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EGFR

EGFR

EGFR (epidermal growth factor receptor) inhibitors are compounds that block the signaling of EGFR, a receptor that is often overexpressed in various cancers and plays a critical role in angiogenesis. EGFR inhibitors are used to prevent tumor growth and metastasis by disrupting the pathways that promote blood vessel formation in tumors. These inhibitors are widely used in cancer research and therapy. At CymitQuimica, we offer a diverse selection of high-quality EGFR inhibitors to support your research in oncology and angiogenesis.

Found 572 products of "EGFR"

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  • EGFR-IN-85
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    EGFR-IN-85

    CAS:
    <p>EGFR-IN-85 (Compound 1), an EGFR inhibitor, exhibits potent activity with an IC50 of 0.19 μM against EGFRvⅢ phosphorylation and can suppress intratumoral EGFR</p>
    Formula:C26H30N8O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:486.57

    Ref: TM-T78574

  • BPIQ-I
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    BPIQ-I

    CAS:
    <p>BPIQ-I (PD 159121), an ATP-competitive EGFR tyrosine kinase inhibitor, exhibits potent anti-proliferative activity.</p>
    Formula:C16H12BrN5
    Color and Shape:Solid
    Molecular weight:354.2

    Ref: TM-T70227

  • PF-06459988
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    PF-06459988

    CAS:
    PF-06459988 is a novel, effective, orally active, irreversible, and selective epidermal growth factor receptor (EGFR) mutant inhibitor.
    Formula:C19H22ClN7O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:431.88

    Ref: TM-T16492

  • (Z)-RG-13022
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    (Z)-RG-13022

    CAS:
    <p>(Z)-RG-13022 is a tyrosine kinase (TK) inhibitor that preferentially inhibits the TK activity of the EGF receptor, restricting the EGF-stimulated growth of cultured cells. It demonstrates an IC50 of 11 μM for DNA synthesis in HN5 cells, showcasing thrice the potency of its isomer, (E)-RG-13022 (IC50 = 38 μM). This compound is applied in breast cancer cell research [1] [2].</p>
    Formula:C16H14N2O2
    Color and Shape:Solid
    Molecular weight:266.29

    Ref: TM-T84525

  • EGFR-IN-61
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    EGFR-IN-61

    CAS:
    <p>EGFR-IN-61 inhibits EGFR kinase (IC50: 42 nM L858R/T790M, 137 nM L858R/T790M/C797S, 743 nM WT) and slows A549 &amp; H1975 cell growth (IC50: 2.14 &amp; 1.82 μM).</p>
    Formula:C33H37ClN8O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:629.15

    Ref: TM-T73128

  • JGK-068S
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    JGK-068S

    CAS:
    <p>Compound I (JGK-068S) is a potent inhibitor of the epidermal growth factor receptor (EGFR) [1].</p>
    Formula:C22H23BrFN5O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:488.35

    Ref: TM-T79124

  • BEBT-109
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    BEBT-109

    CAS:
    <p>BEBT-109 is a selective epidermal growth factor receptor (EGFR) inhibitor that shows anti-tumor activity in EGFR-mutant non-small cell lung cancer.</p>
    Formula:C27H32N8O3
    Purity:97.26%
    Color and Shape:Solid
    Molecular weight:516.6

    Ref: TM-T80643

  • DZD1516
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    DZD1516

    CAS:
    <p>DZD1516, a potent and selective HER2 inhibitor (IC50 = 0.56 nM), demonstrates good blood-brain barrier permeability and exhibits antitumor activity in both</p>
    Formula:C28H27F2N7O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:547.56

    Ref: TM-T79297

  • 2′-Thioadenosine
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    2′-Thioadenosine

    CAS:
    <p>2'-Thioadenosine (PD157432) serves as a selective and irreversible inhibitor of ErbB-1 and ErbB-2 tyrosine kinases, demonstrating an IC50 value of 45 µM against</p>
    Formula:C10H13N5O3S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:283.31

    Ref: TM-T78634

  • Lifirafenib
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    Lifirafenib

    CAS:
    <p>Lifirafenib (Beigene-283) is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM for the recombinant</p>
    Formula:C25H17F3N4O3
    Purity:98% - 98.25%
    Color and Shape:Solid
    Molecular weight:478.42

    Ref: TM-T22272

  • EGFR-IN-71
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    EGFR-IN-71

    CAS:
    <p>EGFR-IN-71 is a potent inhibitor of epidermal growth factor receptor (EGFR) (IC50= 3.7 μM). EGFR-IN-71 has research value in chordoma.</p>
    Formula:C16H9ClIN3
    Color and Shape:Solid
    Molecular weight:405.62

    Ref: TM-T62009

  • HER2-IN-5
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    HER2-IN-5

    CAS:
    <p>HER2-IN-5 is an effective inhibitor of orally active HER-2.</p>
    Formula:C27H33N7O3
    Color and Shape:Solid
    Molecular weight:503.6

    Ref: TM-T63432

  • EGFR-IN-32
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    EGFR-IN-32

    CAS:
    <p>EGFR-IN-32, a potent EGFR blocker, shows promise for EGFR-mutated illnesses. (Patent WO2021185297A1, compound 2)</p>
    Formula:C31H34N6O3
    Color and Shape:Solid
    Molecular weight:538.64

    Ref: TM-T63798

  • BGB-102
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    BGB-102

    CAS:
    <p>BGB-102 (JNJ-26483327) is a kinase inhibitor targeting FLT3 and YES1 and an antagonist targeting EGFR and VEGFR3.</p>
    Formula:C22H25BrN4O2
    Purity:99.02%
    Color and Shape:Solid
    Molecular weight:457.36

    Ref: TM-T10531

  • CymitQuimica logo
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    EGFR/CSC-IN-1

    CAS:
    <p>EGFR/CSC-IN-1 is a dual inhibitor targeting both the epidermal growth factor receptor (EGFR [IC50 10.52 nM]) and cancer stem cells (CSC), with potential</p>
    Formula:C54H54Cl2FN7O7S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1067.08

    Ref: TM-T73995

  • JND3229
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    JND3229

    CAS:
    <p>JND3229 inhibits EGFRC797S; IC50: 5.8-30.5 nM; halts cell growth; effective in non-small cell lung cancer study.</p>
    Formula:C33H41ClN8O2
    Purity:98.75%
    Color and Shape:Solid
    Molecular weight:617.18

    Ref: TM-T15615

  • EGFR-IN-36
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    EGFR-IN-36

    CAS:
    <p>EGFR-IN-36 inhibits EGFR, HER2, &amp; mutants with IC50s: 19.09 nM (EGFR WT), 120.01 nM (HER2 WT), 2.35 nM (HER2 mutant).</p>
    Formula:C26H25ClN6O2
    Color and Shape:Solid
    Molecular weight:488.97

    Ref: TM-T63265

  • BMS-599626 Hydrochloride
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    BMS-599626 Hydrochloride

    CAS:
    <p>BMS-599626 HCl (AC480 HCl) is an oral inhibitor of HER1, HER2, HER4 kinases, potentially blocking tumor growth. IC50: 22/32/190 nM.</p>
    Formula:C27H28ClFN8O3
    Purity:99.98%
    Color and Shape:Solid
    Molecular weight:567.01

    Ref: TM-T5390

  • PAT-505
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    PAT-505

    CAS:
    <p>PAT-505 is an autologous epidermal growth factor inhibitor.</p>
    Formula:C23H18ClF2N3O2S
    Purity:98.84%
    Color and Shape:Solid
    Molecular weight:473.92

    Ref: TM-T12372

  • EGFR mutant-IN-1
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    EGFR mutant-IN-1

    <p>EGFR mutant-in-1, a 5-methylpyrimidopyridone, selectively inhibits EGFRL858R/T790M/C797S mutants with an IC50 of 27.5 nM, lessening EGFRWT impact.</p>
    Formula:C34H39ClFN7O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:632.17

    Ref: TM-T11164