DNA Methyltransferase
DNA methyltransferases (DNMTs) are enzymes that catalyze the addition of methyl groups to cytosine residues in DNA, leading to gene silencing. Aberrant DNA methylation is associated with various diseases, including cancer. DNMT inhibitors block the activity of these enzymes, leading to the reactivation of silenced genes and induction of apoptosis in cancer cells. DNMT inhibitors are widely used in epigenetic research and cancer therapy. At CymitQuimica, we provide a range of high-quality DNMT inhibitors to support your research in epigenetics, DNA methylation, and cancer biology.
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IHMT-EZH2-426
IHMT-EZH2-426 (compound 38) is a potent, covalent degrader of EZH2, demonstrating IC50 values of 1.3 …
Formula:
C31H35FN4O4S
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
578.7
Ref: TM-T79780
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Thursday 5 Dec 2024
SW2_110A acetate
SW2_110A acetate is a selective, cell-permeable chromobox inhibitor of homologue CBX8 (Kd = 800 nM) …
Formula:
C44H64N6O9
Purity:
98%
Color and Shape:
Soild
Molecular weight:
821.01
Ref: TM-T36798L
| 1mg | 153.00 € | ||
| 5mg | 300.00 € | ||
| 10mg | 497.00 € | ||
| 25mg | 937.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
Chaetocin
CAS:28097-03-2
Chaetocin: a natural histone methyltransferase inhibitor; IC50 of 0.8, 2.5, and 3 μM for dSU(VAR)3-9, …
Formula:
C30H28N6O6S4
Purity:
98.82%
Color and Shape:
Solid
Molecular weight:
696.84
Ref: TM-T6803
| 1mg | 134.00 € | ||
| 5mg | 376.00 € | ||
| 10mg | 555.00 € | ||
| 25mg | 879.00 € | ||
| 50mg | 1,208.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
Anticancer agent 126
Anticancer agent 126 (compound 12), a WDR5 inhibitor, exhibits anticancer properties by disrupting the WDR5-MYC …
Formula:
C25H11BBr2F2N2O3S4
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
724.23
Ref: TM-T78929
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Thursday 5 Dec 2024
UNC 0631
CAS:1320288-19-4
UNC 0631 is a effectvie histone methyltransferase G9a inhibitor (IC50=4 nM).
Formula:
C37H61N7O2
Purity:
98.76%
Color and Shape:
Solid
Molecular weight:
635.93
Ref: TM-T2354
| 1mg | 49.00 € | ||
| 5mg | 95.00 € | ||
| 10mg | 150.00 € | ||
| 25mg | 291.00 € | ||
| 50mg | 459.00 € | ||
| 100mg | 668.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
BAY-6035
CAS:2247890-13-5
BAY-6035 is an inhibitor of SET and MYND domain-containing protein 3 (SMYD3). BAY-6035 has more …
Formula:
C22H28N4O3
Purity:
99.39%
Color and Shape:
Liquid
Molecular weight:
396.48
Ref: TM-T36631
| 5mg | 52.00 € | ||
| 10mg | 82.00 € | ||
| 25mg | 151.00 € | ||
| 50mg | 238.00 € | ||
| 100mg | To inquire | ||
| 1mL*10mM (DMSO) | 58.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
Dihydro-5-azacytidine FA
Dihydro-5-azacytidine FA (DHAC) is a pyrimidine analog that has antitumor activity, inhibits cell growth, inhibits …
Formula:
C9H16N4O7
Purity:
100%
Color and Shape:
Liquid
Molecular weight:
292.25
Ref: TM-T40713L
| 1mg | 198.00 € | ||
| 5mg | 490.00 € | ||
| 10mg | 687.00 € | ||
| 25mg | 1,072.00 € | ||
| 50mg | 1,479.00 € | ||
| 100mg | 1,894.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
CARM1 degrader-2
PROTAC CARM1 degrader-2 (compound 3e), with a DC50 value of 8.8 nM, is a VHL- …
Formula:
C72H100N12O7S
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
1277.71
Ref: TM-T79742
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Thursday 5 Dec 2024
Antiproliferative agent-25
Antiproliferative Agent-25 (Compound 3s4) is a selective PRMT5 inhibitor displaying an IC50 of 0.11 μM.
Formula:
C20H21BrN2O2
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
401.3
Ref: TM-T79275
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Thursday 5 Dec 2024
AMI-1 free acid
CAS:134-47-4
AMI-1: Potent reversible PRMT inhibitor; IC50: 8.8 μM (hPRMT1), 3.0 μM (yeast-Hmt1p); blocks substrate binding.
Formula:
C21H16N2O9S2
Purity:
97.8%
Color and Shape:
Solid
Molecular weight:
504.49
Ref: TM-T22239
| 1g | 275.00 € | ||
| 25mg | 47.00 € | ||
| 50mg | 61.00 € | ||
| 100mg | 88.00 € | ||
| 500mg | 186.00 € | ||
| 1mL*10mM (DMSO) | 34.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
O6-Benzylguanine
CAS:19916-73-5
Formula:
C12H11N5O
Purity:
>98.0%(T)(HPLC)
Color and Shape:
White to Light yellow powder to crystal
Molecular weight:
241.25
Ref: 3B-B4208
| 5g | 58.00 € | ||
| 25g | 186.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
MI-3454
CAS:2134169-43-8
MI-3454: potent, oral menin-MLL1 inhibitor, IC50 of 0.51 nM, halts leukemia cells, aids remission in …
Formula:
C32H35F3N8OS
Purity:
99.68%
Color and Shape:
Solid
Molecular weight:
636.73
Ref: TM-T39584
| 1mg | 185.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
(R)-HH2853
CAS:2202678-06-4
(R)-HH2853, a mutant EZH2 inhibitor, IC50 <100 nM for EZH2-Y641F, targets cancer/autoimmune diseases.
Formula:
C31H36F3N7O3
Purity:
100% - 97.14%
Color and Shape:
Liquid
Molecular weight:
611.66
Ref: TM-T73116
| 1mg | 311.00 € | ||
| 5mg | 747.00 € | ||
| 10mg | 1,059.00 € | ||
| 25mg | 1,579.00 € | ||
| 50mg | 2,127.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
BI-9321 trihydrochloride
CAS:2387510-87-2
BI-9321 trihydrochloride (BI9321 trihydrochloride) is an NSD3-PWWP1 antagonist that downregulates Myc messenger RNA expression.
Formula:
C22H24Cl3FN4
Purity:
99.12% - 99.96%
Color and Shape:
Solid
Molecular weight:
469.81
Ref: TM-T10538L
| 1mg | 50.00 € | ||
| 5mg | 105.00 € | ||
| 10mg | 181.00 € | ||
| 25mg | 356.00 € | ||
| 50mg | 601.00 € | ||
| 1mL*10mM (DMSO) | 116.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
SGC-iMLLT
CAS:2255338-25-9
SGC-iMLLT is a potent and selective MLLT1/3-histone interactions inhibitor(IC50 = 0.26 μM),and is a first-in-class …
Formula:
C22H24N6O
Purity:
98%
Color and Shape:
Solid
Molecular weight:
388.47
Ref: TM-T12886
| 2mg | 50.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
EPZ020411
CAS:1700663-41-7
EPZ020411 is a specific and effective inhibitor of PRMT6 (IC50=10 nM).
Formula:
C25H38N4O3
Color and Shape:
Solid
Molecular weight:
442.6
Ref: TM-T4314
| 2mg | 132.00 € | ||
| 5mg | 220.00 € | ||
| 10mg | 367.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
AZ505 ditrifluoroacetate
CAS:1035227-44-1
AZ505 ditrifluoroacetate is an effective and selective SMYD2 inhibitor (IC50: 0.12 μM).
Formula:
C33H40Cl2F6N4O8
Color and Shape:
Solid
Molecular weight:
805.59
Ref: TM-T10427
| 50mg | To inquire | ||
| 100mg | To inquire |
Estimated delivery in United States, on Tuesday 10 Dec 2024
EZM0414 TFA
CAS:2411759-92-5
EZM0414 TFA (SETD2-IN-1 TFA) is a SETD2 inhibitor with anticancer and antiproliferative effects for the …
Formula:
C24H30F4N4O4
Purity:
96.2%
Color and Shape:
Solid
Molecular weight:
514.51
Ref: TM-T36975
| 1mg | 278.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
2’-Deoxy-2’-fluoro-β-D-arabinocytidine hydrochloride
CAS:25183-22-6
2'-Deoxy-2'-fluoro-beta-D-arabinocytidine HCl inhibits DNA methyltransferase with potential anti-tumor properties.
Formula:
C9H13ClFN3O4
Purity:
99.69%
Color and Shape:
Liquid
Molecular weight:
281.67
Ref: TM-TNU0425
| 1mg | 182.00 € | ||
| 5mg | 401.00 € | ||
| 10mg | 591.00 € | ||
| 25mg | 917.00 € | ||
| 50mg | 1,262.00 € | ||
| 100mg | 1,698.00 € | ||
| 500mg | 3,431.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
MS023 dihydrochloride
CAS:1992047-64-9
MS023 dihydrochloride (MS023 2HCl) is a human type I protein arginine methyltransferase inhibitor with antitumour …
Formula:
C17H27Cl2N3O
Purity:
99.52%
Color and Shape:
Solid
Molecular weight:
360.32
Ref: TM-T61338
| 5mg | 83.00 € | ||
| 10mg | 104.00 € | ||
| 25mg | 171.00 € | ||
| 50mg | 246.00 € | ||
| 100mg | 365.00 € | ||
| 1mL*10mM (DMSO) | 47.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
