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DNA Damage/DNA Repair

DNA Damage/DNA Repair

DNA damage/DNA repair inhibitors are compounds that interfere with the processes involved in detecting and repairing DNA damage. These inhibitors are critical for studying the mechanisms of genomic stability, mutagenesis, and the response to DNA damage. They are also important in cancer research, as many tumors rely on specific DNA repair pathways for survival. By inhibiting these pathways, DNA damage/DNA repair inhibitors can enhance the effectiveness of chemotherapy and radiation therapy. At CymitQuimica, we provide a diverse range of high-quality DNA damage/DNA repair inhibitors to support your research in molecular biology, oncology, and pharmacology.

Subcategories of "DNA Damage/DNA Repair"

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Found 958 products of "DNA Damage/DNA Repair"

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  • 17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic Acid
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    17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic Acid

    CAS:
    <p>Aspirin-enhanced COX-2 metabolite of DHA, activates Nrf2 and PPARγ, inhibits inflammation, with EC50 ~200 nM, effective at 5-25 μM.</p>
    Formula:C22H30O3
    Color and Shape:Solid
    Molecular weight:342.479

    Ref: TM-T37633

  • Silatecan
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    Silatecan

    CAS:
    <p>Silatecan is a useful organic compound for research related to life sciences. The catalog number is T67968 and the CAS number is 220913-32-6.</p>
    Formula:C26H30N2O5Si
    Color and Shape:Soild
    Molecular weight:478.61

    Ref: TM-T67968

  • GJ071 oxalate
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    GJ071 oxalate

    CAS:
    <p>GJ071 oxalate is a Nonsense suppressor that induces readthrough by inserting amino acids at premature termination codons.</p>
    Formula:C20H29N3O7S
    Purity:99.97%
    Color and Shape:Solid
    Molecular weight:455.53

    Ref: TM-T31932

  • Saroglitazar Magnesium
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    Saroglitazar Magnesium

    CAS:
    <p>Saroglitazar Magnesium: a PPAR agonist, strong on PPARα (EC50 0.65pM), moderate on PPARγ (EC50 3nM).</p>
    Formula:C50H56MgN2O8S2
    Purity:98.1%
    Color and Shape:Solid
    Molecular weight:901.43

    Ref: TM-T12834

  • Wistin
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    Wistin

    CAS:
    <p>Wistin, isolated from Caragana sinica roots, is a PPARα and PPARγ agonist [1] [2] .</p>
    Formula:C23H24O10
    Color and Shape:Solid
    Molecular weight:460.43

    Ref: TM-T75690

  • TRF1-TIN2 interaction-IN-1
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    TRF1-TIN2 interaction-IN-1

    <p>TRF1-TIN2 interaction-IN-1 (Compound 40) is an inhibitor of the TRF1-TIN2 interaction. It binds to the TRFH domain of TRF1 (KD= 29 μM) and competitively inhibits the binding of the TIN2 peptide (IC50= 67 μM). By occupying a hotspot at the TRF1-TIN2 interface, TRF1-TIN2 interaction-IN-1 disrupts the interaction between TRF1 and TIN2. This compound can remove TRF1 from the shelterin complex, making it useful for research on shelterin-related cancers.</p>
    Formula:C19H18O6S
    Color and Shape:Solid
    Molecular weight:374.41

    Ref: TM-T207708

  • (±)4(5)-DiHDPA lactone
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    (±)4(5)-DiHDPA lactone

    CAS:
    <p>(±)5(6)-DiHET lactone is a 1,5 cyclic ester derived from (±)5(6)-DiHET , which, in turn, is a potential derivative of epoxidation of arachidonic acid at the α-5</p>
    Formula:C22H32O3
    Color and Shape:Solid
    Molecular weight:344.495

    Ref: TM-T37240

  • Z26395438
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    Z26395438

    CAS:
    <p>Z26395438 is an inhibitor of Sirtuin-1 with IC50 of 1.6 μM.</p>
    Formula:C17H15FN2O
    Purity:99.63%
    Color and Shape:Solid
    Molecular weight:282.31

    Ref: TM-T77653

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    PPAR agonist 6

    <p>PPAR agonist6 (compound 5a) acts as an agonist for PPAR, exhibiting EC50 values of 3.6 μM and 2.6 μM for PPARα and PPARβ/δ respectively. Additionally, PPAR agonist6 inhibits the transactivation of a TNFα-dependent NF-κB-driven reporter gene in L929 cells [1].</p>
    Color and Shape:Odour Solid

    Ref: TM-T206860

  • Dichlorogelignate
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    Dichlorogelignate

    CAS:
    <p>Dichlorogelignate (compound 4) acts as a selective inhibitor of topoisomerase II (Topo II), achieving 100% inhibition at 50 μM [1].</p>
    Formula:C32H34O18
    Color and Shape:Solid
    Molecular weight:706.6

    Ref: TM-TN7670

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    GpC Methyltransferase

    <p>GpC Methyltransferase (GpC) is an enzyme that methylates DNA, specifically targeting cytosine residues within GpC dinucleotides of non-nucleosomal DNA in vitro.</p>

    Ref: TM-TRP-00354

  • CAY10599
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    CAY10599

    CAS:
    <p>CAY10599 has a wide range of applications in life science related research.</p>
    Formula:C38H41NO5
    Color and Shape:Solid
    Molecular weight:591.748

    Ref: TM-T37830

  • Topoisomerase IIα-IN-9
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    Topoisomerase IIα-IN-9

    CAS:
    <p>Compound EN300-20599, with CAS No. 16346-97-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound EN300-20599 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>
    Formula:C14H14O4S
    Color and Shape:Solid
    Molecular weight:278.32

    Ref: TM-TPL0577

  • Et-29
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    Et-29

    CAS:
    <p>Et-29 is a selective inhibitor of SIRT5 inhibitor with a Ki of 40 nM.</p>
    Formula:C34H46N6O6S
    Purity:99.52%
    Color and Shape:Solid
    Molecular weight:666.83

    Ref: TM-T35347

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    NHC-triphosphate tetrasodium

    <p>NHC-triphosphate tetrasodium, a metabolite of β-d-N4-Hydroxycytidine, acts as a viral polymerase substrate affecting HCV RNA replication.</p>
    Formula:C9H12N3Na4O15P3
    Color and Shape:Solid
    Molecular weight:587.08

    Ref: TM-T74070

  • HDAC-IN-52
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    HDAC-IN-52

    CAS:
    <p>HDAC-IN-52: Pyridine-based inhibitor for HDAC1/2/3/10 with IC50s 0.189-0.446 μM, used in cancer studies.</p>
    Formula:C24H20N4O2
    Purity:99.47%
    Color and Shape:Solid
    Molecular weight:396.44

    Ref: TM-T67878

  • Anti-obesity agent 1
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    Anti-obesity agent 1

    <p>Compound 4 (Anti-obesity agent 1) demonstrates potential for enhanced lipolysis, highlighting its anti-obesity characteristics.</p>
    Formula:C21H22N2O6
    Color and Shape:Solid
    Molecular weight:398.409

    Ref: TM-T204516

  • Tibesaikosaponin V
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    Tibesaikosaponin V

    CAS:
    <p>TKV, a triterpene diglycoside from Bupleurum chinense, curbs lipid build-up and fat content in adipocytes without harm and hinders fat cell differentiation.</p>
    Formula:C42H68O15
    Color and Shape:Solid
    Molecular weight:812.98

    Ref: TM-T75611

  • (R)-VX-984
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    (R)-VX-984

    CAS:
    <p>(R)-VX-984 ((R)-M9831) is the (R)-enantiomer of VX-984. VX-984 is a potent inhibitor of DNA-PK.</p>
    Formula:C23H21D2N7O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:415.49

    Ref: TM-T12648

  • ABP/PPAR modulator 1
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    ABP/PPAR modulator 1

    <p>ABP/PPAR modulator 1 is an orally active multi-regulator of FABP and PPAR, exhibiting IC50 values of 0.65 μM for FABP1 and 1.08 μM for FABP4, and EC50 values of 9.19 μM, 2.20 μM, and 1.58 μM for PPARα, PPARγ, and PPARδ, respectively. It demonstrates potent activity against metabolic dysfunction-associated steatohepatitis (MASH). Additionally, ABP/PPAR modulator 1 dose-dependently improves various pathological features of fatty liver in a WD + Carbon tetrachloride-induced MASH mouse model.</p>
    Formula:C33H39NO7
    Color and Shape:Solid
    Molecular weight:561.67

    Ref: TM-T207742