DNA Methyltransferase
DNA methyltransferases (DNMTs) are enzymes that catalyze the addition of methyl groups to cytosine residues in DNA, leading to gene silencing. Aberrant DNA methylation is associated with various diseases, including cancer. DNMT inhibitors block the activity of these enzymes, leading to the reactivation of silenced genes and induction of apoptosis in cancer cells. DNMT inhibitors are widely used in epigenetic research and cancer therapy. At CymitQuimica, we provide a range of high-quality DNMT inhibitors to support your research in epigenetics, DNA methylation, and cancer biology.
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MIV-6R
CAS:1560968-55-9
MIV-6R inhibits Menin-MLL interaction (IC50: 56 nM) and can be used to study leukemia.
Formula:
C27H35N3O
Purity:
100.00% - 99.88%
Color and Shape:
Solid
Molecular weight:
417.59
Ref: TM-T24472
| 1mg | 272.00 € | ||
| 5mg | 670.00 € | ||
| 10mg | 916.00 € | ||
| 25mg | 1,437.00 € | ||
| 50mg | 1,872.00 € | ||
| 100mg | 2,561.00 € |
Estimated delivery in United States, on Tuesday 18 Feb 2025
MS023 dihydrochloride
CAS:1992047-64-9
MS023 dihydrochloride (MS023 2HCl) is a human type I protein arginine methyltransferase inhibitor with antitumour …
Formula:
C17H27Cl2N3O
Purity:
99.52%
Color and Shape:
Liquid
Molecular weight:
360.32
Ref: TM-T61338
| 5mg | 83.00 € | ||
| 10mg | 104.00 € | ||
| 25mg | 171.00 € | ||
| 50mg | 246.00 € | ||
| 100mg | 365.00 € | ||
| 1mL*10mM (DMSO) | 47.00 € |
Estimated delivery in United States, on Tuesday 18 Feb 2025
MI-3454
CAS:2134169-43-8
MI-3454: potent, oral menin-MLL1 inhibitor, IC50 of 0.51 nM, halts leukemia cells, aids remission in …
Formula:
C32H35F3N8OS
Purity:
99.68%
Color and Shape:
Solid
Molecular weight:
636.73
Ref: TM-T39584
| 1mg | 185.00 € |
Estimated delivery in United States, on Tuesday 18 Feb 2025
O6-Benzylguanine
CAS:19916-73-5
Formula:
C12H11N5O
Purity:
>98.0%(T)(HPLC)
Color and Shape:
White to Light yellow powder to crystal
Molecular weight:
241.25
Ref: 3B-B4208
| 5g | 58.00 € | ||
| 25g | 186.00 € |
Estimated delivery in United States, on Tuesday 18 Feb 2025
AZ505 ditrifluoroacetate
CAS:1035227-44-1
AZ505 ditrifluoroacetate is an effective and selective SMYD2 inhibitor (IC50: 0.12 μM).
Formula:
C33H40Cl2F6N4O8
Color and Shape:
Solid
Molecular weight:
805.59
Ref: TM-T10427
| 50mg | To inquire | ||
| 100mg | To inquire |
Estimated delivery in United States, on Tuesday 18 Feb 2025
2’-Deoxy-2’-fluoro-β-D-arabinocytidine hydrochloride
CAS:25183-22-6
2'-Deoxy-2'-fluoro-beta-D-arabinocytidine HCl inhibits DNA methyltransferase with potential anti-tumor properties.
Formula:
C9H13ClFN3O4
Purity:
99.69%
Color and Shape:
Liquid
Molecular weight:
281.67
Ref: TM-TNU0425
| 1mg | 182.00 € | ||
| 5mg | 401.00 € | ||
| 10mg | 591.00 € | ||
| 25mg | 917.00 € | ||
| 50mg | 1,262.00 € | ||
| 100mg | 1,698.00 € | ||
| 500mg | 3,431.00 € |
Estimated delivery in United States, on Tuesday 18 Feb 2025
Bleximenib oxalate
CAS:2866179-95-3
Bleximenib oxalate (Menin-MLL inhibitor 24 oxalate) is a menin-MLL inhibitor that blocks the binding of …
Formula:
C34H52FN7O7
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
689.82
Ref: TM-T78151
| 1mg | 564.00 € | ||
| 5mg | 1,225.00 € | ||
| 10mg | 1,655.00 € | ||
| 25mg | 2,458.00 € | ||
| 50mg | 3,332.00 € |
Estimated delivery in United States, on Tuesday 18 Feb 2025
AS-85
CAS:2323623-80-7
AS-85 is an ASH1L inhibitor with anti-leukemic activity that inhibits leukemic cell growth and increases …
Formula:
C26H28F3N5O3S2
Purity:
98.96%
Color and Shape:
Solid
Molecular weight:
579.66
Ref: TM-T39861
| 1mg | 136.00 € | ||
| 5mg | 389.00 € | ||
| 10mg | 649.00 € | ||
| 25mg | 1,403.00 € | ||
| 50mg | 2,241.00 € | ||
| 100mg | 3,569.00 € |
Estimated delivery in United States, on Tuesday 18 Feb 2025
(S)-HH2853
CAS:2202678-05-3
(S)-HH2853 is a potent EZH1/2 inhibitor, aromatic, <100 nM IC50 for EZH2_Y641F, promising for anti-tumor/autoimmune …
Formula:
C31H36F3N7O3
Purity:
97.18% - 99.74%
Color and Shape:
Liquid
Molecular weight:
611.66
Ref: TM-T73115
| 1mg | 311.00 € | ||
| 5mg | 747.00 € | ||
| 10mg | 1,059.00 € | ||
| 25mg | 1,579.00 € | ||
| 50mg | 2,127.00 € |
Estimated delivery in United States, on Tuesday 18 Feb 2025
AMI-1 free acid
CAS:134-47-4
AMI-1: Potent reversible PRMT inhibitor; IC50: 8.8 μM (hPRMT1), 3.0 μM (yeast-Hmt1p); blocks substrate binding.
Formula:
C21H16N2O9S2
Purity:
97.8%
Color and Shape:
Solid
Molecular weight:
504.49
Ref: TM-T22239
| 1g | 275.00 € | ||
| 25mg | 47.00 € | ||
| 50mg | 61.00 € | ||
| 100mg | 88.00 € | ||
| 500mg | 186.00 € | ||
| 1mL*10mM (DMSO) | 34.00 € |
Estimated delivery in United States, on Tuesday 18 Feb 2025
MRK-740
CAS:2387510-80-5
MRK-740 is a PRDM9 histone methyltransferase inhibitor that inhibits H3K4 methylation.
Formula:
C25H32N6O3
Purity:
99.66%
Color and Shape:
Liquid
Molecular weight:
464.56
Ref: TM-T62957
| 5mg | 102.00 € | ||
| 10mg | 167.00 € | ||
| 25mg | 348.00 € | ||
| 50mg | 558.00 € | ||
| 100mg | 822.00 € | ||
| 1mL*10mM (DMSO) | 116.00 € |
Estimated delivery in United States, on Tuesday 18 Feb 2025
TNG-462
CAS:2760483-96-1
TNG-462 (Compound 1143) is a PRMT5 inhibitor with oral activity, being investigated for use in …
Formula:
C28H36N6O2S
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
520.69
Ref: TM-T79873
| 1mg | 496.00 € | ||
| 5mg | 1,097.00 € | ||
| 10mg | 1,711.00 € | ||
| 25mg | 2,911.00 € | ||
| 50mg | 4,498.00 € |
Estimated delivery in United States, on Tuesday 18 Feb 2025
SGC-iMLLT
CAS:2255338-25-9
SGC-iMLLT is a potent and selective MLLT1/3-histone interactions inhibitor(IC50 = 0.26 μM),and is a first-in-class …
Formula:
C22H24N6O
Purity:
99.21%
Color and Shape:
Solid
Molecular weight:
388.47
Ref: TM-T12886
| 2mg | 50.00 € |
Estimated delivery in United States, on Tuesday 18 Feb 2025
EPZ020411
CAS:1700663-41-7
EPZ020411 is a specific and effective inhibitor of PRMT6 (IC50=10 nM).
Formula:
C25H38N4O3
Color and Shape:
Solid
Molecular weight:
442.6
Ref: TM-T4314
| 2mg | 132.00 € | ||
| 5mg | 220.00 € | ||
| 10mg | 367.00 € |
Estimated delivery in United States, on Tuesday 18 Feb 2025
BI-9321 trihydrochloride
CAS:2387510-87-2
BI-9321 trihydrochloride (BI9321 trihydrochloride) is an NSD3-PWWP1 antagonist that downregulates Myc messenger RNA expression.
Formula:
C22H24Cl3FN4
Purity:
99.12% - 99.96%
Color and Shape:
Solid
Molecular weight:
469.81
Ref: TM-T10538L
| 1mg | 51.00 € | ||
| 5mg | 108.00 € | ||
| 10mg | 186.00 € | ||
| 25mg | 365.00 € | ||
| 50mg | 617.00 € | ||
| 1mL*10mM (DMSO) | 119.00 € |
Estimated delivery in United States, on Tuesday 18 Feb 2025
SGC2085
CAS:1821908-48-8
SGC2085 is an effective and selective coactivator-associated arginine methyltransferase 1 (CARM1) inhibitor (IC50: 50 nM).
Formula:
C19H24N2O2
Purity:
99.71% - 99.86%
Color and Shape:
Solid
Molecular weight:
312.41
Ref: TM-T7089
| 1mg | 87.00 € | ||
| 2mg | 118.00 € | ||
| 5mg | 225.00 € | ||
| 10mg | 337.00 € | ||
| 25mg | 557.00 € | ||
| 50mg | 810.00 € | ||
| 100mg | 1,116.00 € | ||
| 1mL*10mM (DMSO) | 159.00 € |
Estimated delivery in United States, on Thursday 20 Feb 2025
EPZ011989
CAS:1598383-40-4
EPZ011989: potent, selective oral EZH2 inhibitor, Ki < 3 nM, 15x more selective than EZH1, >3000x over other HMTases.
Formula:
C35H51N5O4
Purity:
98% - 99.81%
Color and Shape:
Solid
Molecular weight:
605.81
Ref: TM-T2435
| 2mg | 41.00 € | ||
| 5mg | 57.00 € | ||
| 10mg | 83.00 € | ||
| 25mg | 129.00 € | ||
| 50mg | 200.00 € | ||
| 100mg | 359.00 € |
Estimated delivery in United States, on Thursday 20 Feb 2025
UNC0642
CAS:1481677-78-4
UNC0642 is an effective and specific G9a/GLP inhibitor (IC50< 2.5 nM).
Formula:
C29H44F2N6O2
Purity:
98.75% - 99.5%
Color and Shape:
Solid
Molecular weight:
546.7
Ref: TM-T4166
| 1mg | 40.00 € | ||
| 2mg | 52.00 € | ||
| 5mg | 86.00 € | ||
| 10mg | 128.00 € | ||
| 25mg | 226.00 € | ||
| 50mg | 369.00 € | ||
| 100mg | 557.00 € | ||
| 200mg | 806.00 € | ||
| 1mL*10mM (DMSO) | 94.00 € |
Estimated delivery in United States, on Thursday 20 Feb 2025
SGC2085 HCl
CAS:1821908-49-9
SGC2085: potent, selective CARM1 inhibitor; IC50=50 nM; >100x selectivity vs other PRMTs; impacts cancer growth.
Formula:
C19H24N2O2·HCl
Purity:
99.91%
Color and Shape:
Solid
Molecular weight:
348.87
Ref: TM-T4013
| 1mg | 92.00 € | ||
| 2mg | 147.00 € | ||
| 5mg | 186.00 € | ||
| 10mg | 337.00 € | ||
| 25mg | 554.00 € | ||
| 50mg | 807.00 € | ||
| 100mg | 1,112.00 € | ||
| 1mL*10mM (DMSO) | 242.00 € |
Estimated delivery in United States, on Thursday 20 Feb 2025
BCI-121
CAS:432529-82-3
BCI-121 is a substrate-competitive SMYD3 inhibitor that inhibits the proliferation of the cancer cell.
Formula:
C14H18BrN3O2
Purity:
99.67%
Color and Shape:
Solid
Molecular weight:
340.22
Ref: TM-T5322
| 1mg | 35.00 € | ||
| 5mg | 65.00 € | ||
| 10mg | 96.00 € | ||
| 25mg | 185.00 € | ||
| 50mg | 294.00 € | ||
| 100mg | 467.00 € | ||
| 1mL*10mM (DMSO) | 72.00 € |
Estimated delivery in United States, on Thursday 20 Feb 2025
