FAK
FAK (focal adhesion kinase) inhibitors target FAK, a kinase involved in cell adhesion, migration, and angiogenesis. FAK is frequently overexpressed in tumors and contributes to the formation of new blood vessels that supply nutrients to the tumor. Inhibiting FAK can disrupt these processes, making FAK inhibitors valuable tools in cancer therapy and angiogenesis research. At CymitQuimica, we provide a comprehensive range of high-quality FAK inhibitors to support your research in cell biology, cancer, and angiogenesis.
Found 72 products of "FAK"
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GSK215
CAS:<p>GSK215: potent, selective PROTAC degrader of FAK (pDC50=8.4), combines FAK inhibitor VS-4718 and VHL E3 ligase binder, causes fast, lasting FAK degradation.</p>Formula:C50H59F3N10O6SPurity:99.3%Color and Shape:SoildMolecular weight:985.13VnP-16
<p>VnP-16 enhances bone formation by stimulating the differentiation and activity of osteoblasts via direct β1 integrin engagement, which subsequently activates</p>Formula:C82H112N20O17Purity:98%Color and Shape:SolidMolecular weight:1649.89FAK-IN-10
CAS:<p>FAK-IN-10 is an inhibitor of FAK (IC50:76.3 μM).FAK-IN-10 z MCF-7 and A431 cell lines showed antitumor activity with IC50 of 4.23 and 0.78 μM, respectively.</p>Formula:C15H10BrN3O2SPurity:99.78%Color and Shape:SoildMolecular weight:376.23FAK-IN-27
<p>FAK-IN-27 (compound 8A) is a potent and selective inhibitor of FAK, with an IC50 of 4.968 nM. It effectively inhibits the proliferation of H1299 cells, with an IC50 of 0.28 μM, and is applicable for research in non-small cell lung cancer (NSCLC).</p>Formula:C32H28ClN5O6Color and Shape:SolidMolecular weight:613.17281Anti-PTK2 Antibody (4T687)
<p>Anti-PTK2 Antibody (4T687) is an antibody targeting PTK2. Anti-PTK2 Antibody (4T687) can be used in ELISA, IHC.</p>Color and Shape:Odour LiquidConteltinib tetrahydrochloride
<p>Conteltinibtetrahydrochloride (CT-707 tetrahydrochloride) is the tetrahydrochloride form of Conteltinib. It acts as an inhibitor for FAK (IC50=1.6 nM), ALK, and Pyk2. When used in combination with Cabozantinib, Conteltinib tetrahydrochloride exhibits a synergistic antitumor effect.</p>Formula:C32H49Cl4N9O3SColor and Shape:SolidMolecular weight:781.667BI-3663
CAS:<p>BI-3663 is a selective PTK2/FAK PROTAC with cereblon ligands, degrading PTK2 (IC50: 18 nM), and shows anti-cancer properties.</p>Formula:C44H42F3N7O12Purity:98%Color and Shape:SolidMolecular weight:917.84Y15
CAS:<p>Y15 (1,2,4,5-Benzenetetramine tetrahydrochlor) is a potent and specificsmall-molecule FAK scaffolding inhibitor that inhibits its autophosphorylation activity,</p>Formula:C6H14Cl4N4Purity:98% - 99.32%Color and Shape:Dark Brown CrystalsMolecular weight:284.01SU6656
CAS:<p>SU 6656 is a selective inhibitor of Src family kinases, with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively.</p>Formula:C19H21N3O3SPurity:98.21% - 98.73%Color and Shape:SolidMolecular weight:371.45Masitinib
CAS:<p>Masitinib (AB1010) is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs.</p>Formula:C28H30N6OSPurity:97.56% - >99.99%Color and Shape:SolidMolecular weight:498.64GSK2256098
CAS:<p>GSK2256098 (GTPL7939) is a small molecule FAK kinase inhibitor.</p>Formula:C20H23ClN6O2Purity:99.46% - 99.74%Color and Shape:SolidMolecular weight:414.89PF-431396
CAS:<p>PF-431396 is a dual PYK2/FAK inhibitor (IC50: 11/2 nM).</p>Formula:C22H21F3N6O3SPurity:98.83% - 99.82%Color and Shape:SolidMolecular weight:506.5Fangchinoline
CAS:<p>Fangchinoline (Tetrandrine B) is extracted from Stephania tetrandra S. Moore.</p>Formula:C37H40N2O6Purity:99.86% - >99.99%Color and Shape:SolidMolecular weight:608.72AMP-945
CAS:<p>AMP-945 is a proprietary focal adhesion kinase (FAK) inhibitor.</p>Formula:C28H32F3N5O2Purity:99.76%Color and Shape:SolidMolecular weight:527.58PF-562271 hydrochloride
CAS:<p>PF-562271 hydrochloride (PF-562271 HCl) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK.</p>Formula:C21H20F3N7O3SHClPurity:97.08%Color and Shape:SolidMolecular weight:543.95PF-573228
CAS:<p>PF-573228 is an ATP-competitive FAK inhibitor. In a cell-free assay, the IC50 of FAK is 4 nM.</p>Formula:C22H20F3N5O3SPurity:96.58% - 99.51%Color and Shape:SolidMolecular weight:491.49Nitidine chloride
CAS:<p>1.</p>Formula:C21H18ClNO4Purity:96.59% - 98.91%Color and Shape:SolidMolecular weight:383.82BI-4464
CAS:<p>BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC</p>Formula:C28H28F3N5O4Purity:97.43%Color and Shape:SolidMolecular weight:555.55Batatasin III
CAS:<p>Batatasin III inhibits cancer migration and invasion by suppressing epithelial to mesenchymal transition and FAK-AKT signals and possesses anti-cancer</p>Formula:C15H16O3Purity:99.16%Color and Shape:SolidMolecular weight:244.29Defactinib
CAS:<p>Defactinib (VS-6063) is a second-generation inhibitor of FAK. Defactinib has potential antitumor activity. Cost-effective and quality-assured.</p>Formula:C20H21F3N8O3SPurity:98% - 99.71%Color and Shape:SolidMolecular weight:510.49
