Bcr-Abl
Bcr-Abl inhibitors are targeted therapies that inhibit the Bcr-Abl fusion protein, which is formed due to the Philadelphia chromosome translocation and is a driver of chronic myeloid leukemia (CML). This protein also influences angiogenesis, contributing to tumor progression. Bcr-Abl inhibitors are crucial in the treatment of CML and are being explored for their potential in inhibiting angiogenesis in various cancers. At CymitQuimica, we provide high-quality Bcr-Abl inhibitors to support your research in cancer biology, angiogenesis, and targeted therapy.
Found 117 products of "Bcr-Abl"
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PPY A
CAS:PPY A is a potent inhibitor of T315l mutant and wild-type Abl kinase and inhibits the growth of Bcr-Abl T315l mutant or wild-type Bcr-Abl gene-transformed cellsFormula:C22H20N4O2Purity:98.77%Color and Shape:SolidMolecular weight:372.42CGP77675
CAS:CGP77675 (ZINC1488120) is a potent and selective inhibitor of Src family kinase with IC50s of 5-20 and 40 nM for the phosphorylation of peptide substrates andFormula:C26H29N5O2Purity:99.66%Color and Shape:SolidMolecular weight:443.54SKLB 1028
CAS:SKLB 1028, an oral EGFR/FLT3/Abl inhibitor, excels in AML and CML with Abl mutations.Formula:C24H29N9Purity:99.99% - >99.99%Color and Shape:SolidMolecular weight:443.55Ref: TM-T34656
1mg52.00€5mg113.00€10mg177.00€25mg358.00€50mg530.00€100mg758.00€500mg1,558.00€1mL*10mM (DMSO)126.00€BCR-ABL-IN-4
CAS:BCR-ABL-IN-4: Anticancer BCR-ABL inhibitor; stops K562 cells (IC50: 0.67 nM), targets T315I Ba/F3 cells (IC50: 16 nM).Formula:C27H24ClF2N5O4Color and Shape:SolidMolecular weight:555.96Pivanex
CAS:Pivanex, an oral HDAC inhibitor, targets metastasis, angiogenesis, reduces Bcr-Abl protein, and promotes apoptosis.Formula:C10H18O4Purity:≥98%Color and Shape:SolidMolecular weight:202.25Risvodetinib
CAS:Risvodetinib: potent inhibitor of protein tyrosine kinases c-Abl1, c-Abl2, and c-kit.Formula:C33H34N8O2Color and Shape:SolidMolecular weight:574.68DosatiLink-1
CAS:DosatiLink-1 acts as an inhibitor of the Abelson murine leukemia (ABL) enzyme [1].Formula:C69H93Cl2F2N13O17SColor and Shape:SolidMolecular weight:1517.52PonatiLink-1-24
CAS:Ponatinib, also known as PonatiLink-1-24, is a selective inhibitor of the Abelson murine leukemia (ABL) enzyme [1].Formula:C101H144ClF5N12O29Color and Shape:SolidMolecular weight:2120.73CT-721
CAS:CT-721: potent, time-bound Bcr-Abl inhibitor, IC50 21.3 nM, effective against CML.Formula:C30H29ClN6OPurity:98%Color and Shape:SolidMolecular weight:525.04DosatiLink-2
CAS:DosatiLink-2 is an inhibitor of the Abelson murine leukemia (ABL) enzyme [1].Formula:C65H85Cl2F2N13O15SColor and Shape:SolidMolecular weight:1429.42HPK1-IN-61
CAS:HPK1-IN-61 (Compound 1) serves as an inhibitor of hematopoietic progenitor kinase 1 (HPK1) with a Ki of 0.4 nM, and also inhibits Abl with an IC50 of less than 0.51 nM. Additionally, HPK1-IN-61 displays inhibitory activity against LCK, with an IC50 of 24 nM.Formula:C23H22N4O2Color and Shape:SolidMolecular weight:386.45GLPG3312
CAS:GLPG3312 is a selective and potent pan-SIK inhibitor with the advantage of oral activity, for SIK1, SIK2 and SIK3, anti-inflammatory and immunomodulatory .Formula:C23H21F2N5O3Purity:98.53%Color and Shape:SolidMolecular weight:453.44HG-7-86-01
CAS:HG-7-86-01 is a selective type II tyrosine kinase inhibitor with antiproliferative activity against mutant T315I- Bcr-Abl for chronic myeloid leukemia (CML).Formula:C28H21F3N6O2SPurity:99.07%Color and Shape:SolidMolecular weight:562.57HSN748
CAS:HSN748 is an analog of ponatinib and acts as a multi-kinase inhibitor. It exhibits inhibitory activity against kinases such as FLT3, ABL1, RET, PDGFRα/β, MNK1, and MNK2. HSN748 can suppress the growth of chronic myeloid leukemia and acute myeloid leukemia cell lines, making it a useful compound in leukemia research.Formula:C27H24F3N7OColor and Shape:SolidMolecular weight:519.521PP487
CAS:PP487 is a dual tyrosine kinase/PI(3)K inhibitor, exhibiting IC50 values of 0.017 μM, 0.072 μM, 0.004 μM, 0.01 μM, 0.55 μM, 0.22 μM, and < 0.01 μM against DNA-PK, mTOR, Hck, Src, EGFR, EphB4, and PDGFR, respectively. It is applicable in cancer research [1].Formula:C14H14BrN5OColor and Shape:SolidMolecular weight:348.2Tyrosine kinase-IN-9
CAS:Tyrosine kinase-IN-9 (Compound B) is an inhibitor of c-Abl. It is useful for studying neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.Formula:C20H14ClN3O3Color and Shape:SolidMolecular weight:379.796BCR-ABL-IN-8
CAS:BCR-ABL-IN-8 (compound 26f) is a BCR-ABL inhibitor featuring a trimethoxy group [1].
Formula:C30H33N7O5Purity:98%Color and Shape:SolidMolecular weight:571.63
