Topoisomerase
Topoisomerases are enzymes that regulate the topology of DNA during processes such as replication, transcription, and chromosome segregation by introducing transient breaks into the DNA strands to relieve torsional stress. Topoisomerase inhibitors interfere with this process, leading to the accumulation of DNA breaks and the induction of cell death, particularly in rapidly dividing cells. These inhibitors are widely used as chemotherapeutic agents in cancer treatment. At CymitQuimica, we offer a broad range of high-quality topoisomerase inhibitors to support your research in DNA replication, cancer therapy, and cell cycle regulation.
Found 132 products of "Topoisomerase"
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Pirarubicin
CAS:Pirarubicin (Theprubicin), an anthracycline antibiotic, inhibits DNA/RNA synthesis and is used as an antineoplastic.Formula:C32H37NO12Purity:97.80% - 99.15%Color and Shape:Red Crystalline PowderMolecular weight:627.64Garenoxacin mesylate hydrate
CAS:Garenoxacin mesylate hydrate (Garenoxacin mesylate [USAN]) with potent antimicrobial activity, against common respiratory pathogens, including resistant strainsFormula:C23H20F2N2O4·CH4O3S·H2OPurity:99.56%Color and Shape:SolidMolecular weight:540.53Exatecan Mesylate
CAS:Exatecan Mesylate (DX8951f) is a DNA topoisomerase I inhibitor (IC50: 2.2 μM, 0.975 μg/mL).Formula:C25H26FN3O7SPurity:97.32% - 99.9%Color and Shape:SolidMolecular weight:531.55Nitidine chloride
CAS:1.Formula:C21H18ClNO4Purity:96.59% - 99.55%Color and Shape:SolidMolecular weight:383.82Rabdosiin
CAS:Rabdosiin ((+)-Rabdosiin) is a natural product, and has anti-allergic activity, anti-HIV activity and inhibition on DNA topoisomerase.Formula:C36H30O16Purity:98.64% - 99.49%Color and Shape:SolidMolecular weight:718.619-Methoxycamptothecin
CAS:9-Methoxycamptothecin (MCPT) has antitumour activities through topoisomerase inhibition.Formula:C21H18N2O5Purity:98.49% - 99.56%Color and Shape:SolidMolecular weight:378.38Mitoxantrone
CAS:Mitoxantrone: anthracenedione antibiotic, disrupts DNA/RNA replication, binds to topoisomerase II, less cardiotoxic than doxorubicin.
Formula:C22H28N4O6Purity:96.29% - 98.74%Color and Shape:Blue PowderMolecular weight:444.48β-Lapachone
CAS:β-Lapachone (ARQ-501) is a specific DNA topoisomerase I inhibitor, and no inhibitory activities against DNA topoisomerase II or ligase.Formula:C15H14O3Purity:99.76% - 99.88%Color and Shape:SolidMolecular weight:242.27Ellipticine hydrochloride
CAS:Ellipticine hydrochloride (NSC-71795 (hydrochloride)) is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.Formula:C17H15ClN2Purity:97.18%Color and Shape:SolidMolecular weight:282.76Amonafide
CAS:Amonafide (NSC-308847, AS1413) causes DNA breaks via topoisomerase II, not topoisomerase I.Formula:C16H17N3O2Purity:99.39%Color and Shape:SolidMolecular weight:283.33Ref: TM-T6336
1mg39.00€2mg51.00€5mg80.00€10mg87.00€25mg163.00€50mg281.00€100mg467.00€1mL*10mM (DMSO)92.00€Groenlandicine
CAS:Groenlandicine, a protoberberine alkaloid, inhibits HRAR (IC50: 154.2 μM), targets topoisomerase I, and shows potential as an anti-Alzheimer's agent.Formula:C19H16NO4Purity:98.59% - 99.77%Color and Shape:SolidMolecular weight:322.34Irinotecan
CAS:Irinotecan (CPT-11), a camptothecin derivative, inhibits topoisomerase I, used for colorectal cancer treatment.Formula:C33H38N4O6Purity:98% - 99.92%Color and Shape:SolidMolecular weight:586.68Bimolane
CAS:Bimolane is a topoisomerase II inhibitor.Formula:C20H32N6O6Purity:99.13% - 99.29%Color and Shape:SolidMolecular weight:452.5TAS-103 dihydrochloride
CAS:TAS-103 dihydrochloride (BMS-247615 dihydrochloride) is a novel anticancer agent targeting both topoisomerase (Topo) I and Topo II.Formula:C20H21Cl2N3O2Purity:97.78%Color and Shape:SolidMolecular weight:406.31Levofloxacin
CAS:Levofloxacin ((-)-Ofloxacin) is a synthetic fluoroquinolone antibiotic that prevents DNA replication. Cost-effective and quality-assured.Formula:C18H20FN3O4Purity:98.14% - 99.80%Color and Shape:Off-White To Yellow CrystalsMolecular weight:361.37Amsacrine hydrochloride
CAS:Amsacrine hydrochloride (acridinyl anisidide hydrochloride) is topoisomerase II inhibitor , is used in the treatment of acute myelogenous leukemia.Formula:C21H20ClN3O3SPurity:99.05% - 99.92%Color and Shape:SolidMolecular weight:429.92Doxorubicin
CAS:Doxorubicin (Adriamycin) is a Topoisomerase II (Top2) inhibitor with antineoplastic activity.Formula:C27H29NO11Purity:99.31%Color and Shape:Red Crystalline Solid SolidMolecular weight:543.52IndiMitecan
CAS:IndiMitecan (LMP776) is an inhibitor of topoisomerase I (Top1) with anticancer activities [1].
Formula:C25H21N3O6Purity:98.53%Color and Shape:SoildMolecular weight:459.45(±)-10-Hydroxycamptothecin
CAS:(±)-10-Hydroxycamptothecin (Hydroxy Camptothecine) is an alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata.
Formula:C20H16N2O5Purity:98% - 99.06%Color and Shape:SolidMolecular weight:364.35PNU-159682
CAS:PNU-159682 is a highly effective metabolite of the anthracycline nemorubicin.Formula:C32H35NO13Purity:98.24%Color and Shape:SolidMolecular weight:641.62Ref: TM-T16557
1mg87.00€5mg178.00€10mg326.00€25mg537.00€50mg735.00€100mg964.00€1mL*10mM (DMSO)263.00€
