Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2612 products of "Chromatin/Epigenetics"
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GRK6-IN-1
CAS:GRK6-IN-1 (compound 18) is a potent GRK6 blocker, with an IC50 of 120 nM, showing promise for multiple myeloma research.Formula:C22H23ClN6O2Purity:99.37%Color and Shape:SolidMolecular weight:438.91Ref: TM-T62518
1mg54.00€5mg114.00€10mg178.00€25mg409.00€50mg708.00€100mg1,153.00€1mL*10mM (DMSO)126.00€HDAC6 degrader 9c
CAS:HDAC6 degrader 9c is a small molecule histone deacetylase 6 (HDAC6) degrader that can be used to study cancer or other diseases.Formula:C37H45N9O10Purity:>99.99%Color and Shape:SolidMolecular weight:775.81Procainamide
CAS:Procainamide: DNMT1 inhibitor, Class 1A antiarrhythmic, promising for cancer and arrhythmia research.Formula:C13H21N3OPurity:99.79% - 99.92%Color and Shape:SolidMolecular weight:235.33STS-E412
CAS:STS-E412 is a tissue-protective and selective EPOR/CD131 receptor activator for the study of neurological disorders.Formula:C15H15ClN4O2Purity:99.01%Color and Shape:SolidMolecular weight:318.76DCPLA-ME
CAS:DCPLA-ME (2-[(2-Pentylcyclopropyl)methyl]cyclopropaneoctanoic acid methyl ester) is the methyl ester form of DCPLA and can be used to treat neurodegenerativeFormula:C21H38O2Purity:99.80%Color and Shape:SolidMolecular weight:322.53Ref: TM-T10980
1mg62.00€5mg126.00€10mg172.00€25mg350.00€50mg572.00€100mg772.00€200mg1,054.00€1mL*10mM (DMSO)138.00€BAY-299
CAS:BAY-299 inhibits BRPF2, TAF1, and TAF1L with IC50s of 67, 8, and 106 nM.Formula:C25H23N3O4Purity:99.53%Color and Shape:SolidMolecular weight:429.47GSK-690
CAS:GSK-690 is a potent, reversible and selective inhibitors of Lysine Specific Demethylase 1.Formula:C24H23N3OPurity:98.65%Color and Shape:SolidMolecular weight:369.46TGP-377/421
CAS:TGP-377/421 (Targapre-miR-377/421) is a potent miR-377 and miR-421 dual inhibitor that inhibits miR-377 and miR-421 by binding to their functional sites.Formula:C20H16N6Purity:97.02%Color and Shape:SolidMolecular weight:340.38Ref: TM-T61085
1mg63.00€5mg137.00€10mg215.00€25mg430.00€50mg695.00€100mg973.00€500mg1,945.00€1mL*10mM (DMSO)150.00€SK-575
CAS:SK-575 is a potent PARP1-degrading agent effective against BRCA1/2 mutant cancers, even at low doses, and enhances tumor inhibition in mice.Formula:C47H53FN8O8Purity:99.39%Color and Shape:SolidMolecular weight:876.97Cedazuridine
CAS:Cedazuridine ((4R)-2'-Deoxy-2',2'-difluoro-3,4,5,6-tetrahydrouridine) is an oral inhibitor of cytidine deaminase with antineoplastic properties.Formula:C9H14F2N2O5Purity:99.66%Color and Shape:SolidMolecular weight:268.21OXF BD 02
CAS:OXF BD 02 is a potent and selective BRD4(1) inhibitor (IC50: 382 nM) with anticancer and anti-inflammatory activity.Formula:C18H17NO3Purity:98.25%Color and Shape:SolidMolecular weight:295.33TNG908
CAS:TNG908, a brain-penetrant PRMT5 inhibitor, is 15x more selective for MTAP mutant vs WT lines, useful in cancer studies.Formula:C21H23N5O2SPurity:98.08% - 98.24%Color and Shape:SolidMolecular weight:409.51Ref: TM-T73494
1mg66.00€5mg145.00€10mg224.00€25mg358.00€50mg512.00€100mg707.00€1mL*10mM (DMSO)158.00€SIRT6-IN-5
CAS:SIRT6-IN-5: potent, selective SIRT6 inhibitor; IC50=34 μM; immunosuppressive, enhances chemo, boosts H3K9 acetylation, glucose uptake, curbs T-cell growth.Formula:C19H14N2O6Purity:98.77%Color and Shape:SolidMolecular weight:366.32DC-BPi-03
CAS:DC-BPi-03 is a potent BPTF-BRD inhibitor with an IC 50 of 698.3 nM and a K d of 2.81 μM .Formula:C14H14N4O2SPurity:98.96%Color and Shape:SolidMolecular weight:302.35YLF-466D
CAS:YLF-466D (C24) is a newly developed AMPK activator, which inhibits platelet aggregation.Formula:C29H20ClNO3Purity:97.74%Color and Shape:SolidMolecular weight:465.93Ref: TM-T13368
1mg34.00€5mg79.00€10mg111.00€25mg188.00€50mg269.00€100mg371.00€200mg512.00€1mL*10mM (DMSO)82.00€AGI-24512
CAS:AGI-24512 is a inhibitor of methionine adenosyltransferase 2A (MATA2 ).It is useful for treatment of cancer and blocks growth of MTAP-deleted cancer cells inFormula:C24H24N4O2Purity:98.55%Color and Shape:SolidMolecular weight:400.47Ref: TM-T14141
1mg66.00€5mg145.00€10mg224.00€25mg358.00€50mg512.00€100mg707.00€200mg982.00€1mL*10mM (DMSO)195.00€AGI-43192
CAS:AGI-43192: potent MAT2A inhibitor, crosses blood-brain barrier, may help study SAM in CNS and treat cancer.Formula:C23H16ClF3N6OPurity:99.89%Color and Shape:SolidMolecular weight:484.86Ref: TM-T9729
1mg72.00€5mg161.00€10mg250.00€25mg411.00€50mg577.00€100mg772.00€500mg1,558.00€1mL*10mM (DMSO)172.00€EZH2-IN-13
CAS:EZH2-IN-13 is a potent EZH2 inhibitor with potential anticancer activity.EZH2-IN-13 may be used to study diseases associated with EZH2 activity.Formula:C34H45N5O3Purity:98.3%Color and Shape:SolidMolecular weight:571.75Raxofelast
CAS:Raxofelast (IRFI-016), a vitamin-like, hydrophilic antioxidant, mitigates ischemia-reperfusion in testis and may treat diabetic issues and atherosclerosis.Formula:C15H18O5Purity:99.74% - 99.97%Color and Shape:SolidMolecular weight:278.3Flosequinan
CAS:Flosequinan is an arteriovenous vasodilator, which can effectively treat acute heart failure.Formula:C11H10FNO2SPurity:99.95%Color and Shape:SolidMolecular weight:239.27Ref: TM-T31805
1mg175.00€5mg394.00€10mg582.00€25mg888.00€50mg1,243.00€100mg1,674.00€500mg3,348.00€1mL*10mM (DMSO)351.00€DW14800
CAS:DW14800 is an inhibitor of PRMT5 (IC50 = 17 nM), enhances the transcription of HNF4α, and reduces the level of H4R3me2s.Formula:C31H36N4O3Purity:99.55% - 99.68%Color and Shape:SolidMolecular weight:512.64Ref: TM-T11131
1mg93.00€2mg123.00€5mg205.00€10mg358.00€25mg680.00€50mg898.00€100mg1,341.00€1mL*10mM (DMSO)233.00€Givinostat hydrochloride
CAS:Givinostat HCl (ITF2357 HCl) inhibits HDAC1/3 (IC50: 198/157 nM) with anti-inflammatory, anti-angiogenic, and antineoplastic properties.Formula:C24H28ClN3O4Purity:99.39%Color and Shape:SolidMolecular weight:457.95Ref: TM-T6279L
1mg35.00€5mg75.00€10mg120.00€25mg240.00€50mg416.00€100mg663.00€200mg888.00€1mL*10mM (DMSO)77.00€BRD2492
CAS:BRD2492 is an HDAC1 and HDAC2 inhibitor with antiproliferative activity, inhibits HDAC1/2 and induces apoptosis.Formula:C20H18N4O2Purity:99.56%Color and Shape:SolidMolecular weight:346.38Crebinostat
CAS:Crebinostat: potent HDAC inhibitor, boosts synapsin-1 in neurons, enhances memory and gene Egr1 expression in mice.Formula:C20H23N3O3Purity:99.49%Color and Shape:SolidMolecular weight:353.41Corin
CAS:Corin is an irreversible inhibitor of HDAC1(IC50 = 147 nM) and LSD1(Ki = 110 nM).Formula:C26H28N4O2Purity:99.6%Color and Shape:SolidMolecular weight:428.53Ref: TM-T10864
1mg167.00€5mg409.00€10mg605.00€25mg954.00€50mg1,288.00€100mg1,728.00€1mL*10mM (DMSO)442.00€JAK1-IN-8
CAS:JAK1-IN-8, a specific inhibitor of Janus kinase 1 (JAK1, IC50<500 nM).
Formula:C22H23FN4O3SPurity:98.4%Color and Shape:SolidMolecular weight:442.51CEP-9722
CAS:CEP-9722 is a PARP-1 and PARP-2 inhibitor with anticancer activity and is used in the study of ovarian cancer.Formula:C24H26N4O3Purity:98.38% - 98.56%Color and Shape:SolidMolecular weight:418.49ZEN-3219
CAS:ZEN-3219 is a BET inhibitor, which has inhibitory effect on BRD4(BD1), BRD4(BD2) and BRD4(BD1BD2).Formula:C19H18N2O3Purity:99.86%Color and Shape:SolidMolecular weight:322.36NSC 694623
CAS:NSC 694623: Potent HAT inhibitor, IC50=15.9 μM against PCAF, anti-cancer properties.Formula:C16H16N2OSPurity:99.9%Color and Shape:SolidMolecular weight:284.38Bisaramil hydrochloride
CAS:Bisaramil hydrochloride (Bisaramil) is an antiarrhythmic compound that inhibits free radical production.Formula:C17H24Cl2N2O2Purity:98.64% - 99.48%Color and Shape:SolidMolecular weight:359.29LEM-14
CAS:LEM-14 is a potent NSD2-specific inhibitor (IC50:132 μM).LEM-14 may be used in the study of multiple myeloma.
Formula:C25H26N4O4SPurity:98.3%Color and Shape:SolidMolecular weight:478.56OXFBD04
CAS:OXFBD04: Potent BRD4 inhibitor, IC50=166nM, acts on BET bromodomains; moderate CREBBP affinity; anti-cancer properties.Formula:C17H16N2O3Purity:99.56%Color and Shape:SolidMolecular weight:296.32Ref: TM-T12338
1mg52.00€2mg78.00€5mg115.00€10mg182.00€25mg339.00€50mg505.00€100mg685.00€200mg944.00€1mL*10mM (DMSO)126.00€PU139
CAS:PU139 is a novel inhibitor of histone acetyltransferase (HAT).Formula:C12H7FN2OSPurity:99.96%Color and Shape:SolidMolecular weight:246.26MS0124
CAS:MS0124 is a potent and selective G9A-like protein (GLP) inhibitor with IC50 values of 13±4 nM and 440±63 nM, respectively.
Formula:C20H29N5O3Purity:98.97%Color and Shape:SolidMolecular weight:387.48OUL232
CAS:OUL232 is a potent single ARTs PARP7, PARP10, PARP11, PARP12, PARP14 and PARP15 inhibitor for cancer and tumour research.Formula:C10H10N4O2SPurity:99.04%Color and Shape:SolidMolecular weight:250.28UNC8153 TFA
CAS:UNC8153 is a NSD2-specific histone-lysine N-methyltransferase degrader, showing selective activity towards NSD2 over NSD1 and NSD3 at 20 µM, and demonstrating aFormula:C35H38F3N5O7Purity:96.44%Color and Shape:SolidMolecular weight:697.7Bocodepsin hydrochloride
CAS:Bocodepsin hydrochloride (OKI-179) is a selective HDAC inhibitor with antitumor properties, efficacious via oral administration.Formula:C26H40ClN5O6S2Purity:98%Color and Shape:SolidMolecular weight:618.21TCS 21311
CAS:TCS 21311 (NIBR3049) selectively inhibits JAK3 (IC50: 8 nM) and PKCα/θ & GSK3β; >100x selective over JAK1, JAK2, TYK2.Formula:C27H25F3N4O4Purity:99.39% - ≥98%Color and Shape:SolidMolecular weight:526.51GSK761
GSK761 inhibits SP140 (IC50: 77.79 nM), hinders monocyte-to-macrophage differentiation, and prompts CD206+ regulatory macrophages.Formula:C40H46N4O4Color and Shape:SolidMolecular weight:646.82A1B11
CAS:A1B11 is a selective SIRT2 inhibitor.Formula:C22H25N5OColor and Shape:SolidMolecular weight:375.47KDM5-IN-1
CAS:KDM5-IN-1 is an effective and selective inhibitor of KDM5 with an IC50 of 15.1 nM.Formula:C17H20N6OPurity:99.50%Color and Shape:SolidMolecular weight:324.38Ref: TM-T15649
1mg60.00€5mg177.00€10mg269.00€25mg427.00€50mg610.00€100mg820.00€500mgTo inquire1mL*10mM (DMSO)130.00€CLB-016
CAS:CLB-016 is an inhibitor of hypoxia-inducible factor (HIF)-1.Formula:C17H20N6O3Purity:98%Color and Shape:SolidMolecular weight:356.38SMYD3-IN-1
CAS:SMYD3-IN-1 is an irreversible and selective SMYD3 (SET and MYND domain containing 3) inhibitor(IC50 of 11.7 nM).Formula:C28H31ClN4O3Purity:98%Color and Shape:SolidMolecular weight:507.02Nezulcitinib
CAS:Nezulcitinib (TD-0903) is an inhaled pan-JAK inhibitor targeting COVID-19-related acute lung injury.Formula:C30H37N7O2Color and Shape:SolidMolecular weight:527.66CBB1007 hydrochloride
CAS:CBB1007 Hcl inhibits LSD1 selectively (IC50=5.27μM), blocks H3K4 demethylation, activates genes; less effect on other cells/tissues.Formula:C27H39Cl5N8O4Color and Shape:SoildMolecular weight:716.91KH-3
CAS:KH-3: HuR inhibitor, IC50 0.35 μM, halts cell growth, blocks HuR-FOXQ1 mRNA, curbs breast cancer invasion, slows lung colony growth.Formula:C21H22N2O4S2Color and Shape:SolidMolecular weight:430.54CBB1007
CAS:CBB1007 is a potent, reversible, and substrate competitive LSD1 inhibitor (IC50: 5.27 μM for hLSD1).Formula:C27H34N8O4Purity:98%Color and Shape:SolidMolecular weight:534.61JAK-IN-25
CAS:JAK-IN-25 (compound 19), a potent JAK inhibitor, exhibits IC50 values of 6 nM for TYK2, 21 nM for JAK1, 8 nM for JAK2, and 1051 nM for JAK3.Formula:C19H17N5O4Purity:98%Color and Shape:SolidMolecular weight:379.37PIN1 inhibitor 2
CAS:PIN1 inhibitor 2, compound 12, impedes PIN1, shows promise in breast cancer study, and has IC50 of 9.55 μM in MCF7 cells.Formula:C16H21N3S2Color and Shape:SolidMolecular weight:319.49CBP/p300-IN-17
CAS:CBP/p300-IN-17 (compound 7) is a potent inhibitor of EP300/CBP HAT, acting on HAT EP300 (IC50: 0.18 μM) and LK2 H3K27 (IC50: 0.69 μM).Formula:C25H28N4O3Color and Shape:SolidMolecular weight:432.51NHWD-870
CAS:NHWD-870 selectively inhibits BET bromodomains BRD2-4, BRDT; potent anti-cancer effect by inducing apoptosis, halting cell growth.Formula:C29H29N7OPurity:98%Color and Shape:SolidMolecular weight:491.59(-)-Indolactam V
CAS:(-)-Indolactam V: PKC activator, antitumor, Ki 3.36 nM/1.03 μM for η/γ-CRD2, Kd 5.5-213 nM for C1 domains.Formula:C17H23N3O2Purity:98%Color and Shape:SolidMolecular weight:301.38CARM1-IN-3
CAS:CARM1-IN-3 (compound 17b) is a potent, selective inhibitor of co-activator associated arginine methyltransferase (CARM1), exhibiting IC50 values of 0.07 µM forFormula:C24H32N4O2Purity:98%Color and Shape:SolidMolecular weight:408.54(Iso)-MS4322
CAS:(Iso)-MS4322 ((Iso)-YS43-22) is a protein arginine methyltransferase 5 (PRMT5 ) degrader with potential anticancer activity.Formula:C55H76N10O12SPurity:99.05% - 99.79%Color and Shape:SolidMolecular weight:1101.32CM-675
CAS:CM-675 is a dual inhibitor of phosphodiesterase 5 (PDE5) and class I histone deacetylases (IC50s: 114 nM and 673 nM for PDE5 and HDAC1) with the potential toFormula:C31H32N6O3Purity:99.82%Color and Shape:SolidMolecular weight:536.62Ref: TM-T10841
1mg60.00€2mg90.00€5mg138.00€10mg215.00€25mg358.00€50mg510.00€100mg692.00€1mL*10mM (DMSO)152.00€FD1024
CAS:FD1024 is a potent PIM inhibitor, displaying inhibitory concentrations (IC50s) of 1.96 nM, 38.9 nM, and 4.17 nM for PIM1, PIM2, and PIM3, respectively.Formula:C21H20F2N4O2SPurity:98%Color and Shape:SolidMolecular weight:430.47Oxamflatin
CAS:Oxamflatin (Metacept-3) is a selective histone deacetylase (HDAC) inhibitor with an alkyne group capable of azide-alkyne cycloaddition reactions (CuAAc).Formula:C17H14N2O4SPurity:98.25%Color and Shape:SolidMolecular weight:342.37Ref: TM-T16415
1mg58.00€5mg145.00€10mg215.00€25mg477.00€50mg670.00€100mg879.00€200mg1,161.00€1mL*10mM (DMSO)114.00€MPI_5a
CAS:MPI_5a selectively inhibits HDAC6 (IC50=36 nM), slightly affects other HDACs, and blocks acyl-tubulin build-up (IC50=210 nM).Formula:C16H17N3O3Purity:99.62%Color and Shape:SolidMolecular weight:299.32Ref: TM-T16129
1mg250.00€2mg400.00€5mg755.00€10mg1,018.00€25mg1,504.00€50mg2,035.00€100mg2,673.00€1mL*10mM (DMSO)650.00€(S)-Ro 32-0432
CAS:(S)-Ro 32-0432 is a potent, selective inhibitor of protein kinase C (PKC) and G protein-coupled receptor kinase 5 (GRK5), demonstrating ATP-competitive and oral activity. It presents IC50 values of 9.3 nM for PKCα, 28 nM for PKCβI, 30 nM for PKCβII, 36.5 nM for PKCγ, and 108.3 nM for PKCε, showcasing its effectiveness against multiple PKC isoforms. Additionally, (S)-Ro 32-0432 inhibits T-cell activation, indicating its potential application in the research of chronic inflammatory and autoimmune diseases [1] [2].Formula:C28H29ClN4O2Color and Shape:SolidMolecular weight:489.01NT160
CAS:NT160 is a fluorinated radioactive compound, a potent class IIa histone deacetylase (HDAC) inhibitor, used in the study of neurological diseases.Formula:C21H21F3N4O2Purity:99.3%Color and Shape:SolidMolecular weight:418.41Ref: TM-T78709
1mg94.00€5mg222.00€10mg356.00€25mg715.00€50mg1,153.00€100mg1,783.00€1mL*10mM (DMSO)245.00€QC6352
CAS:QC6352 is a selective and effective KDM4C inhibitor (IC50: 35 nM).Formula:C24H25N3O2Purity:98%Color and Shape:SolidMolecular weight:387.47GNE-049
CAS:GNE-049 is a highly selective CBP inhibitor (IC50=1.1 nM) that blocks prostate cancer cell proliferation.Formula:C27H32F2N6O2Purity:98.67%Color and Shape:SolidMolecular weight:510.58FHT-1204
CAS:FHT-1204 is a potent inhibitor of SMARCA4/SMARCA2 ATPase (BRG1 and BRM) (IC50 ≤ 10 nM).Formula:C24H23N5O5S2Color and Shape:SolidMolecular weight:525.6HDAC8-IN-4
CAS:HDAC8-IN-4 is a selective HDAC8 inhibitor, exhibiting inhibitory activity with IC50 values of 0.15 μM for HDAC8 and 12 μM for HDAC3 [1].Formula:C17H14N2O2S2Purity:98%Color and Shape:SolidMolecular weight:342.44HDAC/HSP90-IN-3
CAS:HDAC/HSP90-IN-3, a dual inhibitor targeting fungal Hsp90 (IC50: 0.83 μM) & HDAC (IC50: 0.91 μM), counters azole-resistant C. albicans.Formula:C26H33N5O6Color and Shape:SolidMolecular weight:511.57HDAC/BET-IN-1
CAS:HDAC/BET-IN-1 inhibits HDAC1 (IC50: 0.163 μM), HDAC6 (IC50: 0.067 μM), BRD4 (Ki: 0.076 μM), and fights leukemia.Formula:C29H40N4O8SPurity:98%Color and Shape:SolidMolecular weight:604.71TCS HDAC6 20b
CAS:TCS HDAC6 20b (HDAC6-IN-7) is an HDAC6 inhibitor that blocks the growth of breast cancer cells and can be used in cancer research.Formula:C26H44N2O4SPurity:>99.99%Color and Shape:SolidMolecular weight:480.7HDAC-IN-38
CAS:HDAC-IN-38: Potent HDAC1-3,5,6,8 inhibitor, boosts H3K14/H4K5 acetylation, elevates CBF, lessens cognitive decline & hippocampal atrophy.Formula:C27H28ClN3O2Color and Shape:SolidMolecular weight:461.98PKC-θ inhibitor 1
CAS:PKC-theta inhibitor 1 is an inhibitor of PKCθ (Ki of 6 nM)Formula:C17H15F3N4OPurity:98%Color and Shape:SolidMolecular weight:348.32Aurora kinase inhibitor-8
CAS:Aurora kinase inhibitor-8 is a highly selective inhibitor of Aurora kinase.Formula:C30H29N7O3Color and Shape:SolidMolecular weight:535.6PIM1-IN-1
CAS:PIM1-IN-1 inhibits PIM1/3 with IC50s: PIM1 (7 nM), PIM2 (5530 nM), PIM3 (70 nM); it has anti-cancer properties.Formula:C25H30N8O2Purity:98.59%Color and Shape:SolidMolecular weight:474.56Ref: TM-T12474
1mg117.00€5mg281.00€10mgTo inquire25mg858.00€50mg1,341.00€100mg2,125.00€1mL*10mM (DMSO)To inquireHDAC6/HSP90-IN-1
CAS:HDAC6/HSP90-IN-1 is a potent dual inhibitor of HDAC6 and HSP90 with IC50s 4.3 nM & 46.8 nM, respectively; curbs PD-L1 and tumor growth in H1975 mice.Formula:C28H37N3O6Color and Shape:SolidMolecular weight:511.61Sirtuin modulator 1
CAS:Sirtuin modulator 1 (SRT3025 Hydrochloride) is a modulator of SIRT1 with EC1.5 of < 1 μM.Formula:C31H32ClN5O2S2Purity:99.63%Color and Shape:SolidMolecular weight:606.2HIF-2α-IN-13
CAS:HIF-2α-IN-13 (18) acts as a HIF-2α inhibitor and exhibits an IC 50 value of 2.7 μM.Formula:C15H14ClF4NO2Color and Shape:SolidMolecular weight:351.72Bocodepsin
CAS:Bocodepsin (OKI-179) is a selective, orally active inhibitor of histone deacetylases (HDAC) with demonstrated antitumor efficacy.Formula:C26H39N5O6S2Purity:98%Color and Shape:SolidMolecular weight:581.75JAK-IN-4
CAS:JAK-IN-4 is a prodrug of a JAK inhibitor, effective in murine collagen induced arthritis model.Formula:C18H21N4Na2O6PPurity:98%Color and Shape:SolidMolecular weight:466.341WAY-354574
CAS:WAY-354574 is an active compound that targets the deacetylase Sirtuin, utilized in research focused on Huntington's disease (HD) [1].Formula:C20H23ClN2O3SPurity:98%Color and Shape:SolidMolecular weight:406.93KPZ560
CAS:KPZ560, a potent HDAC 1 and HDAC 2 inhibitor, exhibits IC50 values of 12 nM and 68 nM, respectively.Formula:C26H21N5O3S2Purity:98%Color and Shape:SolidMolecular weight:515.61CM-579 trihydrochloride (1846570-40-8 free base)
CM-579 trihydrochloride is a first-in-class reversible and dual inhibitor of G9a and DNMT (IC50s: 16 nM, 32 nM) with potent in vitro cellular activity in a wideFormula:C29H43Cl3N4O3Purity:98%Color and Shape:SolidMolecular weight:602.04FHT-2344
CAS:FHT-2344, a SMARCA4/SMARCA2 ATPase inhibitor, exhibits anticancer activity with half-maximal inhibitory concentrations (IC 50 ) of 0.026 μM for SMARCA4 and 0.013 μM for SMARCA2, respectively [1].Formula:C23H24N6O5S2Color and Shape:SolidMolecular weight:528.6HDAC6-IN-8
CAS:Compound 12C, with altered cap groups, shows wide-range enzyme inhibition; 9m and 9q target HDAC6 specifically.Formula:C23H17BrFN5O3Purity:98%Color and Shape:SolidMolecular weight:510.32Sirt2-IN-5
CAS:Sirt2-IN-5 is a potent inhibitor of SIRT2.Formula:C26H27Cl2N5O3Color and Shape:SolidMolecular weight:528.43PHD-IN-1
CAS:PHD-IN-1 (compound 80) serves as a potent PHD2 inhibitor, exhibiting an IC50 value of ≤5 nM.Formula:C24H23N7O2Purity:98%Color and Shape:SolidMolecular weight:441.49Vafidemstat
CAS:Vafidemstat (ORY-2001) is a lysine-histone demethylase (LSD1)/MAO-B inhibitor for the study of neurological disorders.Formula:C19H20N4O2Purity:99.53%Color and Shape:SolidMolecular weight:336.39CD235
CAS:CD235 is a structurally similar analog of CD161. CD161 is an orally bioavailable inhibitor of BET bromodomain.Formula:C26H20FN5O2Purity:98%Color and Shape:SolidMolecular weight:453.47YM-08
CAS:YM-08 (Compound 7a), a brain-penetrant SIRT2 inhibitor, exhibits an IC50 of 19.9 μM. Additionally, it acts as an inhibitor of Hsp70 [1].Formula:C19H17N3OS2Purity:98%Color and Shape:SolidMolecular weight:367.49KF21213
CAS:KF21213 shows a high affinity for the adenosine A2A receptors (Ki=3.0 nM). KF21213 is a highly selective ligand for mapping CNS adenosine A2A receptors.Formula:C19H22N4O3Purity:98%Color and Shape:SolidMolecular weight:354.4PARP7-IN-16
CAS:PARP7-IN-16 (compound 36) is a potent, selective, and orally active PARP-1/2/7 inhibitor, exhibiting IC50 values of 0.94, 0.87, and 0.21 nM , respectively.Formula:C25H26FN4NaO4Purity:98%Color and Shape:SolidMolecular weight:488.49GSK-3484862
CAS:Gsk-3484862 is a non covalent inhibitor of DNA methyltransferase DNMT1 with anticancer activity.Formula:C19H19N5OSPurity:99.87% - 99.963%Color and Shape:SolidMolecular weight:365.45Ref: TM-T11469
1mg48.00€5mg113.00€10mg177.00€25mg318.00€50mg485.00€100mg692.00€500mg1,395.00€1mL*10mM (DMSO)203.00€MAK683-CH2CH2COOH
CAS:MAK683-CH2CH2COOH, an EED-targeting chemical, serves as a foundation for EED degrader-1 and PROTAC EED degrader-2 design.Formula:C23H21FN6O3Purity:98%Color and Shape:SolidMolecular weight:448.45MARK-IN-1
CAS:MARK-IN-1 is a potent microtubule affinity regulating kinase (MARK) inhibitor, (IC50<0.25 nM).Formula:C22H23F2N7OSPurity:98%Color and Shape:SolidMolecular weight:471.53CBP/p300-IN-15
CAS:CBP/p300-IN-15 inhibits p300 (IC50: 2.5 nM) & CBP (28 nM), affects OVCAR-3 (EC50: 0.865 μM) & A2780 cells (2.71 μM) for ovarian cancer research.Formula:C26H28N4O5Color and Shape:SolidMolecular weight:476.52Upadacitinib tartrate
CAS:Upadacitinib: potent, selective JAK1 inhibitor, 74x preferential to JAK2, effective in rat arthritis.Formula:C21H33F3N6O11Purity:98%Color and Shape:SolidMolecular weight:602.521HDAC6-IN-34
CAS:HDAC6-IN-34 (compound 21), an orally active, selective HDAC6 inhibitor, exhibits an IC50 of 18 nM. It enhances tubulin acetylation levels without impacting histone acetylation in cutaneous T-cell lymphoma cells and suppresses TNF-α secretion in LPS-stimulated macrophage cells. Furthermore, HDAC6-IN-34 demonstrates outstanding anti-arthritic efficacy in rats [1].Formula:C18H18F3N3O3Color and Shape:SolidMolecular weight:381.35(1s,4s)-Menin-MLL inhibitor-23
(1s,4s)-Menin-MLL Inhibitor-23, an enantiomer of Menin-MLL Inhibitor-23 (Example 99A), functions as an inhibitor of the menin-MLL interaction [1].Formula:C36H53FN6O4Color and Shape:SolidMolecular weight:652.84VTX-27
CAS:VTX-27 is a selective inhibitor of protein kinase C θ (PKC θ) (Kis: 0.08 nM and 16 nM for PKC θ and PKC δ).Formula:C20H24ClFN6OPurity:99.84%Color and Shape:SolidMolecular weight:418.9Ref: TM-T13314
1mg88.00€2mg118.00€5mg230.00€10mg344.00€25mg532.00€50mg740.00€100mg982.00€1mL*10mM (DMSO)213.00€DNMT-IN-3
CAS:DNMT-IN-3 is a DNA Methyltransferase (DNMT) inhibitor with an IC50 of 60 nM against Plasmodium falciparum (Plasmodium), demonstrating antimalarial activity and suitability for malaria-related research [1].Formula:C37H39N7OColor and Shape:SolidMolecular weight:597.75PHD2/HDACs-IN-1
CAS:PHD2/HDACs-IN-1: strong PHD2/HDAC inhibitor (IC50: 1.15-26.60 μM), low-toxicity, protects kidneys from cisplatin-induced AKI.Formula:C18H19N9O4Color and Shape:SolidMolecular weight:425.4BRD-IN-3
CAS:BRD-IN-3 is a highly potent PCAF bromodomain (BRD) inhibitor (IC50: 7 nM). It also exhibits activity against GCN5 and FALZ.Formula:C21H25N5O3Purity:98%Color and Shape:SolidMolecular weight:395.45EPZ-030456
CAS:EPZ-030456 is an effective and selective inhibitor of the SMYD3.Formula:C28H34ClN5O4SColor and Shape:SolidMolecular weight:572.12
