Topoisomerase
Topoisomerases are enzymes that regulate the topology of DNA during processes such as replication, transcription, and chromosome segregation by introducing transient breaks into the DNA strands to relieve torsional stress. Topoisomerase inhibitors interfere with this process, leading to the accumulation of DNA breaks and the induction of cell death, particularly in rapidly dividing cells. These inhibitors are widely used as chemotherapeutic agents in cancer treatment. At CymitQuimica, we offer a broad range of high-quality topoisomerase inhibitors to support your research in DNA replication, cancer therapy, and cell cycle regulation.
Found 136 products of "Topoisomerase"
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Moxifloxacin hydrochloride
CAS:<p>Moxifloxacin hydrochloride (BAY12-8039 HCl) is a fourth generation fluoroquinolone with expanded activity against gram-positive bacteria and atypical pathogens.</p>Formula:C21H25ClFN3O4Purity:99.91% - >99.99%Color and Shape:SolidMolecular weight:437.89XR-11576 HCl
<p>XR-11576 HCl is a novel orally active dual topoisomerase I and II inhibitor with antitumor activity.</p>Formula:C23H25ClN4O2Purity:98.52%Color and Shape:SoildMolecular weight:424.92Berberine chloride
CAS:<p>Berberine chloride (Natural Yellow 18) is an alkaloid from Hydrastis canadensis L., Berberidaceae, and used orally for various fungal and parasitic infections.</p>Formula:C20H18ClNO4Purity:99.47% - 99.93%Color and Shape:Yellow Crystalline PowderMolecular weight:371.8Nalidixic acid
CAS:<p>Nalidixic acid (NSC-82174), a synthetic antimicrobial, targets bacterial DNA gyrase A, with a narrow bactericidal range.</p>Formula:C12H12N2O3Purity:99.9% - 99.95%Color and Shape:Pale Buff Crystalline Powder Physical Description Cream-Colored Powder (Ntp 1992)Molecular weight:232.24Doxorubicin hydrochloride
CAS:<p>Doxorubicin hydrochloride (Adriamycin) belongs to the anthracycline class of antibiotics and is an inhibitor of human DNA topoisomerase I/II (IC50=0.8/2.67 μM).</p>Formula:C27H29NO11·HClPurity:98% - 99.52%Color and Shape:Orange-Red At Neutral Phs And Violet Blue Over Ph 9 (Ntp 1992)Molecular weight:579.99Enoxacin hydrate
CAS:<p>Enoxacin hydrate (AT-2266 hydrate) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent.</p>Formula:C15H17FN4O3H2OPurity:99.50%Color and Shape:SolidMolecular weight:347.34Ciprofloxacin monohydrochloride
CAS:<p>Ciprofloxacin monohydrochloride (Bay-09867 hydrochloride) is a broad-spectrum antimicrobial carboxyfluoroquinoline.</p>Formula:C17H18FN3O3·HClPurity:99.5% - >99.99%Color and Shape:White Or Light Yellow Crystalline PowderMolecular weight:367.80Topotecan hydrochloride
CAS:<p>Topotecan hydrochloride (NSC609699) is an antineoplastic agent used to treat ovarian cancer.</p>Formula:C23H24ClN3O5Purity:97.88% - 99.41%Color and Shape:White Crystalline SolidMolecular weight:457.92DNA Damage & Repair Compound Library
<p>A unique collection of xnum DNA Damage &amp; Repair related compounds for high throughput screening (HTS) and high content screening (HCS);</p>Color and Shape:Odour SolidAuL1
<p>AuL1 is a topoisomerase IIα (Top II) inhibitor with DNA intercalating properties. It exhibits cytotoxic effects on tumor cells, making it a potential subject for anticancer agent research.</p>Formula:C29H50AuCl2N5Color and Shape:SolidMolecular weight:736.61Chimmitecan
CAS:<p>Chimmitecan ((S)-9-Allyl-10-hydroxycamptothecin) is a potent inhibitor of topoisomerase I and displays outstanding activity in vitro and in vivo.</p>Formula:C23H20N2O5Purity:98.35%Color and Shape:SoildMolecular weight:404.42Banoxantrone (D12)
CAS:<p>Banoxantrone D12, deuterium-labeled version, reduces to AQ4 - a stable DNA-targeting topoisomerase II inhibitor.</p>Formula:C22H28N4O6Purity:98%Color and Shape:SolidMolecular weight:456.55Garenoxacin
CAS:<p>Garenoxacin (BMS284756) is a novel oral des-fluoro(6) quinolone for the treatment of Gram-positive and Gram-negative bacterial infections.</p>Formula:C23H20F2N2O4Purity:98%Color and Shape:SolidMolecular weight:426.41CH-0793076
CAS:<p>CH-0793076: hexacyclic camptothecin, TP300 metabolite, targets BCRP, inhibits DNA topo I (IC50: 2.3 μM).</p>Formula:C26H26N4O4Purity:98%Color and Shape:SolidMolecular weight:458.51Topoisomerase II inhibitor 13
CAS:<p>WAY-323966 suppresses Topo II, strongly halts HL-60/MX2 cancer cell growth, resists Topo II toxicity.</p>Formula:C22H23N9Purity:98.4%Color and Shape:SoildMolecular weight:413.48Gimatecan HCl
<p>Gimatecan HCl (ST1481 HCL) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.</p>Formula:C25H26ClN3O5Purity:97.04%Color and Shape:SoildMolecular weight:483.94Top1/2-IN-1
<p>Compound 23, known as Top1/2-IN-1, is a dual inhibitor of Top1/2 that can be administered orally and exhibits antiproliferative effects. It induces apoptosis and cell cycle arrest in cancer cells by damaging DNA and elevating reactive oxygen species levels. Additionally, Top1/2-IN-1 demonstrates antitumor activity in vivo within xenograft models.</p>Formula:C21H21N3O2Color and Shape:SolidMolecular weight:347.41Topoisomerases/ribosomes-IN-1
<p>Topoisomerases/ribosomes-IN-1 (compound 30f) serves as an inhibitor targeting both ribosomes and topoisomerases, specifically exhibiting inhibitory actions against constitutively macrolide-resistant bacteria. This compound effectively suppresses bacterial protein synthesis (IC 50 : 0.647 μM) and hampers DNA replication (IC 50 : 0.218 μM).</p>Formula:C53H83FN6O15Color and Shape:SolidMolecular weight:1063.26TAK1 inhibitor
CAS:<p>TAK1 inhibitor is an inhibitor, which can inhibit MCF-7, A549, DU-145 and MDA MB-231, with IC50 of 0.021, 0.14, 0.064 and 0.19, respectively.</p>Formula:C22H19ClN6O2SPurity:98%Color and Shape:SoildMolecular weight:466.94Banoxantrone-d12 dihydrochloride
CAS:<p>Banoxantrone D12, a deuterium-labeled version, transforms into DNA-binding topoisomerase II inhibitor AQ4 upon reduction.</p>Formula:C22H30Cl2N4O6Purity:98%Color and Shape:SolidMolecular weight:529.48
