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PERK

PERK

PERK (Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase) inhibitors target the PERK pathway, which is involved in the cellular response to endoplasmic reticulum (ER) stress and the regulation of apoptosis. PERK plays a critical role in the unfolded protein response (UPR) by halting protein translation and promoting cell survival under stress conditions. However, prolonged PERK activation can lead to apoptosis. Inhibiting PERK can modulate these stress responses, making these inhibitors valuable in research on neurodegenerative diseases, cancer, and metabolic disorders. At CymitQuimica, we offer a range of high-quality PERK inhibitors to support your research in apoptosis, ER stress, and cellular homeostasis.

Found 25 products of "PERK"

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  • PERK-IN-6
    Targetmol
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    PERK-IN-6

    CAS:
    <p>PERK-IN-6 is a novel and highly potent PERK inhibitor (IC50:2.5 nM).</p>
    Formula:C23H22N6O
    Purity:99.62% - 99.92%
    Color and Shape:Solid
    Molecular weight:398.46

    Ref: TM-T72053

  • PERK-IN-4
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    PERK-IN-4

    CAS:
    <p>PERK-IN-4 is a potent and selective PERK inhibitor with an IC50 value of 0.3 nM.PERK-IN-4 can be used in the study of cancer and neurological disorders.</p>
    Formula:C24H19F4N5O
    Purity:98.07% - 98.95%
    Color and Shape:Solid
    Molecular weight:469.43

    Ref: TM-T38732

  • EIF2α activator 2
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    EIF2α activator 2

    CAS:
    <p>EIF2α activator 2 is an activator of eIF2α phosphorylation, anti-proliferative in SRB, K562, and PBMC cells, suitable for cancer research.</p>
    Formula:C21H20F6N2O2
    Purity:98.86%
    Color and Shape:Solid
    Molecular weight:446.39

    Ref: TM-T62637

  • GSK621
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    GSK621

    CAS:
    <p>GSK621 is a specific and potent AMPK activator.</p>
    Formula:C26H20ClN3O5
    Purity:97.02% - 97.05%
    Color and Shape:Solid
    Molecular weight:489.91

    Ref: TM-T6854

  • IACS-13909
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    IACS-13909

    CAS:
    <p>IACS-13909 (BBP-398), a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway.</p>
    Formula:C17H18Cl2N6
    Purity:98.8%
    Color and Shape:Solid
    Molecular weight:377.27

    Ref: TM-T9196

  • GSK2606414
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    GSK2606414

    CAS:
    <p>GSK2606414 is a cell-permeable and orally active protein kinase R-like endoplasmic reticulum kinase（PERK）inhibitor.Cost-effective and quality-assured.</p>
    Formula:C24H20F3N5O
    Purity:98% - >99.99%
    Color and Shape:Solid
    Molecular weight:451.44

    Ref: TM-T2614

  • Bufotalin
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    Bufotalin

    CAS:
    <p>1. Bufotalin (Bufotaline)e is a kind of poisonous secretions of toads.</p>
    Formula:C26H36O6
    Purity:99.45% - 99.91%
    Color and Shape:White To Off-White Solid
    Molecular weight:444.56

    Ref: TM-T5A2461

  • 4E1rcat
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    4E1rcat

    CAS:
    <p>4E1RCat is a dual inhibitor of eIF4E:eIF4 g and eIF4E:4E-BP1 interaction. And it inhibits the binding of eIF4 g to eIF4E with IC50 of 3.2 μM.</p>
    Formula:C28H18N2O6
    Purity:99.47%
    Color and Shape:Solid
    Molecular weight:478.45

    Ref: TM-T1742

  • ONO-8130
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    ONO-8130

    CAS:
    <p>ONO-8130 is an orally available antagonist of EP1 receptor.</p>
    Formula:C25H28N2O5S2
    Purity:97.82%
    Color and Shape:Solid
    Molecular weight:500.63

    Ref: TM-T21976

  • 2BAct
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    2BAct

    CAS:
    <p>2BAct is a novel eif2b activator, preventing neurological defects caused by a chronic integrated stress response</p>
    Formula:C19H16ClF3N4O3
    Purity:97.97% - 99.04%
    Color and Shape:Solid
    Molecular weight:440.8

    Ref: TM-T9149

  • Takeda-6d
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    Takeda-6d

    CAS:
    <p>Takeda-6d is a novel, potent DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with IC50 of 7.0 nM and 2.2 nM, respectively.</p>
    Formula:C27H19ClFN5O3S
    Purity:98.27%
    Color and Shape:Solid
    Molecular weight:547.99

    Ref: TM-T22436

  • ISRIB (trans-isomer)
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    ISRIB (trans-isomer)

    CAS:
    <p>ISRIB (trans-isomer) is a potent inhibitor of PERK that rescues protein translation and prevents SG formation in the presence of P-eIF2α. Cost effective and quality assured.</p>
    Formula:C22H24Cl2N2O4
    Purity:97.86% - 99.27%
    Color and Shape:Solid
    Molecular weight:451.34

    Ref: TM-T6183

  • SBI-0640756
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    SBI-0640756

    CAS:
    <p>SBI-0640756 (SBI-756) (SBI-756) is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex.</p>
    Formula:C23H14ClFN2O2
    Purity:99.75%
    Color and Shape:Solid
    Molecular weight:404.82

    Ref: TM-T5173

  • GSK2656157
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    GSK2656157

    CAS:
    <p>GSK2656157 is a highly specific and ATP-competitive PERK inhibitor (IC50: 0.9 nM) in a cell-free assay.</p>
    Formula:C23H21FN6O
    Purity:98.59% - >99.99%
    Color and Shape:Solid
    Molecular weight:416.45

    Ref: TM-T2654

  • DNL343
    Targetmol
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    DNL343

    CAS:
    <p>DNL343 is an eIF2B activator that inhibits stress granule (SG) assembly induced by the C9ORF72 dipeptide repeat.</p>
    Formula:C20H19ClF3N3O4
    Purity:99.96%
    Color and Shape:Solid
    Molecular weight:457.83

    Ref: TM-T78876

  • eIF4A3-IN-1
    Targetmol
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    eIF4A3-IN-1

    CAS:
    <p>eIF4A3-IN-1 is an inhibitor of eukaryotic initiation factor 4A3 (eIF4A3). eIF4A3-IN-1 inhibits cytosolic nonsense-mediated RNA decay at high concentrations.</p>
    Formula:C29H23BrClN5O2
    Purity:99.49% - 99.89%
    Color and Shape:Solid
    Molecular weight:588.88

    Ref: TM-T11170

  • AMG PERK 44
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    AMG PERK 44

    CAS:
    <p>AMG PERK 44 is a PERK inhibitor that induces autophagy.AMG PERK 44 inhibits GCN2 and B-Raf and can be used in cancer research.</p>
    Formula:C34H29ClN4O2
    Purity:98.8% - 99.81%
    Color and Shape:Solid
    Molecular weight:561.07

    Ref: TM-T10299

  • PF-07284892
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    PF-07284892

    CAS:
    <p>PF-07284892 (ARRY-558) is an orally active allosteric SHP2 inhibitor (IC50 = 21 nM) that reduces pERK expression and may be employed in solid tumour research.</p>
    Formula:C21H22ClN7S
    Purity:97.77%
    Color and Shape:Solid
    Molecular weight:439.96

    Ref: TM-T79123

  • GCN2-IN-6
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    GCN2-IN-6

    CAS:
    <p>GCN2-IN-6: Potent, oral GCN2/PERK inhibitor; IC50s - GCN2: 1.8 nM (enzymatic), 9.3 nM (cellular); PERK: 0.26 nM (enzymatic), 230 nM (cellular).</p>
    Formula:C19H12Cl2F2N4O3S
    Purity:95.04% - 98%
    Color and Shape:Solid
    Molecular weight:485.29

    Ref: TM-T11374

  • eIF4E-IN-4
    Targetmol
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    eIF4E-IN-4

    CAS:
    <p>eIF4E-IN-4 (Compound 33) is a selective inhibitor of the eukaryotic initiation factor 4E (eIF4E) with a biochemical activity value of 95 nM. It inhibits cap-dependent mRNA translation with an IC50 of 2.5 μM and is applicable in research on breast cancer, colon cancer, and head and neck cancer.</p>
    Formula:C20H19ClN5O5P
    Color and Shape:Solid
    Molecular weight:475.822

    Ref: TM-T206372