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DNA Methyltransferase

DNA Methyltransferase

DNA methyltransferases (DNMTs) are enzymes that catalyze the addition of methyl groups to cytosine residues in DNA, leading to gene silencing. Aberrant DNA methylation is associated with various diseases, including cancer. DNMT inhibitors block the activity of these enzymes, leading to the reactivation of silenced genes and induction of apoptosis in cancer cells. DNMT inhibitors are widely used in epigenetic research and cancer therapy. At CymitQuimica, we provide a range of high-quality DNMT inhibitors to support your research in epigenetics, DNA methylation, and cancer biology.

Found 422 products of "DNA Methyltransferase"

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  • SGC707
    Targetmol
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    SGC707

    CAS:
    <p>SGC707 is a potent, selective, and cell-active allosteric inhibitor of PRMT3.</p>
    Formula:C16H18N4O2
    Purity:98.45% - 99.79%
    Color and Shape:Solid
    Molecular weight:298.34

    Ref: TM-T3084

  • BRD9539
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    BRD9539

    CAS:
    <p>BRD9539 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2), also known as G9a, with an IC50 value of 6.3 μM</p>
    Formula:C24H21N3O3
    Purity:98% - 99.57%
    Color and Shape:Solid
    Molecular weight:399.44

    Ref: TM-T7378

  • EPZ004777
    Targetmol
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    EPZ004777

    CAS:
    <p>EPZ004777 is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM.</p>
    Formula:C28H41N7O4
    Purity:98.99% - 99.32%
    Color and Shape:Solid
    Molecular weight:539.67

    Ref: TM-T3081

  • PF-06726304
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    PF-06726304

    CAS:
    <p>PF-06726304: potent EZH2 inhibitor, effective against tumors, Kis at 0.7 nM (wild-type) and 3.0 nM (Y641N mutant).</p>
    Formula:C22H21Cl2N3O3
    Purity:98.19% - 99.51%
    Color and Shape:Solid
    Molecular weight:446.33

    Ref: TM-T12428L

  • MS049
    Targetmol
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    MS049

    CAS:
    <p>MS 049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC 50 of 34 nM and 43 nM, respectively.</p>
    Formula:C15H24N2O
    Purity:98.91%
    Color and Shape:Solid
    Molecular weight:248.36

    Ref: TM-T4378

  • Tazemetostat
    Targetmol
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    Tazemetostat

    CAS:
    <p>Tazemetostat (EPZ6438): Oral EZH2 inhibitor, blocks histone H3K27 methylation, potential cancer therapy.</p>
    Formula:C34H44N4O4
    Purity:98.24% - ≥95%
    Color and Shape:Solid
    Molecular weight:572.74

    Ref: TM-T1788

  • LLY-507
    Targetmol
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    LLY-507

    CAS:
    <p>LLY-507 is an effective, cell-active, and specific inhibitor of protein-lysine Methyltransferase SMYD2.</p>
    Formula:C36H42N6O
    Purity:99.58% - 99.93%
    Color and Shape:Solid
    Molecular weight:574.76

    Ref: TM-T6879

  • AMI-1
    Targetmol
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    AMI-1

    CAS:
    <p>AMI-1 is an effective and selective Histone Methyltransferase (HMT) inhibitor (IC50: 3.0/8.8 μM, for yeast Hmt1p, and human PRMT1).</p>
    Formula:C21H14N2Na2O9S2
    Purity:97.53% - 99.9%
    Color and Shape:Drypowder
    Molecular weight:548.45

    Ref: TM-T2352

  • 2',3',5'-triacetyl-5-Azacytidine
    Targetmol
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    2',3',5'-triacetyl-5-Azacytidine

    CAS:
    <p>2',3',5'-triacetyl-5-Azacytidine (Nsc291930) is a prodrug form of 5-azacytidine that may be rapidly absorbed orally.</p>
    Formula:C14H18N4O8
    Purity:98.34%
    Color and Shape:Solid
    Molecular weight:370.31

    Ref: TM-T7840

  • UNC1999
    Targetmol
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    UNC1999

    CAS:
    <p>UNC1999 is a orally bioavailable, effective and specific inhibitor of EZH2 (IC50=2 nM) and EZH1 (IC50=45).</p>
    Formula:C33H43N7O2
    Purity:99.19% - >99.99%
    Color and Shape:Solid
    Molecular weight:569.74

    Ref: TM-T3057

  • TC-E 5003
    Targetmol
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    TC-E 5003

    CAS:
    <p>TC-E 5003 (NSC-30176) is a selective inhibitor of PRMT1 with IC50 of 1.5 μM.</p>
    Formula:C16H14Cl2N2O4S
    Purity:97.01%
    Color and Shape:Solid
    Molecular weight:401.26

    Ref: TM-T21826

  • Gambogenic acid
    Targetmol
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    Gambogenic acid

    CAS:
    Gambogenic acid is a natural product,is an effective inhibitor of EZH2,with anticancer activity.
    Formula:C38H46O8
    Purity:97.47% - 99.6%
    Color and Shape:Solid
    Molecular weight:630.77

    Ref: TM-T8201

  • BIX-01294
    Targetmol
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    BIX-01294

    CAS:
    <p>BIX-01294 is an G9a Histone Methyltransferase inhibitor(IC50 : 1.9 μM).</p>
    Formula:C28H38N6O2
    Purity:98.58% - 99.64%
    Color and Shape:Solid
    Molecular weight:490.64

    Ref: TM-T7697

  • MT-DADMe-ImmA
    Targetmol
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    MT-DADMe-ImmA

    CAS:
    <p>MT-DADMe-ImmA (MTDIA) is an inhibitor of human 5'-methylthioadenosine phosphorylase (MTAP, Ki: 90 pM).</p>
    Formula:C13H19N5OS
    Purity:99.56%
    Color and Shape:Solid
    Molecular weight:293.39

    Ref: TM-TQ0008

  • AZ505
    Targetmol
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    AZ505

    CAS:
    <p>AZ505 is an effective and specific SMYD2 inhibitor (IC50: 0.12 μM).</p>
    Formula:C29H38Cl2N4O4
    Purity:98.18%
    Color and Shape:Solid
    Molecular weight:577.54

    Ref: TM-TQ0100

  • Tazemetostat hydrobromide
    Targetmol
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    Tazemetostat hydrobromide

    CAS:
    <p>Tazemetostat hydrobromide: potent, selective EZH2 inhibitor; blocks PRC2/wild-type EZH2 (Ki: 2.5 nM) &amp; EZH1 (IC50: 392 nM).</p>
    Formula:C34H45BrN4O4
    Purity:99.8%
    Color and Shape:Solid
    Molecular weight:653.65

    Ref: TM-T17002

  • EPZ015666
    Targetmol
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    EPZ015666

    CAS:
    <p>EPZ015666 (GSK3235025) is an orally available inhibitor of PRMT5 enzymatic activity.</p>
    Formula:C20H25N5O3
    Purity:98% - 99.64%
    Color and Shape:Solid
    Molecular weight:383.44

    Ref: TM-T6076

  • UNC0646
    Targetmol
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    UNC0646

    CAS:
    <p>UNC0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP with low cellular toxicity.</p>
    Formula:C36H59N7O2
    Purity:>99.99%
    Color and Shape:Solid
    Molecular weight:621.9

    Ref: TM-TQ0232

  • SGC0946
    Targetmol
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    SGC0946

    CAS:
    <p>SGC0946 is a highly effective and specific DOT1L methyltransferase inhibitor (IC50: 0.3 nM); selectively kill mixed lineage leukemia cells.</p>
    Formula:C28H40BrN7O4
    Purity:98% - 99.82%
    Color and Shape:Solid
    Molecular weight:618.57

    Ref: TM-T3082

  • UNC1215
    Targetmol
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    UNC1215

    CAS:
    <p>UNC1215, a potent MBT antagonist, targets L3MBTL3 with high selectivity (IC50: 40 nM, Kd: 120 nM, 50x versus MBT family).</p>
    Formula:C32H43N5O2
    Purity:98% - 99.04%
    Color and Shape:Solid
    Molecular weight:529.72

    Ref: TM-T2379