DNA Methyltransferase
DNA methyltransferases (DNMTs) are enzymes that catalyze the addition of methyl groups to cytosine residues in DNA, leading to gene silencing. Aberrant DNA methylation is associated with various diseases, including cancer. DNMT inhibitors block the activity of these enzymes, leading to the reactivation of silenced genes and induction of apoptosis in cancer cells. DNMT inhibitors are widely used in epigenetic research and cancer therapy. At CymitQuimica, we provide a range of high-quality DNMT inhibitors to support your research in epigenetics, DNA methylation, and cancer biology.
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MS023
CAS:1831110-54-3
MS023 is a potent, selective, and cell-active Type I PRMT inhibitor with IC50 of 30 …
Formula:
C17H25N3O
Purity:
98.31% - 99.28%
Color and Shape:
Solid
Molecular weight:
287.4
Ref: TM-T6900
| 1mg | 39.00 € | ||
| 2mg | 51.00 € | ||
| 5mg | 86.00 € | ||
| 10mg | 118.00 € | ||
| 25mg | 238.00 € | ||
| 50mg | 369.00 € | ||
| 100mg | 550.00 € | ||
| 500mg | 1,194.00 € | ||
| 1mL*10mM (DMSO) | 83.00 € |
Estimated delivery in United States, on Tuesday 17 Dec 2024
SGI-1027
CAS:1020149-73-8
SGI-1027 (DNA Methyltransferase Inhibitor II) is an effective and selective inhibitor of DNA methyltransferase (DNMT).
Formula:
C27H23N7O
Purity:
99.18% - 99.45%
Color and Shape:
Solid
Molecular weight:
461.52
Ref: TM-T1904
| 5mg | 57.00 € | ||
| 10mg | 92.00 € | ||
| 25mg | 160.00 € | ||
| 50mg | 292.00 € | ||
| 100mg | 457.00 € | ||
| 500mg | 1,016.00 € | ||
| 1mL*10mM (DMSO) | 74.00 € |
Estimated delivery in United States, on Tuesday 17 Dec 2024
MR837
CAS:1210906-48-1
MR837 (NSD2-PWWP1 antagonist 3f) is a NSD2-PWWP1 antagonist.
Formula:
C16H14N2OS
Purity:
99.29% - 99.77%
Color and Shape:
Solid
Molecular weight:
282.36
Ref: TM-T8879
| 2mg | 40.00 € | ||
| 5mg | 57.00 € | ||
| 10mg | 94.00 € | ||
| 25mg | 142.00 € | ||
| 50mg | 249.00 € | ||
| 100mg | 365.00 € | ||
| 200mg | 515.00 € | ||
| 1mL*10mM (DMSO) | 69.00 € |
Estimated delivery in United States, on Tuesday 17 Dec 2024
SGC2085
CAS:1821908-48-8
SGC2085 is an effective and selective coactivator-associated arginine methyltransferase 1 (CARM1) inhibitor (IC50: 50 nM).
Formula:
C19H24N2O2
Purity:
99.71% - 99.86%
Color and Shape:
Solid
Molecular weight:
312.41
Ref: TM-T7089
| 1mg | 87.00 € | ||
| 2mg | 118.00 € | ||
| 5mg | 225.00 € | ||
| 10mg | 337.00 € | ||
| 25mg | 557.00 € | ||
| 50mg | 810.00 € | ||
| 100mg | 1,116.00 € | ||
| 1mL*10mM (DMSO) | 159.00 € |
Estimated delivery in United States, on Tuesday 17 Dec 2024
BRD4770
CAS:1374601-40-7
BRD4770 is a histone methyltransferase G9a inhibitor and induces cell senescence.
Formula:
C25H23N3O3
Purity:
99.82%
Color and Shape:
Solid
Molecular weight:
413.47
Ref: TM-T1923
| 2mg | 35.00 € | ||
| 5mg | 52.00 € | ||
| 10mg | 83.00 € | ||
| 25mg | 123.00 € | ||
| 50mg | 193.00 € | ||
| 100mg | 343.00 € | ||
| 1mL*10mM (DMSO) | 58.00 € |
Estimated delivery in United States, on Tuesday 17 Dec 2024
γ-Oryzanol
CAS:11042-64-1
γ-Oryzanol (Gamma-Oryzanol) is a natural nutrient extract isolated from rice bran oil that contains a …
Formula:
C40H58O4
Purity:
mixture - mixture
Color and Shape:
White Or White Crystalline Powder Odourless
Molecular weight:
602.9
Ref: TM-T3606
| 1g | 57.00 € | ||
| 500mg | 53.00 € | ||
| 1mL*10mM (DMSO) | 49.00 € |
Estimated delivery in United States, on Tuesday 17 Dec 2024
JNJ-64619178
CAS:2086772-26-9
JNJ-64619178: selective, oral, pseudo-irreversible PRMT5 inhibitor (IC50: 0.14 nM), effective in lung cancer.
Formula:
C22H23BrN6O2
Purity:
98.44% - 99.63%
Color and Shape:
Solid
Molecular weight:
483.36
Ref: TM-T15624
| 1mg | 88.00 € | ||
| 5mg | 168.00 € | ||
| 10mg | 271.00 € | ||
| 25mg | 560.00 € | ||
| 50mg | 932.00 € | ||
| 100mg | 1,638.00 € | ||
| 1mL*10mM (DMSO) | 182.00 € |
Estimated delivery in United States, on Tuesday 17 Dec 2024
GSK503
CAS:1346572-63-1
GSK-503, a potent EZH2 inhibitor, has potential antitumor activity.
Formula:
C31H38N6O2
Purity:
98% - 99.74%
Color and Shape:
Solid
Molecular weight:
526.67
Ref: TM-T1775
| 1mg | 36.00 € | ||
| 2mg | 52.00 € | ||
| 5mg | 78.00 € | ||
| 10mg | 109.00 € | ||
| 25mg | 204.00 € | ||
| 50mg | 368.00 € | ||
| 100mg | 551.00 € | ||
| 500mg | 1,188.00 € | ||
| 1mL*10mM (DMSO) | 92.00 € |
Estimated delivery in United States, on Tuesday 17 Dec 2024
2',3',5'-triacetyl-5-Azacytidine
CAS:10302-78-0
2',3',5'-triacetyl-5-Azacytidine (Nsc291930) is a prodrug form of 5-azacytidine that may be rapidly absorbed orally.
Formula:
C14H18N4O8
Purity:
98.34%
Color and Shape:
Solid
Molecular weight:
370.31
Ref: TM-T7840
| 2mg | 39.00 € | ||
| 5mg | 51.00 € | ||
| 10mg | 78.00 € | ||
| 25mg | 124.00 € | ||
| 50mg | 181.00 € | ||
| 100mg | 271.00 € | ||
| 200mg | 392.00 € | ||
| 1mL*10mM (DMSO) | 62.00 € |
Estimated delivery in United States, on Tuesday 17 Dec 2024
Hinokitiol
CAS:499-44-5
Hinokitiol prevents UVB-caused cell death, boosts antioxidant activity, and hinders breast cancer growth.
Formula:
C10H12O2
Purity:
99.49% - 99.67%
Color and Shape:
Solid
Molecular weight:
164.2
Ref: TM-T3717
| 1g | 184.00 € | ||
| 50mg | 36.00 € | ||
| 100mg | 60.00 € | ||
| 200mg | 87.00 € | ||
| 500mg | 128.00 € | ||
| 1mL*10mM (DMSO) | 42.00 € |
Estimated delivery in United States, on Tuesday 17 Dec 2024
GSK3685032
CAS:2170137-61-6
GSK3685032 is a non-covalent and selective DNMT1 inhibitor(IC50 = 36 nM).
Formula:
C22H24N6OS
Purity:
99.49%
Color and Shape:
Solid
Molecular weight:
420.53
Ref: TM-T9573
| 1mg | 91.00 € | ||
| 5mg | 184.00 € | ||
| 10mg | 296.00 € | ||
| 25mg | 555.00 € | ||
| 50mg | 795.00 € | ||
| 100mg | 1,087.00 € | ||
| 1mL*10mM (DMSO) | 200.00 € |
Estimated delivery in United States, on Tuesday 17 Dec 2024
MS37452
CAS:423748-02-1
MS37452 is a competitive inhibitor of CBX7 chromodomain binding to H3K27me3 (Ki = 43 µM).
Formula:
C22H26N2O5
Purity:
99.39% - 99.39%
Color and Shape:
Solid
Molecular weight:
398.45
Ref: TM-T21767
| 5mg | 51.00 € | ||
| 10mg | 87.00 € | ||
| 25mg | 167.00 € | ||
| 50mg | 302.00 € | ||
| 100mg | 521.00 € | ||
| 500mg | 1,096.00 € | ||
| 1mL*10mM (DMSO) | 57.00 € |
Estimated delivery in United States, on Tuesday 17 Dec 2024
PFI-2
CAS:1627676-59-8
PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold …
Formula:
C23H25F4N3O3S
Purity:
98%
Color and Shape:
Solid
Molecular weight:
499.52
Ref: TM-T1987
| 5mg | 90.00 € | ||
| 10mg | 126.00 € | ||
| 25mg | 238.00 € | ||
| 50mg | 416.00 € | ||
| 100mg | 750.00 € |
Estimated delivery in United States, on Tuesday 17 Dec 2024
6-Thioguanine
CAS:154-42-7
6-Thioguanine (2-Amino-6-purinethiol) is an antineoplastic compound which also has antimetabolite action. The drug is used …
Formula:
C5H5N5S
Purity:
100% - 98.75%
Color and Shape:
Odorless Or Almost Odorless Pale Yellow Crystalline Powder
Molecular weight:
167.19
Ref: TM-T3089
| 50mg | 52.00 € | ||
| 100mg | 57.00 € | ||
| 500mg | 83.00 € | ||
| 1mL*10mM (DMSO) | 55.00 € |
Estimated delivery in United States, on Tuesday 17 Dec 2024
lutidinic acid
CAS:499-80-9
lutidinic acid (2,4-Dicarboxypyridine) is an in vitro and in cell inhibitor, as well as a …
Formula:
C7H5NO4
Purity:
99.96%
Color and Shape:
White To Off-White Crystalline Powder
Molecular weight:
167.12
Ref: TM-T2167
| 100mg | 34.00 € | ||
| 1mL*10mM (DMSO) | 47.00 € |
Estimated delivery in United States, on Tuesday 17 Dec 2024
EED226
CAS:2083627-02-3
EED226 is a potent, selective, and orally bioavailable embryonic ectoderm development (EED) inhibitor with an …
Formula:
C17H15N5O3S
Purity:
98.14% - 99.66%
Color and Shape:
Solid
Molecular weight:
369.4
Ref: TM-T3458
| 2mg | 40.00 € | ||
| 5mg | 52.00 € | ||
| 10mg | 82.00 € | ||
| 25mg | 121.00 € | ||
| 50mg | 194.00 € | ||
| 100mg | 345.00 € | ||
| 1mL*10mM (DMSO) | 53.00 € |
Estimated delivery in United States, on Tuesday 17 Dec 2024
EPZ011989
CAS:1598383-40-4
EPZ011989: potent, selective oral EZH2 inhibitor, Ki < 3 nM, 15x more selective than EZH1, >3000x over other HMTases.
Formula:
C35H51N5O4
Purity:
98% - 99.81%
Color and Shape:
Solid
Molecular weight:
605.81
Ref: TM-T2435
| 2mg | 41.00 € | ||
| 5mg | 57.00 € | ||
| 10mg | 83.00 € | ||
| 25mg | 129.00 € | ||
| 50mg | 200.00 € | ||
| 100mg | 359.00 € |
Estimated delivery in United States, on Tuesday 17 Dec 2024
UNC3866 TFA(1872382-47-2 free base)
CAS:1872382-48-3
UNC3866 TFA is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen.
Formula:
C45H67F3N6O10
Purity:
98.6%
Color and Shape:
Solid
Molecular weight:
909.04
Ref: TM-T4021L
| 1mg | 37.00 € | ||
| 2mg | 52.00 € | ||
| 5mg | 72.00 € | ||
| 10mg | 116.00 € | ||
| 25mg | 220.00 € | ||
| 50mg | 327.00 € | ||
| 100mg | 455.00 € | ||
| 200mg | 632.00 € | ||
| 1mL*10mM (DMSO) | 149.00 € |
Estimated delivery in United States, on Tuesday 17 Dec 2024
CM-272
CAS:1846570-31-7
CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor.
Formula:
C28H38N4O3
Purity:
98.21%
Color and Shape:
Solid
Molecular weight:
478.63
Ref: TM-T7194
| 1mg | 72.00 € | ||
| 5mg | 157.00 € | ||
| 10mg | 269.00 € | ||
| 25mg | 503.00 € | ||
| 50mg | 722.00 € | ||
| 100mg | 1,012.00 € | ||
| 1mL*10mM (DMSO) | 169.00 € |
Estimated delivery in United States, on Tuesday 17 Dec 2024
GSK343
CAS:1346704-33-3
GSK343, a specific and effective EZH2 inhibitor (IC50=4 nM), exhibits 60 fold specificity activity against …
Formula:
C31H39N7O2
Purity:
98% - 99.9%
Color and Shape:
Solid
Molecular weight:
541.69
Ref: TM-T6059
| 5mg | 58.00 € | ||
| 10mg | 94.00 € | ||
| 25mg | 168.00 € | ||
| 50mg | 276.00 € | ||
| 100mg | 500.00 € | ||
| 1mL*10mM (DMSO) | 71.00 € |
Estimated delivery in United States, on Tuesday 17 Dec 2024
