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HSP

HSP

HSP (Heat Shock Protein) inhibitors target HSPs, a family of molecular chaperones that assist in protein folding, stability, and protection against stress-induced damage. HSPs are often upregulated in cancer cells, helping them survive under stressful conditions such as hypoxia and chemotherapy. Inhibiting HSPs can disrupt these protective mechanisms, leading to cell death. HSP inhibitors are therefore valuable in cancer therapy and research into stress responses. At CymitQuimica, we provide a comprehensive range of high-quality HSP inhibitors to support your research in protein homeostasis, stress responses, and oncology.

Found 169 products of "HSP"

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  • 3-Phenyltoxoflavin

    CAS:
    <p>3-Phenyltoxoflavin (Phenyltoxoflavin) is an inhibitor of HSP90 (Kd = 585 nM) with anti-cancer activity.</p>
    Formula:C13H11N5O2
    Purity:99.88%
    Color and Shape:Solid
    Molecular weight:269.26
  • Chetomin

    CAS:
    <p>Chetomin (BRN0077366) is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar</p>
    Formula:C31H30N6O6S4
    Purity:98%
    Color and Shape:Off-White To Fawn Solid
    Molecular weight:710.87
  • 6BrCaQ-C10-TPP


    <p>6BrCaQ-C10-TPP inhibits TRAP1, halts cancer cell growth (IC50=0.008-0.30µM), disrupts mitochondrial membrane.</p>
    Formula:C45H47Br2N2O3P
    Color and Shape:Solid
    Molecular weight:854.65
  • PROTAC HSP90 degrader BP3

    CAS:
    <p>PROTAC BP3 selectively degrades HSP90, inhibits breast cancer growth (DC50=0.99µM), CRBN-dependent.</p>
    Formula:C32H29ClN8O5
    Color and Shape:Solid
    Molecular weight:641.08
  • MPC-0767

    CAS:
    <p>MPC-0767, a potent, selective, and orally active hsp90 inhibitor, is the L-alanine ester prodrug of MPC-3100, exhibiting enhanced chemical stability.</p>
    Formula:C26H36BrN7O9S2
    Color and Shape:Solid
    Molecular weight:734.64
  • PU-H71 HCl

    CAS:
    <p>PU-H71 HCl (Zelavespib HCl) is a novel Hsp90 inhibitor, a novel purine-based analog, and a radiosensitizer that may be a promising agent for CIRT.</p>
    Formula:C18H22ClIN6O2S
    Purity:98.95%
    Color and Shape:Soild
    Molecular weight:548.83
  • HS-27

    CAS:
    <p>HS-27 is a fluorescently-tethered inhibitor of Hsp90 with SNX-5422 tethered via a PEG linker to a fluorescein isothiocyanate or FITC.</p>
    Formula:C52H60N6O12S
    Purity:97.09%
    Color and Shape:Solid
    Molecular weight:993.13
  • Hsp110-STAT3 interaction-IN-2


    <p>Hsp110-STAT3 interaction-IN-2 (compound 10b) is an inhibitor of the Hsp110-STAT3 interaction. It is utilized in research related to pulmonary arterial hypertension (PAH).</p>
    Formula:C24H18F3N5O3
    Color and Shape:Solid
    Molecular weight:481.43
  • Myrtucommulone

    CAS:
    <p>Myrtucommulone is an inhibitor of the chaperonin activity of HSP60, correlating to LRP130 and LONP aggregation.</p>
    Formula:C38H52O10
    Purity:98%
    Color and Shape:Solid
    Molecular weight:668.81
  • HSP90-IN-35

    CAS:
    <p>HSP90-IN-35 is an inhibitor targeting Hsp90, exhibiting anticancer activity. It demonstrates an IC50 ranging from 0.05 to 0.5 μM against Her2. Additionally, HSP90-IN-35 can be utilized in the synthesis of PROTAC.</p>
    Formula:C27H33N5O5
    Color and Shape:Solid
    Molecular weight:507.58
  • NMS-E973

    CAS:
    <p>NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of &lt;10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.</p>
    Formula:C22H22N4O7
    Purity:99.84%
    Color and Shape:Solid
    Molecular weight:454.43
  • HA15-Biotin

    CAS:
    <p>HA15-Biotin, a synthetic HA15-biotin conjugate, shows similar activity and may aid in proteomics.</p>
    Formula:C37H45N7O5S3
    Color and Shape:Solid
    Molecular weight:763.99
  • Hsp70-derived octapeptide

    CAS:
    <p>TPR proteins including CHIP, TPR1, and hSGT affect luciferase refolding by DnaJ and hsc70.</p>
    Formula:C36H58N8O16
    Purity:98%
    Color and Shape:Solid
    Molecular weight:858.89
  • MAL3-101

    CAS:
    <p>MAL3-101 is a molecular chaperone inhibitor of heat shock protein 70 (Hsp 70).</p>
    Formula:C54H66N4O10
    Color and Shape:Solid
    Molecular weight:931.12
  • Grp94 Inhibitor-3


    <p>Grp94 Inhibitor-3 (Compound C6) is a selective inhibitor of glucose-regulated protein 94 (Grp94), with an affinity of 5.52 μM. It shows potential for research in primary open-angle glaucoma and metastatic cancer.</p>
    Formula:C24H20ClNO4
    Color and Shape:Solid
    Molecular weight:421.87
  • Shepherdin (79-87)

    CAS:
    <p>Shepherdin 79-87: Amino acid fragment 79-87 of Hsp90/Survivin antagonist with anticancer properties.</p>
    Formula:C41H64N12O12S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:949.09
  • JG-258

    CAS:
    <p>JG-258 is an inactive negative control for Hsp70 inhibitors [1] .</p>
    Formula:C20H22ClN3OS3
    Color and Shape:Solid
    Molecular weight:452.06
  • trans-Dehydrocurvularin

    CAS:
    <p>trans-Dehydrocurvularin is a useful organic compound for research related to life sciences. The catalog number is T125357 and the CAS number is 21178-57-4.</p>
    Formula:C16H18O5
    Color and Shape:Solid
    Molecular weight:290.315
  • HSP70/SIRT2-IN-1


    <p>HSP70/SIRT2-IN-1 (Compound 2a) serves as a dual inhibitor targeting both SIRT2 and HSP70, exhibiting an IC50 of 17.3±2.0 μM against SIRT2.</p>
    Purity:98%
    Color and Shape:Odour Solid
  • Zelavespib hydrochloride


    <p>Zelavespib (PU-H71) hydrochloride is a potent inhibitor of Hsp90, exhibiting an IC50 value of 51 nM in MDA-MB-468 cells.</p>
    Purity:98%
    Color and Shape:Odour Solid