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HSP

HSP

HSP (Heat Shock Protein) inhibitors target HSPs, a family of molecular chaperones that assist in protein folding, stability, and protection against stress-induced damage. HSPs are often upregulated in cancer cells, helping them survive under stressful conditions such as hypoxia and chemotherapy. Inhibiting HSPs can disrupt these protective mechanisms, leading to cell death. HSP inhibitors are therefore valuable in cancer therapy and research into stress responses. At CymitQuimica, we provide a comprehensive range of high-quality HSP inhibitors to support your research in protein homeostasis, stress responses, and oncology.

Found 169 products of "HSP"

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  • CH5164840

    CAS:
    <p>CH5164840: strong HSP90 blocker; excels in NSCLC treatment; boosts erlotinib efficacy on EGFR-mutant tumors.</p>
    Formula:C19H23N5O2S
    Color and Shape:Solid
    Molecular weight:385.48
  • Hsp90-Cdc37-IN-1

    CAS:
    <p>Hsp90-Cdc37-IN-1 is an Hsp90-Cdc37 interaction disruptor (IC50: 140 nM) that inhibit cell migration and reverse drug resistance.</p>
    Formula:C43H57FN2O6S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:748.99
  • Vibsanin A

    CAS:
    <p>Vibsanin A, an activator of protein kinase C (PKC) and an inhibitor of HSP90, demonstrates anti-proliferative effects on human cancer cell lines.</p>
    Formula:C25H38O4
    Color and Shape:Solid
    Molecular weight:402.57
  • YM-1

    CAS:
    <p>YM-1, a stable MKT-077 analog, inhibits Hsp70 orally, kills HeLa cells, and boosts p53 and p21 proteins.</p>
    Formula:C20H20ClN3OS2
    Color and Shape:Solid
    Molecular weight:417.98
  • BIIB028

    CAS:
    <p>BIIB028: Hsp90 inhibitor, may degrade oncogenic proteins, potentially hindering tumor growth.</p>
    Formula:C19H21ClN5O5P
    Color and Shape:Solid
    Molecular weight:465.83
  • Retaspimycin

    CAS:
    <p>Retaspimycin is a potent and water-soluble Hsp90 inhibitor(EC50s of 119 nM for both Hsp90 and Grp9).</p>
    Formula:C31H45N3O8
    Purity:98%
    Color and Shape:Solid
    Molecular weight:587.7
  • KUNB31

    CAS:
    <p>KUNB31 is a potent and selective inhibitor of Hsp90β.</p>
    Formula:C19H18N2O3
    Color and Shape:Solid
    Molecular weight:322.36
  • HSP90-IN-20

    CAS:
    <p>HSP90-IN-20, a potent inhibitor of HSP90, exhibits an IC50 of ≤10 μM, indicating its potential application in cancer research.</p>
    Formula:C26H32N4O4
    Color and Shape:Solid
    Molecular weight:464.56
  • Hsp90-IN-17

    CAS:
    <p>Hsp90-IN-17 (Example 5) is an inhibitor of HSP90, applicable in researching proliferative diseases, including cancer and neurodegenerative conditions.</p>
    Formula:C21H20N4O7
    Color and Shape:Solid
    Molecular weight:440.41
  • Heat Shock Protein Inhibitor II

    CAS:
    <p>Hsp inhibitor II, an active benzylidene lactam, blocks inducible Hsp synthesis, reduces tumor thermotolerance, and enhances AmB effects on A. fumigatus.</p>
    Formula:C12H11NO3
    Color and Shape:Solid
    Molecular weight:217.22
  • SW02

    CAS:
    <p>SW02 is a potent ATPase activator of Hsp70 (EC50: 150 μM). SW02 is able to accumulate total tau and phosphorylated tau (pTau).</p>
    Formula:C19H23BrN2O5
    Color and Shape:Solid
    Molecular weight:439.3
  • PU24FCl

    CAS:
    <p>PU24FCl is a specific inhibitor of tumor Hsp90.</p>
    Formula:C20H21ClFN5O3
    Color and Shape:Solid
    Molecular weight:433.86
  • BMS-358233

    CAS:
    <p>BMS-358233 is an effective LCK inhibitor with excellent cell activity against T cell proliferation.</p>
    Formula:C25H25ClN6O2S
    Color and Shape:Solid
    Molecular weight:509.02
  • EC 144

    CAS:
    <p>EC 144, a second-generation selective inhibitor of Hsp90 , inhibits tumor growth for Hsp90α and degradation of Her-2 in MCF-7 cells.</p>
    Formula:C21H24ClN5O2
    Color and Shape:Solid
    Molecular weight:413.9
  • MPC-3100

    CAS:
    <p>MPC-3100 is an orally bioavailable, synthetic, second-generation small-molecule inhibitor of Hsp90 with significant antitumor activity [1].</p>
    Formula:C22H25BrN6O4S
    Color and Shape:Solid
    Molecular weight:549.44
  • Iroxanadine

    CAS:
    <p>Iroxanadine (BRX-005) is a Novel small molecule MAPK p38 inhibitor that induces phosphorylation of p38 SAPK and induces concentration-dependent relaxation in</p>
    Formula:C14H20N4O
    Purity:98.04% - 99.04%
    Color and Shape:Solid
    Molecular weight:260.33
  • AMP-PCP disodium

    CAS:
    <p>AMP-PCP disodium is an ATP analogue with binding affinity to the N-terminal domain of Hsp90, with a Kd value of 3.8 μM.</p>
    Formula:C11H16N5Na2O12P3
    Purity:99.32%
    Color and Shape:Solid
    Molecular weight:549.17
  • SNX0723

    CAS:
    <p>SNX0723 is a potent Hsp90 Inhibitor with anti-Plasmodium activity.</p>
    Formula:C22H26FN3O3
    Purity:99.85%
    Color and Shape:Solid
    Molecular weight:399.46
  • Arimoclomol

    CAS:
    <p>Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP) and can be used in studies about the treatment of amyotrophic lateral sclerosis (</p>
    Formula:C14H20ClN3O3
    Purity:99.15%
    Color and Shape:Solid
    Molecular weight:313.78
  • JG-231

    CAS:
    <p>JG-231, a JG-98 analog, shows anticancer properties by blocking Hsp70-BAG3 interaction and hindering TNBC in MDA-MB-231 models.</p>
    Formula:C22H18BrCl2N3OS4
    Purity:99.79%
    Color and Shape:Solid
    Molecular weight:619.47