ROCK
ROCK (Rho-associated protein kinase) inhibitors target ROCK kinases, which are involved in the regulation of the cytoskeleton, cell shape, and motility. ROCK plays a significant role in the control of cell division, particularly in processes such as cytokinesis. Inhibiting ROCK can lead to changes in cell cycle dynamics, cell motility, and apoptosis, making these inhibitors valuable in cancer research, neurobiology, and cardiovascular studies. At CymitQuimica, we provide a selection of high-quality ROCK inhibitors to support your research in cell biology, cytoskeletal dynamics, and disease mechanisms.
Read more
Hydroxyfasudil
CAS:105628-72-6
Hydroxyfasudil (Hydroxy-Fasudil) is a ROCK inhibitor(IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, …
Formula:
C14H17N3O3S
Purity:
98.13%
Color and Shape:
Solid
Molecular weight:
307.37
Ref: TM-T4276L
| 5mg | 41.00 € | ||
| 10mg | 56.00 € | ||
| 25mg | 93.00 € | ||
| 50mg | 152.00 € | ||
| 100mg | 232.00 € | ||
| 1mL*10mM (DMSO) | 44.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
CCG-222740
CAS:1922098-69-8
CCG-222740 is an inhibitor of Rho/MRTF pathway
Formula:
C23H19ClF2N2O3
Purity:
98.76%
Color and Shape:
Solid
Molecular weight:
444.86
Ref: TM-T7764
| 2mg | 41.00 € | ||
| 5mg | 63.00 € | ||
| 10mg | 97.00 € | ||
| 25mg | 177.00 € | ||
| 50mg | 271.00 € | ||
| 100mg | 402.00 € | ||
| 200mg | 570.00 € | ||
| 1mL*10mM (DMSO) | 69.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
RKI-1447
CAS:1342278-01-6
RKI-1447 is a potent inhibitor of ROCK1 and ROCK2. It has anti-invasive and antitumor activities.
Formula:
C16H14N4O2S
Purity:
98% - 99.73%
Color and Shape:
Solid
Molecular weight:
326.37
Ref: TM-T1898
| 5mg | 51.00 € | ||
| 10mg | 96.00 € | ||
| 25mg | 184.00 € | ||
| 50mg | 305.00 € | ||
| 100mg | 404.00 € | ||
| 200mg | 509.00 € | ||
| 500mg | 822.00 € | ||
| 1mL*10mM (DMSO) | 57.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
GSK-25
CAS:874119-56-9
GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and …
Formula:
C24H16Cl2F2N6O
Purity:
98.59%
Color and Shape:
Solid
Molecular weight:
513.33
Ref: TM-T4488
| 1mg | 46.00 € | ||
| 2mg | 58.00 € | ||
| 5mg | 90.00 € | ||
| 10mg | 115.00 € | ||
| 25mg | 168.00 € | ||
| 50mg | 267.00 € | ||
| 100mg | 444.00 € | ||
| 1mL*10mM (DMSO) | 94.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
GSK429286A
CAS:864082-47-3
GSK429286A (RHO-15) is a specific inhibitor of ROCK1/2 (IC50: 14/63 nM).
Formula:
C21H16F4N4O2
Purity:
97.68% - 98.42%
Color and Shape:
Solid
Molecular weight:
432.37
Ref: TM-T2633
| 2mg | 41.00 € | ||
| 5mg | 66.00 € | ||
| 10mg | 97.00 € | ||
| 25mg | 134.00 € | ||
| 50mg | 206.00 € | ||
| 100mg | 348.00 € | ||
| 1mL*10mM (DMSO) | 69.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
GSK269962A
CAS:850664-21-0
GSK269962A (GSK269962A HCl) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 …
Formula:
C29H30N8O5
Purity:
98.63% - 99.14%
Color and Shape:
Solid
Molecular weight:
570.6
Ref: TM-T3518
| 1mg | 42.00 € | ||
| 5mg | 89.00 € | ||
| 10mg | 119.00 € | ||
| 25mg | 221.00 € | ||
| 50mg | 368.00 € | ||
| 100mg | 538.00 € | ||
| 1mL*10mM (DMSO) | 106.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
SR-3677
CAS:1072959-67-1
SR-3677 is an effective and specific inhibitor of ROCK2 (IC50: 3 nM).
Formula:
C22H24N4O4
Purity:
99.91%
Color and Shape:
Solid
Molecular weight:
408.45
Ref: TM-TQ0187
| 2mg | 36.00 € | ||
| 5mg | 53.00 € | ||
| 10mg | 89.00 € | ||
| 25mg | 154.00 € | ||
| 50mg | To inquire | ||
| 1mL*10mM (DMSO) | 58.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
SAR407899 hydrochloride
CAS:923262-96-8
SAR407899 hydrochloride is a selective, potent and ATP-competitive ROCK inhibitor, with an IC50 of 135 …
Formula:
C14H17ClN2O2
Purity:
98.01%
Color and Shape:
Solid
Molecular weight:
280.75
Ref: TM-T23308
| 5mg | 34.00 € | ||
| 10mg | 50.00 € | ||
| 25mg | 82.00 € | ||
| 50mg | 126.00 € | ||
| 100mg | 195.00 € | ||
| 200mg | 287.00 € | ||
| 1mL*10mM (DMSO) | 34.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
Y-27632
CAS:146986-50-7
Y-27632 (Y-27632) is an orally potent, ATP-competitive inhibitor of ROCK-I and ROCK-II.
Formula:
C14H21N3O
Purity:
99.53% - 99.87%
Color and Shape:
Solid
Molecular weight:
247.34
Ref: TM-T1870
| 5mg | 46.00 € | ||
| 10mg | 60.00 € | ||
| 25mg | 95.00 € | ||
| 50mg | 167.00 € | ||
| 100mg | 270.00 € | ||
| 200mg | 420.00 € | ||
| 500mg | 693.00 € | ||
| 1mL*10mM (DMSO) | 51.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
Belumosudil
CAS:911417-87-3
Belumosudil (Rezurock) is an orally available, and specific ROCK2 inhibitor (IC50/Ki: 60/41 nM).
Formula:
C26H24N6O2
Purity:
97.41% - 98.59%
Color and Shape:
Solid
Molecular weight:
452.51
Ref: TM-T6867
| 2mg | 48.00 € | ||
| 5mg | 72.00 € | ||
| 10mg | 89.00 € | ||
| 25mg | 163.00 € | ||
| 50mg | 245.00 € | ||
| 100mg | 370.00 € | ||
| 500mg | 875.00 € | ||
| 1mL*10mM (DMSO) | 79.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
URMC-099
CAS:1229582-33-5
URMC-099: oral, brain-accessible MLK/LRRK2 inhibitor; IC50 - MLK1/2/3/DLK: 19/42/14/150 nM, LRRK2: 11 nM.
Formula:
C27H27N5
Purity:
98.43% - 99.32%
Color and Shape:
Solid
Molecular weight:
421.54
Ref: TM-T6057
| 5mg | 56.00 € | ||
| 10mg | 85.00 € | ||
| 25mg | 138.00 € | ||
| 50mg | 217.00 € | ||
| 100mg | 371.00 € | ||
| 1mL*10mM (DMSO) | 59.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
Y-27632 dihydrochloride
CAS:129830-38-2
View and buy Y-27632 dihydrochloride from TargetMol.Y-27632 is a selective inhibitor of ROCKs.Cited in 10 …
Formula:
C14H21N3O·2HCl
Purity:
97.96% - 99.98%
Color and Shape:
Solid
Molecular weight:
320.26
Ref: TM-T1725
| 5mg | 46.00 € | ||
| 10mg | 60.00 € | ||
| 25mg | 97.00 € | ||
| 50mg | 167.00 € | ||
| 100mg | 269.00 € | ||
| 200mg | 427.00 € | ||
| 500mg | 706.00 € | ||
| 1mL*10mM (DMSO) | 51.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
BDP5290
CAS:1817698-21-7
BDP5290 is a potent inhibitor of both ROCK and MRCK(IC50s of 5 nM, 50 nM, …
Formula:
C17H18ClN7O
Purity:
97.22%
Color and Shape:
Solid
Molecular weight:
371.82
Ref: TM-T7301
| 1mg | 55.00 € | ||
| 2mg | 80.00 € | ||
| 5mg | 118.00 € | ||
| 10mg | 184.00 € | ||
| 25mg | 380.00 € | ||
| 50mg | 555.00 € | ||
| 100mg | 807.00 € | ||
| 1mL*10mM (DMSO) | 130.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
Afuresertib
CAS:1047644-62-1
Afuresertib (GSK2110183) is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase …
Formula:
C18H17Cl2FN4OS
Purity:
97.51% - 99.17%
Color and Shape:
Solid
Molecular weight:
427.32
Ref: TM-T1911
| 1mg | 39.00 € | ||
| 2mg | 50.00 € | ||
| 5mg | 78.00 € | ||
| 10mg | 95.00 € | ||
| 25mg | 171.00 € | ||
| 50mg | 268.00 € | ||
| 100mg | 467.00 € | ||
| 500mg | 1,013.00 € | ||
| 1mL*10mM (DMSO) | 79.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
SAR407899
CAS:923359-38-0
SAR407899 is Rho kinase inhibitor potently inhibits endothelin-1-induced constriction of renal resistance arteries.
Formula:
C14H16N2O2
Purity:
99.42%
Color and Shape:
Solid
Molecular weight:
244.29
Ref: TM-T7391
| 2mg | 39.00 € | ||
| 5mg | 57.00 € | ||
| 10mg | 92.00 € | ||
| 25mg | 149.00 € | ||
| 50mg | 232.00 € | ||
| 100mg | 369.00 € | ||
| 1mL*10mM (DMSO) | 62.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
CKI-7
CAS:1177141-67-1
CKI-7 is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; …
Formula:
C11H14Cl3N3O2S
Purity:
100.00% - 100.00%
Color and Shape:
Solid
Molecular weight:
358.67
Ref: TM-T19913
| 1mg | 181.00 € | ||
| 2mg | 241.00 € | ||
| 5mg | 359.00 € | ||
| 10mg | 538.00 € | ||
| 25mg | 865.00 € | ||
| 50mg | 1,173.00 € | ||
| 100mg | 1,585.00 € | ||
| 1mL*10mM (DMSO) | 392.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
AT13148
CAS:1056901-62-2
AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
Formula:
C17H16ClN3O
Purity:
98.04% - ≥95%
Color and Shape:
Solid
Molecular weight:
313.78
Ref: TM-T2482
| 1mg | 48.00 € | ||
| 2mg | 67.00 € | ||
| 5mg | 117.00 € | ||
| 10mg | 189.00 € | ||
| 25mg | 329.00 € | ||
| 50mg | 476.00 € | ||
| 1mL*10mM (DMSO) | 126.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
ROCK-IN-2
CAS:867017-68-3
ROCK-IN-2 (Azaindole 1) is a selective and ATP-competitive ROCK inhibitor with IC50 of 0.6 and …
Formula:
C18H13ClF2N6O
Purity:
97.29%
Color and Shape:
Solid
Molecular weight:
402.79
Ref: TM-TQ0110
| 1mg | 112.00 € | ||
| 5mg | 269.00 € | ||
| 10mg | 433.00 € | ||
| 25mg | 712.00 € | ||
| 50mg | 994.00 € | ||
| 100mg | 1,346.00 € | ||
| 1mL*10mM (DMSO) | 370.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
HA-100
CAS:84468-24-6
HA-100 is an inhibitor of protein kinase
Formula:
C13H15N3O2S
Purity:
99.44%
Color and Shape:
Pale Yellow Crystalline Solid
Molecular weight:
277.34
Ref: TM-T7648
| 5mg | 62.00 € | ||
| 10mg | 94.00 € | ||
| 25mg | 203.00 € | ||
| 50mg | 362.00 € | ||
| 100mg | 531.00 € | ||
| 1mL*10mM (DMSO) | 69.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
Narciclasine
CAS:29477-83-6
Narciclasine (Lycoricidinol), a natural product, modulates the Rho/Rho-kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA …
Formula:
C14H13NO7
Purity:
98.79% - 99.58%
Color and Shape:
Solid
Molecular weight:
307.26
Ref: TM-TQ0183
| 1mg | 99.00 € | ||
| 5mg | 406.00 € | ||
| 10mg | 592.00 € | ||
| 25mg | To inquire | ||
| 50mg | To inquire | ||
| 1mL*10mM (DMSO) | 447.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
