Topoisomerase
Topoisomerases are enzymes that regulate the topology of DNA during processes such as replication, transcription, and chromosome segregation by introducing transient breaks into the DNA strands to relieve torsional stress. Topoisomerase inhibitors interfere with this process, leading to the accumulation of DNA breaks and the induction of cell death, particularly in rapidly dividing cells. These inhibitors are widely used as chemotherapeutic agents in cancer treatment. At CymitQuimica, we offer a broad range of high-quality topoisomerase inhibitors to support your research in DNA replication, cancer therapy, and cell cycle regulation.
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Rabdosiin
CAS:263397-69-9
Rabdosiin ((+)-Rabdosiin) is a natural product, and has anti-allergic activity, anti-HIV activity and inhibition on …
Formula:
C36H30O16
Purity:
98.64% - 99.49%
Color and Shape:
Solid
Molecular weight:
718.61
Ref: TM-T12651
| 1mg | 78.00 € | ||
| 5mg | 162.00 € | ||
| 10mg | 234.00 € | ||
| 25mg | 421.00 € | ||
| 50mg | 632.00 € | ||
| 1mL*10mM (DMSO) | 253.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
9-Methoxycamptothecin
CAS:39026-92-1
9-Methoxycamptothecin (MCPT) has antitumour activities through topoisomerase inhibition.
Formula:
C21H18N2O5
Purity:
98.49% - 99.55%
Color and Shape:
Solid
Molecular weight:
378.38
Ref: TM-T5S1952
| 25mg | 52.00 € | ||
| 50mg | 78.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
Mitoxantrone
CAS:65271-80-9
Mitoxantrone: anthracenedione antibiotic, disrupts DNA/RNA replication, binds to topoisomerase II, less cardiotoxic than doxorubicin.
Formula:
C22H28N4O6
Purity:
97.97% - 98.74%
Color and Shape:
Blue Powder
Molecular weight:
444.48
Ref: TM-T6588
| 25mg | 39.00 € | ||
| 50mg | 51.00 € | ||
| 100mg | 70.00 € | ||
| 200mg | 105.00 € | ||
| 1mL*10mM (DMSO) | 55.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
Ellipticine hydrochloride
CAS:5081-48-1
Ellipticine hydrochloride (NSC-71795 (hydrochloride)) is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.
Formula:
C17H15ClN2
Purity:
97.18%
Color and Shape:
Solid
Molecular weight:
282.76
Ref: TM-T4614
| 5mg | 47.00 € | ||
| 10mg | 65.00 € | ||
| 25mg | 119.00 € | ||
| 50mg | 199.00 € | ||
| 100mg | 291.00 € | ||
| 1mL*10mM (DMSO) | 52.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
Amonafide
CAS:69408-81-7
Amonafide (NSC-308847, AS1413) causes DNA breaks via topoisomerase II, not topoisomerase I.
Formula:
C16H17N3O2
Purity:
99.39%
Color and Shape:
Solid
Molecular weight:
283.33
Ref: TM-T6336
| 1mg | 39.00 € | ||
| 2mg | 51.00 € | ||
| 5mg | 79.00 € | ||
| 10mg | 96.00 € | ||
| 25mg | 160.00 € | ||
| 50mg | 275.00 € | ||
| 100mg | 456.00 € | ||
| 1mL*10mM (DMSO) | 92.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
Groenlandicine
CAS:38691-95-1
Groenlandicine, a protoberberine alkaloid, inhibits HRAR (IC50: 154.2 μM), targets topoisomerase I, and shows potential …
Formula:
C19H16NO4
Purity:
98.59%
Color and Shape:
Solid
Molecular weight:
322.34
Ref: TM-TN1037
| 1mg | 90.00 € | ||
| 5mg | 263.00 € | ||
| 10mg | 369.00 € | ||
| 25mg | 550.00 € | ||
| 50mg | 769.00 € | ||
| 100mg | 1,049.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
Irinotecan
CAS:97682-44-5
Irinotecan (CPT-11), a camptothecin derivative, inhibits topoisomerase I, used for colorectal cancer treatment.
Formula:
C33H38N4O6
Purity:
100% - 99.92%
Color and Shape:
Solid
Molecular weight:
586.68
Ref: TM-T6228
| 10mg | 35.00 € | ||
| 25mg | 48.00 € | ||
| 50mg | 64.00 € | ||
| 100mg | 87.00 € | ||
| 200mg | 125.00 € | ||
| 500mg | 214.00 € | ||
| 1mL*10mM (DMSO) | 55.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
Bimolane
CAS:74550-97-3
Bimolane is a topoisomerase II inhibitor.
Formula:
C20H32N6O6
Purity:
99.29% - 99.86%
Color and Shape:
Solid
Molecular weight:
452.5
Ref: TM-T3481
| 2mg | 41.00 € | ||
| 5mg | 56.00 € | ||
| 10mg | 94.00 € | ||
| 25mg | 194.00 € | ||
| 50mg | 336.00 € | ||
| 100mg | 457.00 € | ||
| 500mg | 1,044.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
TAS-103 dihydrochloride
CAS:174634-09-4
TAS-103 dihydrochloride (BMS-247615 dihydrochloride) is a novel anticancer agent targeting both topoisomerase (Topo) I and …
Formula:
C20H21Cl2N3O2
Purity:
97.78%
Color and Shape:
Solid
Molecular weight:
406.31
Ref: TM-T7309
| 1mg | 45.00 € | ||
| 5mg | 96.00 € | ||
| 10mg | 129.00 € | ||
| 25mg | 269.00 € | ||
| 50mg | 400.00 € | ||
| 100mg | 596.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
Levofloxacin
CAS:100986-85-4
Levofloxacin ((-)-Ofloxacin) is a synthetic fluoroquinolone antibiotic that prevents DNA replication. Cost-effective and quality-assured.
Formula:
C18H20FN3O4
Purity:
97.63%
Color and Shape:
Off-White To Yellow Crystals
Molecular weight:
361.37
Ref: TM-T6567
| 5g | 82.00 € | ||
| 100mg | 57.00 € | ||
| 1mL*10mM (DMSO) | 55.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
Amsacrine hydrochloride
CAS:54301-15-4
Amsacrine hydrochloride (acridinyl anisidide hydrochloride) is topoisomerase II inhibitor , is used in the treatment …
Formula:
C21H20ClN3O3S
Purity:
99.05% - 99.92%
Color and Shape:
Solid
Molecular weight:
429.92
Ref: TM-T5820
| 1g | 245.00 € | ||
| 10mg | 51.00 € | ||
| 25mg | 63.00 € | ||
| 50mg | 83.00 € | ||
| 100mg | 99.00 € | ||
| 200mg | 127.00 € | ||
| 500mg | 176.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
(±)-10-Hydroxycamptothecin
CAS:64439-81-2
(±)-10-Hydroxycamptothecin (Hydroxy Camptothecine) is an alkaloid isolated from the stem wood of the Chinese tree, …
Formula:
C20H16N2O5
Purity:
98% - 99.58%
Color and Shape:
Solid
Molecular weight:
364.35
Ref: TM-T1521
| 10mg | 43.00 € | ||
| 25mg | 59.00 € | ||
| 50mg | 85.00 € | ||
| 100mg | 107.00 € | ||
| 500mg | 258.00 € | ||
| 1mL*10mM (DMSO) | 33.00 € |
Estimated delivery in United States, on Thursday 19 Dec 2024
PNU-159682
CAS:202350-68-3
PNU-159682 is a highly effective metabolite of the anthracycline nemorubicin.
Formula:
C32H35NO13
Purity:
98.24%
Color and Shape:
Solid
Molecular weight:
641.62
Ref: TM-T16557
| 1mg | 90.00 € | ||
| 5mg | 184.00 € | ||
| 10mg | 340.00 € | ||
| 25mg | 712.00 € | ||
| 50mg | 1,103.00 € | ||
| 100mg | 1,700.00 € |
Estimated delivery in United States, on Monday 13 Jan 2025
Ellipticine
CAS:519-23-3
Ellipticine is a powerful cancer drug with different actions, IC50: 0.27-1.48 μM for leukemia, breast …
Formula:
C17H14N2
Purity:
97.26% - 99.88%
Color and Shape:
Solid
Molecular weight:
246.31
Ref: TM-T1166
| 5mg | 56.00 € | ||
| 10mg | 83.00 € | ||
| 25mg | 120.00 € | ||
| 50mg | 175.00 € | ||
| 100mg | 244.00 € | ||
| 500mg | 598.00 € | ||
| 1mL*10mM (DMSO) | 55.00 € |
Estimated delivery in United States, on Monday 13 Jan 2025
Camptothecin
CAS:7689-03-4
Camptothecin (CPT) belongs to the alkaloid group of natural products and is a specific DNA …
Formula:
C20H16N2O4
Purity:
98.61% - 99.52%
Color and Shape:
Solid Powder
Molecular weight:
348.35
Ref: TM-T1123
| 100mg | 55.00 € | ||
| 500mg | 132.00 € |
Estimated delivery in United States, on Tuesday 21 Jan 2025
Topoisomerase IV inhibitor 1
CAS:2883403-42-5
Compound 7d: Inhibits TOPO IV (IC50: 0.23 μM), DNA gyrase (IC50: 0.43 μM), antibacterial against …
Formula:
C34H32FN7O6S
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
685.72
Ref: TM-T72153
| 25mg | 1,410.00 € | ||
| 50mg | 1,851.00 € | ||
| 100mg | 2,337.00 € |
Estimated delivery in United States, on Monday 27 Jan 2025
Amsacrine
CAS:51264-14-3
Amsacrine (AMSA) (mAMSA) an antineoplastic agent which can intercalate into the DNA of tumor cells.
Formula:
C21H19N3O3S
Purity:
98.59%
Color and Shape:
Yellow Crystalline Powder Solid
Molecular weight:
393.46
Ref: TM-T1206
| 10mg | 51.00 € | ||
| 25mg | 68.00 € | ||
| 50mg | To inquire | ||
| 1mL*10mM (DMSO) | 36.00 € |
Estimated delivery in United States, on Monday 27 Jan 2025
Exatecan mesylate dihydrate
CAS:197720-53-9
Exatecan mesylate dihydrate (DX-8951), a DNA topoisomerase I inhibitor, exhibits an IC50 of 2.2 μM …
Formula:
C25H30FN3O9S
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
567.58
Ref: TM-T78630
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Monday 27 Jan 2025
Chloroquinoxaline sulfonamide
CAS:97919-22-7
Chloroquinoxaline sulfonamide (Chloroquinoxaline) is an organic micropollutant with antimicrobial activity.
Formula:
C14H11ClN4O2S
Purity:
100% - 98.67%
Color and Shape:
Solid
Molecular weight:
334.78
Ref: TM-T14953
| 1mg | 62.00 € | ||
| 5mg | 124.00 € | ||
| 10mg | 175.00 € | ||
| 25mg | 291.00 € | ||
| 50mg | 432.00 € | ||
| 100mg | 632.00 € | ||
| 500mg | 1,333.00 € | ||
| 1mL*10mM (DMSO) | 135.00 € |
Estimated delivery in United States, on Monday 27 Jan 2025
F-14512
CAS:866874-63-7
F-14512, a DNA topoisomerase II inhibitor, is used potentially for the treatment of acute myeloid …
Formula:
C33H47N5O8
Color and Shape:
Solid
Molecular weight:
641.76
Ref: TM-T27299
| 1mg | 274.00 € | ||
| 5mg | 673.00 € | ||
| 10mg | 920.00 € | ||
| 25mg | 1,417.00 € | ||
| 50mg | 1,846.00 € | ||
| 100mg | 2,330.00 € |
Estimated delivery in United States, on Monday 27 Jan 2025
