppresses SYK kinase activity with an IC50 of 281 nM. This compound is applicable for melanoma research.</p>
    Formula:C22H14Cl2FN5O2S
    Color and Shape:Solid
    Molecular weight:502.348

    Ref: TM-T206251

  • PP487
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    PP487

    CAS:
    <p>PP487 is a dual tyrosine kinase/PI(3)K inhibitor, exhibiting IC50 values of 0.017 μM, 0.072 μM, 0.004 μM, 0.01 μM, 0.55 μM, 0.22 μM, and &lt; 0.01 μM against DNA-PK, mTOR, Hck, Src, EGFR, EphB4, and PDGFR, respectively. It is applicable in cancer research [1].</p>
    Formula:C14H14BrN5O
    Color and Shape:Solid
    Molecular weight:348.2

    Ref: TM-T87238

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    JAK-IN-19

    <p>JAK-IN-19 inhibits JAK (pIC50: 7.2, 7.7), less so for VEGFR2 (7.0) and Aurora B (5.8).</p>
    Formula:C26H36FN5O2
    Color and Shape:Solid
    Molecular weight:469.59

    Ref: TM-T63026

  • JAK3/BTK-IN-3
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    JAK3/BTK-IN-3

    CAS:
    <p>JAK3/BTK-IN-3: strong dual JAK3/BTK suppressor, promising for autoimmune disease research.</p>
    Formula:C22H28N8O
    Color and Shape:Solid
    Molecular weight:420.51

    Ref: TM-T62234

  • CEP-14083
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    CEP-14083

    CAS:
    <p>CEP-14083: potent ALK inhibitor, effective in NPM/ALK T-cell lymphoma, binds ATP site; IC50=11 nmol/L, also inhibits insulin receptor, preclinical efficacy.</p>
    Formula:C31H30N6O2
    Color and Shape:Solid
    Molecular weight:518.61

    Ref: TM-T68538

  • ALKBH5-IN-3
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    ALKBH5-IN-3

    CAS:
    <p>ALKBH5-IN-3 (Compound 20m) is an efficacious and selective inhibitor of ALKBH5, exhibiting an IC50 value of 21 nM. It effectively stabilizes ALKBH5 in HepG2 cells and enhances m6A levels in intact cells.</p>
    Formula:C11H7F3N2O3
    Color and Shape:Solid
    Molecular weight:272.18

    Ref: TM-T201322

  • MM-589 TFA
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    MM-589 TFA

    CAS:
    <p>MM-589 TFA is a potent WD repeat domain 5 (WDR5)inhibitor and mixed lineage leukemia (MLL) protein-protein interaction.</p>
    Formula:C30H45F3N8O7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:686.72

    Ref: TM-T12091L

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    BTK inhibitor 18

    <p>BTK inhibitor 18 is a selective, potent, covalent, orally active Btk inhibitor (IC50: 142 nM) that exhibits anti-inflammatory effects.</p>
    Formula:C29H25N5O4S2
    Color and Shape:Solid
    Molecular weight:571.67

    Ref: TM-T64042

  • JAK1-IN-9
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    JAK1-IN-9

    CAS:
    <p>JAK1-IN-9 (compound 23a) is a potent, selective inhibitor of JAK1, demonstrating an IC50 of 72 nM.</p>
    Formula:C16H13IN6
    Color and Shape:Solid
    Molecular weight:416.22

    Ref: TM-T62155

  • FAK inhibitor 6
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    FAK inhibitor 6

    CAS:
    <p>Compound 26F: potent enzyme inhibitor (IC50=28.2nM), low cytotoxicity (IC50=3.32μM), induces dose-dependent apoptosis in MDA-MB-231, blocks G0/G1 phase.</p>
    Formula:C25H24FN5O2S
    Color and Shape:Solid
    Molecular weight:477.55

    Ref: TM-T63123

  • TX2-121-1
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    TX2-121-1

    CAS:
    <p>TX2-121-1 targets HER3 for proteasome-mediated degradation to inhibit HER3-dependent signalling and growth.</p>
    Formula:C42H52N8O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:716.91

    Ref: TM-T29024

  • EGFR-IN-161
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    EGFR-IN-161

    CAS:
    <p>EGFR-IN-161 (Compound DD-8) is a potent and reversible inhibitor of the L858R/T790M/C797S mutant EGFR kinase, with an IC50 value of 0.87 nM. EGFR-IN-161 effectively inhibits tumor cell apoptosis, G1 phase arrest, and migration.</p>
    Formula:C33H36Cl2N8O2
    Color and Shape:Solid
    Molecular weight:647.597

    Ref: TM-T206760

  • PF-06263276
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    PF-06263276

    CAS:
    <p>PF-06263276 selectively inhibits pan-JAK with IC50: JAK1 (2.2 nM), JAK2 (23.1 nM), JAK3 (59.9 nM), TYK2 (29.7 nM).</p>
    Formula:C31H31FN8O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:566.63

    Ref: TM-T16488

  • JAK2-IN-11
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    JAK2-IN-11

    CAS:
    <p>JAK2-IN-11 (Example 6) is a JAK2 kinase inhibitor with potent antitumor activity, exhibiting an IC50 of ≤10 nM against JH2 BIND WT/V617F. This compound effectively suppresses tumor growth.</p>
    Formula:C31H31F3N8O4
    Color and Shape:Solid
    Molecular weight:639.64

    Ref: TM-T201601

  • ALK/PI3K/AKT-IN-1
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    ALK/PI3K/AKT-IN-1

    CAS:
    <p>ALK/PI3K/AKT-IN-1 (Compound 45) effectively inhibits the proliferation of cancer cell lines A549, H1975, and PC9, with IC50 values of 0.44, 0.83, and 1.51 μM, respectively. This compound enhances the expression of p21 and p27, and decreases the activity of CDK2 and p-Rb, causing cell cycle arrest at the G1 phase. It suppresses the ALK/PI3K/AKT signaling pathway, promotes mitochondrial membrane potential depolarization, and induces apoptosis in A549 cells. Furthermore, ALK/PI3K/AKT-IN-1 inhibits the formation and growth of A549 cell spheres.</p>
    Formula:C25H20FN5O2S
    Color and Shape:Solid
    Molecular weight:473.522

    Ref: TM-T206308

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    FAK-IN-2

    <p>FAK-IN-2: potent oral FAK inhibitor, IC50 35 nM, reduces tumor growth, migration, and induces cell death.</p>
    Formula:C28H31ClN8O3
    Color and Shape:Solid
    Molecular weight:563.05

    Ref: TM-T63978

  • Flonoltinib sulfate
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    Flonoltinib sulfate

    CAS:
    <p>Flonoltinib maleate is an orally active dual inhibitor of JAK2/FLT3, with IC50 values of 0.7 nM for JAK2, 4 nM for FLT3, 26 nM for JAK1, and 39 nM for JAK3. It exhibits anticancer properties.</p>
    Formula:C25H36FN7O5S
    Color and Shape:Solid
    Molecular weight:565.661

    Ref: TM-T204180

  • Pyk2-IN-2
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    Pyk2-IN-2

    CAS:
    <p>Pyk2-IN-2 (compound 13j) acts as a Pyk2 inhibitor, exhibiting an IC 50 value of 0.608 μM for FAK kinase [1].</p>
    Formula:C27H27N7O
    Color and Shape:Solid
    Molecular weight:465.55

    Ref: TM-T87280

  • EGFR-IN-38
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    EGFR-IN-38

    CAS:
    <p>EGFR-IN-38: low-toxic acrylamide-derived EGFR inhibitor, targets NSCLC, patented for research on EGFR mutation-related diseases.</p>
    Formula:C25H24ClN7O2
    Color and Shape:Solid
    Molecular weight:489.96

    Ref: TM-T63283

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    VEGFR-2-IN-16

    <p>VEGFR-2-IN-16 (Compound 15b) is a potent inhibitor of VEGFR-2 (IC50: 86.36 nM) that exhibits antitumour effects.</p>
    Formula:C21H13Cl2N3O2
    Color and Shape:Solid
    Molecular weight:410.25

    Ref: TM-T62071