CDK
CDK (Cyclin-Dependent Kinase) inhibitors are compounds that block the activity of CDKs, a group of protein kinases that regulate the cell cycle, transcription, and other cellular processes. CDKs are activated by binding to cyclins, and their activity is crucial for the progression of cells through different phases of the cell cycle. Inhibiting CDKs can halt cell division, leading to cell cycle arrest and apoptosis, particularly in cancer cells where CDKs are often dysregulated. CDK inhibitors are widely used in cancer research and have therapeutic potential in treating various cancers. At CymitQuimica, we provide a comprehensive selection of high-quality CDK inhibitors to support your research in cell cycle control, cancer, and therapeutic development.
Found 546 products of "CDK"
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Roccellic Acid
CAS:Roccellic acid from R. montagnei lichen has antibacterial, anticancer properties; MIC 46.9 μg/ml; inhibits cancer cells by up to 87.9%.Formula:C17H32O4Color and Shape:SolidMolecular weight:300.43CDK7-IN-21
CAS:CDK7-IN-21 (compound A22) is a potent CDK7 inhibitor [1] .Formula:C33H36FN9O2Color and Shape:SolidMolecular weight:609.7dCeMM3
CAS:dCeMM3 is a glue degrader that induces ubiquitination and degradation of cyclin K by promoting CDK12-cyclin K interaction with CRL4B ligase.
Formula:C14H11ClN4OSPurity:98.48% - 99.41%Color and Shape:SolidMolecular weight:318.78WAY-322243
CAS:WAY-322243 has antibacterial and anti-inflammatory activity and has an inhibitory effect on CLK-1, which can be used to study Alzheimer's disease.Formula:C18H18N2O2SPurity:99.88%Color and Shape:SoildMolecular weight:326.41CDK4/6-IN-5
CAS:CDK4/6-IN-5 inhibits CDK4/6; Ki: 0.2 nM (CDK4/D1) & 4.4 nM (CDK6/D3). (WO2019207463A1, A93)Formula:C22H28ClFN6O4SColor and Shape:SolidMolecular weight:527.01(R)-Enitociclib
CAS:(R)-Enitociclib, an enantiomer of BAY-1251152, is a CDK9 inhibitor with anticancer activity.Formula:C19H18F2N4O2SPurity:98.98%Color and Shape:SoildMolecular weight:404.43YJ9069
YJ9069 is a selective CDK12/CDK13P ROTAC degrader with an IC50 of 22.22 nM in VCaP cells. Rapid degradation of CDK12/13 by this compound triggers transcription elongation defects dependent on gene length, leading to DNA damage and cell cycle arrest. YJ9069 effectively inhibits the proliferation of prostate cancer cell subpopulations and significantly suppresses prostate tumor growth in vivo.Formula:C46H46N10O7Color and Shape:SolidMolecular weight:850.92CPD-39
CAS:CPD-39 is an efficacious and orally active bifunctional PROTAC degrader targeting both CCND1 and CDK4. It exhibits antiproliferative effects.Formula:C46H57N15O4Color and Shape:SolidMolecular weight:884.04CDK2-IN-19
CDK2-IN-19 (Compound 32) is a selective, orally active inhibitor of CDK2 (K i: 0.18 nM) that exhibits anticancer activity in mice with OVCAR3 tumors [1].Formula:C20H21FN6O4SPurity:98%Color and Shape:SolidMolecular weight:460.48IV-361
CAS:IV-361, an orally active and selective CDK7 inhibitor with a Ki value of less than or equal to 50 nM, demonstrates potent anti-cancer activity (US20190256531A1Formula:C23H32FN5O2SiColor and Shape:SolidMolecular weight:457.625PROTAC CDK9 degrader-6
CAS:PROTAC CDK9 degrader-6 targets and degrades CDK9 isoforms via proteasome, with DC50 of 0.10μM and 0.14μM.Formula:C42H49Cl2N9O8Purity:98%Color and Shape:SolidMolecular weight:878.8Multi-target kinase inhibitor 2
Compound 5K (Multi-target kinase inhibitor 2) is a multi-targeted kinase inhibitor demonstrating activity against EGFR, Her2, VEGFR2, and CDK2 with IC50 valuesPurity:98%Color and Shape:Odour SolidTMX-2039
CAS:TMX-2039 is a pan-CDK inhibitor that targets cell cycle CDKs (CDK1, CDK2, CDK4, CDK5, and CDK6) and transcription CDKs (CDK7 and CDK9), with IC50 values of 2.6, 1.0, 52.1, 0.5, 35.0, 32.5, and 25 nM, respectively. It serves as a ligand for the target protein in PROTAC applications.Formula:C17H20BrFN6O3SColor and Shape:SolidMolecular weight:487.347CDK2/PIM1-IN-1
CDK2/PIM1-IN-1 is an inhibitor of the kinases CDK2 (IC50: 0.27 μM) and PIM1 (IC50: 0.67 μM). It can induce apoptosis (cell death) and reduce the expression of TNF-α, which promotes tumors. CDK2/PIM1-IN-1 exhibits antitumor activity.Color and Shape:Odour SolidCDK8/19-IN-3
CDK8/19-IN-3 (compound 3-7) is a potent and selective inhibitor of CDK8 and CDK19. It can increase IL-10 levels and has potential for research in inflammatory bowel disease (IBD).Formula:C20H23FN6O2Color and Shape:SolidMolecular weight:398.434CDK12-Cyclin K Ligand-Linker Conjugates 1
CDK12-Cyclin K Ligand-Linker Conjugates 1 is a Target Protein Ligand-Linker Conjugate that includes a CDK12-Cyclin K ligand and a PROTAC linker, which can recruit E3 ligase. CDK12-Cyclin K Ligand-Linker Conjugates 1 is applicable for the synthesis of PROTACPP-C8.Color and Shape:Odour SolidCdk2/Cyclin Inhibitory Peptide I
CDK2, a Ser/Thr kinase, is akin to yeast cdc28 and human Cdk1, crucial for cell division.Formula:C111H196N48O23Purity:98%Color and Shape:SolidMolecular weight:2571.05BSJ-04-132
Selective Cdk4 degrader. Degrades Cdk4 in Molt-4 cells, with no effect on Cdk6 levels. Displays cereblon-dependent degradation.Color and Shape:LiquidCDK2/4-IN-1
CDK2/4-IN-1 (compound B-4a) serves as both a CDK2/4 inhibitor and a microtubule polymerization inhibitor, making it useful in cancer research.Color and Shape:Odour SolidCDK7-IN-6
CAS:CDK7-IN-6, a potent CDK7 inhibitor (IC50 ≤100 nM), from WO2019197549 A1, is >200x selective over CDK1/2/5, promising for cancer research.Formula:C26H34ClN9OColor and Shape:SolidMolecular weight:524.07CDK-IN-13
CDK-IN-13 (compound 32E) is a potent and selective inhibitor of CDK12/cyclin K, exhibiting an IC50 of 3 nM. Additionally, CDK-IN-13 suppresses the growth of HER2-positive breast cancer cell lines.Formula:C23H27N7O3Molecular weight:449.21754CDK7-IN-2 hydrochloride hydrate
CAS:CDK7-IN-2 HCl hydrate is a potent, specific CDK7 enzyme inhibitor with significant anti-cancer effects.Formula:C26H42ClN7O4Color and Shape:SolidMolecular weight:552.12LL-K8-22
LL-K8-22: potent CDK8/cyclin C degrader; DC50 ~2.5μM; hinders STAT1 phosphorylation; curbs E2F/MYC cancer pathways; for TNBC study.Formula:C37H43N5OColor and Shape:SolidMolecular weight:573.77FDA-Approved Kinase Inhibitor Library
A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.
Color and Shape:LiquidKinase Inhibitor Library
A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;Color and Shape:Odour SolidRef: TM-L1600
1mgTo inquire30μL*10mM (DMSO)To inquire50μL*10mM (DMSO)To inquire100μL*10mM (DMSO)To inquire250μL*10mM (DMSO)To inquirePROTAC FLT3/CDKs degrader-1
PROTACFLT3/CDKs degrader-1 (Compound C3) is an agent that degrades cyclin-dependent kinase (CDK2 with a DC50 of 18.73 nM) and FMS-like tyrosine kinase 3 (FLT3). It induces differentiation in HL-60 cells, achieving a 72.77% differentiation rate at 6.25 nM, and inhibits proliferation of acute myeloid leukemia (AML) cells, with an IC50 ranging from 2.9 to 37 nM. PROTACFLT3/CDKs degrader-1 demonstrates potential for improving the treatment of AML.Formula:C40H42N12O5Molecular weight:770.34011CDK1-IN-2
CAS:CDK1-IN-2 (cdk1 inhibitor 2) is a CDK1 inhibitor with IC50 of 5.8 μM.Formula:C17H11ClN2OPurity:98.53%Color and Shape:SoildMolecular weight:294.73Ref: TM-T64373
1mg50.00€5mg107.00€10mg170.00€25mg354.00€50mg567.00€100mg810.00€500mg1,644.00€1mL*10mM (DMSO)103.00€Olomoucine
CAS:Olomoucine hinders Cdk2, Cdc2, CDK5, ERK1, regulates the cell cycle, and fights melanoma; IC50s: 3-25 µM.
Formula:C15H18N6OPurity:99.77%Color and Shape:White Crystalline PowderMolecular weight:298.34TL12-186
CAS:TL12-186 is a Cereblon-dependent kinase degrader that degrades CDK, BTK, FLT3, Aurora and other kinases.TL12-186 inhibits CDK2/cyclin A and CDK9/cyclin T1 withFormula:C44H51ClN10O9SPurity:98.2%Color and Shape:SolidMolecular weight:931.46Ref: TM-T34888
1mg69.00€2mg89.00€5mg147.00€10mg224.00€25mg358.00€50mg512.00€100mg707.00€200mg973.00€1mL*10mM (DMSO)245.00€YX-2-107
CAS:YX-2-107: CDK6-degrading PROTAC, IC50 of 4.4 nM, hinders RB phosphorylation/FOXM1, counters Ph+ ALL growth in rats, targets Ph+ ALL prophylaxis/treatment.Formula:C45H51N11O9Purity:98.09% - 99.148%Color and Shape:SolidMolecular weight:889.95CDK2-IN-7
CAS:CDK2-IN-7 is a CDK2 inhibitor for treating cancer ( IC 50 < 50 nM).Formula:C24H30N6O4SColor and Shape:SolidMolecular weight:498.6CDK9-IN-35
CDK9-IN-35 (compound 10j) acts as an inhibitor of CDK9/CyclinT1, exhibiting an IC50 of 10.2 nM. It also shows an IC50 of 20 nM against the HCT-116 cell line.Formula:C26H24ClFN4O4SColor and Shape:SolidMolecular weight:543.01Cell Cycle Compound Library
A unique collection of xnum cell cycle related compounds for high throughput screening (HTS) and high content screening (HCS);
Color and Shape:Odour SolidCDK6/9-IN-1
CAS:CDK6/9-IN-1, an oral dual inhibitor of CDK6/9, has IC50s of 40.5nM (CDK6) and 39.5nM (CDK9).Formula:C22H25ClN8OColor and Shape:SolidMolecular weight:452.95CDK12/13-IN-2
CDK12/13-IN-2 (Compound 24) is a covalent inhibitor of CDK12 and CDK13, exhibiting IC50 values of 15.5 nM and 12.2 nM, respectively. It effectively inhibits the proliferation of breast cancer cells and can be utilized in the research of triple-negative breast cancer.Formula:C24H22FN7O2Color and Shape:SolidMolecular weight:459.48CDK-IN-12
CAS:CDK-IN-12 (Example 20), a CDK inhibitor, effectively inhibits CDK4/6, demonstrating IC50 values below 20 nM [1].Formula:C26H29FN6OSColor and Shape:SolidMolecular weight:492.61JH-XVI-178
CAS:JH-XVI-178: potent CDK8/19 inhibitor with good pharmacokinetics, low clearance, moderate oral bioavailability.Formula:C22H22ClN7OColor and Shape:SolidMolecular weight:435.92Leucettine L41
CAS:Leucettine L41 (LeucettineL41) is an inhibitor of DYRKs/CLKs, preferentially targeting DYRK1A, and inhibits DYRK2.Formula:C17H13N3O3Purity:99.08%Color and Shape:SolidMolecular weight:307.3PROTAC CDK9 degrader 4
CAS:PROTAC CDK9 degrader 4 is a CDK9 degrader that targets transcriptional regulation and has potential anticancer activity.Formula:C43H56N10O5Color and Shape:SolidMolecular weight:792.97CDK-IN-15
CAS:CDK-IN-15 (Compound 456) is an effective inhibitor of Cyclin A, exhibiting an IC50 value of 0.14 μM.Formula:C45H63Cl2F4N7O8Color and Shape:SolidMolecular weight:976.92CP-10
CAS:CP-10, a selective PROTAC, degrades CDK6 (DC50: 2.1 nM) and inhibits hematopoietic cancers, including multiple myeloma.Formula:C44H49N13O7Purity:98%Color and Shape:SolidMolecular weight:871.94Ref: TM-T13627
5mg655.00€10mg897.00€50mg1,972.00€100mgTo inquire200mgTo inquire1mL*10mM (DMSO)952.00€Abemaciclib metabolite M18
CAS:Abemaciclib M18 (LSN3106729), a potent CDK inhibitor with antitumor action, used in a PROTAC to degrade CDK4/6.Formula:C25H28F2N8OPurity:98%Color and Shape:SolidMolecular weight:494.54JWZ-5-13
JWZ-5-13 is an effective CDK7 PROTAC degrader that significantly degrades CDK7 via the ubiquitin-proteasome system. JWZ-5-13 also exhibits antitumor activity.Formula:C54H66N10O6SMolecular weight:982.48875CDK9 degrader-1
CDK9degrader-1 is a selective CDK9 degrader (DC50: 0.4073 µM). It recruits ATG101 to initiate the autophagy-lysosome pathway and forms autophagosomes by recruiting LC3, which then fuse with lysosomes to degrade CDK9 and its partner protein, Cyclin T1 (DC50: 1.215 µM). CDK9degrader-1 induces caspase 3-mediated apoptosis and exhibits antitumor activity in a mouse HCT116 xenograft model.Formula:C32H34Cl2N6O4Color and Shape:SolidMolecular weight:637.56CDK7/9-IN-1
CAS:CDK7/9-IN-1 inhibits CDK7/9 with IC50: 0.0656 μM (no pre-incubation), 0.00574 μM (3h pre-inc.), and CDK9: 2.14 μM (3h pre-inc.) for cancer research.Formula:C24H32F3N5O2Color and Shape:SolidMolecular weight:479.548Cdk2/Cyclin Inhibitory Peptide II
CAS:Cdk2/Cyclin Inhibitory Peptide II (Tat-LDL), a CDK2 inhibitor, demonstrates dose-dependent cytotoxic effects on U2OS osteosarcoma cells [1].Formula:C110H200N48O25Color and Shape:SolidMolecular weight:2595.07SNX7
CAS:SNX7 (WAY-323879) inhibits CDKI pathway; useful for studying aging and related diseases.Formula:C15H14N2OPurity:99.96%Color and Shape:SolidMolecular weight:238.28PROTAC CDK9 degrader-9
PROTAC CDK9 degrader-9 (compound 29) is a highly efficient, selective degrader of CDK9 based on PROTAC technology. It is utilized in cancer research.Formula:C42H51FN12O6Color and Shape:SolidMolecular weight:838.93BSJ-03-204
CAS:BSJ-03-204 is a selective Cdk4/6 degrader.Formula:C43H48N10O8Color and Shape:SolidMolecular weight:832.9JH-XI-10-02
CAS:JH-XI-10-02 selectively degrades CDK8 (IC50: 159 nM) through proteasome, sparing CDK8 mRNA and CDK19.Formula:C53H69N5O9Purity:98%Color and Shape:SolidMolecular weight:920.161CDK4/6-IN-23
CDK4/6-IN-23 (Compound 42) is a potent and selective inhibitor of CDK4/6, displaying an IC50 of 11 nM for CDK6. This compound significantly activates immune cells and enhances IL-3 production. In mice undergoing 5-FU chemotherapy, CDK4/6-IN-23 demonstrates dual bone marrow protection and immunomodulatory effects.Formula:C32H34FN7O4Color and Shape:SolidMolecular weight:599.655NCT02
CAS:NCT02 degrades cyclin K, leading to CCNK and CDK12 degradation, potentially aiding metastatic CRC research.Formula:C17H16N2O2SColor and Shape:SolidMolecular weight:312.39CDK5-IN-3
CAS:CDK5-IN-3 is a selective and potent CDK5 inhibitor that inhibits CDK5/p25 and CDK2/CycA, and can be used in the study of cancer.Formula:C22H26N4OPurity:98.21%Color and Shape:SolidMolecular weight:362.47Palbociclib-d8
CAS:Palbociclib-d8 (PD 0332991 D8) is the deuterated form of Palbociclib. Palbociclib is a CDK inhibitor that inhibits CDK4 and CDK6.Formula:C24H21D8N7O2Purity:98%Color and Shape:SolidMolecular weight:455.58TG003
CAS:TG003 is a Clk1/Sty inhibitor that inhibits Clk1 and Clk4, suppresses cancer cell growth, and induces apoptosis.Formula:C13H15NO2SPurity:99.46%Color and Shape:SolidMolecular weight:249.33Ref: TM-T60367
1mg48.00€5mg92.00€10mg150.00€25mg266.00€50mg440.00€100mg530.00€200mg767.00€1mL*10mM (DMSO)167.00€SB1317
CAS:SB1317 (TG02) is a potent inhibitor of cyclin dependant kinases (CDKs), Janus kinase 2 (JAK2), and Fms-like tyrosine kinase-3 (FLT3).Formula:C23H24N4OPurity:99.86%Color and Shape:SolidMolecular weight:372.46LDC4297
CAS:LDC4297 (LDC044297) is a potent and selective CDK7 inhibitor.Formula:C23H28N8OPurity:98.25%Color and Shape:SolidMolecular weight:432.52Ribociclib hydrochloride
CAS:Ribociclib hydrochloride (LEE011 HCl) is a selective, orally active cyclin-dependent kinase CDK4/6 inhibitor (IC50=10/39 nM) that inhibits proliferation.Formula:C23H31ClN8OPurity:99.87%Color and Shape:SolidMolecular weight:471NU6102
CAS:NU6102 is a CDK2 inhibitor with antitumor activity against CDK1/cyclinB, CDK1/CDK2, CDK4, DYRK1A , PDK1, and ROCKII, and it can be used to study rectal cancer.Formula:C18H22N6O3SPurity:99.76%Color and Shape:SolidMolecular weight:402.47GP-82996
CAS:GP-82996 (CINK4) inhibits CDK4/6; IC50s: 1.5 μM (CDK4/D1), 5.6 μM (CDK6/D1), 25 μM (Cdk5/p35); triggers U2OS cancer cell apoptosis.Formula:C27H32N6OPurity:99.94%Color and Shape:SolidMolecular weight:456.58(E/Z)-Zotiraciclib hydrochloride
CAS:(E/Z)-Zotiraciclib ((E/Z)-TG02) hydrochloride is a potent inhibitor of CDK2, JAK2, and FLT3.Formula:C23H25ClN4OColor and Shape:SolidMolecular weight:408.93Palbociclib hydrochloride
CAS:Palbociclib hydrochloride is the salt form of Palbociclib, a selective and orally available CDK4 and CDK6 inhibitor for breast and hepatocellular carcinoma.Formula:C24H31Cl2N7O2Purity:99.89%Color and Shape:SolidMolecular weight:520.46FMF-04-159-2
CAS:FMF-04-159-2 is a potent covalent CDK14 & CDK2 inhibito and is able to reduce α-Syn aggregation in neurons, and inhibits TNBC cancer progression.Formula:C28H30Cl3N7O5SPurity:96.57%Color and Shape:SolidMolecular weight:683.01PROTAC CDK9 Degrader-1
CAS:PROTAC CDK9 Degrader-1 is a selective PROTAC-based CDK9 degrader, composed of a Cereblon ligand and a CDK ligand.Formula:C33H35N5O7Purity:95.1%Color and Shape:SolidMolecular weight:613.66Ribociclib-d6
CAS:Ribociclib-d6 is a deuterated compound of Ribociclib (LEE011) for isotope tracing.Ribociclib is an orally available CDK4/6 inhibitor with antitumor activity.Formula:C23H30N8OColor and Shape:SolidMolecular weight:440.57CDK9-IN-1
CAS:CDK9-IN-1 is a selective and potent CDK9 inhibitor with antiviral activity used in the study of PRRSV infections.Formula:C26H21N5O4SPurity:98.52%Color and Shape:SolidMolecular weight:499.54TG-693
CAS:TG-693, Oral CLK1 inhibitor, promotes exon 31 skipping of dystrophin gene, inhibits CLK1 substrate phosphorylation, for Duchenne muscular dystrophy.Formula:C12H9N3Purity:99.81%Color and Shape:SolidMolecular weight:195.23Dalpiciclib hydrochloride
Dalpiciclib (SHR-6390) HCl is an oral CDK4/6 inhibitor with IC50s of 12.4/9.9 nM, an antitumor for breast and esophageal cancers.Formula:C25H31ClN6O2Color and Shape:SolidMolecular weight:483.011-NM-PP1
CAS:1-NM-PP1 (PP1 Analog II) is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors.Formula:C20H21N5Purity:98% - 98.93%Color and Shape:White Cyrstalline SolidMolecular weight:331.41Ref: TM-T2153
1mg48.00€2mg63.00€5mg84.00€10mg132.00€25mg271.00€50mg505.00€100mg668.00€1mL*10mM (DMSO)90.00€Atuveciclib
CAS:Atuveciclib Racemate is an oral CDK9 inhibitor with a 13 nM IC50, targeting P-TEFb/CDK9 selectively.Formula:C18H18FN5O2SPurity:98.8%Color and Shape:SolidMolecular weight:387.43Ref: TM-T10464L
1mg84.00€2mg114.00€5mg192.00€10mg313.00€25mg580.00€50mg773.00€100mg1,063.00€1mL*10mM (DMSO)212.00€DRB
CAS:DRB is a nucleoside analog that inhibits several carboxyl-terminal domain (CTD) kinases including casein kinase II (IC50 range of 4-10 μM)
Formula:C12H12Cl2N2O4Purity:99.46% - 99.83%Color and Shape:White To Off-White Crystalline SolidMolecular weight:319.14PHA-767491 hydrochloride
CAS:PHA-767491 (CAY-10572) is a potent Cdc7/CDK9 inhibitor (IC50: 10/34 nM), selective against GSK3-β, CDK1/2, CDK5, MK2, CHK2, PLK1.Formula:C12H12ClN3OPurity:99.56% - 99.92%Color and Shape:SolidMolecular weight:249.69Cdk5 Substrate acetate
Cdk5, a serine/threonine kinase active in neurons, phosphorylates proteins like histone H1; its synthetic substrate has a Km of 5 µM.Formula:C55H103N15O14Purity:96.21%Color and Shape:SolidMolecular weight:1198.5PF-06873600
CAS:PF-06873600: oral CDK inhibitor (CDK2/4/6), Ki 0.09-0.16 nM, potential anticancer drug.Formula:C20H27F2N5O4SPurity:98.77% - 99.55%Color and Shape:SolidMolecular weight:471.52Ref: TM-T8463
1mg54.00€5mg114.00€10mg178.00€25mg334.00€50mg557.00€100mg888.00€200mg1,198.00€1mL*10mM (DMSO)118.00€AMG 925 HCl
CAS:AMG 925 HCl is a selective and potent dual inhibitor of FLT3 (IC50: 2±1 nM) and CDK4 (IC50: 3±1 nM).Formula:C26H30ClN7O2Color and Shape:SolidMolecular weight:508.02CDK9-IN-30
CAS:CDK9-IN-30 is one of the Tat peptide derivatives and inhibits HIV-1 long terminal repeat-activated transcription.Formula:C16H20FNO3Purity:99.75%Color and Shape:SolidMolecular weight:293.33Ref: TM-T9632
1mg56.00€5mg119.00€10mg187.00€25mg316.00€50mg472.00€100mg658.00€500mg1,378.00€1mL*10mM (DMSO)114.00€AZD-5438
CAS:AZD-5438 is an effective inhibitor of CDK, for CDK1(IC50=16 nM), CDK2(IC50=6 nM), CDK9(IC50=20 nM).Formula:C18H21N5O2SPurity:99.73% - 99.87%Color and Shape:SolidMolecular weight:371.46Flavopiridol hydrochloride
CAS:Flavopiridol hydrochloride (MDL 107826A), an inhibitor of cyclin-dependent kinase, is a synthetic N-methylpiperidinyl chlorophenyl flavone compound.Formula:C21H21Cl2NO5Purity:98.87% - 99.88%Color and Shape:SolidMolecular weight:438.3AG-494
CAS:AG-494 (Tyrphostin B48) is an inhibitor of epidermal growth factor receptor kinase.Formula:C16H12N2O3Purity:98.69%Color and Shape:SolidMolecular weight:280.28Seliciclib
CAS:Seliciclib (Roscovitine) is a potent inhibitor of Cdk2/cyclin E, also inhibits Cdk7, Cdk5 and Cdc2. Seliciclib has antitumor effect. Cost-effective, quality assurance.Formula:C19H26N6OPurity:97.15% - 99.89%Color and Shape:White To Off-White SolidMolecular weight:354.45Bromosporine
CAS:Bromosporine is a broad spectrum inhibitor for bromodomains for BRD2/4/9 and CECR2 (IC50: 0.41/0.29/0.122/0.017 μM), respectively.Formula:C17H20N6O4SPurity:99.65% - 99.79%Color and Shape:SolidMolecular weight:404.44Ref: TM-T6255
1mg44.00€2mg57.00€5mg93.00€10mg133.00€25mg260.00€50mg416.00€100mg665.00€200mg888.00€1mL*10mM (DMSO)92.00€BSJ-03-123
CAS:BSJ-03-123 is a potent, CDK6-selective small-molecule degrader.Formula:C47H56N10O11Purity:97.78% - 99.38%Color and Shape:SolidMolecular weight:937.01Ref: TM-T5395
1mg87.00€2mg113.00€5mg177.00€10mg259.00€25mg409.00€50mg560.00€100mg800.00€500mg1,611.00€(E/Z)-Zotiraciclib
CAS:(E/Z)-Zotiraciclib ((E/Z)-TG02) inhibits CDK2, JAK2, and FLT3 effectively with IC50s of 13, 73, and 56 nM, respectively.Formula:C23H24N4OPurity:97.75% - 99.92%Color and Shape:SolidMolecular weight:372.46Ref: TM-T21503
1mg43.00€2mg56.00€5mg93.00€10mg113.00€25mg200.00€50mg330.00€100mg480.00€1mL*10mM (DMSO)90.00€PF-562271 besylate
CAS:PF-562271 besylate: potent, ATP-competitive FAK inhibitor, IC50 1.5 nM, 10x less effective on Pyk2, highly selective vs other kinases.Formula:C21H20F3N7O3S·C6H6O3SPurity:97.65% - 99.01%Color and Shape:SolidMolecular weight:665.66Ref: TM-T6177
1mg35.00€5mg74.00€10mg94.00€25mg138.00€50mg198.00€100mg296.00€200mg427.00€1mL*10mM (DMSO)89.00€Indirubin-3'-monoxime
CAS:Indirubin-3'-monoxime (Indirubin-3'-oxime) is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/Formula:C16H11N3O2Purity:99.55%Color and Shape:Dark Red SolidMolecular weight:277.28JSH-150
CAS:JSH-150 is a highly selective CDK9 inhibitor(IC50 : 1 nM).Formula:C24H33ClN6O2SPurity:99.96% - 99.96%Color and Shape:SolidMolecular weight:505.08THZ1 Hydrochloride
THZ1 Hydrochloride: selective covalent CDK7 inhibitor, IC50 of 3.2 nM; affects CDK12/13 & lowers MYC expression.Formula:C31H29Cl2N7O2Color and Shape:SolidMolecular weight:602.51Dinaciclib
CAS:Dinaciclib (SCH 727965) is a CDK inhibitor that selectively inhibits CDK1, CDK2, CDK5, and CDK9 (IC50 = 3/1/1/4 nM).Formula:C21H28N6O2Purity:98.21% - 99.75%Color and Shape:SolidMolecular weight:396.49LY3143921
CAS:LY3143921 ((S)-Example 2) is an orally active inhibitor of CDC7 kinase with broad in vitro anticancer activity [1].Formula:C16H12FN5OColor and Shape:SolidMolecular weight:309.37BIO
CAS:7BIO triggers nonapoptotic death, blocks FLT3, DYRK1A/2, Aurora B/C kinases.
Formula:C16H10BrN3O2Purity:99.67%Color and Shape:SolidMolecular weight:356.17PF-562271
CAS:PF-562271 is an effective ATP-competitive, reversible inhibitor of FAK(IC50=1.5 nM) and Pyk2 kinase(IC50=13 nM).Formula:C21H20F3N7O3SPurity:97.17% - >99.99%Color and Shape:SolidMolecular weight:507.49BS-181 dihydrochloride
CAS:BS-181 dihydrochloride: Potent CDK7 inhibitor (IC50: 21 nM), less effective on CDK2/5/9, no impact on CDK1/4/6, halts cancer cell growth, triggers apoptosis.Formula:C22H34Cl2N6Color and Shape:SolidMolecular weight:453.46THZ1
CAS:THZ1 (CDK7 inhibitor) is a selective inhibitor of CDK7, binding to the Cys residue located at the outer end of the classical kinase domain. Cost-effective and quality-assured.Formula:C31H28ClN7O2Purity:97.42% - 99.27%Color and Shape:SolidMolecular weight:566.05PHA-767491
CAS:PHA-767491 (CAY10572) is a potent ATP-competitive dual Cdc7/CDK9 inhibitor with IC50 of 10 nM and 34 nM, respectively.Formula:C12H11N3OPurity:99.49% - >99.99%Color and Shape:SolidMolecular weight:213.24Ref: TM-T6206
2mg34.00€5mg49.00€10mg64.00€25mg92.00€50mg138.00€100mg197.00€200mg295.00€1mL*10mM (DMSO)50.00€2-Chloropyrazine
CAS:2-Chloropyrazine is used in chemical industry.Formula:C4H3ClN2Purity:98.98% - 99.89%Color and Shape:Clear Colorless To Yellowish LiquidMolecular weight:114.53RGB-286638 free base
CAS:RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.Formula:C29H35N7O4Purity:98% - 99.91%Color and Shape:SolidMolecular weight:545.63CKI-7
CAS:CKI-7 is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor.Formula:C11H14Cl3N3O2SPurity:>99.99%Color and Shape:SolidMolecular weight:358.67Ref: TM-T19913
1mg73.00€5mg128.00€10mg185.00€25mg299.00€50mg405.00€100mg545.00€1mL*10mM (DMSO)140.00€AT7519 Hydrochloride
CAS:AT7519 Hydrochloride (AT7519 HCl) is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9.Formula:C16H18Cl3N5O2Purity:99.66% - 99.9%Color and Shape:SolidMolecular weight:418.71SR-4835
CAS:SR-4835 is a highly selective dual inhibitor of CDK12 and CDK13(CDK12: IC50=99 nM, Kd=98 nM; CDK13: Kd=4.9 nM), which disables triple-negative breast cancer (Formula:C21H20Cl2N10OPurity:98.09% - >99.99%Color and Shape:SolidMolecular weight:499.36BMS-265246
CAS:BMS-265246 is a potent and selective CDK1/2 inhibitor.Formula:C18H17F2N3O2Purity:99.25% - 99.57%Color and Shape:SolidMolecular weight:345.34Ref: TM-T2679
1mg34.00€5mg71.00€10mg110.00€25mg210.00€50mg318.00€100mg455.00€200mg617.00€1mL*10mM (DMSO)78.00€
