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FAK

FAK

FAK (focal adhesion kinase) inhibitors target FAK, a kinase involved in cell adhesion, migration, and angiogenesis. FAK is frequently overexpressed in tumors and contributes to the formation of new blood vessels that supply nutrients to the tumor. Inhibiting FAK can disrupt these processes, making FAK inhibitors valuable tools in cancer therapy and angiogenesis research. At CymitQuimica, we provide a comprehensive range of high-quality FAK inhibitors to support your research in cell biology, cancer, and angiogenesis.

Found 74 products for "FAK".

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  • Roslin 2 bromide
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    Roslin 2 bromide

    CAS:
    Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator that disrupts the binding of FAK and p5.
    Formula:C13H19BrN4
    Purity:99.34%
    Color and Shape:Solid
    Molecular weight:311.221

    Ref: TM-T24730

  • FC 11
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    FC 11

    CAS:
    FC 11 is a reversible FAK PROTAC Degrader with DC50 of 40-370 pM and degrades pFAKtyr397 in TM3 cells within 3 hours at 100 nM.
    Formula:C41H42F3N13O9S
    Color and Shape:Solid
    Molecular weight:949.91

    Ref: TM-T41164

  • Ifebemtinib
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    Ifebemtinib

    CAS:
    Ifebemtinib (BI-853520) is an adhesion plaque kinase inhibitor with anti-tumour activity for the study of breast cancer.
    Formula:C28H28F4N6O4
    Purity:98.47% - 99.93%
    Color and Shape:White Solid
    Molecular weight:588.5533

    Ref: TM-T64167

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    FAK-IN-3

    FAK-IN-3 inhibits FAK, reduces PA-1 cell migration/invasion, and tumor growth, with no major side effects.
    Formula:C28H28N6O4
    Color and Shape:Solid
    Molecular weight:512.56

    Ref: TM-T63545

  • FAK-IN-23
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    FAK-IN-23

    CAS:
    FAK-IN-23 (Compound II) is an inhibitor of focal adhesion kinase (FAK).
    Formula:C32H38F3N5O8
    Color and Shape:Solid
    Molecular weight:677.668

    Ref: TM-T204586

  • FAK-IN-26
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    FAK-IN-26

    CAS:
    FAK-IN-26 is a blood-brain barrier-penetrating inhibitor of Focal Adhesion Kinase (FAK) with an IC50 of 0.87 nM. It significantly reduces tumor cell viability, cancer stem cell activity, and cell migration in A549 and SKOV-3 cell lines. FAK-IN-26 exhibits potent anticancer activity, achieving tumor inhibition rates of 59.15% and 57.9% in A549 and SKOV-3 tumor mouse models, respectively.
    Formula:C20H19BrFN5O2
    Color and Shape:Solid
    Molecular weight:460.30

    Ref: TM-T207475

  • OXA-11
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    OXA-11

    CAS:
    OXA-11 (FAK-IN-16) is a FAK inhibitor with anti-tumor activity, useful for cancer research.
    Formula:C37H49F3N7O5P
    Purity:98.70% - 99.20%
    Color and Shape:White Solid
    Molecular weight:759.8

    Ref: TM-T28277

  • FAK-IN-21
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    FAK-IN-21

    CAS:
    FAK-IN-21 (compound 9) is a FAK inhibitor with an IC50 value of 37.52 nM. It inhibits cell growth and the phosphorylation of FAK, making it useful for research into diffuse gastric cancer.
    Formula:C22H22F2N8O3S
    Color and Shape:Solid
    Molecular weight:516.52

    Ref: TM-T201079

  • FAK inhibitor 6
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    FAK inhibitor 6

    CAS:
    Compound 26F: potent enzyme inhibitor (IC50=28.2nM), low cytotoxicity (IC50=3.32μM), induces dose-dependent apoptosis in MDA-MB-231, blocks G0/G1 phase.
    Formula:C25H24FN5O2S
    Color and Shape:Solid
    Molecular weight:477.55

    Ref: TM-T63123

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    FAK activator-1

    CAS:
    FAKactivator-1 (5aHCl) is a compound that functions as a FAK activator and mucosal healing inducer. It enhances the phosphorylation of FAK at the Tyr-397 site, thereby facilitating FAK activation. This agent promotes mucosal healing and is applicable in research related to gastrointestinal mucosal injury associated with non-steroidal anti-inflammatory drugs.
    Formula:C21H27ClF3N5O2
    Molecular weight:473.92

    Ref: TM-T217790

  • JP-153
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    JP-153

    CAS:
    JP-153 is an inhibitor of Src-FAK-Paxillin signaling. It suppresses Src-dependent phosphorylation of paxillin (Y118) and subsequent activation of Akt (S473). JP-153 reduces VEGF-induced migration and proliferation of retinal endothelial cells and is applicable in the study of neovascular eye diseases.
    Formula:C21H19NO5
    Color and Shape:Solid
    Molecular weight:365.379

    Ref: TM-T206442

  • Pyk2-IN-2
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    Pyk2-IN-2

    CAS:
    Pyk2-IN-2 (compound 13j) acts as a Pyk2 inhibitor, exhibiting an IC 50 value of 0.608 μM for FAK kinase [1].
    Formula:C27H27N7O
    Color and Shape:Solid
    Molecular weight:465.55

    Ref: TM-T87280

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    FAK-IN-6

    FAK-IN-6: Potent FAK inhibitor (IC50=1.415 nM), anti-cancer, for pancreatic studies.
    Formula:C25H31ClN5O6PS
    Color and Shape:Solid
    Molecular weight:596.04

    Ref: TM-T64207

  • Ifebemtinib tosylate
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    Ifebemtinib tosylate

    CAS:
    Ifebemtinib (tosylate) (BI-853520 (tosylate); IN-10018 (tosylate)) is a highly selective PTK2 kinase inhibitor with anti-tumor properties. It inhibits FAK autophosphorylation in prostate cancer cells and suppresses spheroid formation and in situ tumor growth in vivo. Ifebemtinib (tosylate) is applicable in cancer research, including studies on solid tumors, breast cancer, and malignant pleural mesothelioma.
    Formula:C35H36F4N6O7S
    Color and Shape:Solid
    Molecular weight:760.76

    Ref: TM-T211841