ROCK
ROCK (Rho-associated protein kinase) inhibitors target ROCK kinases, which are involved in the regulation of the cytoskeleton, cell shape, and motility. ROCK plays a significant role in the control of cell division, particularly in processes such as cytokinesis. Inhibiting ROCK can lead to changes in cell cycle dynamics, cell motility, and apoptosis, making these inhibitors valuable in cancer research, neurobiology, and cardiovascular studies. At CymitQuimica, we provide a selection of high-quality ROCK inhibitors to support your research in cell biology, cytoskeletal dynamics, and disease mechanisms.
Found 62 products for "ROCK".
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H-1152
CAS:H-1152 is a potent, specific, ATP-competitive, and cell permeable ROCK inhibitor (Ki = 1.6 nM).Formula:C16H21N3O2SPurity:98%Color and Shape:SolidMolecular weight:319.42Y-33075
CAS:Y-33075 (Y-39983 free base) is a ROCK inhibitor that lowers IOP, increases blood flow to ONH, and increases the number of RGCs with regenerating axons.Formula:C16H16N4OPurity:98%Color and Shape:SolidMolecular weight:280.32SB-772077B dihydrochloride
CAS:SB-772077B dihydrochloride is an aminofurazan-based Rho kinase inhibitor (IC50s: 5.6 nM and 6 nM toward ROCK1 and ROCK2, respectively).Formula:C15H20Cl2N8O2Purity:98%Color and Shape:SolidMolecular weight:415.28CAY10746
CAS:CAY10746 selectively inhibits ROCK I/II with IC50s: 0.014/0.003 μM, useful for diabetic retinopathy research.Formula:C26H23N3O5Purity:99.71%Color and Shape:SolidMolecular weight:457.48Ref: TM-T36196
2mg34.00€5mg54.00€1mL*10mM (DMSO)54.00€10mg86.00€25mg172.00€50mg260.00€100mg411.00€200mg552.00€CID-5056270
CAS:CID-5056270 has anticancer activity and can inhibit lung cancer, anal cancer, bladder cancer, cervical cancer, vulvar cancer, penile cancer, Burkitt's lymphomaFormula:C17H13N3O3SPurity:99.6%Color and Shape:White SolidMolecular weight:339.37Ref: TM-T23888
1mg110.00€5mg250.00€1mL*10mM (DMSO)253.00€10mg349.00€25mg515.00€50mg702.00€100mg928.00€Rhodblock 6
CAS:Rhodblock 6 is a Rho kinase inhibitor, blocking phosphorylated MRLC localization by targeting ROCK activity.Formula:C12H13N3OPurity:99.87%Color and Shape:SolidMolecular weight:215.25Rho-Kinase-IN-1
CAS:Rho-Kinase-IN-1: ROCK inhibitor, Ki of 30.5 nM (ROCK1) & 3.9 nM (ROCK2), used in research for diseases linked to cell overgrowth and inflammation.Formula:C20H24N4SPurity:99.8%Color and Shape:Yellow SolidMolecular weight:352.5Ref: TM-T12721
1mg71.00€1mL*10mM (DMSO)105.00€5mg138.00€10mg205.00€25mg358.00€50mg502.00€100mg665.00€200mg893.00€AS 1892802
CAS:AS 1892802, a ROCK inhibitor: IC50 - 52nM (hROCK2), 57nM (rROCK2), 122nM (hROCK1). Fast antinociceptive effect similar to Tramadol, Diclofenac.Formula:C20H19N3O2Purity:99.86%Color and Shape:Yellow SolidMolecular weight:333.38Ref: TM-T22037
1mg49.00€5mg92.00€1mL*10mM (DMSO)109.00€10mg166.00€25mg358.00€50mg530.00€100mg758.00€200mg1,044.00€LX7101
CAS:LX7101 is an effective inhibitor of LIMK and ROCK2 (IC50: 24, 1.6, and 10 nM for LIMK1, LIMK2, and ROCK2, respectively). It also inhibits PKA (IC50 <1 nM).Formula:C23H29N7O3Purity:99.08%Color and Shape:SolidMolecular weight:451.52ROCK2-IN-2
CAS:ROCK2-IN-2 is a selective inhibitor of ROCK2 (IC50 of <1 μM).Formula:C18H12N6OSPurity:99.65%Color and Shape:SolidMolecular weight:360.39Ref: TM-T12747
1mg50.00€5mg111.00€1mL*10mM (DMSO)136.00€10mg177.00€25mg304.00€50mg447.00€100mg692.00€200mg888.00€ROCK2-IN-6 hydrochloride
CAS:ROCK2-IN-6 hydrochloride (Comp A)为一种选择性ROCK2抑制剂，适用于研究ROCK介导的疾病、自身免疫性病症与炎症。Formula:C26H22ClF2N7OPurity:98%Color and Shape:SolidMolecular weight:521.95Chroman 1
CAS:Chroman 1 is a potent inhibitor of ROCK1 (IC50 = 52 pM) and ROCK2 (IC50 = 1 pM).Formula:C24H28N4O4Purity:99.67% - 99.84%Color and Shape:SolidMolecular weight:436.5Ref: TM-T14960
1mg73.00€5mg160.00€1mL*10mM (DMSO)173.00€10mg250.00€25mg430.00€50mg645.00€100mg888.00€ROCK-IN-7
CAS:ROCK-IN-7 (compound 9) serves as a ROCK kinase inhibitor and is utilized in the investigation of ocular conditions, including glaucoma and retinal diseases [1].Formula:C17H17N3O2SPurity:98%Color and Shape:SolidMolecular weight:327.4ROCK-IN-9
CAS:ROCK-IN-9 (Compound T345), a ROCK inhibitor, exhibits cytotoxicity in HepG2 cells with an IC50 of 40.8 μM.Formula:C20H20FN5O2Purity:98%Color and Shape:SolidMolecular weight:381.4ROCK-IN-8
CAS:ROCK-IN-8 (Example 4), a ROCK inhibitor, exhibits anti-inflammatory properties and is suitable for respiratory and gastro-intestinal disease research,Formula:C30H25FN4O4SPurity:98%Color and Shape:SolidMolecular weight:556.61H-1152 dihydrochloride
CAS:H-1152 2HCl: ROCK inhibitor, IC50=12 nM, Ki=1.6 nM. Blocks PKA, PKC, PKG, Aurora A, CaMKII with higher IC50s.Formula:C16H23Cl2N3O2SPurity:99.85%Color and Shape:White SolidMolecular weight:392.34Ref: TM-T35328
1mg60.00€5mg135.00€1mL*10mM (DMSO)147.00€10mg215.00€25mg415.00€50mg655.00€100mg888.00€ROCK-IN-1
CAS:ROCK-IN-1 is a potent ROCK inhibitor that inhibits ROCK2-mediated signaling with an IC50 value of 1.2 nM.ROCK-IN-1 can be used in the study of neurologicalFormula:C20H18FN3OPurity:99.80%Color and Shape:Yellow SolidMolecular weight:335.37ROCK-IN-11
CAS:ROCK-IN-11 (example 94) is an effective inhibitor of ROCK1 and ROCK2, with an IC50 of ≤ 5 μM, and plays a significant role in cancer research.Formula:C22H20N4O4SColor and Shape:SolidMolecular weight:436.484ROCK2-IN-12
CAS:ROCK2-IN-12 (Compound A25) is a selective inhibitor of ROCK2, exhibiting an IC50 of 7.0 nM for ROCK2, demonstrating greater efficacy compared to ROCK1 inhibition. It exerts potent anti-fibrotic effects via the TGF-β/Smad and ROCK2/STAT3 signaling pathways. In a Bleomycin-induced mouse pulmonary fibrosis (PF) model, ROCK2-IN-12 significantly reduces collagen deposition and reverses fibrosis progression. This compound is applicable in research on pulmonary diseases such as lung fibrosis.Formula:C23H18FN9OMolecular weight:455.46Rhodblock 1a
CAS:Rhodblock 1a is an inhibitor of the Rho kinase signaling pathway, which disrupts the localization and function of proteins within the Rho pathway. This interference hinders the proper formation of the cleavage furrow during cell division, leading to some cells either failing to form the cleavage furrow or forming a ruptured furrow, resulting in binucleated cells. Rhodblock 1a can be utilized for investigating cell division mechanisms and holds potential for research into cardiovascular diseases and cancer.Formula:C20H16N2O2Color and Shape:SolidMolecular weight:316.353
