DNA Methyltransferase
DNA methyltransferases (DNMTs) are enzymes that catalyze the addition of methyl groups to cytosine residues in DNA, leading to gene silencing. Aberrant DNA methylation is associated with various diseases, including cancer. DNMT inhibitors block the activity of these enzymes, leading to the reactivation of silenced genes and induction of apoptosis in cancer cells. DNMT inhibitors are widely used in epigenetic research and cancer therapy. At CymitQuimica, we provide a range of high-quality DNMT inhibitors to support your research in epigenetics, DNA methylation, and cancer biology.
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PRMT5-IN-28
CAS:2242753-66-6
PRMT5-IN-28 (compound 36) serves as an inhibitor of the protein arginine methyltransferase 5 (PRMT5) enzyme, …
Formula:
C18H19ClN4O5
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
406.82
Ref: TM-T79035
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 11 Feb 2025
EPZ031686
CAS:1808011-22-4
EPZ031686 is an effective inhibitor of SMYD3 inhibitor with an IC50 of 3 nM and …
Formula:
C26H34ClF3N4O4S
Purity:
97.91%
Color and Shape:
Solid
Molecular weight:
591.09
Ref: TM-TQ0263
| 1mg | 109.00 € | ||
| 5mg | 244.00 € | ||
| 10mg | 368.00 € | ||
| 25mg | 731.00 € | ||
| 50mg | 1,054.00 € | ||
| 100mg | 1,412.00 € | ||
| 1mL*10mM (DMSO) | 339.00 € |
Estimated delivery in United States, on Tuesday 11 Feb 2025
PRMT5-IN-29
CAS:2242788-69-6
PRMT5-IN-29 is a potent, orally active inhibitor of PRMT5, exhibiting an IC50 value of 1.5 …
Formula:
C18H20Cl3N5O5
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
492.74
Ref: TM-T78172
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 11 Feb 2025
PRMT5-IN-25
CAS:2691869-82-4
PRMT5-IN-25 (compound 503) is a potent inhibitor of PRMT5, exhibiting an inhibition constant (K i) …
Formula:
C24H21F3N6O
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
466.46
Ref: TM-T78152
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 11 Feb 2025
Igermetostat
CAS:2409538-60-7
Igermetostat, an EZH2 inhibitor, is utilized both in vivo and in vitro for cancer research …
Formula:
C32H46N4O4
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
550.73
Ref: TM-T79849
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 11 Feb 2025
SMYD3-IN-1
CAS:2095160-79-3
SMYD3-IN-1 is an irreversible and selective SMYD3 (SET and MYND domain containing 3) inhibitor(IC50 of …
Formula:
C28H31ClN4O3
Purity:
98%
Color and Shape:
Solid
Molecular weight:
507.02
Ref: TM-T12940
| 25mg | 1,688.00 € | ||
| 50mg | 2,217.00 € | ||
| 100mg | 2,888.00 € |
Estimated delivery in United States, on Tuesday 11 Feb 2025
BBDDL2059
CAS:2691174-27-1
BBDDL2059 is a selective covalent inhibitor targeting EZH2, exhibiting an IC50 of 1.5 nM against …
Formula:
C27H36N4O4S
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
512.66
Ref: TM-T79200
| 25mg | 1,549.00 € | ||
| 50mg | 2,038.00 € | ||
| 100mg | 2,617.00 € |
Estimated delivery in United States, on Tuesday 11 Feb 2025
Antitumor agent-101
CAS:2848632-52-8
Antitumor agent-101 is a selective, covalent inhibitor targeting lysine methyltransferases G9a/GLP, demonstrating IC50 values of …
Formula:
C26H38N6O3
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
482.62
Ref: TM-T79249
| 25mg | 1,410.00 € | ||
| 50mg | 1,851.00 € | ||
| 100mg | 2,337.00 € |
Estimated delivery in United States, on Tuesday 11 Feb 2025
YM458
CAS:2770108-93-3
YM458 inhibits EZH2 (490 nM) and BRD4 (34 nM), curbing tumor cell growth and inducing …
Formula:
C53H61ClN8O5S
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
957.62
Ref: TM-T74542
| 25mg | 1,410.00 € | ||
| 50mg | 1,851.00 € | ||
| 100mg | 2,337.00 € |
Estimated delivery in United States, on Tuesday 11 Feb 2025
GSK-3484862
CAS:2170136-65-7
Gsk-3484862 is a non covalent inhibitor of DNA methyltransferase DNMT1 with anticancer activity.
Formula:
C19H19N5OS
Purity:
100% - 97.83%
Color and Shape:
Solid
Molecular weight:
365.45
Ref: TM-T11469
| 1mg | 51.00 € | ||
| 5mg | 118.00 € | ||
| 10mg | 183.00 € | ||
| 25mg | 328.00 € | ||
| 50mg | 500.00 € | ||
| 100mg | 716.00 € | ||
| 500mg | 1,440.00 € | ||
| 1mL*10mM (DMSO) | 214.00 € |
Estimated delivery in United States, on Tuesday 11 Feb 2025
MS023 trihydrochloride
CAS:2108631-19-0
MS023 trihydrochloride (MS023 3HCl) is a PRMT inhibitor with potential anticancer activity against PRMT1, PRMT3, …
Formula:
C17H28Cl3N3O
Purity:
99.81%
Color and Shape:
Liquid
Molecular weight:
396.78
Ref: TM-T77787
| 1mg | 141.00 € | ||
| 5mg | 591.00 € | ||
| 10mg | 1,034.00 € | ||
| 25mg | 2,267.00 € |
Estimated delivery in United States, on Tuesday 11 Feb 2025
DY-46-2
CAS:1105110-83-5
DY-46-2 is a DNMT3A inhibitor (IC50: 0.39 ± 0.23 μM) with anticancer activity and is …
Formula:
C19H22N6O5S
Purity:
99.12% - 99.12%
Color and Shape:
Liquid
Molecular weight:
446.48
Ref: TM-T62643
| 1mg | 150.00 € | ||
| 25mg | 1,343.00 € | ||
| 50mg | 1,749.00 € | ||
| 100mg | 2,364.00 € |
Estimated delivery in United States, on Tuesday 11 Feb 2025
UNC8153 TFA
CAS:2929304-61-8
UNC8153 is a NSD2-specific histone-lysine N-methyltransferase degrader, showing selective activity towards NSD2 over NSD1 and …
Formula:
C35H38F3N5O7
Purity:
96.44%
Color and Shape:
Liquid
Molecular weight:
697.7
Ref: TM-T83867
| 1mg | 78.00 € | ||
| 5mg | 216.00 € | ||
| 10mg | 352.00 € | ||
| 25mg | 579.00 € | ||
| 50mg | 820.00 € |
Estimated delivery in United States, on Tuesday 11 Feb 2025
TNG-462
CAS:2760483-96-1
TNG-462 (Compound 1143) is a PRMT5 inhibitor with oral activity, being investigated for use in …
Formula:
C28H36N6O2S
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
520.69
Ref: TM-T79873
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 11 Feb 2025
CARM1-IN-3
CAS:912970-67-3
CARM1-IN-3 (compound 17b) is a potent, selective inhibitor of co-activator associated arginine methyltransferase (CARM1), exhibiting …
Formula:
C24H32N4O2
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
408.54
Ref: TM-T79007
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 11 Feb 2025
Dot1L-IN-1
CAS:2088518-50-5
The Ki value of DOT1L-in-1 is 2pm.It is a highly effective, selective and novel Dot1L …
Formula:
C32H36ClN9O2S
Purity:
98%
Color and Shape:
Solid
Molecular weight:
646.21
Ref: TM-T11081
| 25mg | 2,523.00 € | ||
| 50mg | 3,346.00 € | ||
| 100mg | 4,580.00 € |
Estimated delivery in United States, on Tuesday 11 Mar 2025
GSK3368715
CAS:1629013-22-4
GSK3368715 is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases …
Formula:
C20H38N4O2
Purity:
98%
Color and Shape:
Solid
Molecular weight:
366.54
Ref: TM-T11500
| 25mg | 2,523.00 € | ||
| 50mg | 3,348.00 € | ||
| 100mg | 4,583.00 € |
Estimated delivery in United States, on Tuesday 11 Mar 2025
AMI-408
CAS:78866-14-5
AMI-408 is a PRMT1 inhibitor that effectively reduces the levels of H4R3me2as in MLL-GAS7 leukemia …
Formula:
C20H13Cl2N6NaO5S
Color and Shape:
Liquid
Molecular weight:
543.32
Ref: TM-T200391
| 10mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 11 Mar 2025
AMG-193
CAS:2790567-82-5
AMG-193 is an inhibitor of the MTA-PRMT5 complex and is used in the study of …
Formula:
C22H19F3N4O3
Color and Shape:
Liquid
Molecular weight:
444.41
Ref: TM-T85645
| 1mg | 182.00 € | ||
| 5mg | 451.00 € | ||
| 10mg | 646.00 € | ||
| 25mg | 1,008.00 € | ||
| 50mg | 1,391.00 € | ||
| 100mg | 1,839.00 € | ||
| 1mL*10mM (DMSO) | 578.00 € |
Estimated delivery in United States, on Tuesday 11 Mar 2025
GSK3368715 dihydrochloride
CAS:1628925-77-8
GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) is a PRMTs inhibitor , with anticancer activity, for the study …
Formula:
C20H40Cl2N4O2
Purity:
99.66% - 99.66%
Color and Shape:
Solid
Molecular weight:
439.46
Ref: TM-T11500L
| 1mg | 61.00 € | ||
| 1mL*10mM (DMSO) | 92.00 € |
Estimated delivery in United States, on Tuesday 11 Mar 2025
