Topoisomerase
Topoisomerases are enzymes that regulate the topology of DNA during processes such as replication, transcription, and chromosome segregation by introducing transient breaks into the DNA strands to relieve torsional stress. Topoisomerase inhibitors interfere with this process, leading to the accumulation of DNA breaks and the induction of cell death, particularly in rapidly dividing cells. These inhibitors are widely used as chemotherapeutic agents in cancer treatment. At CymitQuimica, we offer a broad range of high-quality topoisomerase inhibitors to support your research in DNA replication, cancer therapy, and cell cycle regulation.
Read more
Garenoxacin mesylate hydrate
CAS:223652-90-2
Garenoxacin mesylate hydrate (Garenoxacin mesylate [USAN]) with potent antimicrobial activity, against common respiratory pathogens, including …
Formula:
C23H20F2N2O4·CH4O3S·H2O
Purity:
99.56%
Color and Shape:
Solid
Molecular weight:
540.53
Ref: TM-T7804
| 1mg | 40.00 € | ||
| 5mg | 86.00 € | ||
| 10mg | 90.00 € | ||
| 25mg | 166.00 € | ||
| 50mg | 279.00 € | ||
| 100mg | 452.00 € | ||
| 1mL*10mM (DMSO) | 90.00 € |
Estimated delivery in United States, on Tuesday 29 Apr 2025
Exatecan Mesylate
CAS:169869-90-3
Exatecan Mesylate (DX8951f) is a DNA topoisomerase I inhibitor (IC50: 2.2 μM, 0.975 μg/mL).
Formula:
C25H26FN3O7S
Purity:
97.32% - 99.89%
Color and Shape:
Solid
Molecular weight:
531.55
Ref: TM-TQ0088
| 10mg | 37.00 € | ||
| 25mg | 70.00 € | ||
| 50mg | 92.00 € | ||
| 100mg | 137.00 € | ||
| 500mg | 283.00 € |
Estimated delivery in United States, on Tuesday 29 Apr 2025
Nitidine chloride
CAS:13063-04-2
1.
Formula:
C21H18ClNO4
Purity:
96.59% - 98.91%
Color and Shape:
Solid
Molecular weight:
383.82
Ref: TM-T5S0761
| 1mg | 35.00 € | ||
| 5mg | 70.00 € | ||
| 10mg | 111.00 € | ||
| 25mg | 175.00 € | ||
| 50mg | 304.00 € | ||
| 100mg | 452.00 € | ||
| 500mg | 938.00 € |
Estimated delivery in United States, on Tuesday 29 Apr 2025
Prulifloxacin
CAS:123447-62-1
Prulifloxacin (NM441) is a broad-spectrum fluoroquinolone that inhibits bacterial DNA synthesis by blocking topoisomerase II …
Formula:
C21H20FN3O6S
Purity:
99.47%
Color and Shape:
Yellow Or Slightly Yellow Power
Molecular weight:
461.46
Ref: TM-T5394
| 50mg | 48.00 € | ||
| 100mg | 63.00 € | ||
| 200mg | 95.00 € | ||
| 500mg | 171.00 € |
Estimated delivery in United States, on Tuesday 29 Apr 2025
Rabdosiin
CAS:263397-69-9
Rabdosiin ((+)-Rabdosiin) is a natural product, and has anti-allergic activity, anti-HIV activity and inhibition on …
Formula:
C36H30O16
Purity:
98.64% - 99.49%
Color and Shape:
Solid
Molecular weight:
718.61
Ref: TM-T12651
| 1mg | 79.00 € | ||
| 5mg | 165.00 € | ||
| 10mg | 238.00 € | ||
| 25mg | 427.00 € | ||
| 50mg | 642.00 € | ||
| 1mL*10mM (DMSO) | 256.00 € |
Estimated delivery in United States, on Tuesday 29 Apr 2025
9-Methoxycamptothecin
CAS:39026-92-1
9-Methoxycamptothecin (MCPT) has antitumour activities through topoisomerase inhibition.
Formula:
C21H18N2O5
Purity:
98.49% - 99.55%
Color and Shape:
Solid
Molecular weight:
378.38
Ref: TM-T5S1952
| 25mg | 52.00 € | ||
| 50mg | 79.00 € |
Estimated delivery in United States, on Tuesday 29 Apr 2025
Mitoxantrone
CAS:65271-80-9
Mitoxantrone: anthracenedione antibiotic, disrupts DNA/RNA replication, binds to topoisomerase II, less cardiotoxic than doxorubicin.
Formula:
C22H28N4O6
Purity:
97.97% - 98.74%
Color and Shape:
Blue Powder
Molecular weight:
444.48
Ref: TM-T6588
| 25mg | 39.00 € | ||
| 50mg | 51.00 € | ||
| 100mg | 71.00 € | ||
| 200mg | 107.00 € | ||
| 1mL*10mM (DMSO) | 55.00 € |
Estimated delivery in United States, on Tuesday 29 Apr 2025
Ellipticine hydrochloride
CAS:5081-48-1
Ellipticine hydrochloride (NSC-71795 (hydrochloride)) is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.
Formula:
C17H15ClN2
Purity:
97.18%
Color and Shape:
Solid
Molecular weight:
282.76
Ref: TM-T4614
| 5mg | 48.00 € | ||
| 10mg | 66.00 € | ||
| 25mg | 120.00 € | ||
| 50mg | 202.00 € | ||
| 100mg | 298.00 € | ||
| 1mL*10mM (DMSO) | 52.00 € |
Estimated delivery in United States, on Tuesday 29 Apr 2025
Amonafide
CAS:69408-81-7
Amonafide (NSC-308847, AS1413) causes DNA breaks via topoisomerase II, not topoisomerase I.
Formula:
C16H17N3O2
Purity:
99.39%
Color and Shape:
Solid
Molecular weight:
283.33
Ref: TM-T6336
| 1mg | 39.00 € | ||
| 2mg | 51.00 € | ||
| 5mg | 80.00 € | ||
| 10mg | 87.00 € | ||
| 25mg | 163.00 € | ||
| 50mg | 281.00 € | ||
| 100mg | 467.00 € | ||
| 1mL*10mM (DMSO) | 92.00 € |
Estimated delivery in United States, on Tuesday 29 Apr 2025
Groenlandicine
CAS:38691-95-1
Groenlandicine, a protoberberine alkaloid, inhibits HRAR (IC50: 154.2 μM), targets topoisomerase I, and shows potential …
Formula:
C19H16NO4
Purity:
98.59% - 99.77%
Color and Shape:
Solid
Molecular weight:
322.34
Ref: TM-TN1037
| 1mg | 92.00 € | ||
| 5mg | 269.00 € | ||
| 10mg | 378.00 € | ||
| 25mg | 562.00 € | ||
| 50mg | 787.00 € | ||
| 100mg | 1,074.00 € |
Estimated delivery in United States, on Tuesday 29 Apr 2025
Irinotecan
CAS:97682-44-5
Irinotecan (CPT-11), a camptothecin derivative, inhibits topoisomerase I, used for colorectal cancer treatment.
Formula:
C33H38N4O6
Purity:
100% - 99.92%
Color and Shape:
Solid
Molecular weight:
586.68
Ref: TM-T6228
| 10mg | 34.00 € | ||
| 25mg | 48.00 € | ||
| 50mg | 64.00 € | ||
| 100mg | 96.00 € | ||
| 200mg | 125.00 € | ||
| 500mg | 217.00 € | ||
| 1mL*10mM (DMSO) | 55.00 € |
Estimated delivery in United States, on Tuesday 29 Apr 2025
Bimolane
CAS:74550-97-3
Bimolane is a topoisomerase II inhibitor.
Formula:
C20H32N6O6
Purity:
99.29% - 99.86%
Color and Shape:
Solid
Molecular weight:
452.5
Ref: TM-T3481
| 2mg | 42.00 € | ||
| 5mg | 57.00 € | ||
| 10mg | 95.00 € | ||
| 25mg | 197.00 € | ||
| 50mg | 343.00 € | ||
| 100mg | 467.00 € | ||
| 500mg | 1,064.00 € |
Estimated delivery in United States, on Tuesday 29 Apr 2025
TAS-103 dihydrochloride
CAS:174634-09-4
TAS-103 dihydrochloride (BMS-247615 dihydrochloride) is a novel anticancer agent targeting both topoisomerase (Topo) I and …
Formula:
C20H21Cl2N3O2
Purity:
97.78%
Color and Shape:
Solid
Molecular weight:
406.31
Ref: TM-T7309
| 1mg | 46.00 € | ||
| 5mg | 87.00 € | ||
| 10mg | 131.00 € | ||
| 25mg | 274.00 € | ||
| 50mg | 406.00 € | ||
| 100mg | 607.00 € |
Estimated delivery in United States, on Tuesday 29 Apr 2025
Levofloxacin
CAS:100986-85-4
Levofloxacin ((-)-Ofloxacin) is a synthetic fluoroquinolone antibiotic that prevents DNA replication. Cost-effective and quality-assured.
Formula:
C18H20FN3O4
Purity:
98.14% - 99.75%
Color and Shape:
Off-White To Yellow Crystals
Molecular weight:
361.37
Ref: TM-T6567
| 5g | 84.00 € | ||
| 100mg | 52.00 € | ||
| 1mL*10mM (DMSO) | 55.00 € |
Estimated delivery in United States, on Tuesday 29 Apr 2025
Amsacrine hydrochloride
CAS:54301-15-4
Amsacrine hydrochloride (acridinyl anisidide hydrochloride) is topoisomerase II inhibitor , is used in the treatment …
Formula:
C21H20ClN3O3S
Purity:
99.05% - 99.92%
Color and Shape:
Solid
Molecular weight:
429.92
Ref: TM-T5820
| 1g | 249.00 € | ||
| 10mg | 47.00 € | ||
| 25mg | 59.00 € | ||
| 50mg | 79.00 € | ||
| 100mg | 96.00 € | ||
| 200mg | 124.00 € | ||
| 500mg | 170.00 € |
Estimated delivery in United States, on Tuesday 29 Apr 2025
(±)-10-Hydroxycamptothecin
CAS:64439-81-2
(±)-10-Hydroxycamptothecin (Hydroxy Camptothecine) is an alkaloid isolated from the stem wood of the Chinese tree, …
Formula:
C20H16N2O5
Purity:
98% - 99.58%
Color and Shape:
Solid
Molecular weight:
364.35
Ref: TM-T1521
| 10mg | 44.00 € | ||
| 25mg | 62.00 € | ||
| 50mg | 88.00 € | ||
| 100mg | 111.00 € | ||
| 500mg | 269.00 € | ||
| 1mL*10mM (DMSO) | 34.00 € |
Estimated delivery in United States, on Friday 2 May 2025
Ellipticine
CAS:519-23-3
Ellipticine is a powerful cancer drug with different actions, IC50: 0.27-1.48 μM for leukemia, breast …
Formula:
C17H14N2
Purity:
97.26% - 99.88%
Color and Shape:
Solid
Molecular weight:
246.31
Ref: TM-T1166
| 5mg | 51.00 € | ||
| 10mg | 79.00 € | ||
| 25mg | 117.00 € | ||
| 50mg | 167.00 € | ||
| 100mg | 249.00 € | ||
| 500mg | 610.00 € | ||
| 1mL*10mM (DMSO) | 55.00 € |
Estimated delivery in United States, on Tuesday 27 May 2025
PNU-159682
CAS:202350-68-3
PNU-159682 is a highly effective metabolite of the anthracycline nemorubicin.
Formula:
C32H35NO13
Purity:
98.24%
Color and Shape:
Solid
Molecular weight:
641.62
Ref: TM-T16557
| 1mg | 92.00 € | ||
| 5mg | 188.00 € | ||
| 10mg | 344.00 € | ||
| 25mg | 728.00 € | ||
| 50mg | 1,121.00 € | ||
| 100mg | 1,738.00 € |
Estimated delivery in United States, on Tuesday 27 May 2025
Camptothecin
CAS:7689-03-4
Camptothecin (CPT) belongs to the alkaloid group of natural products and is a specific DNA …
Formula:
C20H16N2O4
Purity:
98.61% - 99.52%
Color and Shape:
Solid Powder
Molecular weight:
348.35
Ref: TM-T1123
| 100mg | 50.00 € | ||
| 500mg | 134.00 € |
Estimated delivery in United States, on Tuesday 3 Jun 2025
Topoisomerase II inhibitor 16
CAS:2403729-27-9
Topoisomerase II Inhibitor 16 (compound CT3) is a selective, orally bioavailable, and irreversible inhibitor of …
Formula:
C19H12F4N6O
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
416.33
Ref: TM-T79539
| 1mg | 120.00 € | ||
| 5mg | 275.00 € | ||
| 500µg | 71.00 € |
Estimated delivery in United States, on Tuesday 10 Jun 2025
