DNA Damage/DNA Repair

DNA damage/DNA repair inhibitors are compounds that interfere with the processes involved in detecting and repairing DNA damage. These inhibitors are critical for studying the mechanisms of genomic stability, mutagenesis, and the response to DNA damage. They are also important in cancer research, as many tumors rely on specific DNA repair pathways for survival. By inhibiting these pathways, DNA damage/DNA repair inhibitors can enhance the effectiveness of chemotherapy and radiation therapy. At CymitQuimica, we provide a diverse range of high-quality DNA damage/DNA repair inhibitors to support your research in molecular biology, oncology, and pharmacology.

Subcategories of "DNA Damage/DNA Repair"

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Found 957 products of "DNA Damage/DNA Repair"

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Antitumor agent-28
CAS:
- 2097499-67-5
Antitumor agent-28 inhibits ATM kinase, blocking ATM disease progression and showing anti-cancer effects.
Formula:C₂₅H₃₂N₆O₄S
Color and Shape:Solid
Molecular weight:512.63
Ref: TM-T39523
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Becatecarin
CAS:
- 119673-08-4
Becatecarin, water-soluble and anti-cancer, inhibits topoisomerases I/II and induces DNA cleavage and apoptosis; has myelosuppressive effects; ABCG2 substrate.
Formula:C₃₃H₃₄Cl₂N₄O₇
Color and Shape:Solid
Molecular weight:669.56
Ref: TM-T36485
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CUDA disodium
CUDA disodium is an effective, soluble epoxide hydrolase (sEH) inhibitor, with IC50 values of 11.1 nM for murine sEH and 112 nM for human sEH. It selectively enhances the activity of peroxisome proliferator-activated receptor PPARalpha. CUDA disodium may be valuable for cardiovascular disease research.
Color and Shape:Odour Solid
Ref: TM-T206289
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Wistin
CAS:
- 19046-26-5
Wistin, isolated from Caragana sinica roots, is a PPARα and PPARγ agonist [1] [2] .
Formula:C₂₃H₂₄O₁₀
Color and Shape:Solid
Molecular weight:460.43
Ref: TM-T75690
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WAY-323061
CAS:
- 550301-63-8
WAY-323061 is a SIRT2 inhibitor.
Formula:C₂₅H₂₁N₅O₂S
Purity:99.33%
Color and Shape:Solid
Molecular weight:455.53
Ref: TM-T77605
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Hippeastrine Hydrobromide
CAS:
- 22352-41-6
Hippeastrine hydrobromide is a natural alkaloid which demonstrates significant cytotoxicity against a panel of human and murine tumor cell lines.
Formula:C₁₇H₁₈BrNO₅
Color and Shape:Solid
Molecular weight:396.237
Ref: TM-T32077
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Sulotroban
CAS:
- 72131-33-0
sulotroban is a TXA2 receptor antagonist that acts synergistically with iloprost to inhibit TXA2-dependent platelet activation.
Formula:C₁₆H₁₇NO₅S
Purity:98.86% - 99.88%
Color and Shape:Solid
Molecular weight:335.37
Ref: TM-T68022
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TAS-103
CAS:
- 174634-08-3
TAS-103 is a dual inhibitor of DNA topoisomerase I/II, used for cancer research.
Formula:C₂₀H₁₉N₃O₂
Color and Shape:Solid
Molecular weight:333.38
Ref: TM-T36695
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Leriglitazone hydrochloride
CAS:
- 146062-46-6
Leriglitazone hydrochloride, a pioglitazone metabolite, is a PPARγ agonist with Ki of 1.2 μM and EC50 of 680 nM.
Formula:C₁₉H₂₁ClN₂O₄S
Color and Shape:Solid
Molecular weight:408.90
Ref: TM-T73842
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DNA Damage & Repair Compound Library
A unique collection of xnum DNA Damage &amp; Repair related compounds for high throughput screening (HTS) and high content screening (HCS);
Color and Shape:Odour Solid
Ref: TM-L3900
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GW 1929 hydrochloride
CAS:
- 1217466-21-1
Oral PPARγ agonist with pEC50 of 8.05; low affinity for PPARα, PPARδ. Reduces blood glucose, fatty acids, triglycerides in vivo.
Formula:C₃₀H₃₀ClN₃O₄
Color and Shape:Solid
Molecular weight:532.04
Ref: TM-T37579
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Gemfibrozil 1-O-β-glucuronide
CAS:
- 91683-38-4
Gemfibrozil 1-O-β-Glucuronide, a metabolite of Gemfibrozil , is a potent and competitive P450 (CYP) isoform CYP2C8 inhibitor with an IC50 of 4.07 μM.
Formula:C₂₁H₃₀O₉
Purity:98%
Color and Shape:Solid
Molecular weight:426.46
Ref: TM-T11387
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PR-104 sodium
CAS:
- 851627-80-0
PR-104 sodium: hypoxia-activated, tumor-targeting pre-prodrug; turns into PR-104A for research.
Formula:C₁₄H₁₉BrN₄NaO₁₂PS
Color and Shape:Solid
Molecular weight:601.25
Ref: TM-T40947
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Banoxantrone (D12)
CAS:
- 1562067-05-3
Banoxantrone D12, deuterium-labeled version, reduces to AQ4 - a stable DNA-targeting topoisomerase II inhibitor.
Formula:C₂₂H₂₈N₄O₆
Purity:98%
Color and Shape:Solid
Molecular weight:456.55
Ref: TM-T10458
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Monascin
CAS:
- 21516-68-7
Monascin: azaphilonoid in red-mold rice; anti-tumor and anti-inflammatory.
Formula:C₂₁H₂₆O₅
Purity:98%
Color and Shape:Solid
Molecular weight:358.43
Ref: TM-T12093
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ARN24139
ARN24139: a topoisomerase II poison; IC50=7.3μM. Inhibits DU145, HeLa, A549 cell growth; IC50s=4.7, 3.8, 3.1μM.
Color and Shape:Solid
Ref: TM-T36969
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Methylation Compound Library
xnum methylation-related compounds that can be used for high-throughput and high-content screening.
Color and Shape:Odour Solid
Ref: TM-L3510
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15-deoxy-Δ-12,14-Prostaglandin J2
CAS:
- 87893-55-8
15-deoxy-Δ-12,14-Prostaglandin J2 is a PPARγ agonist.
Formula:C₂₀H₂₈O₃
Purity:98%
Color and Shape:Neat Oil
Molecular weight:316.43
Ref: TM-T22473
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CL2-MMT-SN38
CAS:
- 1084888-82-3
CL2-MMT-SN38 is a derivative of SN-38, which is a potent anticancer agent and the active metabolite of Irinotecan (CPT-11), a Topoisomerase I inhibitor.
Formula:C₁₀₂H₁₂₂N₁₂O₂₄
Color and Shape:Solid
Molecular weight:1900.158
Ref: TM-T38474
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CH-0793076
CAS:
- 534605-78-2
CH-0793076: hexacyclic camptothecin, TP300 metabolite, targets BCRP, inhibits DNA topo I (IC50: 2.3 μM).
Formula:C₂₆H₂₆N₄O₄
Purity:98%
Color and Shape:Solid
Molecular weight:458.51
Ref: TM-T14945
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DB1255 2TFA
DB1255 2TFA is an ERG/DNA binding inhibitor with an unusual and potent monomer binding pattern at the minor groove site for the study of genetic disorders.
Formula:C₂₆H₂₀F₆N₄O₄S₂
Purity:98.32%
Color and Shape:Solid
Molecular weight:630.58
Ref: TM-T68359L
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25-Hydroxytachysterol3
CAS:
- 39932-44-0
25-Hydroxytachysterol3 is a metabolite of Vitamin D3 that inhibits the proliferation of epidermal keratinocytes and dermal fibroblasts while promoting the differentiation of keratinocytes and the expression of antioxidant-related genes. It activates receptors including the vitamin D receptor (VDR), aryl hydrocarbon receptor (AhR), liver X receptor α/β (LXRα/β), and peroxisome proliferator-activated receptor γ (PPARγ), and enhances the expression of CYP24A1.
Formula:C₂₇H₄₄O₂
Color and Shape:Solid
Molecular weight:400.64
Ref: TM-T88081
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(±)9-HEPE
CAS:
- 286390-03-2
(±)9-HEPE is produced by non-enzymatic oxidation of EPA.
Formula:C₂₀H₃₀O₃
Color and Shape:Solid
Molecular weight:318.457
Ref: TM-T36609
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1-O-Hexadecyl-Rac-Glycerol
CAS:
- 6145-69-3
1-O-Hexadecyl-Rac-Glycerol (1-O-Hexadecylglycerol) is a marine derived natural products found in Tritoniella belli.
Formula:C₁₉H₄₀O₃
Purity:99.94%
Color and Shape:Solid
Molecular weight:316.52
Ref: TM-TN7182
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HDAC6-IN-50
HDAC6-IN-50 (Compound 4) is an effective inhibitor of HDAC6 with an IC50 value of 35 nM. It is utilized in the study of Parkinson's disease (PD) and Alzheimer's disease (AD).
Color and Shape:Odour Solid
Ref: TM-T200562
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TRF1-TIN2 interaction-IN-1
TRF1-TIN2 interaction-IN-1 (Compound 40) is an inhibitor of the TRF1-TIN2 interaction. It binds to the TRFH domain of TRF1 (KD= 29 μM) and competitively inhibits the binding of the TIN2 peptide (IC50= 67 μM). By occupying a hotspot at the TRF1-TIN2 interface, TRF1-TIN2 interaction-IN-1 disrupts the interaction between TRF1 and TIN2. This compound can remove TRF1 from the shelterin complex, making it useful for research on shelterin-related cancers.
Formula:C₁₉H₁₈O₆S
Color and Shape:Solid
Molecular weight:374.41
Ref: TM-T207708
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Gimatecan HCl
Gimatecan HCl (ST1481 HCL) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.
Formula:C₂₅H₂₆ClN₃O₅
Purity:97.04%
Color and Shape:Soild
Molecular weight:483.94
Ref: TM-T21319L
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Multi-target kinase inhibitor 4
Multi-target kinase inhibitor 4 (Compound 2) is a PI3K/DNA-PK inhibitor and a potent chemosensitizer that enhances the number of DNA double-strand breaks induced by Doxorubicin. It serves as an effective multidrug resistance (MDR) inhibitor, demonstrating inhibitory activity against P-glycoprotein (P-gp) mediated drug efflux. Multi-target kinase inhibitor 4 can be encapsulated in PEG-coated lipid nanoparticles.
Color and Shape:Odour Solid
Ref: TM-T206635
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Hippeastrine
CAS:
- 477-17-8
Hippeastrine is an alkaloid that inhibits Top I dose-dependently with a 7.25 μg/mL IC50 and has anticancer properties.
Formula:C₁₇H₁₇NO₅
Color and Shape:Solid
Molecular weight:315.32
Ref: TM-T75655
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Et-29
CAS:
- 2166487-23-4
Et-29 is a selective inhibitor of SIRT5 inhibitor with a Ki of 40 nM.
Formula:C₃₄H₄₆N₆O₆S
Purity:99.52%
Color and Shape:Solid
Molecular weight:666.83
Ref: TM-T35347
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(±)4(5)-DiHDPA lactone
CAS:
- 845673-68-9
(±)5(6)-DiHET lactone is a 1,5 cyclic ester derived from (±)5(6)-DiHET , which, in turn, is a potential derivative of epoxidation of arachidonic acid at the α-5
Formula:C₂₂H₃₂O₃
Color and Shape:Solid
Molecular weight:344.495
Ref: TM-T37240
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CP 84364
CAS:
- 114457-62-4
CP 84364 is a metabolite of CP-80794.
Formula:C₁₄H₁₈N₂O₄
Color and Shape:Solid
Molecular weight:278.30
Ref: TM-T31034
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AsCas12a Nuclease
AsCas12a Nuclease is a CRISPR nuclease capable of specifically cleaving double-stranded DNA. It is used in gene editing research.
Ref: TM-TRP-00356
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HDAC-IN-52
CAS:
- 2075787-77-6
HDAC-IN-52: Pyridine-based inhibitor for HDAC1/2/3/10 with IC50s 0.189-0.446 μM, used in cancer studies.
Formula:C₂₄H₂₀N₄O₂
Purity:99.47%
Color and Shape:Solid
Molecular weight:396.44
Ref: TM-T67878
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17-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid
CAS:
- 1233715-33-7
DPA metabolite 17-oxo-DPA, found in fish oil, spurs antioxidant genes, modulates inflammation, and activates PPARγ (EC50 ≈ 200 nM).
Formula:C₂₂H₃₂O₃
Color and Shape:Solid
Molecular weight:344.495
Ref: TM-T37634
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17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic Acid
CAS:
- 1233715-28-0
Aspirin-enhanced COX-2 metabolite of DHA, activates Nrf2 and PPARγ, inhibits inflammation, with EC50 ~200 nM, effective at 5-25 μM.
Formula:C₂₂H₃₀O₃
Color and Shape:Solid
Molecular weight:342.479
Ref: TM-T37633
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Saroglitazar Magnesium
CAS:
- 1639792-20-3
Saroglitazar Magnesium: a PPAR agonist, strong on PPARα (EC50 0.65pM), moderate on PPARγ (EC50 3nM).
Formula:C₅₀H₅₆MgN₂O₈S₂
Purity:98.1%
Color and Shape:Solid
Molecular weight:901.43
Ref: TM-T12834
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Stearolic acid
CAS:
- 506-24-1
Stearolic acid is a useful organic compound for research related to life sciences. The catalog number is T124753 and the CAS number is 506-24-1.
Formula:C₁₈H₃₂O₂
Color and Shape:Solid
Molecular weight:280.452
Ref: TM-T124753
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Amorfrutin B
CAS:
- 78916-42-4
Amorfrutin B is a useful organic compound for research related to life sciences. The catalog number is T124211 and the CAS number is 78916-42-4.
Formula:C₂₆H₃₂O₄
Color and Shape:Solid
Molecular weight:408.538
Ref: TM-T124211
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STAT3/HDAC-IN-2
STAT3/HDAC-IN-2 (compound 18), a dual inhibitor of STAT3 and HDAC, promotes autophagy and apoptosis. This compound features an amphiphilic hydroxamic acid hybrid structure, derived from the natural product isopropanol lactone (IAL), and functions as a nanoscale anticancer agent. It has the ability to self-assemble into nanoparticles in aqueous environments, leading to enhanced tumor tissue accumulation, increased cellular uptake, and improved anticancer efficacy compared to its free state.
Formula:C₂₈H₃₂N₂O₇
Color and Shape:Solid
Molecular weight:508.56
Ref: TM-T200341
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Larsucosterol Ammonium salt
CAS:
- 2655654-16-1
Larsucosterol ammonium salt is a derivative of 25HC3S. It is a DNMT inhibitor, a LXR antagonist, an endogenous epigenetic modulator of lipid metabolism.
Formula:C₂₇H₄₉NO₅S
Purity:>99.99% - >99.99%
Color and Shape:Soild
Molecular weight:499.75
Ref: TM-T41015L
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PDPH Crosslinker
CAS:
- 115616-51-8
PDPH crosslinker(SPDP Hydrazide) is a lytic heterobisfunctional protein crosslinker.
Formula:C₈H₁₁N₃OS₂
Color and Shape:Solid
Molecular weight:229.32
Ref: TM-T33904
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GJ071 oxalate
CAS:
- 1216676-34-4
GJ071 oxalate is a Nonsense suppressor that induces readthrough by inserting amino acids at premature termination codons.
Formula:C₂₀H₂₉N₃O₇S
Purity:99.97%
Color and Shape:Solid
Molecular weight:455.53
Ref: TM-T31932
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SIRT3 activator 2
SIRT3 activator2 (compound 2a) acts as an activator of SIRT3. It is presumed to bind directly with SIRT3 in SH-SY5Y cells, as inferred through thermal stability, facilitating the SIRT3-dependent clearance of α-Syn. Furthermore, SIRT3 activator2 enhances motor functions in Parkinsonian mice and dose-dependently prevents the loss of dopaminergic (DA) neurons in the substantia nigra.
Formula:C₂₂H₂₄N₂O₉S
Color and Shape:Solid
Molecular weight:492.5
Ref: TM-T200160
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HDAC-IN-76
HDAC-IN-76 (compound 6i), a histone deacetylase (HDAC) inhibitor, demonstrates robust antimalarial activity, particularly against the asexual blood stages of Plasmodium. The compound exhibits potent efficacy with IC 50 values of 30 nM and 98 nM against Pf3D7 (chloroquine drug-susceptible strain) and PfDd2 (chloroquine drug-resistant strain), respectively. Moreover, HDAC-IN-76 shows selective inhibition towards parasites, displaying IC 50 values of 7 nM and 9 nM against human HDAC1 and HDAC6, respectively, and effectively inhibits PfHDAC1.
Formula:C₂₇H₂₆N₄O₄
Color and Shape:Solid
Molecular weight:470.52
Ref: TM-T200090
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(iso)-BRD20322
CAS:
- 2986118-54-9
(iso)-BRD20322 is an isomer of BRD20322, a novel potent inhibitor of spCas9，disrupts the binding of spCas9 to DNA and reduces non-specific DNA editing events.
Formula:C₂₇H₃₁N₃O₂
Purity:99.60% - 99.60%
Color and Shape:Soild
Molecular weight:429.55
Ref: TM-T69645L
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CHDI 00484077
CAS:
- 3025894-92-9
CHDI 00484077 is a highly selective, central nervous system (CNS) permeable Class IIa HDAC inhibitor, and can be used to study Huntington's disease.
Formula:C₁₈H₂₁F₃N₄O₂
Purity:99.26%
Color and Shape:Solid
Molecular weight:382.38
Ref: TM-T83946
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HDAC1/6-IN-2
HDAC1/6-IN-2 (I-c4), a dual inhibitor of HDAC1 and HDAC6, exhibits potent activity with IC50 values of 3.1 nM for HDAC1 and 2.95 nM for HDAC6. This compound demonstrates notable antitumor activity.
Formula:C₂₂H₁₇FN₄O₃
Color and Shape:Solid
Molecular weight:404.39
Ref: TM-T200400
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1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC
CAS:
- 59403-52-0
Phospholipid with stearic and docosahexaenoic acids used in membrane studies; decreases in ALS mouse model.
Formula:C₄₈H₈₄NO₈P
Color and Shape:Solid
Molecular weight:834.16
Ref: TM-T38218
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(R)-VX-984
CAS:
- 2448475-19-0
(R)-VX-984 ((R)-M9831) is the (R)-enantiomer of VX-984. VX-984 is a potent inhibitor of DNA-PK.
Formula:C₂₃H₂₁D₂N₇O
Purity:98%
Color and Shape:Solid
Molecular weight:415.49
Ref: TM-T12648