Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2235 products of "Chromatin/Epigenetics"
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AZD-1897
CAS:<p>AZD-1897 is a highly efficient ATP-competitive pan-PIM inhibitor with anti-cancer and anti-leukemia activity, used in multiple myeloma research.</p>Formula:C18H23N3O3SPurity:99.49%Color and Shape:SolidMolecular weight:361.46PNZ5
CAS:<p>PNZ5, an isoxazole-based pan-BET inhibitor, demonstrates potent activity and high selectivity comparable to the established (+)-JQ1, exhibiting a dissociation</p>Formula:C20H18N2O2Purity:99.51% - 99.61%Color and Shape:SolidMolecular weight:318.37KBH-A42
CAS:<p>KBH-A42 is an inhibitor of histone deacetylase.</p>Formula:C17H22N2O3Purity:98%Color and Shape:SolidMolecular weight:302.37JAK3/BTK-IN-1
CAS:<p>JAK3/ BTk-in-1 is a dual JAK3/BTK inhibitor that specifically targets and inhibits Janus kinase 3 (JAK3) and Bruton's tyrosine kinase (BTK), two important</p>Formula:C25H28N8OPurity:97.89%Color and Shape:SolidMolecular weight:456.54DS-437
CAS:<p>DS-437 is a dual PRMT5/7 inhibitor (IC50s: 6 μM). DS-437 also inhibits DNMT3A and DNMT3B (IC50s: 52 and 62 μM). DS-437 inhibits the methylation of FOXP3.</p>Formula:C15H23N7O4SPurity:98%Color and Shape:SolidMolecular weight:397.45JAK-IN-10
CAS:<p>JAK-IN-10 is a JAK inhibitor. JAK-IN-10 can be used for the research of dry eye disorders.</p>Formula:C20H18FN5O3SPurity:99.53%Color and Shape:SolidMolecular weight:427.45(2R/S)-6-PNG
CAS:<p>(2R/S)-6-PNG (6-Prenylnaringenin) from hops is a natural histone deacetylase inhibitor that blocks T-type calcium channels reducing neurogenicity in mice.</p>Formula:C20H20O5Purity:98%Color and Shape:SolidMolecular weight:340.37SW155246
CAS:<p>SW155246 is a potent and selective inhibitor of DNMT1 (DNA methyltransferase 1; IC50 of 1.2 μM).</p>Formula:C16H11ClN2O5SPurity:98.99%Color and Shape:SolidMolecular weight:378.79SIRT5 inhibitor 5
CAS:<p>SIRT5 inhibitor 5 is a selective and substrate-competitive SIRT5 inhibitor, which does not occupy the NAD+ binding pocket,cancer and metabolism-related disease.</p>Formula:C21H14ClN3O3SPurity:99.33%Color and Shape:SolidMolecular weight:423.87EPZ032597
CAS:<p>EPZ032597 is a novel selective inhibitor of SMYD2 with an IC50 of 16 nM. EPZ032597 has anticancer activity and prevent and treat pancreatic cancer</p>Formula:C20H23N7OPurity:99.70%Color and Shape:SolidMolecular weight:377.44KP-302
CAS:<p>KP-302 is a selective PAD inhibitor, reversing physical disability in multiple sclerosis (MS) mice and clearing T-cell infiltration in the brain.</p>Formula:C20H23N5O2Purity:99.77%Color and Shape:SolidMolecular weight:365.43JAK-IN-28
CAS:<p>JAK-IN-28 (Compound 111) is a Janus kinase (JAK) inhibitor potentially applicable in the research of cancer and inflammatory diseases [1].</p>Formula:C20H18ClN7OPurity:98%Color and Shape:SolidMolecular weight:407.86Valemetostat tosylate
CAS:<p>Valemetostat tosylate is a dual inhibitor of EZH1/2 and used in the research of relapsed/refractory peripheral T-cell lymphoma.</p>Formula:C33H42ClN3O7SPurity:98%Color and Shape:SolidMolecular weight:660.22BET-IN-7
CAS:<p>BET-IN-7 is a potent BET inhibitor with a Ki of 12.27 μM and Kd of 89.3 μM, useful in sepsis research.</p>Formula:C18H12ClN3OSColor and Shape:SolidMolecular weight:353.83Furamidine
CAS:<p>Furamidine is a PRMT1-selective, cell-permeable inhibitor (IC50: 9.4μM), also targeting TDP-1, and is an antiparasitic bisbenzamidine derivative.</p>Formula:C18H16N4OPurity:98%Color and Shape:SolidMolecular weight:304.35GSK360A
CAS:<p>GSK360A is a novel prolyl hydroxylase (PHD) domain-containing enzyme inhibitor.</p>Formula:C17H17FN2O5Purity:98%Color and Shape:SolidMolecular weight:348.33Ilorasertib hydrochloride
CAS:<p>Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s:</p>Formula:C25H22ClFN6O2SPurity:98.45%Color and Shape:SolidMolecular weight:525JAK-IN-14
CAS:<p>JAK-IN-14 (compound 16) is a specific JAK1 inhibitor. It prevents JAK1 phosphorylation by binding to the active site of JAK in immune, inflammation and cancer.</p>Formula:C19H15FN4OPurity:98.27%Color and Shape:SolidMolecular weight:334.35Aurora kinase inhibitor-10
CAS:<p>Aurora kinase inhibitor-10 is an orally active Aurora B inhibitor (IC50: 8 nM) that exhibits antitumour effects.</p>Formula:C21H19F5N6O4SColor and Shape:SolidMolecular weight:546.47MT477
CAS:<p>MT477 inhibits PKC-α, impairs Ras/ERK1/2 phosphorylation, induces apoptosis, and reduces proliferation in various cancer cells.</p>Formula:C31H30N2O12S3Color and Shape:SolidMolecular weight:718.77Rucaparib camsylate
CAS:<p>Rucaparib camsylate, a PARP-1, -2, -3 inhibitor (Ki=1.4 nM for PARP-1) & H6PD blocker, may treat resistant prostate cancer.</p>Formula:C19H18FN3O·xC10H16O4SColor and Shape:SolidHIF-PHD-IN-2
CAS:<p>HIF-PHD-IN-2 (compound 25) is a highly effective PHD inhibitor, displaying IC50 values below 100 nM for PHD1, PHD2, and PHD3 [1].</p>Formula:C17H15N5O3SColor and Shape:SolidMolecular weight:369.4dWIZ-1
CAS:<p>dWIZ-1 ((rac)-dWIZ-1) is a potent WIZ molecular gel degrader tha induction of haemoglobin fetalis (HbF) in erythroblasts, sickle cell disease (SCD).</p>Formula:C22H29N3O4Purity:92.87% - 92.87%Color and Shape:SolidMolecular weight:399.48Y08284
CAS:<p>Y08284: selective CBP bromodomain inhibitor, IC50: 4.21 nM, oral. Halts prostate cancer cell growth; anti-tumor.</p>Formula:C26H25FN4O4Color and Shape:SolidMolecular weight:476.5HIF-1/2α-IN-2
CAS:<p>HIF-1/2α-IN-2 is a potent inhibitor of HIF-1/2α, which effectively reduces the levels of HIF-1/2α.</p>Formula:C16H11FN4O2SColor and Shape:SolidMolecular weight:342.35Tetrahydrouridine
CAS:<p>Tetrahydrouridine (NSC-112907; THU) is a multidrug resistance modulator.</p>Formula:C9H16N2O6Purity:98%Color and Shape:SolidMolecular weight:248.23Bizine
CAS:<p>Bizine, a Phenelzine analogue, selectively inhibits LSD1 (Ki=59 nM), modulates histone methylation in cancer, and may have neuroprotective uses.</p>Formula:C18H23N3OColor and Shape:SolidMolecular weight:297.39Thi-DPPY
CAS:<p>Thi-DPPY: Potent JAK3/BTK inhibitor (IC50: 1.38/62.4 nM), anti-proliferative, anti-inflammatory, potential in IPF research.</p>Formula:C28H28ClN5O4SColor and Shape:SolidMolecular weight:566.07HDAC3-IN-T247
CAS:<p>HDAC3-IN-T247 (HDAC3 inhibitor T247) is a histone deacetylase 3 (HDAC3) inhibitor with antiviral activity that inhibits the proliferation of cancer cells.</p>Formula:C21H19N5OSPurity:98.11% - 98.94%Color and Shape:SolidMolecular weight:389.47SIRT1-IN-2
CAS:<p>SIRT1-IN-2 (compound 3h) is a potent and selective inhibitor of SIRT1 (silent information regulator 1) with an IC 50 of 1.6 μM [1].</p>Formula:C13H15ClN2OColor and Shape:SolidMolecular weight:250.72IDO1 and HDAC1 Inhibitor
CAS:<p>IDO1 and HDAC1 Inhibitor is a dual IDO1 and HDAC1 inhibitor (IC50s: 69.0 nM and 66.5 nM).</p>Formula:C25H22BrFN8O4Purity:98%Color and Shape:SolidMolecular weight:597.4HDAC-IN-49
<p>HDAC-IN-49: potent, broad HDAC inhibitor; IC50s: 10-1880 nM for HDAC1-6; strong anti-leukemic, low toxicity to healthy cells.</p>Formula:C26H27FN4O4Color and Shape:SolidMolecular weight:478.52CYP51/HDAC-IN-1
CAS:<p>Orally active CYP51/HDAC-IN-1 dual inhibitor targets virulence factors and resistance genes; effective against Candidiasis and Cryptococcal meningitis.</p>Formula:C30H40F2N6O4Color and Shape:SolidMolecular weight:586.67TFMB-(S)-2-HG
CAS:<p>TFMB-(S)-2-HG (TFMB S 2 HG) is a highly effective inhibitor of TET2, the 5'-methylcytosine hydroxylase.</p>Formula:C13H11F3O4Purity:98.07%Color and Shape:SolidMolecular weight:288.22Sirt1/2-IN-1
CAS:<p>Sirt1/2-IN-1 inhibits SIRT1 (IC50: 1.81 μg/mL) and SIRT2 (2.10 μg/mL), less on SIRT3 (20.5 μg/mL), with anticancer properties.</p>Formula:C22H13ClN2OS2Color and Shape:SolidMolecular weight:420.93HDAC6-IN-15
<p>HDAC6-IN-15: selective HDAC6 inhibitor, IC50 of 38.2 nM, for cancer and neurodegenerative research.</p>Formula:C25H28FFeN3O2Color and Shape:SolidMolecular weight:477.35M133
CAS:<p>M133 is a selective histone deacetylase HDAC1 and HDAC2 inhibitor and potent antitumor agent.</p>Formula:C23H24N4OS2Color and Shape:SolidMolecular weight:436.59CBHA
CAS:<p>m-Carboxycinnamic bishydroxamide: HDAC inhibitor, ID50 = 10 nM (HDAC1), 70 nM (HDAC3), induces apoptosis and tumor growth suppression.</p>Formula:C10H10N2O4Color and Shape:SolidMolecular weight:222.2Peficitinib hydrobromide
CAS:<p>Peficitinib hydrobromide is used in the treatment of Psoriasis and Rheumatoid Arthritis.</p>Formula:C18H23BrN4O2Color and Shape:SolidMolecular weight:407.312PIM-1 Inhibitor 2
CAS:<p>PIM-1 Inhibitor 2 (PIM1-IN-2) is a potent Pim-1 inhibitor with potential anti-cancer activity, used in cancer research.</p>Formula:C17H11ClN4OPurity:98.81%Color and Shape:SolidMolecular weight:322.75MI-2-2
CAS:<p>MI-2-2 is an inhibitor of bivalent protein-protein interaction between menin and MLL with an IC50 of 46 nM. MI-2-2 binds to menin with Kd of 22 nM.</p>Formula:C17H20F3N5S2Purity:99.65%Color and Shape:SolidMolecular weight:415.5OUL245
CAS:<p>OUL245: A selective PARP2 inhibitor (IC50=44nM), also inhibits other PARPs/TNKS (IC50=2.9-8.8μM).</p>Formula:C8H5N3OSColor and Shape:SolidMolecular weight:191.21YM-53601
CAS:<p>YM-53601 is an SQS inhibitor that inhibits adipogenic biosynthesis and lipid secretion in rodents.YM-53601 is a cholesterol-lowering agent that inhibits FDFT1.</p>Formula:C21H22ClFN2OPurity:99.65%Color and Shape:SolidMolecular weight:372.86IACS-9571
CAS:<p>IACS-9571 is a selective and potent inhibitor of TRIM24 and BRPF1, (IC50: 8 nM for TRIM24; Kds: 31 nM and 14 nM for TRIM24 and BRPF1).</p>Formula:C32H42N4O8SPurity:98%Color and Shape:SolidMolecular weight:642.76Tyk2-IN-5
CAS:<p>Tyk2-IN-5 is a selective and orally active inhibitor of Tyk2 JH2 (Ki: 0.086 nM for Tyk2 JH2; IC50: 25 nM for IFNα).</p>Formula:C21H19FN8O2Purity:98%Color and Shape:SolidMolecular weight:434.43CPI703
CAS:<p>CPI703 is a novel potent and specific CBP/EP300 bromodomain inhibitor.</p>Formula:C17H22N4OPurity:98%Color and Shape:SolidMolecular weight:298.38JAK3/BTK-IN-2
CAS:<p>JAK3/ BTk-in-2 is a potent JAK3/BTK inhibitor.</p>Formula:C25H32N8O2Purity:99.64% - 99.87%Color and Shape:SolidMolecular weight:476.57Bromodomain IN-1
CAS:<p>Bromodomain IN-1 is an inhibitor of Bromodomain.</p>Formula:C22H23ClN4O3SPurity:98%Color and Shape:SolidMolecular weight:458.962′-Deoxy-5-nitrocytidine
CAS:<p>2′-Deoxy-5-nitrocytidine is a DNA Methyltransferase inhibitor that can be used for cancer research[1].</p>Formula:C9H12N4O6Color and Shape:SolidMolecular weight:272.216-Methyl-5-azacytidine
CAS:<p>6-Methyl-5-azacytidine is a potent DNMT inhibitor.</p>Formula:C9H14N4O5Purity:98%Color and Shape:SolidMolecular weight:258.23
