ROCK
ROCK (Rho-associated protein kinase) inhibitors target ROCK kinases, which are involved in the regulation of the cytoskeleton, cell shape, and motility. ROCK plays a significant role in the control of cell division, particularly in processes such as cytokinesis. Inhibiting ROCK can lead to changes in cell cycle dynamics, cell motility, and apoptosis, making these inhibitors valuable in cancer research, neurobiology, and cardiovascular studies. At CymitQuimica, we provide a selection of high-quality ROCK inhibitors to support your research in cell biology, cytoskeletal dynamics, and disease mechanisms.
Found 70 products of "ROCK"
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Afuresertib
CAS:<p>Afuresertib (GSK2110183) is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic</p>Formula:C18H17Cl2FN4OSPurity:97.51% - 99.51%Color and Shape:SolidMolecular weight:427.32SR-3677
CAS:<p>SR-3677 is an effective and specific inhibitor of ROCK2 (IC50: 3 nM).</p>Formula:C22H24N4O4Purity:98.46%Color and Shape:SolidMolecular weight:408.45GSK269962A
CAS:<p>GSK269962A (GSK269962A HCl) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.</p>Formula:C29H30N8O5Purity:99.14% - 99.71%Color and Shape:SolidMolecular weight:570.6GSK-25
CAS:<p>GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K, and a dramatically improved P450 profile.</p>Formula:C24H16Cl2F2N6OPurity:98.59%Color and Shape:SolidMolecular weight:513.33Netarsudil mesylate
CAS:<p>Netarsudil mesylate (AR-13324 mesylate) is a Rho-related protein kinase inhibitor used to study glaucoma and hypertension.</p>Formula:C30H35N3O9S2Purity:99.7%Color and Shape:SolidMolecular weight:645.74CAY10746
CAS:<p>CAY10746 selectively inhibits ROCK I/II with IC50s: 0.014/0.003 μM, useful for diabetic retinopathy research.</p>Formula:C26H23N3O5Purity:99.04%Color and Shape:SolidMolecular weight:457.48H-1152
CAS:<p>H-1152 is a potent, specific, ATP-competitive, and cell permeable ROCK inhibitor (Ki = 1.6 nM).</p>Formula:C16H21N3O2SPurity:98%Color and Shape:SolidMolecular weight:319.42SB-772077B dihydrochloride
CAS:<p>SB-772077B dihydrochloride is an aminofurazan-based Rho kinase inhibitor (IC50s: 5.6 nM and 6 nM toward ROCK1 and ROCK2, respectively).</p>Formula:C15H20Cl2N8O2Purity:98%Color and Shape:SolidMolecular weight:415.28Y-33075
CAS:<p>Y-33075 (Y-39983 free base) is a ROCK inhibitor that lowers IOP, increases blood flow to ONH, and increases the number of RGCs with regenerating axons.</p>Formula:C16H16N4OPurity:98%Color and Shape:SolidMolecular weight:280.32CID-5056270
CAS:<p>CID-5056270 has anticancer activity and can inhibit lung cancer, anal cancer, bladder cancer, cervical cancer, vulvar cancer, penile cancer, Burkitt's lymphoma</p>Formula:C17H13N3O3SPurity:99.6%Color and Shape:SolidMolecular weight:339.37Rhodblock 6
CAS:<p>Rhodblock 6 is a Rho kinase inhibitor, blocking phosphorylated MRLC localization by targeting ROCK activity.</p>Formula:C12H13N3OPurity:98.27%Color and Shape:SolidMolecular weight:215.25Rho-Kinase-IN-1
CAS:<p>Rho-Kinase-IN-1: ROCK inhibitor, Ki of 30.5 nM (ROCK1) & 3.9 nM (ROCK2), used in research for diseases linked to cell overgrowth and inflammation.</p>Formula:C20H24N4SPurity:99.8%Color and Shape:SolidMolecular weight:352.5CRT0066854 hydrochloride
CAS:<p>CRT0066854 HCl inhibits atypical PKCs; IC50: PKCι 132 nM, PKCζ 639 nM, ROCK-II 620 nM.</p>Formula:C24H27Cl2N5SPurity:99.63%Color and Shape:SolidMolecular weight:488.48AS 1892802
CAS:<p>AS 1892802, a ROCK inhibitor: IC50 - 52nM (hROCK2), 57nM (rROCK2), 122nM (hROCK1). Fast antinociceptive effect similar to Tramadol, Diclofenac.</p>Formula:C20H19N3O2Purity:99.86%Color and Shape:SolidMolecular weight:333.38LX7101
CAS:<p>LX7101 is an effective inhibitor of LIMK and ROCK2 (IC50: 24, 1.6, and 10 nM for LIMK1, LIMK2, and ROCK2, respectively). It also inhibits PKA (IC50 <1 nM).</p>Formula:C23H29N7O3Purity:99.08%Color and Shape:SolidMolecular weight:451.52ROCK-IN-7
CAS:<p>ROCK-IN-7 (compound 9) serves as a ROCK kinase inhibitor and is utilized in the investigation of ocular conditions, including glaucoma and retinal diseases [1].</p>Formula:C17H17N3O2SPurity:98%Color and Shape:SolidMolecular weight:327.4ROCK-IN-9
CAS:<p>ROCK-IN-9 (Compound T345), a ROCK inhibitor, exhibits cytotoxicity in HepG2 cells with an IC50 of 40.8 μM.</p>Formula:C20H20FN5O2Purity:98%Color and Shape:SolidMolecular weight:381.4ROCK2-IN-6 hydrochloride
CAS:<p>ROCK2-IN-6 hydrochloride (Comp A)为一种选择性ROCK2抑制剂，适用于研究ROCK介导的疾病、自身免疫性病症与炎症。</p>Formula:C26H22ClF2N7OPurity:98%Color and Shape:SolidMolecular weight:521.95Chroman 1
CAS:<p>Chroman 1 is a potent inhibitor of ROCK1 (IC50 = 52 pM) and ROCK2 (IC50 = 1 pM).</p>Formula:C24H28N4O4Purity:99.67% - 99.84%Color and Shape:SolidMolecular weight:436.5ROCK2-IN-2
CAS:<p>ROCK2-IN-2 is a selective inhibitor of ROCK2 (IC50 of <1 μM).</p>Formula:C18H12N6OSPurity:99.65%Color and Shape:SolidMolecular weight:360.39
