FAK
FAK (focal adhesion kinase) inhibitors target FAK, a kinase involved in cell adhesion, migration, and angiogenesis. FAK is frequently overexpressed in tumors and contributes to the formation of new blood vessels that supply nutrients to the tumor. Inhibiting FAK can disrupt these processes, making FAK inhibitors valuable tools in cancer therapy and angiogenesis research. At CymitQuimica, we provide a comprehensive range of high-quality FAK inhibitors to support your research in cell biology, cancer, and angiogenesis.
Found 72 products of "FAK"
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ProMMP-9 inhibitor-3c
CAS:<p>ProMMP-9 inhibitor-3c hinders MMP-9 homodimers, blocks proMMP-9/α4β1 integrin/CD44 binding, and detaches EGFR.</p>Formula:C18H20FN3O2SColor and Shape:SolidMolecular weight:361.43FAK inhibitor 5
CAS:<p>FAK inhibitor 5 is a novel allosteric FAK inhibitor, with IC50 values in the low micromolar range.</p>Formula:C20H21N3O2SPurity:98%Color and Shape:SolidMolecular weight:367.46NAMI-A
CAS:<p>NAMI-A is a ruthenium-based compound with selective activity against tumor metastasis.NAMI-A inhibits cancer cell adhesion and migration.</p>Formula:C8H15Cl4N4ORuSPurity:98%Color and Shape:SolidMolecular weight:458.18FAK inhibitor 2
CAS:<p>FAK inhibitor 2, antitumor and anti-angiogenesis activitiesis ,is a potent focal adhesion kinase (FAK) inhibitor with an IC50 of 0.07 nM .</p>Formula:C29H33F3N8O2S2Color and Shape:SolidMolecular weight:646.75Adhesamine
CAS:<p>Adhesamine, a dumbbell molecule, enhances cell adhesion, growth, neuron differentiation, and survival via MAPK/FAK.</p>Formula:C24H32Cl4N8O2S2Color and Shape:SolidMolecular weight:670.51Defactinib hydrochloride
CAS:<p>Defactinib hydrochloride (PF 04554878 hydrochloride) is a novel inhibitor of FAK.</p>Formula:C20H22ClF3N8O3SPurity:98.06% - 98.78%Color and Shape:SolidMolecular weight:546.95Conteltinib
CAS:<p>Conteltinib (CT-707) is an enzyme inhibitor with antitumor activity targeting FAK, ALK and Pyk2. It can be used to study lymphoma.</p>Formula:C32H45N9O3SPurity:98.12% - 99.54%Color and Shape:SolidMolecular weight:635.82Roslin 2 bromide
CAS:<p>Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator that disrupts the binding of FAK and p5.</p>Formula:C13H19BrN4Purity:99.34%Color and Shape:SolidMolecular weight:311.22FC 11
CAS:<p>FC 11 is a reversible FAK PROTAC Degrader with DC50 of 40-370 pM and degrades pFAKtyr397 in TM3 cells within 3 hours at 100 nM.</p>Formula:C41H42F3N13O9SColor and Shape:SolidMolecular weight:949.91Ifebemtinib
CAS:<p>Ifebemtinib (BI-853520) is an adhesion plaque kinase inhibitor with anti-tumour activity for the study of breast cancer.</p>Formula:C28H28F4N6O4Purity:98.84% - 99.85%Color and Shape:SolidMolecular weight:588.55FAK-IN-21
CAS:<p>FAK-IN-21 (compound 9) is a FAK inhibitor with an IC50 value of 37.52 nM. It inhibits cell growth and the phosphorylation of FAK, making it useful for research into diffuse gastric cancer.</p>Formula:C22H22F2N8O3SColor and Shape:SolidMolecular weight:516.52OXA-11
CAS:<p>OXA-11 (FAK-IN-16) is a FAK inhibitor with anti-tumor activity, useful for cancer research.</p>Formula:C37H49F3N7O5PPurity:98.70% - 99.20%Color and Shape:SolidMolecular weight:759.8FAK-IN-6
<p>FAK-IN-6: Potent FAK inhibitor (IC50=1.415 nM), anti-cancer, for pancreatic studies.</p>Formula:C25H31ClN5O6PSColor and Shape:SolidMolecular weight:596.04FAK-IN-23
CAS:<p>FAK-IN-23 (Compound II) is an inhibitor of focal adhesion kinase (FAK).</p>Formula:C32H38F3N5O8Color and Shape:SolidMolecular weight:677.668FAK inhibitor 6
CAS:<p>Compound 26F: potent enzyme inhibitor (IC50=28.2nM), low cytotoxicity (IC50=3.32μM), induces dose-dependent apoptosis in MDA-MB-231, blocks G0/G1 phase.</p>Formula:C25H24FN5O2SColor and Shape:SolidMolecular weight:477.55Pyk2-IN-2
CAS:<p>Pyk2-IN-2 (compound 13j) acts as a Pyk2 inhibitor, exhibiting an IC 50 value of 0.608 μM for FAK kinase [1].</p>Formula:C27H27N7OColor and Shape:SolidMolecular weight:465.55FAK-IN-3
<p>FAK-IN-3 inhibits FAK, reduces PA-1 cell migration/invasion, and tumor growth, with no major side effects.</p>Formula:C28H28N6O4Color and Shape:SolidMolecular weight:512.56FAK-IN-26
CAS:<p>FAK-IN-26 is a blood-brain barrier-penetrating inhibitor of Focal Adhesion Kinase (FAK) with an IC50 of 0.87 nM. It significantly reduces tumor cell viability, cancer stem cell activity, and cell migration in A549 and SKOV-3 cell lines. FAK-IN-26 exhibits potent anticancer activity, achieving tumor inhibition rates of 59.15% and 57.9% in A549 and SKOV-3 tumor mouse models, respectively.</p>Formula:C20H19BrFN5O2Color and Shape:SolidMolecular weight:460.30FAK inhibitor 7
CAS:<p>FAK inhibitor7, a potent FAK inhibitor, demonstrates an IC50 of 3.58 nM. This compound effectively inhibits downstream signaling cascades of FAK (such as Src and AKT), which leads to cell cycle arrest at the G0/G1 phase and induces cytotoxic autophagy in ovarian cancer cells. Additionally, FAK inhibitor7 has been shown to suppress tumor metastasis and growth in ovarian cancer mouse models.</p>Formula:C32H37N7O3Color and Shape:SolidMolecular weight:567.68JP-153
CAS:<p>JP-153 is an inhibitor of Src-FAK-Paxillin signaling. It suppresses Src-dependent phosphorylation of paxillin (Y118) and subsequent activation of Akt (S473). JP-153 reduces VEGF-induced migration and proliferation of retinal endothelial cells and is applicable in the study of neovascular eye diseases.</p>Formula:C21H19NO5Color and Shape:SolidMolecular weight:365.379Si306
CAS:<p>Si306, an Src inhibitor, exhibits antitumor activity by reducing the phosphorylation of focal adhesion kinase (FAK) and the expression of epidermal growth factor receptor (EGFR), thereby inhibiting the invasion of human glioblastoma (GBM).</p>Formula:C25H26BrClN6OSColor and Shape:SolidMolecular weight:573.94PF-03814735
CAS:<p>PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1. Phase 1.</p>Formula:C23H25F3N6O2Purity:98%Color and Shape:SolidMolecular weight:474.48
