ROCK
ROCK (Rho-associated protein kinase) inhibitors target ROCK kinases, which are involved in the regulation of the cytoskeleton, cell shape, and motility. ROCK plays a significant role in the control of cell division, particularly in processes such as cytokinesis. Inhibiting ROCK can lead to changes in cell cycle dynamics, cell motility, and apoptosis, making these inhibitors valuable in cancer research, neurobiology, and cardiovascular studies. At CymitQuimica, we provide a selection of high-quality ROCK inhibitors to support your research in cell biology, cytoskeletal dynamics, and disease mechanisms.
Found 62 products of "ROCK"
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Netarsudil Dihydrochloride
CAS:Netarsudil Dihydrochloride (AR-13324 Dihydrochloride) is an inhibitor of Rho-related protein kinase (ROCK) and norepinephrine transporter (NET) and is effective in reducing intraocular pressure (IOP).Cost-effective and quality-assured.Formula:C28H29Cl2N3O3Purity:99.94% - 99.98%Color and Shape:SolidMolecular weight:526.45ROCK inhibitor-2
CAS:ROCK inhibitor-2 is a selective dual inhibitor of ROCK1 and ROCK2 (IC50s of 17 nM and 2 nM, respectively).Formula:C21H20N2O2Purity:99.85%Color and Shape:SolidMolecular weight:332.4Ref: TM-T12746
1mg66.00€5mg144.00€10mg216.00€25mg432.00€50mg645.00€100mg905.00€1mL*10mM (DMSO)106.00€CMPD101
CAS:CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM).Formula:C24H21F3N6OPurity:99.01% - 99.04%Color and Shape:SolidMolecular weight:466.46Y-33075 dihydrochloride
CAS:Y-33075 dihydrochloride is a selective inhibitor of ROCK(IC50 of 3.6 nM).Formula:C16H18Cl2N4OPurity:98.88% - 99.89%Color and Shape:SolidMolecular weight:353.25Ref: TM-T13384L
1mg34.00€5mg66.00€10mg102.00€25mg192.00€50mg341.00€100mg510.00€200mg732.00€1mL*10mM (DMSO)78.00€GKI-1 HCl
GKI-1 HCl is a Greatwall (GWL) kinase inhibitor that inhibits hGWLFL and hGWL-KinDom.The inhibitory effect of GKI-1 HCl on ROCK1 is more significant.Formula:C15H13Cl2N3Purity:98.1%Color and Shape:SoildMolecular weight:306.19Ref: TM-T11402L
1mg71.00€5mg154.00€10mg221.00€25mg354.00€50mg497.00€100mg705.00€200mg928.00€1mL*10mM (DMSO)167.00€Ripasudil free base
CAS:Ripasudil free base (K-115 (free base)) is a selective and potent ROCK inhibitor, is a novel and potent antiglaucoma agent.Formula:C15H18FN3O2SPurity:98%Color and Shape:SolidMolecular weight:323.39Ref: TM-T7492
1mg75.00€5mg150.00€10mg238.00€25mg530.00€50mg873.00€100mg1,459.00€1mL*10mM (DMSO)166.00€Fasudil
CAS:Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.Formula:C14H17N3O2SPurity:99.79% - 99.84%Color and Shape:SolidMolecular weight:291.37WAY-656935
CAS:WAY-656935 inhibits ROCK.Formula:C20H28ClN3O3SPurity:97%Color and Shape:SolidMolecular weight:425.97ROCK2-IN-9
ROCK2-IN-9 (compound 7u), a selective ROCK2 inhibitor with an IC50 value of 36.8 nM, demonstrates anticancer properties by impeding cancer cell migration and invasion. This action is achieved through the regulation of various actin cytoskeleton cellular activities. It holds potential for use in breast cancer research.Formula:C28H30N8O2Color and Shape:SolidMolecular weight:510.59LX-7101 hydrochloride
CAS:LX-7101 hydrochloride is a potent LIMK and ROCK2 inhibitor with antihypertensive activity, inhibits LIMK1/2, ROCK, PKA, and can be used to study glaucoma.
Formula:C23H29N7O3xHClPurity:98.96%Color and Shape:SolidMolecular weight:487.99GSK269962A hydrochloride
CAS:GSK269962A hydrochloride (GSK 269962 hydrochloride) is a ROCK inhibitor with anti-inflammatory and vasodilatory effects and inhibits ROCK1 and ROCK2.Formula:C29H31ClN8O5Color and Shape:SolidMolecular weight:607.06Belumosudil mesylate
CAS:Belumosudil mesylate (KD025 mesylate) is a ROCK2 inhibitor with antifibrotic activity, and can be used in chronic graft-versus-host disease research.Formula:C27H28N6O5SPurity:98.73%Color and Shape:SolidMolecular weight:548.61Ref: TM-T39555
1mg34.00€2mg46.00€5mg71.00€10mg96.00€25mg155.00€50mg230.00€100mg353.00€200mg517.00€1mL*10mM (DMSO)85.00€Verosudil
CAS:Verosudil (AR-12286), a ROCK1/2 inhibitor (Ki: 2 nM), lowers intraocular pressure in mice by enhancing aqueous outflow.Formula:C17H17N3O2SPurity:99.68%Color and Shape:SolidMolecular weight:327.4Ref: TM-T60924
1mg55.00€5mg147.00€10mg231.00€25mg370.00€50mg522.00€100mg692.00€1mL*10mM (DMSO)161.00€Cotosudil
CAS:Cotosudil is a ROCK kinase inhibitor with antihypertensive activity used to treat or prevent neurodegenerative diseases.Formula:C16H21N3O2SPurity:98.41%Color and Shape:SolidMolecular weight:319.42Narciclasine
CAS:Narciclasine (Lycoricidinol), a natural product, modulates the Rho/Rho-kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity.Formula:C14H13NO7Purity:98.16% - 99.58%Color and Shape:SolidMolecular weight:307.26SAR407899
CAS:SAR407899 is Rho kinase inhibitor potently inhibits endothelin-1-induced constriction of renal resistance arteries.Formula:C14H16N2O2Purity:99.42%Color and Shape:SolidMolecular weight:244.29Ref: TM-T7391
2mg34.00€5mg50.00€10mg75.00€25mg128.00€50mg200.00€100mg319.00€200mg474.00€1mL*10mM (DMSO)55.00€SR-3677
CAS:SR-3677 is an effective and specific inhibitor of ROCK2 (IC50: 3 nM).Formula:C22H24N4O4Purity:98.46%Color and Shape:SolidMolecular weight:408.45SAR407899 hydrochloride
CAS:SAR407899 hydrochloride is a selective, potent and ATP-competitive ROCK inhibitor, with an IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human andFormula:C14H17ClN2O2Purity:99.15%Color and Shape:SolidMolecular weight:280.75RKI1313
CAS:RKI1313 (RKI-1313) was a selective inhibitor for ROCK-dependent signaling, cytoskeletal changes, anchorage-independent colony formation, migration, and invasionFormula:C17H16N4O2SPurity:99.53% - ≥95%Color and Shape:SolidMolecular weight:340.4Ref: TM-T2011
1mg70.00€5mg142.00€10mg207.00€25mg369.00€50mg540.00€100mg772.00€500µg49.00€1mL*10mM (DMSO)160.00€Afuresertib hydrochloride
CAS:Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)
Formula:C18H18Cl3FN4OSPurity:99.96%Color and Shape:SolidMolecular weight:463.8
