DNA Damage/DNA Repair
DNA damage/DNA repair inhibitors are compounds that interfere with the processes involved in detecting and repairing DNA damage. These inhibitors are critical for studying the mechanisms of genomic stability, mutagenesis, and the response to DNA damage. They are also important in cancer research, as many tumors rely on specific DNA repair pathways for survival. By inhibiting these pathways, DNA damage/DNA repair inhibitors can enhance the effectiveness of chemotherapy and radiation therapy. At CymitQuimica, we provide a diverse range of high-quality DNA damage/DNA repair inhibitors to support your research in molecular biology, oncology, and pharmacology.
Subcategories of "DNA Damage/DNA Repair"
- ATM/ATR(71 products)
- DNA Alkylation(11 products)
- DNA Methyltransferase(421 products)
- DNA gyrase(11 products)
- DNA-PK(51 products)
- MTH1(1 products)
- Nucleoside Antimetabolite/Analog(1,388 products)
- Reverse Transcriptase(43 products)
- Sirtuin(88 products)
- Telomerase(33 products)
- Topoisomerase(136 products)
Show 3 more subcategories
Found 958 products of "DNA Damage/DNA Repair"
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CAY10599
CAS:<p>CAY10599 has a wide range of applications in life science related research.</p>Formula:C38H41NO5Color and Shape:SolidMolecular weight:591.748Murrayanol
<p>Murrayanol is a useful organic compound for research related to life sciences and the catalog number is T125851.</p>Formula:C24H29NO2Color and Shape:SolidMolecular weight:363.501Top1/2-IN-1
<p>Compound 23, known as Top1/2-IN-1, is a dual inhibitor of Top1/2 that can be administered orally and exhibits antiproliferative effects. It induces apoptosis and cell cycle arrest in cancer cells by damaging DNA and elevating reactive oxygen species levels. Additionally, Top1/2-IN-1 demonstrates antitumor activity in vivo within xenograft models.</p>Formula:C21H21N3O2Color and Shape:SolidMolecular weight:347.41CUDA disodium
<p>CUDA disodium is an effective, soluble epoxide hydrolase (sEH) inhibitor, with IC50 values of 11.1 nM for murine sEH and 112 nM for human sEH. It selectively enhances the activity of peroxisome proliferator-activated receptor PPARalpha. CUDA disodium may be valuable for cardiovascular disease research.</p>Color and Shape:Odour SolidSP4e
<p>SP4e is a PPAR-γ activator.SP4e was effective in decreasing blood glucose, total cholesterol, triglycerides and LDL levels and increasing HDL levels.</p>Formula:C22H17ClN2O2S2Purity:99.79%Color and Shape:SoildMolecular weight:440.97TUG-499
CAS:<p>TUG-499 is a selective free fatty acid receptor 1 (FFAR1 or GPR40) agonist (EC50: 7.39).TUG-499 has an affinity for FFAR1 or GPR40 over the related receptors</p>Formula:C16H11Cl2NO2Purity:99.93%Color and Shape:SoildMolecular weight:320.17NSC 370284
CAS:<p>NSC 370284 inhibits STAT3/5, reducing AML cell viability with TET1 overexpression in vitro/in vivo.</p>Formula:C21H25NO6Purity:99.74%Color and Shape:SolidMolecular weight:387.43Stearolic acid
CAS:<p>Stearolic acid is a useful organic compound for research related to life sciences. The catalog number is T124753 and the CAS number is 506-24-1.</p>Formula:C18H32O2Color and Shape:SolidMolecular weight:280.452MPT0B390
CAS:<p>MPT0B390 is an inhibitor of HDAC and a TIMP3 inducer inhibiting tumor growth, metastasis, and angiogenesis.</p>Formula:C17H17N3O5SPurity:99.4%Color and Shape:SolidMolecular weight:375.4GpC Methyltransferase
<p>GpC Methyltransferase (GpC) is an enzyme that methylates DNA, specifically targeting cytosine residues within GpC dinucleotides of non-nucleosomal DNA in vitro.</p>Becatecarin
CAS:<p>Becatecarin, water-soluble and anti-cancer, inhibits topoisomerases I/II and induces DNA cleavage and apoptosis; has myelosuppressive effects; ABCG2 substrate.</p>Formula:C33H34Cl2N4O7Color and Shape:SolidMolecular weight:669.56WAY-323061
CAS:<p>WAY-323061 is a SIRT2 inhibitor.</p>Formula:C25H21N5O2SPurity:99.33%Color and Shape:SolidMolecular weight:455.53AsCas12a Nuclease
<p>AsCas12a Nuclease is a CRISPR nuclease capable of specifically cleaving double-stranded DNA. It is used in gene editing research.</p>Cytidine 5'-diphosphate trisodium salt
CAS:<p>CDP, a trisodium salt, helps synthesize DNA/RNA by aiding phosphoryl transfer from ATP to CMP via UMPK.</p>Formula:C9H15N3Na3O11P2Purity:99.55%Color and Shape:White Crystalline PowderMolecular weight:472.15PPARγ/GR modulator 1
<p>PPARγ/GR Modulator 1, an orally active dual agonist for the Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) and Glucocorticoid Receptor (GR), exhibits</p>Formula:C14H10FNO4Color and Shape:SolidMolecular weight:275.23Heliotrine N-oxide
CAS:<p>Heliotrine N-oxide, a PA N-oxide, triggers pyrrolic DNA adducts and may cause liver tumors.</p>Formula:C16H27NO6Color and Shape:SolidMolecular weight:329.393TNKS-2-IN-1
CAS:<p>TNKS-2-IN-1 inhibits TNKS1/2 (IC50: 259/1100 nM), has antimicrobial effects on E. coli/S. aureus, and blocks NLRP3/IL-1β release (IC50: 5 μM).</p>Formula:C14H9N3O3Purity:98.34%Color and Shape:SolidMolecular weight:267.24Dichlorogelignate
CAS:<p>Dichlorogelignate (compound 4) acts as a selective inhibitor of topoisomerase II (Topo II), achieving 100% inhibition at 50 μM [1].</p>Formula:C32H34O18Color and Shape:SolidMolecular weight:706.6PPAR agonist 6
<p>PPAR agonist6 (compound 5a) acts as an agonist for PPAR, exhibiting EC50 values of 3.6 μM and 2.6 μM for PPARα and PPARβ/δ respectively. Additionally, PPAR agonist6 inhibits the transactivation of a TNFα-dependent NF-κB-driven reporter gene in L929 cells [1].</p>Color and Shape:Odour SolidPARP/HDAC-IN-1
<p>PARP/HDAC-IN-1 is a PARP and HDAC inhibitor that inhibits PARP1, PARP2, and HDAC1, and may be used to study pancreatic cancer.</p>Formula:C36H32F2N6O3Purity:95.00%Color and Shape:SolidMolecular weight:634.67DNA Damage & Repair Compound Library
<p>A unique collection of xnum DNA Damage &amp; Repair related compounds for high throughput screening (HTS) and high content screening (HCS);</p>Color and Shape:Odour SolidSaroglitazar Magnesium
CAS:<p>Saroglitazar Magnesium: a PPAR agonist, strong on PPARα (EC50 0.65pM), moderate on PPARγ (EC50 3nM).</p>Formula:C50H56MgN2O8S2Purity:98.1%Color and Shape:SolidMolecular weight:901.43CH-0793076
CAS:<p>CH-0793076: hexacyclic camptothecin, TP300 metabolite, targets BCRP, inhibits DNA topo I (IC50: 2.3 μM).</p>Formula:C26H26N4O4Purity:98%Color and Shape:SolidMolecular weight:458.51Silatecan
CAS:<p>Silatecan is a useful organic compound for research related to life sciences. The catalog number is T67968 and the CAS number is 220913-32-6.</p>Formula:C26H30N2O5SiColor and Shape:SoildMolecular weight:478.61NHC-triphosphate tetrasodium
<p>NHC-triphosphate tetrasodium, a metabolite of β-d-N4-Hydroxycytidine, acts as a viral polymerase substrate affecting HCV RNA replication.</p>Formula:C9H12N3Na4O15P3Color and Shape:SolidMolecular weight:587.08Pericosine A
CAS:<p>Pericosine A, a fungal metabolite from P. byssoides, shows anticancer effects (GI50s = 0.05-24.55 μM) and EGFR inhibition (40-70% at 100 μg/ml).</p>Formula:C8H11ClO5Color and Shape:SolidMolecular weight:222.62ABP/PPAR modulator 1
<p>ABP/PPAR modulator 1 is an orally active multi-regulator of FABP and PPAR, exhibiting IC50 values of 0.65 μM for FABP1 and 1.08 μM for FABP4, and EC50 values of 9.19 μM, 2.20 μM, and 1.58 μM for PPARα, PPARγ, and PPARδ, respectively. It demonstrates potent activity against metabolic dysfunction-associated steatohepatitis (MASH). Additionally, ABP/PPAR modulator 1 dose-dependently improves various pathological features of fatty liver in a WD + Carbon tetrachloride-induced MASH mouse model.</p>Formula:C33H39NO7Color and Shape:SolidMolecular weight:561.67Gimatecan HCl
<p>Gimatecan HCl (ST1481 HCL) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.</p>Formula:C25H26ClN3O5Purity:97.04%Color and Shape:SoildMolecular weight:483.94Antitumor agent-63
CAS:<p>Compound 40, a non-toxic 20(S)-O-CPT glycoconjugate, is stable, with low Topo I inhibition.</p>Formula:C38H46N4O18Color and Shape:SolidMolecular weight:846.79SCR7
CAS:<p>SCR7, a specific DNA Ligase IV inhibitor, blocks nonhomologous end-joining (NHEJ).</p>Formula:C18H14N4OSPurity:98%Color and Shape:SolidMolecular weight:334.4CP 84364
CAS:<p>CP 84364 is a metabolite of CP-80794.</p>Formula:C14H18N2O4Color and Shape:SolidMolecular weight:278.30SpCas9 D10A Nickase
<p>SpCas9 D10A Nickase is a variant of the Cas9 protein. This mutation retains the functionality of one cleavage domain of the Cas9 nuclease, allowing it to specifically nick a target single strand. Additionally, SpCas9 D10A Nickase is effective in reducing off-target effects.</p>HDAC-IN-78
<p>HDAC-IN-78 (compound 66a) is an HDAC inhibitor utilized for cancer research.</p>Color and Shape:Odour SolidBanoxantrone (D12)
CAS:<p>Banoxantrone D12, deuterium-labeled version, reduces to AQ4 - a stable DNA-targeting topoisomerase II inhibitor.</p>Formula:C22H28N4O6Purity:98%Color and Shape:SolidMolecular weight:456.55DNMT1/HDAC-IN-1
<p>DNMT1/HDAC-IN-1 (compound (R)-23a), a potent dual inhibitor targeting both DNMT1 and HDAC, exhibits impressive inhibitory effects specifically on HDAC1 (HDAC1:IC50=0.05 μM), a major HDAC isoform that interacts with DNMT1 across multiple protein complexes involved in the transcriptional silencing of TSGs. This compound has been shown to remodel the tumor immune microenvironment and induce tumor regression, effectively reversing cancer-specific epigenetic abnormalities.</p>Color and Shape:Odour Solid20-carboxy Arachidonic Acid
CAS:<p>20-COOH-AA, 20-HETE metabolite, inhibits kidney ion transport, relaxes constricted vessels, and activates PPARα/γ.</p>Formula:C20H30O4Color and Shape:SolidMolecular weight:334.456SIRT-IN-5
<p>SIRT-IN-5, a selective inhibitor of SIRT3 with an IC50 of 2.88 μM, facilitates the differentiation of multiple myeloma cells. This differentiation is associated with increased expression of the differentiation antigens CD49e and human immunoglobulin light chains λ and κ.</p>Color and Shape:Odour SolidPR-104 sodium
CAS:<p>PR-104 sodium: hypoxia-activated, tumor-targeting pre-prodrug; turns into PR-104A for research.</p>Formula:C14H19BrN4NaO12PSColor and Shape:SolidMolecular weight:601.25Abd110
CAS:<p>Abd110 (compound 42i), a Lenalidomide-based PROTAC ATR kinase degrader, selectively reduces levels of ATR and phospho-ATR while not impacting the related kinases ATM and DNA-PKcs [1].</p>Formula:C41H42N8O7SColor and Shape:SolidMolecular weight:790.89nTZDpa
CAS:<p>nTZDpa is an antibiotic with antimicrobial activity.</p>Formula:C22H15Cl2NO2SColor and Shape:SolidMolecular weight:428.33PARP1-IN-8
CAS:<p>PARP1-IN-8 (N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide) is an effective inhibito of PARP1 (IC50 = 97 nM).</p>Formula:C23H18ClN3O2Purity:99.04%Color and Shape:SolidMolecular weight:403.86Anti-obesity agent 1
<p>Compound 4 (Anti-obesity agent 1) demonstrates potential for enhanced lipolysis, highlighting its anti-obesity characteristics.</p>Formula:C21H22N2O6Color and Shape:SolidMolecular weight:398.409Mca-VDQVDGW-Lys(Dnp)-NH2
<p>Mca-VDQVDGW-Lys(Dnp)-NH2, a fluorogenic substrate specific to caspase-7, facilitates the quantification of caspase-7 activity.</p>Formula:C60H74N14O21Color and Shape:SolidMolecular weight:1327.31Elomotecan
CAS:<p>Elomotecan (BN 80927 free base) is a potent inhibitor of topoisomerases I and II.Cost-effective and quality-assured.</p>Formula:C29H32ClN3O4Color and Shape:SolidMolecular weight:522.04IC 86621
CAS:<p>IC 86621: DNA-PK ATP-competitive inhibitor, IC50 120 nM, enhances DSB antitumor effects, EC50 68 µM for repair.</p>Formula:C12H15NO3Purity:99.68%Color and Shape:SolidMolecular weight:221.25Phosphoramide mustard
CAS:<p>Phosphoramide mustard is a toxic metabolite of cyclophosphamide with anticancer activity and ovarian toxicity that induces DNA damage.</p>Formula:C4H11Cl2N2O2PPurity:93.00%Color and Shape:SolidMolecular weight:221.0225-Hydroxytachysterol3
CAS:<p>25-Hydroxytachysterol3 is a metabolite of Vitamin D3 that inhibits the proliferation of epidermal keratinocytes and dermal fibroblasts while promoting the differentiation of keratinocytes and the expression of antioxidant-related genes. It activates receptors including the vitamin D receptor (VDR), aryl hydrocarbon receptor (AhR), liver X receptor α/β (LXRα/β), and peroxisome proliferator-activated receptor γ (PPARγ), and enhances the expression of CYP24A1.</p>Formula:C27H44O2Color and Shape:SolidMolecular weight:400.64GW 1929 hydrochloride
CAS:<p>Oral PPARγ agonist with pEC50 of 8.05; low affinity for PPARα, PPARδ. Reduces blood glucose, fatty acids, triglycerides in vivo.</p>Formula:C30H30ClN3O4Color and Shape:SolidMolecular weight:532.04Topoisomerase IIα-IN-9
CAS:<p>Compound EN300-20599, with CAS No. 16346-97-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound EN300-20599 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>Formula:C14H14O4SColor and Shape:SolidMolecular weight:278.32Anticancer agent 177
<p>Anticanceragent 177 (Compound 11b) is an NAMPT inhibitor and DNA alkylating agent with antitumor activity both in vitro and in vivo.</p>Formula:C28H36Cl2N4O2Molecular weight:530.22153
