PERK
PERK (Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase) inhibitors target the PERK pathway, which is involved in the cellular response to endoplasmic reticulum (ER) stress and the regulation of apoptosis. PERK plays a critical role in the unfolded protein response (UPR) by halting protein translation and promoting cell survival under stress conditions. However, prolonged PERK activation can lead to apoptosis. Inhibiting PERK can modulate these stress responses, making these inhibitors valuable in research on neurodegenerative diseases, cancer, and metabolic disorders. At CymitQuimica, we offer a range of high-quality PERK inhibitors to support your research in apoptosis, ER stress, and cellular homeostasis.
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PERK-IN-6
CAS:1337532-14-5
PERK-IN-6 is a novel and highly potent PERK inhibitor (IC50:2.5 nM).
Formula:
C23H22N6O
Purity:
98.77% - 99.78%
Color and Shape:
Liquid
Molecular weight:
398.46
Ref: TM-T72053
| 1mg | 156.00 € | ||
| 5mg | 369.00 € | ||
| 10mg | 550.00 € | ||
| 25mg | 872.00 € |
Estimated delivery in United States, on Tuesday 7 Jan 2025
PERK-IN-4
CAS:1337531-89-1
PERK-IN-4 is a potent and selective PERK inhibitor with an IC50 value of 0.3 nM.PERK-IN-4 …
Formula:
C24H19F4N5O
Purity:
100% - 98.14%
Color and Shape:
Liquid
Molecular weight:
469.43
Ref: TM-T38732
| 1mg | 64.00 € | ||
| 5mg | 142.00 € | ||
| 10mg | 212.00 € | ||
| 25mg | 398.00 € | ||
| 50mg | 591.00 € | ||
| 100mg | 824.00 € |
Estimated delivery in United States, on Tuesday 7 Jan 2025
ATPγS tetralithium salt
CAS:93839-89-5
ATPγS tetralithium salt is a good substrate for RNA-stimulated nucleotide hydrolysis and RNA unwinding activity …
Formula:
C10H12Li4N5O12P3S
Purity:
90% - ≥98%
Color and Shape:
White Powder
Molecular weight:
546.98
Ref: TM-T22592
| 1mg | 143.00 € | ||
| 5mg | 346.00 € | ||
| 10mg | 482.00 € | ||
| 25mg | 828.00 € | ||
| 50mg | 1,188.00 € | ||
| 100mg | 1,652.00 € |
Estimated delivery in United States, on Tuesday 7 Jan 2025
BAY 2965501
CAS:2732902-08-6
BAY 2965501 is a potent and selective diacylglycerol kinase zeta (DGKζ) inhibitor that induces pERK …
Formula:
C20H19FN4O3S
Purity:
99.4%
Color and Shape:
Liquid
Molecular weight:
414.45
Ref: TM-T73053
| 1mg | 90.00 € | ||
| 5mg | 184.00 € | ||
| 10mg | 345.00 € | ||
| 25mg | 639.00 € | ||
| 50mg | 827.00 € | ||
| 100mg | 1,141.00 € |
Estimated delivery in United States, on Tuesday 7 Jan 2025
Bufotalin
CAS:471-95-4
1. Bufotalin (Bufotaline)e is a kind of poisonous secretions of toads.
Formula:
C26H36O6
Purity:
99.45% - 99.67%
Color and Shape:
White To Off-White Solid
Molecular weight:
444.56
Ref: TM-T5A2461
| 1mg | 47.00 € | ||
| 5mg | 95.00 € | ||
| 10mg | 142.00 € | ||
| 25mg | 232.00 € | ||
| 50mg | 344.00 € | ||
| 100mg | 507.00 € | ||
| 500mg | 1,083.00 € | ||
| 1mL*10mM (DMSO) | 96.00 € |
Estimated delivery in United States, on Friday 10 Jan 2025
4E1rcat
CAS:328998-25-0
4E1RCat is a dual inhibitor of eIF4E:eIF4 g and eIF4E:4E-BP1 interaction. And it inhibits the …
Formula:
C28H18N2O6
Purity:
99.36%
Color and Shape:
Solid
Molecular weight:
478.45
Ref: TM-T1742
| 2mg | 51.00 € | ||
| 5mg | 74.00 € | ||
| 10mg | 90.00 € | ||
| 25mg | 159.00 € | ||
| 50mg | 193.00 € | ||
| 100mg | 344.00 € | ||
| 1mL*10mM (DMSO) | 82.00 € |
Estimated delivery in United States, on Friday 10 Jan 2025
ONO-8130
CAS:459841-96-4
ONO-8130 is an orally available antagonist of EP1 receptor.
Formula:
C25H28N2O5S2
Purity:
97.82%
Color and Shape:
Solid
Molecular weight:
500.63
Ref: TM-T21976
| 1mg | 156.00 € | ||
| 5mg | 337.00 € | ||
| 10mg | 551.00 € | ||
| 25mg | 880.00 € | ||
| 50mg | 1,202.00 € |
Estimated delivery in United States, on Friday 10 Jan 2025
GSK621
CAS:1346607-05-3
GSK621 is a specific and potent AMPK activator.
Formula:
C26H20ClN3O5
Purity:
97.02% - 97.05%
Color and Shape:
Solid
Molecular weight:
489.91
Ref: TM-T6854
| 1mg | 54.00 € | ||
| 5mg | 105.00 € | ||
| 10mg | 177.00 € | ||
| 25mg | 346.00 € | ||
| 50mg | 510.00 € | ||
| 100mg | 727.00 € |
Estimated delivery in United States, on Friday 10 Jan 2025
IACS-13909
CAS:2160546-07-4
IACS-13909 (BBP-398), a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the …
Formula:
C17H18Cl2N6
Purity:
98.80%
Color and Shape:
Solid
Molecular weight:
377.27
Ref: TM-T9196
| 1mg | 93.00 € | ||
| 5mg | 222.00 € | ||
| 10mg | 353.00 € | ||
| 25mg | 501.00 € | ||
| 50mg | 709.00 € | ||
| 100mg | 918.00 € | ||
| 1mL*10mM (DMSO) | 249.00 € |
Estimated delivery in United States, on Friday 10 Jan 2025
GSK2606414
CAS:1337531-36-8
GSK2606414 is a cell-permeable and orally active protein kinase R-like endoplasmic reticulum kinase(PERK)inhibitor.Cost-effective and quality-assured.
Formula:
C24H20F3N5O
Purity:
100% - 98.44%
Color and Shape:
Solid
Molecular weight:
451.44
Ref: TM-T2614
| 2mg | 66.00 € | ||
| 5mg | 92.00 € | ||
| 10mg | 124.00 € | ||
| 50mg | 324.00 € | ||
| 1mL*10mM (DMSO) | 96.00 € |
Estimated delivery in United States, on Friday 10 Jan 2025
2BAct
CAS:2143542-28-1
2BAct is a novel eif2b activator, preventing neurological defects caused by a chronic integrated stress …
Formula:
C19H16ClF3N4O3
Purity:
97.97% - 98.11%
Color and Shape:
Solid
Molecular weight:
440.8
Ref: TM-T9149
| 1mg | 57.00 € | ||
| 5mg | 128.00 € | ||
| 10mg | 198.00 € | ||
| 25mg | 328.00 € | ||
| 50mg | 460.00 € | ||
| 100mg | 630.00 € | ||
| 1mL*10mM (DMSO) | 152.00 € |
Estimated delivery in United States, on Friday 10 Jan 2025
Takeda-6d
CAS:1125632-93-0
Takeda-6d is a novel, potent DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with …
Formula:
C27H19ClFN5O3S
Purity:
98.27%
Color and Shape:
Solid
Molecular weight:
547.99
Ref: TM-T22436
| 1mg | 93.00 € | ||
| 2mg | 130.00 € | ||
| 5mg | 182.00 € | ||
| 10mg | 272.00 € | ||
| 25mg | 446.00 € | ||
| 50mg | 621.00 € | ||
| 100mg | 835.00 € | ||
| 200mg | 1,116.00 € | ||
| 1mL*10mM (DMSO) | 247.00 € |
Estimated delivery in United States, on Friday 10 Jan 2025
ISRIB (trans-isomer)
CAS:1597403-47-8
ISRIB (trans-isomer) is a potent inhibitor of PERK that rescues protein translation and prevents SG …
Formula:
C22H24Cl2N2O4
Purity:
98.81% - 99.27%
Color and Shape:
Solid
Molecular weight:
451.34
Ref: TM-T6183
| 1mg | 36.00 € | ||
| 2mg | 48.00 € | ||
| 5mg | 71.00 € | ||
| 10mg | 97.00 € | ||
| 25mg | 183.00 € | ||
| 50mg | 320.00 € | ||
| 100mg | 577.00 € | ||
| 500mg | 1,235.00 € |
Estimated delivery in United States, on Friday 10 Jan 2025
ISRIB
CAS:548470-11-7
ISRIB is a potent and selective PERK inhibitor.
Formula:
C22H24Cl2N2O4
Purity:
99.93% - ≥95%
Color and Shape:
Solid
Molecular weight:
451.34
Ref: TM-T2027
| 5mg | 57.00 € | ||
| 10mg | 89.00 € | ||
| 25mg | 156.00 € | ||
| 50mg | 253.00 € | ||
| 100mg | 363.00 € |
Estimated delivery in United States, on Friday 10 Jan 2025
SBI-0640756
CAS:1821280-29-8
SBI-0640756 (SBI-756) (SBI-756) is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex.
Formula:
C23H14ClFN2O2
Purity:
99.75%
Color and Shape:
Solid
Molecular weight:
404.82
Ref: TM-T5173
| 1mg | 38.00 € | ||
| 5mg | 95.00 € | ||
| 10mg | 136.00 € | ||
| 25mg | 262.00 € | ||
| 50mg | 373.00 € | ||
| 100mg | 522.00 € | ||
| 200mg | 708.00 € | ||
| 1mL*10mM (DMSO) | 90.00 € |
Estimated delivery in United States, on Friday 10 Jan 2025
GSK2656157
CAS:1337532-29-2
GSK2656157 is a highly specific and ATP-competitive PERK inhibitor (IC50: 0.9 nM) in a cell-free …
Formula:
C23H21FN6O
Purity:
100% - 99.89%
Color and Shape:
Solid
Molecular weight:
416.45
Ref: TM-T2654
| 2mg | 38.00 € | ||
| 5mg | 55.00 € | ||
| 10mg | 80.00 € | ||
| 25mg | 140.00 € | ||
| 50mg | 253.00 € | ||
| 100mg | 457.00 € | ||
| 200mg | 622.00 € | ||
| 1mL*10mM (DMSO) | 89.00 € |
Estimated delivery in United States, on Friday 10 Jan 2025
CCT020312
CAS:324759-76-4
CCT020312 (0-9 µM, 24 h) treatment of medium HT29 cells for 24 h resulted in …
Formula:
C31H30Br2N4O2
Purity:
98.36%
Color and Shape:
Solid
Molecular weight:
650.4
Ref: TM-T14902
| 1mg | 61.00 € | ||
| 5mg | 139.00 € | ||
| 10mg | 238.00 € | ||
| 25mg | 401.00 € | ||
| 50mg | 590.00 € | ||
| 100mg | 824.00 € | ||
| 500mg | 1,700.00 € | ||
| 1mL*10mM (DMSO) | 186.00 € |
Estimated delivery in United States, on Friday 21 Feb 2025
AMG PERK 44
CAS:1883548-84-2
AMG PERK 44 is a PERK inhibitor that induces autophagy.AMG PERK 44 inhibits GCN2 and …
Formula:
C34H29ClN4O2
Purity:
99.81% - ≥98%
Color and Shape:
Solid
Molecular weight:
561.07
Ref: TM-T10299
| 1mg | 56.00 € | ||
| 5mg | 119.00 € | ||
| 10mg | 185.00 € | ||
| 25mg | 425.00 € | ||
| 50mg | 644.00 € | ||
| 100mg | 918.00 € |
Estimated delivery in United States, on Friday 21 Feb 2025
DNL343
CAS:2278265-85-1
DNL343 is an eIF2B activator that inhibits stress granule (SG) assembly induced by the C9ORF72 …
Formula:
C20H19ClF3N3O4
Purity:
100%
Color and Shape:
Liquid
Molecular weight:
457.83
Ref: TM-T78876
| 1mg | 142.00 € | ||
| 5mg | 344.00 € | ||
| 10mg | 573.00 € | ||
| 25mg | 1,138.00 € | ||
| 50mg | 1,831.00 € | ||
| 100mg | 3,033.00 € |
Estimated delivery in United States, on Friday 21 Feb 2025
eIF4A3-IN-1
CAS:2095486-67-0
eIF4A3-IN-1 is an inhibitor of eukaryotic initiation factor 4A3 (eIF4A3). eIF4A3-IN-1 inhibits cytosolic nonsense-mediated RNA …
Formula:
C29H23BrClN5O2
Purity:
99.49%
Color and Shape:
Solid
Molecular weight:
588.88
Ref: TM-T11170
| 1mg | 146.00 € | ||
| 5mg | 325.00 € | ||
| 10mg | 602.00 € | ||
| 25mg | 1,071.00 € | ||
| 1mL*10mM (DMSO) | 45.00 € |
Estimated delivery in United States, on Friday 21 Feb 2025
