DNA Methyltransferase
DNA methyltransferases (DNMTs) are enzymes that catalyze the addition of methyl groups to cytosine residues in DNA, leading to gene silencing. Aberrant DNA methylation is associated with various diseases, including cancer. DNMT inhibitors block the activity of these enzymes, leading to the reactivation of silenced genes and induction of apoptosis in cancer cells. DNMT inhibitors are widely used in epigenetic research and cancer therapy. At CymitQuimica, we provide a range of high-quality DNMT inhibitors to support your research in epigenetics, DNA methylation, and cancer biology.
Found 422 products of "DNA Methyltransferase"
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FTX-6058
CAS:<p>FTX-6058 is an oral inhibitor of EED that induces HbF and may treat hemoglobinopathies like sickle cell and β-thalassemia.</p>Formula:C22H18FN5O2Color and Shape:SolidMolecular weight:403.417PROTAC EED degrader-1
<p>PROTAC EED degrader-1 is a PROTAC targeting EED (pKD = 9.02), is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.17.</p>Formula:C55H60FN11O8SPurity:98%Color and Shape:SolidMolecular weight:1054.2GSK3735967
CAS:<p>GSK3735967: DNMT1 inhibitor, IC50 40 nM, dicyanopyridine core, binds hemimethylated CpG, interacts with H4K20me3.</p>Formula:C25H31N7OSColor and Shape:SolidMolecular weight:477.62A-893
CAS:<p>A-893 is a cell-active inhibitor of Methyltransferase SMYD2 (IC 50 = 2.8 nM) .</p>Formula:C29H38Cl2N4O4Color and Shape:SolidMolecular weight:577.54UNC4976
<p>UNC4976 is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids.</p>Formula:C47H70N6O8Purity:98%Color and Shape:SolidMolecular weight:847.09PROTAC EED degrader-2
<p>PROTAC EED degrader-2 is a PROTAC targeting EED (pKD of 9.27),is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.11.</p>Formula:C50H58FN11O6SPurity:98%Color and Shape:SolidMolecular weight:960.13PRMT5-IN-41
CAS:PRMT5-IN-41 (compound 130) is an effective orally active inhibitor of PRMT5. It inhibits the hERG ion channel with an IC50 of 1.36 µM.Formula:C22H16F5N5O2Molecular weight:477.39PARP/EZH2-IN-2
<p>PARP/EZH2-IN-2 (compound 12e) functions as a dual inhibitor targeting both PARP1 and EZH2, with IC50 values of 6.89 and 27.34 nM, respectively. This compound exhibits anticancer activity without toxicity to normal cells, achieving synthetic lethality indirectly by increasing PARP1 sensitivity through EZH2 inhibition, and inducing cell death by modulating excessive autophagy.</p>Formula:C33H31N7O3Molecular weight:573.24884Histone H3K9me3 (1-15) TFA
<p>Histone H3K9me3 (1-15) (H3(1-15)K9me3) TFA is used as a substrate. This post-translational modification (PTM) of histone H3K9me3 is indicative of heterochromatin surrounding the centromere.</p>Formula:C66H124N25O21·xC2HF3O2PRMT5-IN-12
CAS:<p>PRMT5-IN-12 shows remarkable inhibitory activity on PRMT5 .</p>Formula:C32H40N4O4Color and Shape:SolidMolecular weight:544.696PRMT4-IN-3
<p>PRMT4-IN-3 (compound 56) serves as a potent class I protein arginine methyltransferase (PRMT) inhibitor, specifically targeting PRMT4 with an IC50 value of 37</p>Formula:C23H29N7OPurity:98%Color and Shape:SolidMolecular weight:419.52EML734
CAS:<p>EML734 is a potent, selective inhibitor of PRMT7 and PRMT9, demonstrating inhibitory concentration 50 (IC50) values of 315 nM for PRMT7 and 0.89 μM for PRMT9.</p>Formula:C27H32N10O7Purity:98%Color and Shape:SolidMolecular weight:608.61EPZ-719
CAS:<p>EPZ-719: Potent SETD2 inhibitor, IC50=0.005μM, high selectivity, potential for targeted epigenetic therapy.</p>Formula:C22H31FN4O3SColor and Shape:SolidMolecular weight:450.57MC3343
CAS:<p>MC3343, a DNMT1/3A inhibitor, affects tumor proliferation by blocking osteosarcoma cells in the G1 or G2/M phase and induces osteogenic differentiation.</p>Formula:C27H23N7OPurity:99.73%Color and Shape:SolidMolecular weight:461.52ORIC-944 TFA
<p>ORIC-944 TFA is an orally bioavailable selective polycomb repressive complex 2 (PRC2) inhibitor with antitumor activity.</p>Formula:C28H26F4N6O3Color and Shape:SoildMolecular weight:570.54UNC7096
<p>UNC7096 is a potent, selective degrader of NSD2-PWWP1, exhibiting a dissociation constant (Kd) of 46 nM, and shows promise for treating NSD2-related diseases [1</p>Formula:C61H87N7O18SPurity:98%Color and Shape:SolidMolecular weight:1238.44UNC2399
CAS:<p>UNC2399, a biotinylated version of UNC1999, functions as a selective degrader of EZH2 and exhibits strong in vitro efficacy against EZH2, demonstrated by its IC</p>Formula:C67H104N10O17SColor and Shape:SolidMolecular weight:1353.68MS9024
<p>MS9024 is a degrader of DNA methyltransferase 1 (DNMT1), facilitating its degradation in HCT116 cells via the ubiquitin-proteasome pathway, with a DC50 of 35 nM (DC50 values are 254 nM in MDA-MB-468 and 101 nM in H1299). Additionally, MS9024 inhibits DNMT1 with an IC50 of 0.43 μM.</p>Color and Shape:Odour SolidMS9715
<p>MS9715 is a potent and selective NSD3-targeting PROTAC, designed by leveraging BI-9321, which targets the PWWP1 domain of NSD3, in conjunction with an E3 ligase</p>Formula:C58H74FN9O5SPurity:98%Color and Shape:SolidMolecular weight:1028.33EPZ-025654
CAS:<p>EPZ-025654 is an effective and selective inhibitor of arginine methyltransferase CARM1.</p>Formula:C29H33ClN8O3Color and Shape:SolidMolecular weight:577.08FTX-6058 hydrochloride
CAS:<p>FTX-6058 hydrochloride is a potent EED inhibitor, induces HbF, and aids sickle cell and β-thalassemia research.</p>Formula:C22H19ClFN5O2Color and Shape:SolidMolecular weight:439.87MS33
CAS:<p>MS33 degrades WDR5 protein, Kd 870 nM (VCB), 120 nM (WDR5); uses VHL ligase, aids acute myeloid leukemia study.</p>Formula:C64H84F3N11O7SColor and Shape:SolidMolecular weight:1208.5EEDi-5285
CAS:<p>EEDi-5285: potent EED inhibitor, orally active, IC50=0.2nM, targets EED protein, anti-cancer properties.</p>Formula:C24H22FN5O3SPurity:100%Color and Shape:SolidMolecular weight:479.53WDR5-47
CAS:<p>WDR5-47 is a potent small molecule to disturb the interaction of MLL1-WDR5 with IC50 value of 0.3μM.</p>Formula:C19H20ClFN4O3Purity:98.15%Color and Shape:SoildMolecular weight:406.84EZH2-IN-4
CAS:<p>EZH2-IN-4, an oral EZH2 inhibitor, targets WT and mutant forms with IC50s of 0.923 nM and 2.65 nM, showing strong anti-cancer effects.</p>Formula:C29H41N3O3SColor and Shape:SolidMolecular weight:511.73ND-L11B free base
<p>ND-L11B is an effective degrader of the nuclear receptor binding SET domain protein 2 (NSD2) and RE-IIBP, with DC50 values of 1.48 μM and 0.8 μM, respectively, and a Dmax close to 80%.</p>Formula:C37H51F3N10O2Color and Shape:SolidMolecular weight:724.862PRMT1-IN-1
CAS:<p>PRMT1-IN-1 is a PRMT1 inhibitor.</p>Formula:C20H7Br6NO5Color and Shape:SolidMolecular weight:820.702CM112
<p>CM112 is a selective degrader of protein arginine methyltransferase 1 (PRMT1), which connects a hydrophobic adamantane tag to MS023 via a 5-PEG linker. It induces the degradation of PRMT1 in various solid tumor cell lines. CM112 also targets the non-enzymatic functions of PRMT1 by reducing the stability of the orphan receptor TR3. This compound shows potential for cancer research.</p>Formula:C39H61N5O7Color and Shape:SolidMolecular weight:711.4571MAK-683 hydrochloride
CAS:MAK683 hydrochloride is an inhibitor of embryonic ectoderm development (EED), with IC50 values of 59, 26nM measured in EED Alphascreen, ELISA.Cost-effective and quality-assured.Formula:C20H18ClFN6OPurity:97.02% - >99.99%Color and Shape:SolidMolecular weight:412.85SGC3027
<p>SGC3027 is an inhibitor of histone methyltransferase,also is a first potent, selective and cell active chemical probe for PRMT7.</p>Formula:C41H47ClN6O6SPurity:98%Color and Shape:SolidMolecular weight:787.37Dot1L-IN-8
<p>Dot1L-IN-8 (Compound 15) is an effective Dot1L inhibitor. It suppresses the viability of HL-60, K562, MV4-11, HH, and KG-1 cells, with IC50 values of 0.45, 1.03, 0.68, 1.66, and 1.12 μM, respectively.</p>Formula:C41H53N7O3SColor and Shape:SolidMolecular weight:723.97NSD2-IN-4
<p>NSD2-IN-4 is a potent, selective inhibitor of the NSD2-SET domain, showing promise for the treatment of diseases related to NSD2 [1].</p>Formula:C18H14ClN3O3Purity:98%Color and Shape:SolidMolecular weight:355.78NSC 370284
CAS:<p>NSC 370284 inhibits STAT3/5, reducing AML cell viability with TET1 overexpression in vitro/in vivo.</p>Formula:C21H25NO6Purity:99.74%Color and Shape:SolidMolecular weight:387.43AS-254s
<p>AS-254s is an inhibitor of absent, small, or homeotic-like 1 protein (ASH1L), with an IC50 of 94 nM (FP assay). It exhibits antiproliferative activity against leukemia cells with MLL1 rearrangement, with a GI50 of less than 1 μM. Additionally, AS-254s can induce differentiation in MLL1-r leukemia cells.</p>Formula:C36H41ClN6O3S2Color and Shape:SolidMolecular weight:705.332GSK 591 dihydrochloride
CAS:<p>Strong PRMT5 inhibitor with 4 nM IC50, surpassing other PRMTs; halts MCL growth in lab tests.</p>Formula:C22H30Cl2N4O2Color and Shape:SolidMolecular weight:453.41Dot1L-IN-1 TFA
<p>Dot1L-IN-1 TFA: potent inhibitor, K i =2 pM, IC 50 <0.1 nM; reduces H3K79 dimethylation (IC 50 =3 nM) & HoxA9 promoter activity (IC 50 =17 nM).</p>Formula:C34H37ClF3N9O4SColor and Shape:SolidMolecular weight:760.23SAH-EZH2
CAS:<p>EZH2/EPP inhibitor, Kd 320 nM. Reduces EZH2, H3K27me3; halts MLL-AF9 leukemia growth; drives monocyte-macrophage differentiation.</p>Formula:C155H256N48O40Purity:98%Color and Shape:SolidMolecular weight:3432.05Gintemetostat
CAS:<p>Gintemetostat (KTX-1001) is a potent NSD2 inhibitor (IC50=0.001-0.01μM) for treating NSD2-dysregulated cancers.</p>Formula:C25H26F4N8O2Color and Shape:SolidMolecular weight:546.52AMI-1 free acid
CAS:<p>AMI-1: Potent reversible PRMT inhibitor; IC50: 8.8 μM (hPRMT1), 3.0 μM (yeast-Hmt1p); blocks substrate binding.</p>Formula:C21H16N2O9S2Purity:97.8%Color and Shape:SolidMolecular weight:504.49PROTAC EZH2 Degrader-1
CAS:<p>PROTAC EZH2 Degrader-1 suppresses EZH2 methyltransferase activity with IC50 2.7 nM, serving as a potent tool in cancer research and EZH2 inhibition studies.</p>Formula:C54H67N7O8Color and Shape:SolidMolecular weight:942.15MS8511 hydrochloride
CAS:<p>MS8511 hydrochloride is a selective G9a/GLP inhibitor with IC50 values of 100 nM and 140 nM respectively, exhibiting covalent and irreversible characteristics.</p>Formula:C28H42ClN5O3Color and Shape:SolidMolecular weight:532.122'-Deoxy-2'-fluoro-β-D-arabinocytidine hydrochloride
CAS:<p>2'-Deoxy-2'-fluoro-beta-D-arabinocytidine HCl inhibits DNA methyltransferase with potential anti-tumor properties.</p>Formula:C9H13ClFN3O4Purity:99.69%Color and Shape:SolidMolecular weight:281.67(R)-GSK-3685032
CAS:<p>(R)-GSK-3685032 is a selective, reversible DNMT1 inhibitor, non-covalent, IC50: 0.036 μM; reduces DNA methylation, inhibits cancer growth.</p>Formula:C22H24N6OSColor and Shape:SolidMolecular weight:420.545-Aza-2'-deoxycytidine
CAS:Formula:C8H12N4O4Purity:>98.0%(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:228.21DA-3003-1
CAS:<p>DA-3003-1 (NSC 663284) is a Cdc25 dual specificity phosphatase inhibitor with antitumor activity and inhibits Cdc25B2, Cdc25A, Cdc25B2, and Cdc25C.</p>Formula:C15H16ClN3O3Purity:99.27% - 99.79%Color and Shape:SolidMolecular weight:321.76EHMT2-IN-1
CAS:<p>EHMT2-IN-1: potent EHMT inhibitor, for blood disorders/cancer research; IC50s <100 nM for EHMT1/2 peptides and cellular EHMT2.</p>Formula:C18H23N7OColor and Shape:SolidMolecular weight:353.42O6-Benzylguanine
CAS:Formula:C12H11N5OPurity:>98.0%(T)(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:241.25O6BTG-octylglucoside
CAS:O6BTG-octylglucoside is a potent O6-methylguanine-DNAmethyl-transferase (MGMT) inhibitor (IC50s: 10 nM and 32 nM in HeLa S3 cells and in vitro (cell extracts)).Formula:C24H34BrN5O7SPurity:98%Color and Shape:SolidMolecular weight:616.53EZM0414 TFA
CAS:<p>EZM0414 TFA (SETD2-IN-1 TFA) is a SETD2 inhibitor with anticancer and antiproliferative effects for the study of leukemia and immune dysfunction.</p>Formula:C24H30F4N4O4Purity:98.88%Color and Shape:SolidMolecular weight:514.51(R)-HH2853
CAS:<p>(R)-HH2853, a mutant EZH2 inhibitor, IC50 <100 nM for EZH2-Y641F, targets cancer/autoimmune diseases.</p>Formula:C31H36F3N7O3Purity:97.53% - 98.85%Color and Shape:SolidMolecular weight:611.665'-Azido-5'-deoxyadenosine
CAS:<p>5'-Azido-5'-deoxyadenosine is a purine nucleoside analogue, inhibit Trichomonas vaginalis and PRMT5 , click chemistry alkyne, DBCO, or BCN groups.</p>Formula:C10H12N8O3Purity:99.84%Color and Shape:SolidMolecular weight:292.25PR5-LL-CM01
CAS:<p>PR5-LL-CM01 is a novel protein arginine methyltransferase 5 (PRMT5) inhibitor in colorectal and pancreatic cancers.</p>Formula:C23H27N7Color and Shape:SolidMolecular weight:401.51AZ505 ditrifluoroacetate
CAS:<p>AZ505 ditrifluoroacetate is an effective and selective SMYD2 inhibitor (IC50: 0.12 μM).</p>Formula:C33H40Cl2F6N4O8Color and Shape:SolidMolecular weight:805.59AS-85
CAS:<p>AS-85 is an ASH1L inhibitor with anti-leukemic activity that inhibits leukemic cell growth and increases cLogP.</p>Formula:C26H28F3N5O3S2Purity:98.96%Color and Shape:SolidMolecular weight:579.66EPZ020411
CAS:<p>EPZ020411 is a specific and effective inhibitor of PRMT6 (IC50=10 nM).</p>Formula:C25H38N4O3Color and Shape:SolidMolecular weight:442.66-Thioguanine
CAS:<p>6-Thioguanine (2-Amino-6-purinethiol) is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.</p>Formula:C5H5N5SPurity:98.34% - >99.99%Color and Shape:Odorless Or Almost Odorless Pale Yellow Crystalline PowderMolecular weight:167.195-Methyl-2'-deoxycytidine
CAS:<p>5-Methyl-2'-deoxycytidine (5MedCyd) is a pyrimidine nucleoside that when incorporated into single-stranded DNA can act in cis to signal de novo.</p>Formula:C10H15N3O4Purity:99.18% - 99.69%Color and Shape:SolidMolecular weight:241.24GSK503
CAS:<p>GSK-503, a potent EZH2 inhibitor, has potential antitumor activity.</p>Formula:C31H38N6O2Purity:98% - 99.89%Color and Shape:SolidMolecular weight:526.675-Fluoro-2'-deoxycytidine
CAS:<p>5-Fluoro-2'-deoxycytidine (2'-DEOXY-5-FLUOROCYTIDINE) is an inhibitor of DNA methyltransferase (DNMT) .</p>Formula:C9H12FN3O4Purity:97.91%Color and Shape:Fine White PowderMolecular weight:245.21MR837
CAS:<p>MR837 (NSD2-PWWP1 antagonist 3f) is a NSD2-PWWP1 antagonist.</p>Formula:C16H14N2OSPurity:99.77% - 99.85%Color and Shape:SolidMolecular weight:282.36SGC2085
CAS:<p>SGC2085 is an effective and selective coactivator-associated arginine methyltransferase 1 (CARM1) inhibitor (IC50: 50 nM).</p>Formula:C19H24N2O2Purity:99.61% - 99.71%Color and Shape:SolidMolecular weight:312.41Zebularine
CAS:<p>Zebularine (4-Deoxyuridine) is a DNA methylation inhibitor.</p>Formula:C9H12N2O5Purity:99.04% - >99.99%Color and Shape:SolidMolecular weight:228.2BRD4770
CAS:<p>BRD4770 is a histone methyltransferase G9a inhibitor and induces cell senescence.</p>Formula:C25H23N3O3Purity:99.82%Color and Shape:SolidMolecular weight:413.47UNC3866 TFA(1872382-47-2 free base)
CAS:<p>UNC3866 TFA is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen.</p>Formula:C45H67F3N6O10Purity:98.43%Color and Shape:SolidMolecular weight:909.04GSK343
CAS:<p>GSK343, a specific and effective EZH2 inhibitor (IC50=4 nM), exhibits 60 fold specificity activity against EZH1, and >1000 fold specificity activity against</p>Formula:C31H39N7O2Purity:98% - 99.9%Color and Shape:SolidMolecular weight:541.69EED226
CAS:<p>EED226 is a potent, selective, and orally bioavailable embryonic ectoderm development (EED) inhibitor with an IC50 of 22 nM.</p>Formula:C17H15N5O3SPurity:98.14% - 99.33%Color and Shape:SolidMolecular weight:369.4Succinic acid sodium
CAS:<p>Succinic acid sodium is an orally active anxiolytic.</p>Formula:C4H6O4·xNaColor and Shape:Solidγ-Oryzanol
CAS:<p>γ-Oryzanol (Gamma-Oryzanol) is a natural nutrient extract isolated from rice bran oil that contains a mixture of sterols and ferulic acids, which may aid in the</p>Formula:C40H58O4Purity:mixture - mixtureColor and Shape:White Or White Crystalline Powder OdourlessMolecular weight:602.93-deazaneplanocin A HCl
CAS:<p>3-deazaneplanocin A HCl is both an S-adenosyl-l-homocysteine hydrolase inhibitor and an enhancer of zeste homolog 2(EZH2) inhibitor.</p>Formula:C12H15ClN4O3Purity:93.24% - 98.9%Color and Shape:SolidMolecular weight:298.73MS023
CAS:<p>MS023 is a potent, selective, and cell-active Type I PRMT inhibitor with IC50 of 30 nM, 119 nM, 83 nM, 4 nM, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8,</p>Formula:C17H25N3OPurity:98.31% - 99.87%Color and Shape:SolidMolecular weight:287.4UNC3866
CAS:<p>UNC3866 is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen.</p>Formula:C43H66N6O8Purity:88.06% - 99.62%Color and Shape:SolidMolecular weight:795.02JNJ-64619178
CAS:<p>JNJ-64619178: selective, oral, pseudo-irreversible PRMT5 inhibitor (IC50: 0.14 nM), effective in lung cancer.</p>Formula:C22H23BrN6O2Purity:98.44% - 99.63%Color and Shape:SolidMolecular weight:483.36OTS186935 hydrochloride
<p>OTS186935 HCl inhibits SUV39H2 (IC50 6.49 nM), curbs tumor growth in mice, and modulates γ-H2AX in cancer cells.</p>Formula:C25H27Cl2N5O2Color and Shape:SolidMolecular weight:522.31MRTX9768
CAS:<p>MRTX-9768 is a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors.</p>Formula:C24H17FN6OPurity:97.02%Color and Shape:SolidMolecular weight:424.43OICR-9429
CAS:<p>OICR-9429 blocks WDR5 binding to MLL/Histone 3, hindering acute myeloid leukemia cell growth in vitro.</p>Formula:C29H32F3N5O3Purity:97.07% - 99.93%Color and Shape:SolidMolecular weight:555.59Pinometostat
CAS:<p>Pinometostat (EPZ-5676) is a potent DOT1L histone methyltransferase inhibitor. Pinometostat has antitumor activity. Cost effective and quality assured.</p>Formula:C30H42N8O3Purity:99.19% - 99.86%Color and Shape:SolidMolecular weight:562.71TP-064
CAS:<p>TP-064: Potent, selective PRMT4 inhibitor, IC50 < 10nM for H3 methylation, 100x selectivity, blocks MED12 methylation at 43nM.</p>Formula:C28H34N4O2Purity:97.85%Color and Shape:SolidMolecular weight:458.6SETDB1-TTD-IN-1
CAS:<p>SETDB1-TTD-IN-1 is a potent and selective inhibitor of SET domain bifurcated protein 1 tandem tudor domain (SETDB1-TTD, Kd = 88 nM).Cost-effective and quality-assured.</p>Formula:C28H31N5O2Purity:98.26% - 99.96%Color and Shape:SolidMolecular weight:469.58CM-579 trihydrochloride
<p>CM-579 trihydrochloride: reversible G9a/DNMT inhibitor with IC50s 16 nM (G9a) & 32 nM (DNMT); potent against various cancer cells.</p>Formula:C29H43Cl3N4O3Color and Shape:SolidMolecular weight:602.04HLCL-61 hydrochloride
CAS:<p>HLCL-61 hydrochloride (HLCL-61 HCL) is a potent and selective PRMT5 inhibitor for the treatment of acute myeloid leukemia.</p>Formula:C23H24N2O·ClHPurity:99.88% - 99.95%Color and Shape:SolidMolecular weight:380.91SGC707
CAS:<p>SGC707 is a potent, selective, and cell-active allosteric inhibitor of PRMT3.</p>Formula:C16H18N4O2Purity:98.45% - 99.79%Color and Shape:SolidMolecular weight:298.34BRD9539
CAS:<p>BRD9539 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2), also known as G9a, with an IC50 value of 6.3 μM</p>Formula:C24H21N3O3Purity:98% - 99.57%Color and Shape:SolidMolecular weight:399.44EPZ004777
CAS:<p>EPZ004777 is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM.</p>Formula:C28H41N7O4Purity:98.99% - 99.32%Color and Shape:SolidMolecular weight:539.67PF-06726304
CAS:<p>PF-06726304: potent EZH2 inhibitor, effective against tumors, Kis at 0.7 nM (wild-type) and 3.0 nM (Y641N mutant).</p>Formula:C22H21Cl2N3O3Purity:98.19% - 99.51%Color and Shape:SolidMolecular weight:446.33MS049
CAS:<p>MS 049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC 50 of 34 nM and 43 nM, respectively.</p>Formula:C15H24N2OPurity:98.91%Color and Shape:SolidMolecular weight:248.36Tazemetostat
CAS:<p>Tazemetostat (EPZ6438): Oral EZH2 inhibitor, blocks histone H3K27 methylation, potential cancer therapy.</p>Formula:C34H44N4O4Purity:98.24% - ≥95%Color and Shape:SolidMolecular weight:572.74LLY-507
CAS:<p>LLY-507 is an effective, cell-active, and specific inhibitor of protein-lysine Methyltransferase SMYD2.</p>Formula:C36H42N6OPurity:99.58% - 99.93%Color and Shape:SolidMolecular weight:574.76AMI-1
CAS:<p>AMI-1 is an effective and selective Histone Methyltransferase (HMT) inhibitor (IC50: 3.0/8.8 μM, for yeast Hmt1p, and human PRMT1).</p>Formula:C21H14N2Na2O9S2Purity:97.53% - 99.9%Color and Shape:DrypowderMolecular weight:548.452',3',5'-triacetyl-5-Azacytidine
CAS:<p>2',3',5'-triacetyl-5-Azacytidine (Nsc291930) is a prodrug form of 5-azacytidine that may be rapidly absorbed orally.</p>Formula:C14H18N4O8Purity:98.34%Color and Shape:SolidMolecular weight:370.31UNC1999
CAS:<p>UNC1999 is a orally bioavailable, effective and specific inhibitor of EZH2 (IC50=2 nM) and EZH1 (IC50=45).</p>Formula:C33H43N7O2Purity:99.19% - >99.99%Color and Shape:SolidMolecular weight:569.74TC-E 5003
CAS:<p>TC-E 5003 (NSC-30176) is a selective inhibitor of PRMT1 with IC50 of 1.5 μM.</p>Formula:C16H14Cl2N2O4SPurity:97.01%Color and Shape:SolidMolecular weight:401.26Gambogenic acid
CAS:Gambogenic acid is a natural product,is an effective inhibitor of EZH2,with anticancer activity.Formula:C38H46O8Purity:97.47% - 99.6%Color and Shape:SolidMolecular weight:630.77BIX-01294
CAS:<p>BIX-01294 is an G9a Histone Methyltransferase inhibitor(IC50 : 1.9 μM).</p>Formula:C28H38N6O2Purity:98.58% - 99.64%Color and Shape:SolidMolecular weight:490.64MT-DADMe-ImmA
CAS:<p>MT-DADMe-ImmA (MTDIA) is an inhibitor of human 5'-methylthioadenosine phosphorylase (MTAP, Ki: 90 pM).</p>Formula:C13H19N5OSPurity:99.56%Color and Shape:SolidMolecular weight:293.39AZ505
CAS:<p>AZ505 is an effective and specific SMYD2 inhibitor (IC50: 0.12 μM).</p>Formula:C29H38Cl2N4O4Purity:98.18%Color and Shape:SolidMolecular weight:577.54Tazemetostat hydrobromide
CAS:<p>Tazemetostat hydrobromide: potent, selective EZH2 inhibitor; blocks PRC2/wild-type EZH2 (Ki: 2.5 nM) & EZH1 (IC50: 392 nM).</p>Formula:C34H45BrN4O4Purity:99.8%Color and Shape:SolidMolecular weight:653.65EPZ015666
CAS:<p>EPZ015666 (GSK3235025) is an orally available inhibitor of PRMT5 enzymatic activity.</p>Formula:C20H25N5O3Purity:98% - 99.64%Color and Shape:SolidMolecular weight:383.44UNC0646
CAS:<p>UNC0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP with low cellular toxicity.</p>Formula:C36H59N7O2Purity:>99.99%Color and Shape:SolidMolecular weight:621.9SGC0946
CAS:<p>SGC0946 is a highly effective and specific DOT1L methyltransferase inhibitor (IC50: 0.3 nM); selectively kill mixed lineage leukemia cells.</p>Formula:C28H40BrN7O4Purity:98% - 99.82%Color and Shape:SolidMolecular weight:618.57UNC1215
CAS:<p>UNC1215, a potent MBT antagonist, targets L3MBTL3 with high selectivity (IC50: 40 nM, Kd: 120 nM, 50x versus MBT family).</p>Formula:C32H43N5O2Purity:98% - 99.04%Color and Shape:SolidMolecular weight:529.72
