Topoisomerase
Topoisomerases are enzymes that regulate the topology of DNA during processes such as replication, transcription, and chromosome segregation by introducing transient breaks into the DNA strands to relieve torsional stress. Topoisomerase inhibitors interfere with this process, leading to the accumulation of DNA breaks and the induction of cell death, particularly in rapidly dividing cells. These inhibitors are widely used as chemotherapeutic agents in cancer treatment. At CymitQuimica, we offer a broad range of high-quality topoisomerase inhibitors to support your research in DNA replication, cancer therapy, and cell cycle regulation.
Found 135 products of "Topoisomerase"
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Topoisomerase I inhibitor 9
CAS:Topoisomerase I Inhibitor 9 (compound 3d), a specific inhibitor of leishmanial topoisomerase IB, exhibits antileishmanial activity, demonstrating an IC50 valueFormula:C23H15Br2FN2Purity:98%Color and Shape:SolidMolecular weight:498.19NH2-methylpropanamide-Exatecan TFA
CAS:Exatecan TFA, a methylpropanamide-modified derivative of the common ADC cytotoxin Exatecan, serves as a DNA topoisomerase I inhibitor with an IC50 of 2.2 μM (0.Formula:C30H30F4N4O7Purity:98%Color and Shape:SolidMolecular weight:634.58Trovafloxacin mesylate
CAS:Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).Formula:C21H19F3N4O6SPurity:99.18%Color and Shape:SolidMolecular weight:512.469-Chloromethyl-10-hydroxy-11-F-Camptothecin
CAS:9-Chloromethyl-10-hydroxy-11-F-Camptothecin, a novel derivative of camptothecin, functions as a DNA topoisomerase I (Topo I) inhibitor with potentialFormula:C22H18ClFN2O4Purity:98%Color and Shape:SolidMolecular weight:428.84Intoplicine
CAS:Intoplicine is an inhibitor of DNA topoisomerase I and II.Formula:C21H24N4OPurity:98%Color and Shape:SolidMolecular weight:348.44Topotecan acetate
CAS:Topotecan acetate is an inhibitor of topoisomerase.Formula:C25H27N3O7Color and Shape:SolidMolecular weight:481.498Anticancer agent 215
CAS:Anticanceragent 215 (1) is a camptothecin derivative with IC50 values of 5.2 nM and 8.2 nM against MCF-7 and MDA-MB-231 cells, respectively.Formula:C23H22FN3O4Color and Shape:SolidMolecular weight:423.44Topoisomerase I/II inhibitor 7
CAS:Compound 5h (Topoisomerase I/II inhibitor 7) is a Topoisomerase I/II inhibitor.Formula:C18H13ClN2O3Color and Shape:SolidMolecular weight:340.76Gimatecan
CAS:Gimatecan (STI481) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.Formula:C25H25N3O5Purity:98.47%Color and Shape:SolidMolecular weight:447.48LMP517
CAS:LMP517 (NSC 781517), an indenoisoquinoline, is a potent dual TOP1 and TOP2 inhibitor that shows better antitumor activity than its parent compound LMP744 against H82 (Small Cell Lung Cancer) xenografts, inducing TOP1 cleavage complexes (TOP1ccs) and TOP2ccs [1].Formula:C22H19FN2O5Color and Shape:SolidMolecular weight:410.4TH1338
CAS:TH1338 is an orally active camptothecin derivative with significant blood-brain barrier permeability and cytotoxicity, used in cancer research.
Formula:C22H21N3O4Purity:98.77%Color and Shape:SolidMolecular weight:391.42Topoisomerase II inhibitor 18
CAS:Topoisomerase II inhibitor 18 (Compound IV), a Quinoxaline derivative, exhibits an IC 50 of 7.5 μM in inhibiting topoisomerase II. It impedes PC-3 cell proliferation, arrests the cell cycle at the S phase, and induces apoptosis. Moreover, this compound demonstrates substantial antitumor activity against cancer [1].Formula:C20H21N3OSColor and Shape:SolidMolecular weight:351.47Karenitecin
CAS:Karenitecin (Cositecan) is an inhibitor of topoisomerase I. It has potent anti-cancer activity.
Formula:C25H28N2O4SiPurity:98%Color and Shape:SolidMolecular weight:448.59Edotecarin
CAS:Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM).Formula:C29H28N4O11Purity:98%Color and Shape:SolidMolecular weight:608.55Saintopin
CAS:Saintopin is an antitumor antibiotic and an inhibitor of DNA topoisomerases I and II, which induces DNA cleavage [1] [2].Formula:C18H10O7Color and Shape:SolidMolecular weight:338.27
