Topoisomerase
Topoisomerases are enzymes that regulate the topology of DNA during processes such as replication, transcription, and chromosome segregation by introducing transient breaks into the DNA strands to relieve torsional stress. Topoisomerase inhibitors interfere with this process, leading to the accumulation of DNA breaks and the induction of cell death, particularly in rapidly dividing cells. These inhibitors are widely used as chemotherapeutic agents in cancer treatment. At CymitQuimica, we offer a broad range of high-quality topoisomerase inhibitors to support your research in DNA replication, cancer therapy, and cell cycle regulation.
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EIDD-1931
CAS:3258-02-4
EIDD-1931 (Beta-d-N4-hydroxycytidine) is a ribonucleoside analog with antiviral activity. It inhibits replication of SARS-CoV, MERS-CoV, …
Formula:
C9H13N3O6
Purity:
99.14% - 99.18%
Color and Shape:
Solid
Molecular weight:
259.22
Ref: TM-T8498
| 2mg | 35.00 € | ||
| 5mg | 50.00 € | ||
| 10mg | 76.00 € | ||
| 25mg | 114.00 € | ||
| 50mg | 166.00 € | ||
| 100mg | 230.00 € | ||
| 200mg | 335.00 € |
Estimated delivery in United States, on Tuesday 12 Nov 2024
Berberine hydrogen sulphate
CAS:633-66-9
Berberine hydrogen sulphate, a plant alkaloid, has broad antimicrobial effects on bacteria, fungi, and protozoa.
Formula:
C20H19NO8S
Purity:
99% - 99.79%
Color and Shape:
Yellow Crystals Off-White To Yellow Powder
Molecular weight:
433.43
Ref: TM-T5S0814
| 1g | 145.00 € | ||
| 50mg | 37.00 € | ||
| 100mg | 51.00 € | ||
| 500mg | 93.00 € |
Estimated delivery in United States, on Tuesday 12 Nov 2024
Belotecan hydrochloride
CAS:213819-48-8
Belotecan hydrochloride (CKD-602) is a synthetic water-soluble camptothecin derivative and topoisomerase I inhibitor with potential …
Formula:
C25H28ClN3O4
Purity:
99.06% - ≥95%
Color and Shape:
Solid
Molecular weight:
469.96
Ref: TM-T7551
| 2mg | 35.00 € | ||
| 5mg | 44.00 € | ||
| 10mg | 62.00 € | ||
| 25mg | 89.00 € | ||
| 50mg | 128.00 € | ||
| 100mg | 173.00 € | ||
| 1mL*10mM (DMSO) | 47.00 € |
Estimated delivery in United States, on Tuesday 12 Nov 2024
Coralyne chloride
CAS:38989-38-7
Coralyne chloride is a protoberberine with strong anticancer activity.
Formula:
C22H22ClNO4
Purity:
99.35%
Color and Shape:
Solid
Molecular weight:
399.87
Ref: TM-T31011
| 5mg | 50.00 € | ||
| 10mg | 83.00 € | ||
| 25mg | 166.00 € | ||
| 50mg | 253.00 € | ||
| 100mg | 373.00 € |
Estimated delivery in United States, on Tuesday 12 Nov 2024
Levofloxacin hydrochloride
CAS:177325-13-2
Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial …
Formula:
C18H21ClFN3O4
Purity:
≥98%
Color and Shape:
Solid
Molecular weight:
397.8
Ref: TM-T8747
| 1g | 44.00 € |
Estimated delivery in United States, on Tuesday 12 Nov 2024
Indotecan
CAS:915303-09-2
Indotecan (LMP-400) is an effective inhibitor of topoisomerase 1(Top1) (IC50: 300, 1200, 560 nM for …
Formula:
C26H26N2O7
Purity:
97% - 98%
Color and Shape:
Solid
Molecular weight:
478.49
Ref: TM-T15578
| 1mg | 69.00 € | ||
| 5mg | 123.00 € | ||
| 10mg | 193.00 € | ||
| 25mg | 346.00 € | ||
| 50mg | 547.00 € |
Estimated delivery in United States, on Tuesday 12 Nov 2024
Bimolane
CAS:74550-97-3
Bimolane is a topoisomerase II inhibitor.
Formula:
C20H32N6O6
Purity:
99.29% - 99.86%
Color and Shape:
Solid
Molecular weight:
452.5
Ref: TM-T3481
| 2mg | 41.00 € | ||
| 5mg | 56.00 € | ||
| 10mg | 94.00 € | ||
| 25mg | 194.00 € | ||
| 50mg | 336.00 € | ||
| 100mg | 457.00 € | ||
| 500mg | 1,044.00 € |
Estimated delivery in United States, on Tuesday 12 Nov 2024
Berberine
CAS:2086-83-1
1.
Formula:
C20H18NO4
Purity:
95.71% - 99.38%
Color and Shape:
Solid
Molecular weight:
336.36
Ref: TM-T4S0797
| 20mg | 54.00 € | ||
| 1mL*10mM (DMSO) | 55.00 € |
Estimated delivery in United States, on Tuesday 12 Nov 2024
TAS-103 dihydrochloride
CAS:174634-09-4
TAS-103 dihydrochloride (BMS-247615 dihydrochloride) is a novel anticancer agent targeting both topoisomerase (Topo) I and …
Formula:
C20H21Cl2N3O2
Purity:
97.78%
Color and Shape:
Solid
Molecular weight:
406.31
Ref: TM-T7309
| 1mg | 45.00 € | ||
| 5mg | 96.00 € | ||
| 10mg | 129.00 € | ||
| 25mg | 269.00 € | ||
| 50mg | 400.00 € | ||
| 100mg | 596.00 € |
Estimated delivery in United States, on Tuesday 12 Nov 2024
(±)-10-Hydroxycamptothecin
CAS:64439-81-2
(±)-10-Hydroxycamptothecin (Hydroxy Camptothecine) is an alkaloid isolated from the stem wood of the Chinese tree, …
Formula:
C20H16N2O5
Purity:
98% - 99.58%
Color and Shape:
Solid
Molecular weight:
364.35
Ref: TM-T1521
| 10mg | 43.00 € | ||
| 25mg | 59.00 € | ||
| 50mg | 85.00 € | ||
| 100mg | 107.00 € | ||
| 500mg | 258.00 € | ||
| 1mL*10mM (DMSO) | 33.00 € |
Estimated delivery in United States, on Friday 15 Nov 2024
PNU-159682
CAS:202350-68-3
PNU-159682 is a highly effective metabolite of the anthracycline nemorubicin.
Formula:
C32H35NO13
Purity:
98.24%
Color and Shape:
Solid
Molecular weight:
641.62
Ref: TM-T16557
| 1mg | 90.00 € | ||
| 5mg | 184.00 € | ||
| 10mg | 340.00 € | ||
| 25mg | 712.00 € | ||
| 50mg | 1,103.00 € | ||
| 100mg | 1,700.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Ellipticine
CAS:519-23-3
Ellipticine is a powerful cancer drug with different actions, IC50: 0.27-1.48 μM for leukemia, breast …
Formula:
C17H14N2
Purity:
98.17% - 99.88%
Color and Shape:
Solid
Molecular weight:
246.31
Ref: TM-T1166
| 5mg | 56.00 € | ||
| 10mg | 83.00 € | ||
| 25mg | 120.00 € | ||
| 50mg | 175.00 € | ||
| 100mg | 244.00 € | ||
| 500mg | 598.00 € | ||
| 1mL*10mM (DMSO) | 55.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Camptothecin
CAS:7689-03-4
Camptothecin (CPT) belongs to the alkaloid group of natural products and is a specific DNA …
Formula:
C20H16N2O4
Purity:
98.61% - 99.52%
Color and Shape:
Solid Powder
Molecular weight:
348.35
Ref: TM-T1123
| 100mg | 55.00 € | ||
| 500mg | 132.00 € |
Estimated delivery in United States, on Tuesday 17 Dec 2024
Pegamotecan
CAS:581079-18-7
Pegamotecan (PEG-camptothecin) is a topoisomerase I (TOP1) inhibitor with anticancer activity, and it is used …
Formula:
C52H48N6O14
Purity:
96.52% - 97.96%
Color and Shape:
Solid
Molecular weight:
980.984
Ref: TM-T24610
| 1mg | 364.00 € | ||
| 5mg | 867.00 € | ||
| 10mg | 1,177.00 € | ||
| 25mg | 1,746.00 € | ||
| 50mg | 2,349.00 € |
Estimated delivery in United States, on Friday 27 Dec 2024
Amsacrine
CAS:51264-14-3
Amsacrine (AMSA) (mAMSA) an antineoplastic agent which can intercalate into the DNA of tumor cells.
Formula:
C21H19N3O3S
Purity:
98.59%
Color and Shape:
Yellow Crystalline Powder Solid
Molecular weight:
393.46
Ref: TM-T1206
| 10mg | 51.00 € | ||
| 25mg | 68.00 € | ||
| 50mg | To inquire | ||
| 1mL*10mM (DMSO) | 36.00 € |
Estimated delivery in United States, on Friday 27 Dec 2024
Chloroquinoxaline sulfonamide
CAS:97919-22-7
Chloroquinoxaline sulfonamide (Chloroquinoxaline) is an organic micropollutant with antimicrobial activity.
Formula:
C14H11ClN4O2S
Purity:
100% - 98.67%
Color and Shape:
Solid
Molecular weight:
334.78
Ref: TM-T14953
| 1mg | 62.00 € | ||
| 5mg | 124.00 € | ||
| 10mg | 175.00 € | ||
| 25mg | 291.00 € | ||
| 50mg | 432.00 € | ||
| 100mg | 632.00 € | ||
| 500mg | 1,333.00 € | ||
| 1mL*10mM (DMSO) | 135.00 € |
Estimated delivery in United States, on Friday 27 Dec 2024
F-14512
CAS:866874-63-7
F-14512, a DNA topoisomerase II inhibitor, is used potentially for the treatment of acute myeloid …
Formula:
C33H47N5O8
Color and Shape:
Solid
Molecular weight:
641.76
Ref: TM-T27299
| 1mg | 274.00 € | ||
| 5mg | 673.00 € | ||
| 10mg | 920.00 € | ||
| 25mg | 1,417.00 € | ||
| 50mg | 1,846.00 € | ||
| 100mg | 2,330.00 € |
Estimated delivery in United States, on Friday 27 Dec 2024
Topoisomerase IV inhibitor 2
CAS:2883403-36-7
Compound 5d, a potent TOPO IV inhibitor (IC50: 0.35 μM), also inhibits DNA gyrase (IC50: …
Formula:
C33H30FN7O6S
Purity:
98%
Color and Shape:
Solid
Molecular weight:
671.7
Ref: TM-T72154
| 25mg | 1,410.00 € | ||
| 50mg | 1,851.00 € | ||
| 100mg | 2,337.00 € |
Estimated delivery in United States, on Friday 27 Dec 2024
Topoisomerase II inhibitor 16
CAS:2403729-27-9
Topoisomerase II Inhibitor 16 (compound CT3) is a selective, orally bioavailable, and irreversible inhibitor of …
Formula:
C19H12F4N6O
Purity:
98%
Color and Shape:
Solid
Molecular weight:
416.33
Ref: TM-T79539
| 1mg | 121.00 € | ||
| 5mg | 275.00 € | ||
| 500µg | 72.00 € |
Estimated delivery in United States, on Friday 27 Dec 2024
Aldoxorubicin
CAS:1361644-26-9
Aldoxorubicin, an albumin-binding prodrug of Doxorubicin, exhibits potent antitumor effects in cancer lines and mouse …
Formula:
C37H42N4O13
Purity:
98%
Color and Shape:
Solid
Molecular weight:
750.75
Ref: TM-T11090L
| 25mg | To inquire | ||
| 50mg | To inquire | ||
| 100mg | To inquire |
Estimated delivery in United States, on Friday 27 Dec 2024
