HSP
HSP (Heat Shock Protein) inhibitors target HSPs, a family of molecular chaperones that assist in protein folding, stability, and protection against stress-induced damage. HSPs are often upregulated in cancer cells, helping them survive under stressful conditions such as hypoxia and chemotherapy. Inhibiting HSPs can disrupt these protective mechanisms, leading to cell death. HSP inhibitors are therefore valuable in cancer therapy and research into stress responses. At CymitQuimica, we provide a comprehensive range of high-quality HSP inhibitors to support your research in protein homeostasis, stress responses, and oncology.
Found 196 products for "HSP".
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MAO A/HSP90-IN-2
CAS:MAO A/HSP90-IN-2 (compound 4-C), a dual inhibitor of HSP90 and MAO A, exhibits IC50 values of 0.016 μM for MAO A and 4.58 μM for HSP90.Formula:C25H31ClN2O4Purity:98%Color and Shape:SolidMolecular weight:458.98HSP90-IN-29
CAS:HSP90-IN-29 (Compound 13), a benzoxazole derivative, serves as a potent and selective HSP-90 inhibitor, exhibiting a low IC50 value of 30 nM. This compound demonstrates significant antitumor activity [1].Formula:C19H20ClN3O4Color and Shape:SolidMolecular weight:389.83Colletofragarone A2
CAS:Colletofragarone A2 from Colletotrichum sp. blocks mutant p53 and HSP90, aiding cancer treatment.Formula:C22H26O6Color and Shape:SolidMolecular weight:386.44HA15-Biotin
CAS:HA15-Biotin, a synthetic HA15-biotin conjugate, shows similar activity and may aid in proteomics.Formula:C37H45N7O5S3Color and Shape:SolidMolecular weight:763.99MAO A/HSP90-IN-1
CAS:MAO A/HSP90-IN-1 (4-b) is a dual inhibitor of MAO A and HSP90, exhibiting IC50 values of 1.77 μM in glioblastoma (GBM) GL26 cells and 0.019 μM against HSP90α.Formula:C24H29ClN2O4Purity:98%Color and Shape:SolidMolecular weight:444.95Iroxanadine sulfate
CAS:Iroxanadine sulfate is a MAPK p38 inhibitor potentially for the treatment of atherosclerosis.Formula:C14H22N4O5SColor and Shape:SolidMolecular weight:358.41GRP78-IN-2
CAS:GRP78-IN-2 inhibits surface GRP78, showing anti-angiogenic and anti-cancer properties, sparing normal cells.Formula:C29H29NO6Color and Shape:SolidMolecular weight:487.54Flavokawain 1i
CAS:Flavokawain 1i, a derivative of chalcones flavokawain A, flavokawain B, and flavokawain C, exhibits anticancer and antiviral properties.Formula:C21H18O4Color and Shape:SolidMolecular weight:334.37YM-08
CAS:YM-08 (Compound 7a), a brain-penetrant SIRT2 inhibitor, exhibits an IC50 of 19.9 μM. Additionally, it acts as an inhibitor of Hsp70 [1].Formula:C19H17N3OS2Purity:98%Color and Shape:SolidMolecular weight:367.49Myrtucommulone
CAS:Myrtucommulone is an inhibitor of the chaperonin activity of HSP60, correlating to LRP130 and LONP aggregation.Formula:C38H52O10Purity:98%Color and Shape:SolidMolecular weight:668.81HSP90-IN-27
CAS:HSP90-IN-27 (compound 19) is an effective HSP90 inhibitor for cancer research.Formula:C18H21N3O2SPurity:99.94%Color and Shape:White SolidMolecular weight:343.44HSP70/SIRT2-IN-2
CAS:HSP70/SIRT2-IN-2 (Compounds 1a), a dual inhibitor of SIRT2 and HSP70, exhibits an IC50 of 45.1±5.0 μM against SIRT2 and demonstrates antitumor activity [1].Formula:C17H13N3S3Purity:98%Color and Shape:SolidMolecular weight:355.5HSP90-IN-28
CAS:HSP90-IN-28 (compound 12 h) is a potent and selective Hsp90 inhibitor, with an IC50 of 0.46 μM for Hsp90α. It demonstrates approximately 48 times more selectivity for Hsp90α compared to Hsp90β (IC50 = 22.28 μM).Formula:C23H21NO2SMolecular weight:375.49Hsp90-IN-37
CAS:Hsp90-IN-37 (Z-2) is an inhibitor of heat shock protein 90 (Hsp90), demonstrating a 69% inhibition rate on Hsp90 enzyme activity. It exhibits antitumor properties.Formula:C12H15N3O2Color and Shape:SolidMolecular weight:233.2664Iroxanadine hydrobromide
CAS:Iroxanadine hydrobromide is a MAPK p38 inhibitor potentially for the treatment of atherosclerosis.Formula:C14H21BrN4OColor and Shape:SolidMolecular weight:341.25C086
CAS:C086 is a novel and potent Hsp90 inhibitor that suppresses cell cycle progression, induces apoptosis, and exhibits anti-metastatic properties by modulating various mechanisms in different cell types.Formula:C29H28O8Color and Shape:SolidMolecular weight:504.53HSP90-IN-11
HSP90-IN-11: potent HSP90 inhibitor, akin to AUY-922; hinders CRC/NSCLC cell proliferation; degrades EGFR, Akt proteins.Formula:C27H30FN3O6Color and Shape:SolidMolecular weight:511.54ETB
CAS:ETB is a potent inhibitor of Hsp60 chaperone activity. It can impede the chaperone function of both wild-type proteins and the C237A and C447A mutant proteins. ETB binds to Hsp60 at Cys442, and the C442A mutant demonstrates resistance to ETB inhibition.Formula:C24H33NO6Color and Shape:SolidMolecular weight:431.52Monorden diacetate
CAS:Monorden diacetate a Hsp90 Inhibitor. Monorden diacetate is a Promising Lead Compound for the Development of Novel Fungicides.Formula:C22H21ClO8Color and Shape:SolidMolecular weight:448.85KUNG65
CAS:KUNG65 acts as a selective Grp94 inhibitor, demonstrating a target dissociation constant (K_d) of 540 nM. It exhibits a minimum selectivity of 73-fold compared to other Hsp90 isoforms.Formula:C23H20ClFO4Color and Shape:SolidMolecular weight:414.85
