Topoisomerase
Topoisomerases are enzymes that regulate the topology of DNA during processes such as replication, transcription, and chromosome segregation by introducing transient breaks into the DNA strands to relieve torsional stress. Topoisomerase inhibitors interfere with this process, leading to the accumulation of DNA breaks and the induction of cell death, particularly in rapidly dividing cells. These inhibitors are widely used as chemotherapeutic agents in cancer treatment. At CymitQuimica, we offer a broad range of high-quality topoisomerase inhibitors to support your research in DNA replication, cancer therapy, and cell cycle regulation.
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Leurubicin
CAS:70774-25-3
Leurubicin is used as a prodrug of doxorubicin.
Formula:
C33H40N2O12
Purity:
100% - 100%
Color and Shape:
Solid
Molecular weight:
656.68
Ref: TM-T25688
| 1mg | 274.00 € | ||
| 2mg | 408.00 € |
Estimated delivery in United States, on Friday 27 Dec 2024
Daniquidone
CAS:67199-66-0
Daniquidone (Batracylin) is a potent dual inhibitor of DNA topoisomerase I and DNA topoisomerase II …
Formula:
C15H11N3O
Purity:
98.59% - 99.52%
Color and Shape:
Solid
Molecular weight:
249.27
Ref: TM-T68896
| 1mg | 52.00 € | ||
| 5mg | 105.00 € | ||
| 10mg | 157.00 € | ||
| 25mg | 251.00 € | ||
| 50mg | 367.00 € | ||
| 100mg | 626.00 € | ||
| 500mg | 2,368.00 € |
Estimated delivery in United States, on Friday 27 Dec 2024
Exatecan mesylate dihydrate
CAS:197720-53-9
Exatecan mesylate dihydrate (DX-8951), a DNA topoisomerase I inhibitor, exhibits an IC50 of 2.2 μM …
Formula:
C25H30FN3O9S
Purity:
98%
Color and Shape:
Solid
Molecular weight:
567.58
Ref: TM-T78630
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Friday 27 Dec 2024
Pyrazoloacridine
CAS:99009-20-8
Pyrazoloacridine (PD 115934) binds DNA, inhibits topo I/II, has 1.25 μM IC50 in K562 cells, …
Formula:
C19H21N5O3
Purity:
98.99%
Color and Shape:
Solid
Molecular weight:
367.4
Ref: TM-T28475
| 1mg | 42.00 € | ||
| 5mg | 95.00 € | ||
| 10mg | 138.00 € | ||
| 25mg | 266.00 € | ||
| 50mg | 384.00 € | ||
| 100mg | 547.00 € | ||
| 500mg | 1,087.00 € |
Estimated delivery in United States, on Friday 27 Dec 2024
Topoisomerase IV inhibitor 1
CAS:2883403-42-5
Compound 7d: Inhibits TOPO IV (IC50: 0.23 μM), DNA gyrase (IC50: 0.43 μM), antibacterial against …
Formula:
C34H32FN7O6S
Purity:
98%
Color and Shape:
Solid
Molecular weight:
685.72
Ref: TM-T72153
| 25mg | 1,410.00 € | ||
| 50mg | 1,851.00 € | ||
| 100mg | 2,337.00 € |
Estimated delivery in United States, on Friday 27 Dec 2024
Topoisomerase I inhibitor 9
CAS:1228150-86-4
Topoisomerase I Inhibitor 9 (compound 3d), a specific inhibitor of leishmanial topoisomerase IB, exhibits antileishmanial …
Formula:
C23H15Br2FN2
Purity:
98%
Color and Shape:
Solid
Molecular weight:
498.19
Ref: TM-T80967
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 7 Jan 2025
Topoisomerase II inhibitor 15
CAS:451516-79-3
Topoisomerase II inhibitor 15 (compound 2g) serves as a potent apoptotic inducer, exhibiting heightened selectivity …
Formula:
C15H11Cl2N5
Purity:
98%
Color and Shape:
Solid
Molecular weight:
332.19
Ref: TM-T79506
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 7 Jan 2025
9-Chloromethyl-10-hydroxy-11-F-Camptothecin
CAS:2414594-22-0
9-Chloromethyl-10-hydroxy-11-F-Camptothecin, a novel derivative of camptothecin, functions as a DNA topoisomerase I (Topo I) inhibitor …
Formula:
C22H18ClFN2O4
Purity:
98%
Color and Shape:
Solid
Molecular weight:
428.84
Ref: TM-T79883
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 7 Jan 2025
Trovafloxacin mesylate
CAS:147059-75-4
Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).
Formula:
C21H19F3N4O6S
Purity:
99.12%
Color and Shape:
Solid
Molecular weight:
512.46
Ref: TM-T13231L
| 1mg | 37.00 € | ||
| 5mg | 78.00 € | ||
| 10mg | 118.00 € | ||
| 25mg | 184.00 € | ||
| 50mg | 359.00 € | ||
| 100mg | 537.00 € | ||
| 1mL*10mM (DMSO) | 98.00 € |
Estimated delivery in United States, on Tuesday 7 Jan 2025
LMP744 hydrochloride
CAS:308246-57-3
LMP744 hydrochloride (NSC-706744 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor …
Formula:
C24H25ClN2O7
Purity:
98.44%
Color and Shape:
Solid
Molecular weight:
488.92
Ref: TM-T11872L
| 1mg | 118.00 € | ||
| 5mg | 223.00 € | ||
| 10mg | 347.00 € | ||
| 25mg | 579.00 € | ||
| 50mg | 828.00 € | ||
| 100mg | 1,138.00 € |
Estimated delivery in United States, on Tuesday 7 Jan 2025
Topoisomerase inhibitor 2
CAS:2713986-17-3
Topoisomerase Inhibitor 2 (18C) is a broad-spectrum bacterial topoisomerase inhibitor effective against multidrug-resistant Gram-negative bacteria …
Formula:
C23H23N5O4
Purity:
98%
Color and Shape:
Solid
Molecular weight:
433.46
Ref: TM-T78717
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 7 Jan 2025
CPT-Se3
CAS:2968315-02-6
CPT-Se3, a camptothecin derivative, boosts anticancer activity, triggers apoptosis in Hep G2, and is cytotoxic …
Formula:
C24H20N2O6Se2
Purity:
98%
Color and Shape:
Solid
Molecular weight:
590.35
Ref: TM-T73421
| 25mg | 1,549.00 € | ||
| 50mg | 2,038.00 € | ||
| 100mg | 2,617.00 € |
Estimated delivery in United States, on Tuesday 7 Jan 2025
SDOX
CAS:2921601-78-5
SDOX, a prodrug, releases Doxorubicin selectively in high-GSH tumor cells, minimizing harm to healthy tissue.
Formula:
C69H97NO20S2
Purity:
98%
Color and Shape:
Solid
Molecular weight:
1324.63
Ref: TM-T74364
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 7 Jan 2025
CPT-Se4
CAS:2968315-03-7
CPT-Se4, a seleno-derivative of CPT, effectively kills cancer cells, triggers apoptosis, and is cytotoxic against …
Formula:
C25H24N2O7Se2
Purity:
98%
Color and Shape:
Solid
Molecular weight:
622.39
Ref: TM-T73422
| 25mg | 1,549.00 € | ||
| 50mg | 2,038.00 € | ||
| 100mg | 2,617.00 € |
Estimated delivery in United States, on Tuesday 7 Jan 2025
NH2-methylpropanamide-Exatecan TFA
CAS:1817857-35-4
Exatecan TFA, a methylpropanamide-modified derivative of the common ADC cytotoxin Exatecan, serves as a DNA …
Formula:
C30H30F4N4O7
Purity:
98%
Color and Shape:
Solid
Molecular weight:
634.58
Ref: TM-T77889
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 7 Jan 2025
ARN-21934
CAS:2230854-93-8
ARN-21934 inhibits human topoisomerase II α/β; IC50=2μM; stronger than Etoposide (IC50=120μM) in DNA relaxation.
Formula:
C21H24N6
Purity:
100%
Color and Shape:
Solid
Molecular weight:
360.46
Ref: TM-T36968
| 1mg | 60.00 € | ||
| 2mg | 87.00 € | ||
| 5mg | 130.00 € | ||
| 10mg | 205.00 € | ||
| 25mg | 360.00 € | ||
| 50mg | 491.00 € | ||
| 100mg | 677.00 € | ||
| 200mg | 911.00 € | ||
| 1mL*10mM (DMSO) | 145.00 € |
Estimated delivery in United States, on Tuesday 7 Jan 2025
Intoplicine
CAS:125974-72-3
Intoplicine is an inhibitor of DNA topoisomerase I and II.
Formula:
C21H24N4O
Purity:
98%
Color and Shape:
Solid
Molecular weight:
348.44
Ref: TM-T15586
| 25mg | 2,106.00 € | ||
| 50mg | 2,776.00 € | ||
| 100mg | 3,726.00 € |
Estimated delivery in United States, on Tuesday 4 Feb 2025
Edotecarin
CAS:174402-32-5
Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 …
Formula:
C29H28N4O11
Purity:
98%
Color and Shape:
Solid
Molecular weight:
608.55
Ref: TM-T15200
| 25mg | 2,106.00 € | ||
| 50mg | 2,785.00 € | ||
| 100mg | 3,739.00 € |
Estimated delivery in United States, on Tuesday 4 Feb 2025
Gimatecan
CAS:292618-32-7
Gimatecan (STI481) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue …
Formula:
C25H25N3O5
Purity:
98.47%
Color and Shape:
Solid
Molecular weight:
447.48
Ref: TM-T21319
| 1mg | 112.00 € | ||
| 5mg | 268.00 € | ||
| 10mg | 444.00 € | ||
| 25mg | 737.00 € | ||
| 50mg | 1,007.00 € | ||
| 1mL*10mM (DMSO) | 301.00 € |
Estimated delivery in United States, on Tuesday 4 Feb 2025
Karenitecin
CAS:203923-89-1
Karenitecin (Cositecan) is an inhibitor of topoisomerase I. It has potent anti-cancer activity.
Formula:
C25H28N2O4Si
Purity:
98%
Color and Shape:
Solid
Molecular weight:
448.59
Ref: TM-T14703
| 25mg | 1,419.00 € | ||
| 50mg | 1,854.00 € | ||
| 100mg | 2,897.00 € |
Estimated delivery in United States, on Tuesday 4 Feb 2025
