DNA Alkylation
DNA alkylation involves the addition of alkyl groups to the DNA molecule, leading to the formation of lesions that can interfere with DNA replication and transcription. DNA alkylating agents are commonly used in cancer chemotherapy to induce DNA damage in rapidly dividing cells. However, cells have mechanisms to repair these lesions, and inhibitors of DNA alkylation repair pathways can enhance the efficacy of alkylating agents. At CymitQuimica, we offer a selection of high-quality DNA alkylation reagents and inhibitors to support your research in DNA damage, repair mechanisms, and cancer therapy.
Found 22 products for "DNA Alkylation".
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Methyl methanesulfonate
CAS:Methyl methanesulfonate alkylates adenine and guanine, causing base mismatches and replication issues.Formula:C2H6O3SPurity:99.69%Color and Shape:SolidMolecular weight:110.13Chlorambucil
CAS:Chlorambucil (CB-1348) is an orally-active antineoplastic aromatic nitrogen mustard.Formula:C14H19Cl2NO2Purity:97.37% - 98.45%Color and Shape:Off-White Slightly Granular Powder Melting Point 65-69°CMolecular weight:304.21Altretamine
CAS:Altretamine (ENT-50852) is an alkylating agent with antineoplastic activity.Formula:C9H18N6Purity:99.54%Color and Shape:White SolidMolecular weight:210.2794N-Ethyl-N-nitrosourea
CAS:N-Ethyl-N-nitrosourea (ENU) is a DNA alkylating agent that damages DNA, inducing bone marrow suppression, leukemia, tumorigenesis, and genetic disorders.Formula:C3H7N3O2Purity:99.97%Color and Shape:White SolidMolecular weight:117.11Phosphoramide mustard
CAS:Phosphoramide mustard is a toxic metabolite of cyclophosphamide with anticancer activity and ovarian toxicity that induces DNA damage.Formula:C4H11Cl2N2O2PPurity:93% - 93.00%Color and Shape:SolidMolecular weight:221.02Melphalan
CAS:Melphalan is an orally bioavailable DNA alkylating agent exhibiting antitumour activity, commonly employed in cancer chemotherapy.Formula:C13H18Cl2N2O2Purity:98.03%Color and Shape:White SolidMolecular weight:305.2Methyl methanesulfonate (Standard)
CAS:Methyl methanesulfonate (Standard) is a standard material used in the analysis of methyl methanesulfonate, typically referenced in its research and analysis.Formula:C2H6O3SColor and Shape:SolidMolecular weight:110.13Phosphoramide mustard cyclohexanamine
CAS:Phosphoramide mustard cyclohexanamine is active metabolite of cyclophosphamide, an alkylating agent that cross-links DNA strands,causes cell death, antitumor.Formula:C10H24Cl2N3O2PPurity:95%Color and Shape:SolidMolecular weight:320.20GNE-3511
CAS:GNE-3511 is a potent and selective dual leucine zipper kinase inhibitors.Formula:C23H26F2N6OPurity:98.3% - 99.51%Color and Shape:SolidMolecular weight:440.4889VAL-083
CAS:VAL-083 (Dianhydrogalactitol) is an alkylating compound that creates N7 methylation on DNA. It also has antitumor activity.Formula:C6H10O4Purity:97.94%Color and Shape:SolidMolecular weight:146.1412Treosulfan
CAS:Treosulfan (NSC 39069) is a bifunctional alkylating agent used in the treatment of advanced ovarian cancer.Cost-effective and quality-assured.Formula:C6H14O8S2Purity:99.26% - 99.83%Color and Shape:SolidMolecular weight:278.301Carmustine
CAS:Carmustine (bis-chloroethylnitrosourea) is a cell-cycle phase nonspecific alkylating antineoplastic agent.Formula:C5H9Cl2N3O2Purity:98% - 99.97%Color and Shape:Yellow LiquidMolecular weight:214.05Palifosfamide
CAS:Palifosfamide lysine (ZIO-201) stable, effective vs. sarcomas in vitro. IC50: 2.25-6.75 μM, except OS222 at 31.5 μM.Formula:C4H11Cl2N2O2PPurity:99.72%Color and Shape:Transparent ViscousMolecular weight:221.02Lomeguatrib
CAS:Lomeguatrib (PaTrin-2), a modified guanine base, inhibits the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) .Formula:C10H8BrN5OSPurity:99.26% - >99.99%Color and Shape:SolidMolecular weight:326.17Tretazicar
CAS:CB1954, an anticancer prodrug, turns into a potent alkylating agent when activated by NQO2 and EP-0152R.Formula:C9H8N4O5Purity:99.41% - 99.7%Color and Shape:White SolidMolecular weight:252.1836Satraplatin
CAS:Satraplatin (BMS182751) is an orally available antineoplastic platinum(IV) complex.Satraplatin has a favorable toxicity profile and appears to have clinicalFormula:C10H22Cl2N2O4PtPurity:98.25%Color and Shape:SolidMolecular weight:500.28LIV-1205
LIV-1205 is an antibody inhibitor that targets DLK1 and can be used to study DLK1-related signaling pathways and mechanisms.Purity:97.5% (SDS-PAGE); 100% (SEC-HPLC) - 97.5% (SDS-PAGE); 100% (SEC-HPLC)Miriplatin hydrate
CAS:Miriplatin hydrate (SM-11355 (hydrate)) (MPT) is a novel platinum complex used in TACE that shows promise for the treatment of hepatocellular carcinoma (HCC).Formula:C34H70N2O5PtPurity:99.6%Color and Shape:White SolidMolecular weight:782.01DN-1289
DN-1289: oral, BBB-penetrating, selectively inhibits DLK (IC50=17nM) & LZK (IC50=40nM), blocks p-c-Jun in mouse optic nerve crush.Formula:C18H19F4N7O2Purity:99.03%Color and Shape:SolidMolecular weight:441.38GNE-8505
CAS:GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK).Formula:C21H24F3N5OColor and Shape:SolidMolecular weight:419.44
