PERK
PERK (Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase) inhibitors target the PERK pathway, which is involved in the cellular response to endoplasmic reticulum (ER) stress and the regulation of apoptosis. PERK plays a critical role in the unfolded protein response (UPR) by halting protein translation and promoting cell survival under stress conditions. However, prolonged PERK activation can lead to apoptosis. Inhibiting PERK can modulate these stress responses, making these inhibitors valuable in research on neurodegenerative diseases, cancer, and metabolic disorders. At CymitQuimica, we offer a range of high-quality PERK inhibitors to support your research in apoptosis, ER stress, and cellular homeostasis.
Found 34 products for "PERK".
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Daraxonrasib
CAS:Daraxonrasib is a potent RAS(ON)MULTI inhibitor with broad-spectrum inhibitory activity against RAS-GTP.Cost-effective and quality-assured.Formula:C44H58N8O5SPurity:98.24% - 99.98%Color and Shape:White SolidMolecular weight:811.05ISR-IN-3
ISR-IN-3 (Compound 7a) is an eIF2B activator with a pEC50 value of 7.3. It also exhibits significant hERG inhibitory activity, with a pIC50 value of 5.7. ISR-IN-3 is applicable in research related to Huntington's disease, Parkinson's disease, and amyotrophic lateral sclerosis (als).eIF4E-IN-3
CAS:eIF4E-IN-3 is an eIF4E inhibitor that blocks cap-dependent translation and is used in cancer-related mechanism studies.Formula:C34H30ClF3N6O4SColor and Shape:SolidMolecular weight:711.16PERK-IN-6
CAS:PERK-IN-6 is a novel and highly potent PERK inhibitor (IC50:2.5 nM).Formula:C23H22N6OPurity:99.62% - 99.97%Color and Shape:SolidMolecular weight:398.46PERK-IN-4
CAS:PERK-IN-4 is a potent and selective PERK inhibitor with an IC50 value of 0.3 nM.PERK-IN-4 can be used in the study of cancer and neurological disorders.Formula:C24H19F4N5OPurity:99.44% - 99.49%Color and Shape:SolidMolecular weight:469.4342Claturafenib
CAS:Claturafenib is a brain-permeable, selective, all-mutant BRAF inhibitor.PF-07799933 has shown antitumor activity, used in combination with MEK inhibitors.Formula:C18H15Cl2F2N5O3SPurity:98.68% - 99.85%Color and Shape:SolidMolecular weight:490.31ML-291
CAS:ML-291 is a potent UPR inducer; activates PERK/eIF2α/CHOP apoptotic arm; cancer cell death research tool.Formula:C16H16ClN3O6SPurity:99.79%Color and Shape:White SolidMolecular weight:413.833EIF2α activator 2
CAS:EIF2α activator 2 is an activator of eIF2α phosphorylation, anti-proliferative in SRB, K562, and PBMC cells, suitable for cancer research.Formula:C21H20F6N2O2Purity:98.86%Color and Shape:White SolidMolecular weight:446.39GSK2656157
CAS:GSK2656157 is a highly specific and ATP-competitive PERK inhibitor (IC50: 0.9 nM) in a cell-free assay.Formula:C23H21FN6OPurity:98.59% - >99.99%Color and Shape:SolidMolecular weight:416.4508IACS-13909
CAS:IACS-13909 (BBP-398), a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway.Formula:C17H18Cl2N6Purity:98.8%Color and Shape:SolidMolecular weight:377.271GSK2606414
CAS:GSK2606414 is a cell-permeable and orally active protein kinase R-like endoplasmic reticulum kinase（PERK）inhibitor.Cost-effective and quality-assured.Formula:C24H20F3N5OPurity:98% - >99.99%Color and Shape:White SolidMolecular weight:451.44Bufotalin
CAS:1. Bufotalin (Bufotaline)e is a kind of poisonous secretions of toads.Formula:C26H36O6Purity:99.45% - 99.91%Color and Shape:SolidMolecular weight:444.5604ONO-8130
CAS:ONO-8130 is an orally available antagonist of EP1 receptor.Formula:C25H28N2O5S2Purity:97.82% - 98.94%Color and Shape:White SolidMolecular weight:500.632BAct
CAS:2BAct is a novel eif2b activator, preventing neurological defects caused by a chronic integrated stress responseFormula:C19H16ClF3N4O3Purity:97.61% - 99.04%Color and Shape:SolidMolecular weight:440.804GSK621
CAS:GSK621 is a specific and potent AMPK activator.Formula:C26H20ClN3O5Purity:97.02% - 97.05%Color and Shape:SolidMolecular weight:489.907ISRIB (trans-isomer)
CAS:ISRIB (trans-isomer) is a potent inhibitor of PERK that rescues protein translation and prevents SG formation in the presence of P-eIF2α. Cost effective and quality assured.Formula:C22H24Cl2N2O4Purity:97.86% - 99.27%Color and Shape:SolidMolecular weight:451.34Takeda-6d
CAS:Takeda-6d is a novel, potent DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with IC50 of 7.0 nM and 2.2 nM, respectively.Formula:C27H19ClFN5O3SPurity:98.27%Color and Shape:Yellow SolidMolecular weight:547.988PERK/eIF2α activator 1
CAS:Compound V8 (PERK/eIF2α activator 1), a flavonoid, exhibits anti-tumor properties by inducing apoptosis and activating the PERK-eIF2α-ATF4 pathway. It effectively inhibits the proliferation of HepG2 cells, with an IC 50 value of 23 μM [1].Formula:C24H29NO7Color and Shape:SolidMolecular weight:443.49DNL343
CAS:DNL343 is an eIF2B activator that inhibits stress granule (SG) assembly induced by the C9ORF72 dipeptide repeat.Formula:C20H19ClF3N3O4Purity:99.96%Color and Shape:SolidMolecular weight:457.83eIF4A3-IN-1
CAS:eIF4A3-IN-1 is an inhibitor of eukaryotic initiation factor 4A3 (eIF4A3). eIF4A3-IN-1 inhibits cytosolic nonsense-mediated RNA decay at high concentrations.Formula:C29H23BrClN5O2Purity:99.49% - 99.89%Color and Shape:SolidMolecular weight:588.882
