DNA Methyltransferase
DNA methyltransferases (DNMTs) are enzymes that catalyze the addition of methyl groups to cytosine residues in DNA, leading to gene silencing. Aberrant DNA methylation is associated with various diseases, including cancer. DNMT inhibitors block the activity of these enzymes, leading to the reactivation of silenced genes and induction of apoptosis in cancer cells. DNMT inhibitors are widely used in epigenetic research and cancer therapy. At CymitQuimica, we provide a range of high-quality DNMT inhibitors to support your research in epigenetics, DNA methylation, and cancer biology.
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EPZ032597
CAS:1887193-58-9
EPZ032597 is a novel selective inhibitor of SMYD2 with an IC50 of 16 nM. EPZ032597 …
Formula:
C20H23N7O
Purity:
99.41%
Color and Shape:
Liquid
Molecular weight:
377.44
Ref: TM-T70087
| 1mg | 327.00 € | ||
| 5mg | 904.00 € | ||
| 10mg | 1,119.00 € | ||
| 25mg | 1,486.00 € | ||
| 50mg | 1,846.00 € | ||
| 100mg | 2,336.00 € |
Estimated delivery in United States, on Thursday 23 Jan 2025
PRMT4-IN-1
CAS:912970-79-7
PRMT4-IN-1 is a selective inhibitor of PRMT4, demonstrating an IC50 value of 3.2 nM, and …
Formula:
C23H28FN3O
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
381.49
Ref: TM-T68378
| 25mg | 1,549.00 € | ||
| 50mg | 2,038.00 € | ||
| 100mg | 2,617.00 € |
Estimated delivery in United States, on Thursday 23 Jan 2025
3-Deazaneplanocin A
CAS:102052-95-9
3-Deazaneplanocin A (DZNep) is an attractive epigenetic anticancer agent through the inhibition of the cellular …
Formula:
C12H14N4O3
Purity:
98%
Color and Shape:
Solid
Molecular weight:
262.26
Ref: TM-T6292
| 1mg | 153.00 € | ||
| 5mg | 398.00 € |
Estimated delivery in United States, on Thursday 23 Jan 2025
SMYD2-IN-1
CAS:2023788-96-5
SMYD2-IN-1 is an inhibitor of SMYD2 (IC50 of 4.45 nM).
Formula:
C25H25Cl2F2N7O2
Purity:
98%
Color and Shape:
Solid
Molecular weight:
564.41
Ref: TM-T12939
| 25mg | 1,410.00 € |
Estimated delivery in United States, on Thursday 23 Jan 2025
EML741
CAS:2328074-38-8
EML741 also inhibits DNMT1 (IC50, 3.1 μM), with no effect on DNMT3a or DNMT3b.
Formula:
C31H49N5O2
Purity:
98%
Color and Shape:
Solid
Molecular weight:
523.75
Ref: TM-T11185
| 25mg | 1,406.00 € |
Estimated delivery in United States, on Thursday 23 Jan 2025
UNC0321
CAS:1238673-32-9
UNC0321 is an effective inhibitor of histone methyltransferase G9a with a Ki of 63 pM …
Formula:
C27H45N7O3
Purity:
99.25%
Color and Shape:
Solid
Molecular weight:
515.69
Ref: TM-T17204
| 1mg | 46.00 € | ||
| 5mg | 94.00 € | ||
| 10mg | 146.00 € | ||
| 25mg | 278.00 € | ||
| 50mg | 437.00 € | ||
| 100mg | 629.00 € |
Estimated delivery in United States, on Thursday 23 Jan 2025
EZM 2302
CAS:1628830-21-6
EZM 2302 (GSK3359088) is a selective, and orally available arginine methyltransferase CARM1 inhibitor (IC50: 6 …
Formula:
C29H37ClN6O5
Purity:
97.47% - ≥98%
Color and Shape:
Solid
Molecular weight:
585.09
Ref: TM-T5605
| 1mg | 73.00 € | ||
| 5mg | 160.00 € | ||
| 10mg | 231.00 € | ||
| 25mg | 441.00 € | ||
| 50mg | 588.00 € | ||
| 100mg | 831.00 € |
Estimated delivery in United States, on Thursday 23 Jan 2025
Dot1L-IN-2
CAS:1940206-71-2
Dot1l-in-2 is an effective, selective and oral bioutilization inhibitor of histone methyltransferase Dot1L, with IC50 …
Formula:
C27H24N8O
Purity:
98%
Color and Shape:
Solid
Molecular weight:
476.53
Ref: TM-T11082
| 25mg | 1,545.00 € | ||
| 50mg | 2,031.00 € | ||
| 100mg | 2,609.00 € |
Estimated delivery in United States, on Thursday 23 Jan 2025
Guadecitabine sodium
CAS:929904-85-8
Guadecitabine sodium is a inhibitor of second-generation DNA methyltransferases (DNMT) .
Formula:
C18H24N9NaO10P
Purity:
98%
Color and Shape:
Solid
Molecular weight:
580.407
Ref: TM-T12790
| 25mg | 1,549.00 € | ||
| 50mg | 2,038.00 € | ||
| 100mg | 2,617.00 € |
Estimated delivery in United States, on Thursday 23 Jan 2025
DW14800
CAS:2243709-60-4
DW14800 is an inhibitor of PRMT5 (IC50 = 17 nM), enhances the transcription of HNF4α, …
Formula:
C31H36N4O3
Purity:
97.26% - 99.12%
Color and Shape:
Solid
Molecular weight:
512.64
Ref: TM-T11131
| 1mg | 87.00 € | ||
| 2mg | 127.00 € | ||
| 5mg | 214.00 € | ||
| 10mg | 373.00 € | ||
| 25mg | 708.00 € | ||
| 50mg | 935.00 € | ||
| 100mg | 1,383.00 € | ||
| 1mL*10mM (DMSO) | 242.00 € |
Estimated delivery in United States, on Thursday 23 Jan 2025
MS0124
CAS:1197196-63-6
MS0124 is a potent and selective G9A-like protein (GLP) inhibitor with IC50 values of 13±4 …
Formula:
C20H29N5O3
Purity:
99.56%
Color and Shape:
Solid
Molecular weight:
387.48
Ref: TM-T28112
| 1mg | 306.00 € | ||
| 5mg | 741.00 € | ||
| 10mg | 1,013.00 € | ||
| 25mg | 1,532.00 € | ||
| 50mg | 2,083.00 € | ||
| 100mg | 2,719.00 € |
Estimated delivery in United States, on Thursday 23 Jan 2025
MI-2-2
CAS:1454920-20-7
MI-2-2 is an inhibitor of bivalent protein-protein interaction between menin and MLL with an IC50 …
Formula:
C17H20F3N5S2
Purity:
99.56%
Color and Shape:
Solid
Molecular weight:
415.5
Ref: TM-T28036
| 1mg | 63.00 € | ||
| 5mg | To inquire |
Estimated delivery in United States, on Thursday 23 Jan 2025
GNA002
CAS:1385035-79-9
GNA002 is a highly potent, specific, and covalent EZH2 (Enhancer of zeste homolog 2) inhibitor …
Formula:
C42H55NO8
Purity:
98%
Color and Shape:
Solid
Molecular weight:
701.89
Ref: TM-T11436
| 25mg | 1,104.00 € |
Estimated delivery in United States, on Thursday 23 Jan 2025
ZLD1039
CAS:1826865-46-6
ZLD1039, an oral EZH2 inhibitor, shows strong PRC2 inhibition at low nanomolar IC50s, and halts …
Formula:
C36H48N6O3
Purity:
99.82%
Color and Shape:
Solid
Molecular weight:
612.8
Ref: TM-T29231
| 1mg | 35.00 € | ||
| 5mg | 72.00 € | ||
| 10mg | 102.00 € | ||
| 25mg | 221.00 € | ||
| 50mg | To inquire |
Estimated delivery in United States, on Thursday 23 Jan 2025
PRMT5-IN-2
CAS:1989620-04-3
PRMT5-IN-2 is an inhibitor of protein arginine methyltransferase 5.
Formula:
C17H16ClFN4O4
Purity:
98%
Color and Shape:
Solid
Molecular weight:
394.78
Ref: TM-T16577
| 25mg | 1,549.00 € | ||
| 50mg | 2,031.00 € | ||
| 100mg | 2,609.00 € |
Estimated delivery in United States, on Thursday 23 Jan 2025
EZH2-IN-13
CAS:1403255-41-3
EZH2-IN-13 is a potent EZH2 inhibitor with potential anticancer activity.EZH2-IN-13 may be used to study …
Formula:
C34H45N5O3
Purity:
98.3%
Color and Shape:
Liquid
Molecular weight:
571.75
Ref: TM-T64043
| 5mg | 232.00 € | ||
| 10mg | 373.00 € | ||
| 25mg | 739.00 € | ||
| 50mg | 1,107.00 € | ||
| 100mg | 1,754.00 € |
Estimated delivery in United States, on Thursday 23 Jan 2025
DC_517
CAS:500017-70-9
DC_517 is an inhibitor of DNA methyltransferase 1 (DNMT1) ( IC50: 1.7 μM; Kd: 0.91 …
Formula:
C33H35N3O2
Color and Shape:
Solid
Molecular weight:
505.65
Ref: TM-T15081
| 2mg | 186.00 € | ||
| 25mg | 1,271.00 € | ||
| 50mg | 1,676.00 € | ||
| 100mg | 2,340.00 € |
Estimated delivery in United States, on Thursday 23 Jan 2025
TNG908
CAS:2760481-53-4
TNG908, a brain-penetrant PRMT5 inhibitor, is 15x more selective for MTAP mutant vs WT lines, …
Formula:
C21H23N5O2S
Purity:
98.24% - 99.79%
Color and Shape:
Liquid
Molecular weight:
409.51
Ref: TM-T73494
| 1mg | 294.00 € | ||
| 5mg | 637.00 € | ||
| 10mg | 994.00 € | ||
| 25mg | 1,548.00 € | ||
| 50mg | 2,032.00 € | ||
| 100mg | 2,610.00 € |
Estimated delivery in United States, on Thursday 23 Jan 2025
Sarmustine
CAS:81965-43-7
SarCNU is an alkylating anticancer drug targeting prostate cancer through p53 pathways and selects P140K …
Formula:
C6H11ClN4O3
Purity:
100% - 99.71%
Color and Shape:
Solid
Molecular weight:
222.63
Ref: TM-T28663
| 1mg | 185.00 € | ||
| 5mg | 456.00 € | ||
| 10mg | 653.00 € | ||
| 25mg | 1,020.00 € | ||
| 50mg | 1,406.00 € | ||
| 100mg | 1,859.00 € |
Estimated delivery in United States, on Thursday 23 Jan 2025
WM-586
CAS:2894832-05-2
WM-586 is a covalent inhibitor of WDR5 that impedes the WDR5-MYC binding.
Formula:
C20H20F3N5O3S
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
467.47
Ref: TM-T79120
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Thursday 6 Feb 2025
