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FAK

FAK

FAK (focal adhesion kinase) inhibitors target FAK, a kinase involved in cell adhesion, migration, and angiogenesis. FAK is frequently overexpressed in tumors and contributes to the formation of new blood vessels that supply nutrients to the tumor. Inhibiting FAK can disrupt these processes, making FAK inhibitors valuable tools in cancer therapy and angiogenesis research. At CymitQuimica, we provide a comprehensive range of high-quality FAK inhibitors to support your research in cell biology, cancer, and angiogenesis.

Found 72 products of "FAK"

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  • FAK-IN-21
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    FAK-IN-21

    CAS:
    <p>FAK-IN-21 (compound 9) is a FAK inhibitor with an IC50 value of 37.52 nM. It inhibits cell growth and the phosphorylation of FAK, making it useful for research into diffuse gastric cancer.</p>
    Formula:C22H22F2N8O3S
    Color and Shape:Solid
    Molecular weight:516.52

    Ref: TM-T201079

  • OXA-11
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    OXA-11

    CAS:
    <p>OXA-11 (FAK-IN-16) is a FAK inhibitor with anti-tumor activity, useful for cancer research.</p>
    Formula:C37H49F3N7O5P
    Purity:98.70% - 99.20%
    Color and Shape:Solid
    Molecular weight:759.8

    Ref: TM-T28277

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    FAK-IN-6

    <p>FAK-IN-6: Potent FAK inhibitor (IC50=1.415 nM), anti-cancer, for pancreatic studies.</p>
    Formula:C25H31ClN5O6PS
    Color and Shape:Solid
    Molecular weight:596.04

    Ref: TM-T64207

  • FAK-IN-23
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    FAK-IN-23

    CAS:
    <p>FAK-IN-23 (Compound II) is an inhibitor of focal adhesion kinase (FAK).</p>
    Formula:C32H38F3N5O8
    Color and Shape:Solid
    Molecular weight:677.668

    Ref: TM-T204586

  • FAK inhibitor 6
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    FAK inhibitor 6

    CAS:
    <p>Compound 26F: potent enzyme inhibitor (IC50=28.2nM), low cytotoxicity (IC50=3.32μM), induces dose-dependent apoptosis in MDA-MB-231, blocks G0/G1 phase.</p>
    Formula:C25H24FN5O2S
    Color and Shape:Solid
    Molecular weight:477.55

    Ref: TM-T63123

  • Pyk2-IN-2
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    Pyk2-IN-2

    CAS:
    <p>Pyk2-IN-2 (compound 13j) acts as a Pyk2 inhibitor, exhibiting an IC 50 value of 0.608 μM for FAK kinase [1].</p>
    Formula:C27H27N7O
    Color and Shape:Solid
    Molecular weight:465.55

    Ref: TM-T87280

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    FAK-IN-3

    <p>FAK-IN-3 inhibits FAK, reduces PA-1 cell migration/invasion, and tumor growth, with no major side effects.</p>
    Formula:C28H28N6O4
    Color and Shape:Solid
    Molecular weight:512.56

    Ref: TM-T63545

  • FAK-IN-26
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    FAK-IN-26

    CAS:
    <p>FAK-IN-26 is a blood-brain barrier-penetrating inhibitor of Focal Adhesion Kinase (FAK) with an IC50 of 0.87 nM. It significantly reduces tumor cell viability, cancer stem cell activity, and cell migration in A549 and SKOV-3 cell lines. FAK-IN-26 exhibits potent anticancer activity, achieving tumor inhibition rates of 59.15% and 57.9% in A549 and SKOV-3 tumor mouse models, respectively.</p>
    Formula:C20H19BrFN5O2
    Color and Shape:Solid
    Molecular weight:460.30

    Ref: TM-T207475

  • FAK inhibitor 7
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    FAK inhibitor 7

    CAS:
    <p>FAK inhibitor7, a potent FAK inhibitor, demonstrates an IC50 of 3.58 nM. This compound effectively inhibits downstream signaling cascades of FAK (such as Src and AKT), which leads to cell cycle arrest at the G0/G1 phase and induces cytotoxic autophagy in ovarian cancer cells. Additionally, FAK inhibitor7 has been shown to suppress tumor metastasis and growth in ovarian cancer mouse models.</p>
    Formula:C32H37N7O3
    Color and Shape:Solid
    Molecular weight:567.68

    Ref: TM-T200444

  • JP-153
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    JP-153

    CAS:
    <p>JP-153 is an inhibitor of Src-FAK-Paxillin signaling. It suppresses Src-dependent phosphorylation of paxillin (Y118) and subsequent activation of Akt (S473). JP-153 reduces VEGF-induced migration and proliferation of retinal endothelial cells and is applicable in the study of neovascular eye diseases.</p>
    Formula:C21H19NO5
    Color and Shape:Solid
    Molecular weight:365.379

    Ref: TM-T206442

  • Si306
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    Si306

    CAS:
    <p>Si306, an Src inhibitor, exhibits antitumor activity by reducing the phosphorylation of focal adhesion kinase (FAK) and the expression of epidermal growth factor receptor (EGFR), thereby inhibiting the invasion of human glioblastoma (GBM).</p>
    Formula:C25H26BrClN6OS
    Color and Shape:Solid
    Molecular weight:573.94

    Ref: TM-T89964

  • PF-03814735
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    PF-03814735

    CAS:
    <p>PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1. Phase 1.</p>
    Formula:C23H25F3N6O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:474.48

    Ref: TM-T6936

    1mg
    Discontinued
    Discontinued product