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DNA Damage/DNA Repair

DNA Damage/DNA Repair

DNA damage/DNA repair inhibitors are compounds that interfere with the processes involved in detecting and repairing DNA damage. These inhibitors are critical for studying the mechanisms of genomic stability, mutagenesis, and the response to DNA damage. They are also important in cancer research, as many tumors rely on specific DNA repair pathways for survival. By inhibiting these pathways, DNA damage/DNA repair inhibitors can enhance the effectiveness of chemotherapy and radiation therapy. At CymitQuimica, we provide a diverse range of high-quality DNA damage/DNA repair inhibitors to support your research in molecular biology, oncology, and pharmacology.

Subcategories of "DNA Damage/DNA Repair"

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Found 958 products of "DNA Damage/DNA Repair"

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  • Tenifatecan
    Targetmol
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    Tenifatecan

    CAS:
    <p>Tenifatecan (SN2310) is a highly lipophilic preparation of 7-ethyl-10-hydroxycamptothecin (SN) with potential antitumor activity.</p>
    Formula:C55H72N2O9
    Purity:99.58% - 99.82%
    Color and Shape:Solid
    Molecular weight:905.17

    Ref: TM-T67812

  • SS-208
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    SS-208

    CAS:
    <p>SS-208 is a selective inhibitor of HDAC6 (IC50 = 12 nM) with anti-tumor activity. SS-208 shows selectivity over other HDAC subtypes.</p>
    Formula:C13H11Cl2N3O4
    Purity:99.69%
    Color and Shape:Solid
    Molecular weight:344.15

    Ref: TM-T16936

  • (R)-(-)-Rolipram
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    (R)-(-)-Rolipram

    CAS:
    <p>(R)-(-)-Rolipram ((-)-Rolipram) is an R-enantiomer of Rolipram which is a PDE4 inhibitor.</p>
    Formula:C16H21NO3
    Purity:99.54%
    Color and Shape:Solid
    Molecular weight:275.34

    Ref: TM-T13448

  • Givinostat hydrochloride
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    Givinostat hydrochloride

    CAS:
    <p>Givinostat HCl (ITF2357 HCl) inhibits HDAC1/3 (IC50: 198/157 nM) with anti-inflammatory, anti-angiogenic, and antineoplastic properties.</p>
    Formula:C24H28ClN3O4
    Purity:99.39%
    Color and Shape:Solid
    Molecular weight:457.95

    Ref: TM-T6279L

  • EB-47
    Targetmol
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    EB-47

    CAS:
    <p>EB-47 imitates NAD+, spans nicotinamide to adenosine sites, inhibits PARP-1 (IC50: 45 nM) and is less effective on ARTD5 (IC50: 410 nM).</p>
    Formula:C24H27N9O6
    Purity:99.81%
    Color and Shape:Solid
    Molecular weight:537.53

    Ref: TM-T11143

  • CEP-9722
    Targetmol
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    CEP-9722

    CAS:
    <p>CEP-9722 is a PARP-1 and PARP-2 inhibitor with anticancer activity and is used in the study of ovarian cancer.</p>
    Formula:C24H26N4O3
    Purity:98.38% - 98.56%
    Color and Shape:Solid
    Molecular weight:418.49

    Ref: TM-T62196

  • ACY-957
    Targetmol
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    ACY-957

    CAS:
    <p>ACY-957: Oral HDAC1/2 inhibitor (IC50: HDAC1=7nM, HDAC2=18nM, HDAC3=1300nM); inactive on HDAC4/5/6/7/8/9.</p>
    Formula:C24H23N5OS
    Purity:99.79%
    Color and Shape:Solid
    Molecular weight:429.54

    Ref: TM-T10245

  • OUL232
    Targetmol
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    OUL232

    CAS:
    <p>OUL232 is a potent single ARTs PARP7, PARP10, PARP11, PARP12, PARP14 and PARP15 inhibitor for cancer and tumour research.</p>
    Formula:C10H10N4O2S
    Purity:99.04%
    Color and Shape:Solid
    Molecular weight:250.28

    Ref: TM-T73496

  • ACY-1083
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    ACY-1083

    CAS:
    <p>ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor (IC50: 3 nM) and effectively reverses chemotherapy-induced peripheral neuropathy.</p>
    Formula:C17H18F2N4O2
    Purity:99.19% - 99.43%
    Color and Shape:Solid
    Molecular weight:348.35

    Ref: TM-T10244

  • BRD4097
    Targetmol
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    BRD4097

    CAS:
    <p>BRD4097, a negative control in the HDAC1/2/3/8 assay, is a selective histone deacetylase (HDAC3) inhibitor that can be used to protect b-cells and improve</p>
    Formula:C16H17N3O2
    Purity:99.75%
    Color and Shape:Solid
    Molecular weight:283.33

    Ref: TM-T30579

  • BRD2492
    Targetmol
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    BRD2492

    CAS:
    <p>BRD2492 is an HDAC1 and HDAC2 inhibitor with antiproliferative activity, inhibits HDAC1/2 and induces apoptosis.</p>
    Formula:C20H18N4O2
    Purity:99.56%
    Color and Shape:Solid
    Molecular weight:346.38

    Ref: TM-T26897

  • KRP-101
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    KRP-101

    CAS:
    <p>KRP-101, a PPARɑ agonist, is used potentially for the treatment of diabetes and hyperlipidaemia.</p>
    Formula:C26H26FNO5
    Color and Shape:Solid
    Molecular weight:451.49

    Ref: TM-T27746

  • PPARγ agonist 7
    Targetmol
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    PPARγ agonist 7

    CAS:
    <p>PPARγ agonist 7 (Compound 3a) is a highly potent and selective agonist of the peroxisome proliferator-activated receptor gamma (PPARγ).</p>
    Formula:C20H30O6
    Color and Shape:Solid
    Molecular weight:366.45

    Ref: TM-T61417

  • K-756
    Targetmol
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    K-756

    CAS:
    <p>K-756 is a direct and selective inhibitor of tankyrase (TNKS), which inhibits the ADP-ribosylation activity of TNKS1 (IC50 = 31 nM) and TNKS2 (IC50 = 36 nM).</p>
    Formula:C24H27N5O3
    Purity:99.81%
    Color and Shape:Solid
    Molecular weight:433.5

    Ref: TM-T15639

  • L-783483
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    L-783483

    CAS:
    <p>L-783483 is an agonist of PPAR.</p>
    Formula:C22H21ClF3NO4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:487.92

    Ref: TM-T27784

  • ATR-IN-21
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    ATR-IN-21

    CAS:
    <p>ATR-IN-21, also known as compound 60, is a potent inhibitor of ATR, exhibiting an IC50 of less than 1000 nM [1].</p>
    Formula:C23H27N7O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:417.51

    Ref: TM-T79031

  • HDAC8-IN-4
    Targetmol
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    HDAC8-IN-4

    CAS:
    <p>HDAC8-IN-4 is a selective HDAC8 inhibitor, exhibiting inhibitory activity with IC50 values of 0.15 μM for HDAC8 and 12 μM for HDAC3 [1].</p>
    Formula:C17H14N2O2S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:342.44

    Ref: TM-T79082

  • Duocarmycin analog-2
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    Duocarmycin analog-2

    CAS:
    <p>Duocarmycin analog-2 is a potent DNA alkylating agent that exhibits antitumor effects and can be used in the synthesis of immunocouplers.</p>
    Formula:C29H23ClN4O3
    Color and Shape:Solid
    Molecular weight:510.97

    Ref: TM-T63523

  • GNE-8505
    Targetmol
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    GNE-8505

    CAS:
    <p>GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK).</p>
    Formula:C21H24F3N5O
    Color and Shape:Solid
    Molecular weight:419.44

    Ref: TM-T11440

  • CM-579 trihydrochloride (1846570-40-8 free base)
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    CM-579 trihydrochloride (1846570-40-8 free base)

    <p>CM-579 trihydrochloride is a first-in-class reversible and dual inhibitor of G9a and DNMT (IC50s: 16 nM, 32 nM) with potent in vitro cellular activity in a wide</p>
    Formula:C29H43Cl3N4O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:602.04

    Ref: TM-T10840

  • LCB-2853
    Targetmol
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    LCB-2853

    CAS:
    <p>LCB-2853 is a potent thromboxane A2/prostaglandin H2 (TXA2/PGH2) receptor antagonist with antiplatelet aggregation, antivasospasm, and antithrombotic effects.</p>
    Formula:C21H24ClNO4S
    Purity:97.15%
    Color and Shape:Solid
    Molecular weight:421.94

    Ref: TM-T11825

  • ARN-21934
    Targetmol
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    ARN-21934

    CAS:
    <p>ARN-21934 inhibits human topoisomerase II α/β; IC50=2μM; stronger than Etoposide (IC50=120μM) in DNA relaxation.</p>
    Formula:C21H24N6
    Purity:99.8%
    Color and Shape:Solid
    Molecular weight:360.46

    Ref: TM-T36968

  • XY-4
    Targetmol
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    XY-4

    CAS:
    <p>XY-4, a derivative of 1-palmitoyl lysophosphatidic acid (1-palmitoyl LPA094) and an agonist of peroxisome proliferator-activated receptor γ (PPARγ), effectively</p>
    Formula:C19H37F2O6P
    Color and Shape:Solid
    Molecular weight:430.46

    Ref: TM-T83882

  • Bocodepsin hydrochloride
    Targetmol
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    Bocodepsin hydrochloride

    CAS:
    <p>Bocodepsin hydrochloride (OKI-179) is a selective HDAC inhibitor with antitumor properties, efficacious via oral administration.</p>
    Formula:C26H40ClN5O6S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:618.21

    Ref: TM-T79840

  • TP0480066
    Targetmol
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    TP0480066

    CAS:
    <p>TP0480066 inhibits topoisomerase II, DNA gyrase (IC50=1.1nM), topo IV (IC50=62.89nM), effective against drug-resistant bacteria and N. gonorrhoeae.</p>
    Formula:C18H14FN3O5
    Color and Shape:Solid
    Molecular weight:371.32

    Ref: TM-T61481

  • Topoisomerase IIα-IN-8
    Targetmol
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    Topoisomerase IIα-IN-8

    CAS:
    <p>Topoisomerase IIα-IN-8 (compound 15) serves as a modest inhibitor of human DNA topoisomerase IIα (htIIα), exhibiting an inhibitory concentration (IC50) of 462 ± 38.0 μM [1].</p>
    Formula:C15H15FN6O
    Color and Shape:Solid
    Molecular weight:314.324

    Ref: TM-T84739

  • ATR-IN-13
    Targetmol
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    ATR-IN-13

    CAS:
    <p>ATR-IN-13 is a potent inhibitor of ATR kinases (IC50: 2 nM) and can be used to study ATR kinase-mediated diseases (e.g. proliferative diseases, cancer).</p>
    Formula:C24H24FN9O
    Color and Shape:Solid
    Molecular weight:473.51

    Ref: TM-T63066

  • GSK-3484862
    Targetmol
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    GSK-3484862

    CAS:
    <p>Gsk-3484862 is a non covalent inhibitor of DNA methyltransferase DNMT1 with anticancer activity.</p>
    Formula:C19H19N5OS
    Purity:99.87% - 99.963%
    Color and Shape:Solid
    Molecular weight:365.45

    Ref: TM-T11469

  • Peliglitazar
    Targetmol
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    Peliglitazar

    CAS:
    <p>Peliglitazar is a activator of α/γ peroxisome proliferator-activated receptor.</p>
    Formula:C30H30N2O7
    Color and Shape:Solid
    Molecular weight:530.57

    Ref: TM-T28354

  • SR 2595
    Targetmol
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    SR 2595

    CAS:
    <p>SR2595 is an inverse agonist of nuclear receptor PPARγ with an IC 50 of 30 nM [1].</p>
    Formula:C37H38N2O3
    Color and Shape:Solid
    Molecular weight:558.71

    Ref: TM-T22154

  • BMS-250749
    Targetmol
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    BMS-250749

    CAS:
    <p>BMS-250749 is a fluoroglycosylated fluoroindolocarbazole, it has antitumor activity.</p>
    Formula:C26H18F3N3O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:525.43

    Ref: TM-T26845

  • HDAC6-IN-21
    Targetmol
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    HDAC6-IN-21

    CAS:
    <p>HDAC6-IN-21 (compound 13) is an irreversible inhibitor of histone deacetylase 6 (HDAC6) [1].</p>
    Formula:C14H13F2N5O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:321.28

    Ref: TM-T82226

  • DS-6930
    Targetmol
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    DS-6930

    CAS:
    <p>DS-6930 is an potent and selective PPAR γ Agonists with EC50 of 41 nM.</p>
    Formula:C23H21N3O4
    Color and Shape:Solid
    Molecular weight:403.43

    Ref: TM-T61976

  • CM-675
    Targetmol
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    CM-675

    CAS:
    <p>CM-675 is a dual inhibitor of phosphodiesterase 5 (PDE5) and class I histone deacetylases (IC50s: 114 nM and 673 nM for PDE5 and HDAC1) with the potential to</p>
    Formula:C31H32N6O3
    Purity:99.82%
    Color and Shape:Solid
    Molecular weight:536.62

    Ref: TM-T10841

  • SIRT6-IN-3
    Targetmol
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    SIRT6-IN-3

    CAS:
    <p>SIRT6-IN-3 (compound 8a), a selective SIRT6 inhibitor (IC50 = 7.49 μM), impedes the proliferation of pancreatic ductal adenocarcinoma (PDAC) cells and prompts</p>
    Formula:C21H30Br3ClN6S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:673.73

    Ref: TM-T79689

  • Makaluvamine A
    Targetmol
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    Makaluvamine A

    CAS:
    <p>Makaluvamine A comes from the fruiting bodies of Didymium bahiense that act as active anti-cancer agents and DNA topo II inhibitors.</p>
    Formula:C11H11N3O
    Color and Shape:Solid
    Molecular weight:201.22

    Ref: TM-T70592

  • Tankyrase-IN-5
    Targetmol
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    Tankyrase-IN-5

    CAS:
    <p>Tankyrase-IN-5 (Compound 30f), structurally related to MSC2504877, effectively inhibits tankyrase isoforms TNKS1 and TNKS2, with half-maximal inhibitory</p>
    Formula:C17H18N2O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:282.34

    Ref: TM-T79026

  • SU-11752
    Targetmol
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    SU-11752

    CAS:
    <p>SU-11752 selectively inhibits DNA-PK by competing with ATP, enhances ionizing radiation sensitivity without affecting cell cycle or ATM activity.</p>
    Formula:C26H27N3O5S
    Color and Shape:Solid
    Molecular weight:493.57

    Ref: TM-T68870

  • Pparδ agonist 1
    Targetmol
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    Pparδ agonist 1

    CAS:
    <p>Pparδ agonist 1 is an agonist of PPAR-δ(EC50 of 5.06 nM).</p>
    Formula:C26H27NO5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:433.5

    Ref: TM-T12528

  • U-46619
    Targetmol
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    U-46619

    CAS:
    <p>U-46619 is an effective thromboxane A2 (TXA2) agonist and a thromboxane A2 analog (endoperoxide), capable of inducing contraction in the aortic smooth muscle (</p>
    Formula:C21H34O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:350.49

    Ref: TM-T17189

  • ATR-IN-20
    Targetmol
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    ATR-IN-20

    <p>ATR-IN-20: potent ATR inhibitor, IC50=3nM; inhibits mTOR, IC50=18nM; selective vs PI3Kα, ATM, DNA-PK; good pharmacokinetics; anticancer.</p>
    Formula:C29H31N5O4S
    Color and Shape:Solid
    Molecular weight:545.65

    Ref: TM-T73301

  • CAY10410
    Targetmol
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    CAY10410

    CAS:
    <p>CAY10410 is a PGD2/PGJ2 analog, modified for enhanced PPARγ activity and metabolic stability, non-toxic to SH-SY5Y cells at ≤25μM.</p>
    Formula:C20H30O3
    Color and Shape:Solid
    Molecular weight:318.45

    Ref: TM-T35811

  • LMP744 hydrochloride
    Targetmol
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    LMP744 hydrochloride

    CAS:
    <p>LMP744 hydrochloride (NSC-706744 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity. </p>
    Formula:C24H25ClN2O7
    Purity:99.59% - 99.85%
    Color and Shape:Solid
    Molecular weight:488.92

    Ref: TM-T11872L

  • AZ 5704
    Targetmol
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    AZ 5704

    CAS:
    <p>ATM kinase inhibitor with 0.6 nM IC50, &gt;600-fold selective, enhances irinotecan effects, oral use.</p>
    Formula:C23H23FN6O2
    Color and Shape:Solid
    Molecular weight:434.47

    Ref: TM-T35942

  • 9A1P9
    Targetmol
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    9A1P9

    CAS:
    <p>9A1P9, a multi-tail ionizable cationic phospholipid, facilitates membrane destabilization and is applicable for CRISPR-Cas9 gene editing in mice [1].</p>
    Formula:C27H58NO4P
    Color and Shape:Solid
    Molecular weight:491.73

    Ref: TM-T84640

  • BO 2367
    Targetmol
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    BO 2367

    CAS:
    <p>BO 2367, a topoisomerase inhibitor, is used to suppress the growth of tumor .</p>
    Formula:C21H22ClF2N3O3
    Color and Shape:Solid
    Molecular weight:437.87

    Ref: TM-T26883

  • ATR-IN-22
    Targetmol
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    ATR-IN-22

    CAS:
    <p>ATR-IN-22 (Compound 34), an orally active ATR inhibitor, exhibits potent anti-proliferative effects on MIAPaCa-2 cells with an IC50 value of less than 1 μM and</p>
    Formula:C25H31N7O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:445.56

    Ref: TM-T79033

  • ATR-IN-5
    Targetmol
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    ATR-IN-5

    CAS:
    <p>ATR-IN-5 is a potent inhibitor of ATR, a member of the PIKK family of proteins involved in genome stability and DNA damage repair.</p>
    Formula:C27H32F3N9O
    Color and Shape:Solid
    Molecular weight:555.6

    Ref: TM-T63923

  • Topoisomerase I inhibitor 9
    Targetmol
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    Topoisomerase I inhibitor 9

    CAS:
    <p>Topoisomerase I Inhibitor 9 (compound 3d), a specific inhibitor of leishmanial topoisomerase IB, exhibits antileishmanial activity, demonstrating an IC50 value</p>
    Formula:C23H15Br2FN2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:498.19

    Ref: TM-T80967

  • Topoisomerase inhibitor 2
    Targetmol
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    Topoisomerase inhibitor 2

    CAS:
    <p>Topoisomerase Inhibitor 2 (18C) is a broad-spectrum bacterial topoisomerase inhibitor effective against multidrug-resistant Gram-negative bacteria [1].</p>
    Formula:C23H23N5O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:433.46

    Ref: TM-T78717