PERK
PERK (Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase) inhibitors target the PERK pathway, which is involved in the cellular response to endoplasmic reticulum (ER) stress and the regulation of apoptosis. PERK plays a critical role in the unfolded protein response (UPR) by halting protein translation and promoting cell survival under stress conditions. However, prolonged PERK activation can lead to apoptosis. Inhibiting PERK can modulate these stress responses, making these inhibitors valuable in research on neurodegenerative diseases, cancer, and metabolic disorders. At CymitQuimica, we offer a range of high-quality PERK inhibitors to support your research in apoptosis, ER stress, and cellular homeostasis.
Found 26 products of "PERK"
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Daraxonrasib
CAS:Daraxonrasib is a potent RAS(ON)MULTI inhibitor with broad-spectrum inhibitory activity against RAS-GTP.Cost-effective and quality-assured.Formula:C44H58N8O5SPurity:98.24% - 99.96%Color and Shape:SolidMolecular weight:811.05PERK-IN-6
CAS:PERK-IN-6 is a novel and highly potent PERK inhibitor (IC50:2.5 nM).Formula:C23H22N6OPurity:99.62% - 99.92%Color and Shape:SolidMolecular weight:398.46PERK-IN-4
CAS:PERK-IN-4 is a potent and selective PERK inhibitor with an IC50 value of 0.3 nM.PERK-IN-4 can be used in the study of cancer and neurological disorders.Formula:C24H19F4N5OPurity:99.44% - 99.49%Color and Shape:SolidMolecular weight:469.43Claturafenib
CAS:Claturafenib is a brain-permeable, selective, all-mutant BRAF inhibitor.PF-07799933 has shown antitumor activity, used in combination with MEK inhibitors.Formula:C18H15Cl2F2N5O3SPurity:98.68% - 99.85%Color and Shape:SolidMolecular weight:490.31EIF2α activator 2
CAS:EIF2α activator 2 is an activator of eIF2α phosphorylation, anti-proliferative in SRB, K562, and PBMC cells, suitable for cancer research.Formula:C21H20F6N2O2Purity:98.86%Color and Shape:SolidMolecular weight:446.39Ref: TM-T62637
1mg62.00€5mg130.00€10mg203.00€25mg380.00€50mg556.00€100mg799.00€200mg1,094.00€1mL*10mM (DMSO)144.00€2BAct
CAS:2BAct is a novel eif2b activator, preventing neurological defects caused by a chronic integrated stress responseFormula:C19H16ClF3N4O3Purity:97.97% - 99.04%Color and Shape:SolidMolecular weight:440.8Takeda-6d
CAS:Takeda-6d is a novel, potent DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with IC50 of 7.0 nM and 2.2 nM, respectively.Formula:C27H19ClFN5O3SPurity:98.27%Color and Shape:SolidMolecular weight:547.99Ref: TM-T22436
1mg92.00€2mg128.00€5mg178.00€10mg268.00€25mg439.00€50mg610.00€100mg820.00€200mg1,099.00€1mL*10mM (DMSO)243.00€ONO-8130
CAS:ONO-8130 is an orally available antagonist of EP1 receptor.Formula:C25H28N2O5S2Purity:97.82%Color and Shape:SolidMolecular weight:500.63GSK621
CAS:GSK621 is a specific and potent AMPK activator.Formula:C26H20ClN3O5Purity:97.02% - 97.05%Color and Shape:SolidMolecular weight:489.91Ref: TM-T6854
1mg52.00€2mgTo inquire5mg106.00€10mg180.00€25mg311.00€50mg502.00€100mg743.00€200mg1,026.00€IACS-13909
CAS:IACS-13909 (BBP-398), a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway.Formula:C17H18Cl2N6Purity:98.8%Color and Shape:SolidMolecular weight:377.27GSK2606414
CAS:GSK2606414 is a cell-permeable and orally active protein kinase R-like endoplasmic reticulum kinase（PERK）inhibitor.Cost-effective and quality-assured.Formula:C24H20F3N5OPurity:98% - >99.99%Color and Shape:SolidMolecular weight:451.44Bufotalin
CAS:<p>1. Bufotalin (Bufotaline)e is a kind of poisonous secretions of toads.</p>Formula:C26H36O6Purity:99.45% - 99.91%Color and Shape:White To Off-White SolidMolecular weight:444.56SHP099
CAS:SHP099 (SHP099 free base) free base is an effective, selective, orally bioavailable, and efficacious SHP2 inhibitor (IC50 =0.07 μM and p-ERK modulation in cellsFormula:C16H19Cl2N5Purity:98.73% - 99.4%Color and Shape:SolidMolecular weight:352.26Ref: TM-T3564
1mg34.00€2mg49.00€5mg74.00€10mg94.00€25mg165.00€50mg213.00€100mg388.00€1mL*10mM (DMSO)57.00€ISRIB (trans-isomer)
CAS:ISRIB (trans-isomer) is a potent inhibitor of PERK that rescues protein translation and prevents SG formation in the presence of P-eIF2α. Cost effective and quality assured.Formula:C22H24Cl2N2O4Purity:97.86% - 99.27%Color and Shape:SolidMolecular weight:451.34GSK2656157
CAS:GSK2656157 is a highly specific and ATP-competitive PERK inhibitor (IC50: 0.9 nM) in a cell-free assay.Formula:C23H21FN6OPurity:98.59% - >99.99%Color and Shape:SolidMolecular weight:416.45Ref: TM-T2654
2mg35.00€5mg50.00€10mg81.00€25mg142.00€50mg259.00€100mg467.00€200mg632.00€1mL*10mM (DMSO)56.00€SHP389
CAS:SHP389 is a highly effective allosteric inhibitor of SHP2, inhibiting SHP2 and p-ERK, used in cancer research.Formula:C23H29ClN8O2Purity:98.24%Color and Shape:SolidMolecular weight:484.98DNL343
CAS:DNL343 is an eIF2B activator that inhibits stress granule (SG) assembly induced by the C9ORF72 dipeptide repeat.Formula:C20H19ClF3N3O4Purity:99.96%Color and Shape:SolidMolecular weight:457.83eIF4A3-IN-1
CAS:<p>eIF4A3-IN-1 is an inhibitor of eukaryotic initiation factor 4A3 (eIF4A3). eIF4A3-IN-1 inhibits cytosolic nonsense-mediated RNA decay at high concentrations.</p>Formula:C29H23BrClN5O2Purity:99.49% - 99.89%Color and Shape:SolidMolecular weight:588.88PF-07284892
CAS:PF-07284892 (ARRY-558) is an orally active allosteric SHP2 inhibitor (IC50 = 21 nM) that reduces pERK expression and may be employed in solid tumour research.Formula:C21H22ClN7SPurity:97.77%Color and Shape:SolidMolecular weight:439.96GCN2-IN-6
CAS:GCN2-IN-6: Potent, oral GCN2/PERK inhibitor; IC50s - GCN2: 1.8 nM (enzymatic), 9.3 nM (cellular); PERK: 0.26 nM (enzymatic), 230 nM (cellular).Formula:C19H12Cl2F2N4O3SPurity:95.04% - 98%Color and Shape:SolidMolecular weight:485.29
