HSP
HSP (Heat Shock Protein) inhibitors target HSPs, a family of molecular chaperones that assist in protein folding, stability, and protection against stress-induced damage. HSPs are often upregulated in cancer cells, helping them survive under stressful conditions such as hypoxia and chemotherapy. Inhibiting HSPs can disrupt these protective mechanisms, leading to cell death. HSP inhibitors are therefore valuable in cancer therapy and research into stress responses. At CymitQuimica, we provide a comprehensive range of high-quality HSP inhibitors to support your research in protein homeostasis, stress responses, and oncology.
Found 197 products for "HSP".
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Hsp90-IN-37
CAS:Hsp90-IN-37 (Z-2) is an inhibitor of heat shock protein 90 (Hsp90), demonstrating a 69% inhibition rate on Hsp90 enzyme activity. It exhibits antitumor properties.Formula:C12H15N3O2Color and Shape:SolidMolecular weight:233.2664DCEM1
CAS:DCEM1 binds to heat shock protein 60 (HSP60) and inhibits the interaction between HSP60 and ClpP, thereby blocking the mitochondrial unfolded protein response. Additionally, DCEM1 suppresses the expression of β-catenin and reduces ATP production in PC-3 and TKO cells. It is utilized in research related to prostate cancer.Formula:C22H23N3O2SColor and Shape:SolidMolecular weight:393.50KU-32
CAS:KU-32 is a novel and novobiocin-based Hsp90 inhibitor. It can protect against neuronal cell death.Formula:C20H25NO8Purity:98%Color and Shape:SolidMolecular weight:407.41Hsp90-IN-34
CAS:Hsp90-IN-34 (compound HAM-1) is a chemical inhibitor that targets the Aha1-Hsp90 chaperone complex with high affinity (KDapp=23.5 µM). It modulates the ATPase activity of Hsp90 by affecting the interaction between Hsp90 and Aha1.Formula:C22H14F2N6OColor and Shape:SolidMolecular weight:416.38Antiproliferative agent-72
CAS:Antiproliferative agent-72 (Compound 10) is an Hsp90 inhibitor with a dissociation constant (Kd) of 11 nM. It exhibits antiproliferative activity with IC50 values of 1.5 μM and 1.1 μM against HCT116 and NCI-N87 cells, respectively. Antiproliferative agent-72 is suitable for cancer research applications.Formula:C20H17Cl2N3O2SMolecular weight:434.34Macbecin I
CAS:Hsp90 inhibitorFormula:C30H42N2O8Purity:98%Color and Shape:SolidMolecular weight:558.66TBPH-1
CAS:TBPH is a brominated flame retardant that exacerbates hepatic steatosis, inflammation, and fibrosis in non-alcoholic steatohepatitis (NASH) mouse models. It disrupts phospholipid metabolism, reducing levels of cardiolipin (CL) and phosphatidylserine (PS). TBPH impairs endoplasmic reticulum-mitochondria (ER-Mito) contact, leading to mitochondrial dysfunction. Additionally, TBPH induces lung injury through a mitochondrial-derived ds-DNA mediated inflammatory response. It is also used to investigate the role of MFN2-mediated ER-Mito contact in lipid metabolism homeostasis.Formula:C24H34Br4O4Molecular weight:706.14TRAP1-IN-2
CAS:TRAP1-IN-2, also known as compound 36, is a selective degrader of the TRAP1 client protein that does not affect Hsp90-cytosolic clients.Formula:C46H42F6N2O5P2Purity:98%Color and Shape:SolidMolecular weight:878.77Iroxanadine hydrobromide
CAS:Iroxanadine hydrobromide is a MAPK p38 inhibitor potentially for the treatment of atherosclerosis.Formula:C14H21BrN4OColor and Shape:SolidMolecular weight:341.25HSP90-IN-11
HSP90-IN-11: potent HSP90 inhibitor, akin to AUY-922; hinders CRC/NSCLC cell proliferation; degrades EGFR, Akt proteins.Formula:C27H30FN3O6Color and Shape:SolidMolecular weight:511.54ETB
CAS:ETB is a potent inhibitor of Hsp60 chaperone activity. It can impede the chaperone function of both wild-type proteins and the C237A and C447A mutant proteins. ETB binds to Hsp60 at Cys442, and the C442A mutant demonstrates resistance to ETB inhibition.Formula:C24H33NO6Color and Shape:SolidMolecular weight:431.52Monorden diacetate
CAS:Monorden diacetate a Hsp90 Inhibitor. Monorden diacetate is a Promising Lead Compound for the Development of Novel Fungicides.Formula:C22H21ClO8Color and Shape:SolidMolecular weight:448.85HSP90-IN-32
CAS:HSP90-IN-32, a carboxy-terminus inhibitor of Hsp90C, exhibits antiproliferative activity in various cell lines including SKMel173, SKMel103, SKMel19, and A375, with IC50 values of 1.01 μM, 0.782 μM, 0.607 μM, and 1.413 μM, respectively. This compound holds potential for research in anticancer agents.Formula:C33H40N2O4Color and Shape:SolidMolecular weight:528.68Hsp110-STAT3 interaction-IN-1
CAS:Row174336 (compound 29) serves as an efficient inhibitor of the Hsp110-STAT3 interaction, exhibiting antiproliferative activity in the HPAEC cell line with an IC50 of 22.67 μM.Formula:C23H31N3O4SColor and Shape:SolidMolecular weight:445.58Onalespib lactate
CAS:Onalespib lactate is a second-generation, potent and selective HSP90 Inhibitor with antitumor activity.Formula:C27H37N3O6Color and Shape:SolidMolecular weight:499.6DDO-6691
CAS:DDO-6691 is an inhibitor of heat shock protein 90 (HSP90). It exhibits antiproliferative effects against various tumor cells, with the highest sensitivity observed in HCT-116 colon cancer cells (IC50: 1.08 μM). DDO-6691 also demonstrates potent tumor growth inhibition in HCT-116 xenograft mouse models.Formula:C22H17N3O2SColor and Shape:SolidMolecular weight:387.45VER-49009
CAS:VER-49009 (CCT 129397) is a potent Hsp90 inhibitor(IC50 of 25 nM and Kd of 78 nM).Formula:C19H18ClN3O4Purity:99.36% - 99.99%Color and Shape:SolidMolecular weight:387.82
